| Project/Area Number |
21390062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Keio University |
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Principal Investigator |
MATSUZAKI Yumi 慶應義塾大学, 医学部, 特任准教授 (50338183)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMURA Yoshimi 慶應義塾大学, 医学部, 助教 (20505044)
SUZUKI Sadafumi 慶應義塾大学, 医学部, 研究員 (70465003)
MORIKAWA Satoru 慶應義塾大学, 医学部, 助教 (00424169)
MABUCHI Yo 慶應義塾大学, 医学部, 助教 (50424172)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 間葉系幹細胞 / 再生医学 / 細胞・組織 / 移植・再生医療 / 間薬系幹細胞 |
|---|
| Research Abstract |
It has been advocated that Wnt, Notch signals involve molecular mechanism of self-renewal or differentiation in various somatic stem cells. In mammalian development, stem cell controls complicated organizational structure as high-order function, while controlling self-renew and differentiation. In this project, we attempted to clarify self-renewal and cell lineage decision mechanism of MSC. Our method was to visualize Wnt, Notch signals, which has a potential for temporospatial controls of stem cells. By visualizing Wnt, Notch signals, we could analyze how Wnt/Notch separates their roles, or interacts with other molecules in order for self-replication.
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