| Project/Area Number |
21390059
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Kagoshima University |
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Principal Investigator |
KAMEYAMA Masaki 鹿児島大学, 医歯学総合研究科, 教授 (60150059)
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| Co-Investigator(Kenkyū-buntansha) |
YAZAWA Kazuto 鹿児島大学, 大学院・医歯学総合研究科, 講師 (90212274)
MINOBE Etsuko 鹿児島大学, 大学院・医歯学総合研究科, 助教 (00448581)
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| Co-Investigator(Renkei-kenkyūsha) |
XU Jian-jun 鹿児島大学, 大学院・医歯学総合研究科, 助教 (10581689)
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| Research Collaborator |
KAMEYAMA Asako 鹿児島大学, 大学院・医歯学総合研究科, 客員研究員
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 生体膜 / チャネル / シグナル伝達 / リン酸化 / トランスポーター / 能動輸送 |
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| Research Abstract |
We investigated regulation of L-type Ca2+channels by calmodulin(CaM) and phosphorylation. CaM bound to preIQ and IQ regions in the C-terminal of the channel. PKA phosphorylated Ser1574 and Ser1626 as well as Ser1927(guinea-pig). The facilitatory effect of CaM was enhanced by CaMKII-mediated phosphorylation of Thr1603, suggesting a cross-talk between the CaM's effect and channel phosphorylation.
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