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Integration of multi-oscillator circadian clock: in vivo and ex vivo imaging of clock gene expression

Research Project

Project/Area Number 21390064
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionHokkaido University

Principal Investigator

HONMA Sato  北海道大学, 大学院・医学研究科, 特任教授 (20142713)

Co-Investigator(Kenkyū-buntansha) 吉川 朋子 (仲村 朋子)  北海道大学, 大学院・医学研究科, 特任助教 (30451397)
西出 真也  北海道大学, 大学院・医学研究科, 助教 (40451398)
Co-Investigator(Renkei-kenkyūsha) HAMADA Toshiyuki  北海道大学, 大学院・医学研究科, 特任講師 (20360208)
NAKAMURA Tomoko (YOSHIKAWA Tomoko)  北海道大学, 大学院・医学研究科, 特任助教 (30451397)
NISHIDE Shin-ya  北海道大学, 大学院・医学研究科, 助教 (40451398)
ENOKI Ryosuke  北海道大学, 大学院・医学研究科, 助教 (00528341)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywords生体リズム / 時計遺伝子 / イメージング / ルシフェラーゼ / 視交叉上核 / 生物リズム / 生物時計 / 発光イメージング / リズム同期 / 自発発火
Research Abstract

We aimed to clarify mutual coupling mechanisms of oscillator cells in the central circadian clock, the suprachiasmatic nucleus (SCN). We developed in vivo monitoring systems for clock gene expression from the SCN of unanesthetized and unrestrained animals and a long-term and real-time ex vivo monitoring systems for intracellular Ca++ levels from the entire neurons of cultured SCN slices. We demonstrated that all SCN neurons exhibit robust circadian rhythms in Ca++ levels which are topologically specific and the coupling between the pacemakers in the dorsal and ventral SCN depends on synaptic interaction. We further demonstrated that clock gene Cry is essential for the development of oscillator cell network in the SCN for the coherent rhythm expression which takes place around weaning period.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (90 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (30 results) (of which Peer Reviewed: 27 results) Presentation (45 results) (of which Invited: 9 results) Book (12 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus2013

    • Author(s)
      Ono D, Honma S, and Honma K
    • Journal Title

      Nat. Comm

      Volume: (in press) Issue: 1 Pages: 1666-1666

    • DOI

      10.1038/ncomms2670

    • NAID

      120005343762

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fast synchronous oscillations of firing rate in cultured rat suprachiasmatic nucleus neurons:possible role in circadian synchronization in the intact nucleus2013

    • Author(s)
      Kononenko NI, Honma K and Honma S
    • Journal Title

      Neurosci. Res

      Volume: 75 Issue: 3 Pages: 218-227

    • DOI

      10.1016/j.neures.2013.01.003

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Daily exposure to cold phase-shifts circadian clock of neonatal rat in vivo2013

    • Author(s)
      Yoshikawa T, Matsuno A, Yamanaka Y, Nishide S, Honma S and Honma K
    • Journal Title

      Eur.J.Neurosci

      Volume: 37 Issue: 3 Pages: 491-497

    • DOI

      10.1111/ejn.12052

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential responses of circadian Per2 expression rhythms in discrete brain areas to daily injection of methamphetamine and restricted feeding in rats.2013

    • Author(s)
      Natsubori A. et al.
    • Journal Title

      Eur.J.Neurosci.

      Volume: 37 Issue: 2 Pages: 251-258

    • DOI

      10.1111/ejn.12034

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Topological specificity and hierarchical network of the circadian calcium rhythm in the suprachiasmatic nucleus2012

    • Author(s)
      Enoki R, Kuroda S, Ono C, Hasan MT, Honma S, Ueda T and Honma K
    • Journal Title

      Proc.Natl. Acad.Sci USA

      Volume: 109 Issue: 52 Pages: 21498-21503

    • DOI

      10.1073/pnas.1214415110

    • NAID

      120005295647

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human blood metabolite timetable indicates internal body time2012

    • Author(s)
      Kasukawa T, Sugimoto M, Hida A, Minami Y, Mori M, Honma S, Honma K, Mishima K, Soga T, Ueda HR
    • Journal Title

      Proc.Natl. Acad. Sci. U.S.A

      Volume: 109(37) Issue: 37 Pages: 15036-41

    • DOI

      10.1073/pnas.1207768109

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suprachiasmatic nucleus: cellular clocks and networks2012

    • Author(s)
      Honma S, Ono D, Suzuki Y, Inagaki N, Yoshikawa T, Nakamura W and Honma K
    • Journal Title

      In Progress in Brain Res

      Volume: 199 Pages: 129-141

    • DOI

      10.1016/b978-0-444-59427-3.00029-0

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single-cell resolution fluorescence imaging of circadian rhythms detected with a Nipkow spinning disk confocal system.2012

    • Author(s)
      Enoki R. et al.
    • Journal Title

      J Neurosci Methods

      Volume: 202 Issue: 1 Pages: 72-79

    • DOI

      10.1016/j.jneumeth.2012.03.004

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] JNK regulates the photic response of the mammalian circadian clock2012

    • Author(s)
      Yoshitane, H., Honma, S., Fukada, Y., 他11名、6番目
    • Journal Title

      EMBO Rep.

      Volume: (印刷中) Issue: 5 Pages: 455-461

    • DOI

      10.1038/embor.2012.37

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synchronized ATP oscillations have a critical role in prechondrogenic condensation during chondrogenesis2012

    • Author(s)
      Kwon HJ, Ohmiya Y, Honma K-I, Hnma S, nagai T, Saito K, Yasuda K
    • Journal Title

      Cell Death and Disease

      Volume: 3 Issue: 3 Pages: e278-e278

    • DOI

      10.1038/cddis.2012.20

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] De novo synthesis of PERIOD initiates circadian oscillation in cultured mouse suprachiasmatic nucleus after prolonged inhibition of protein synthesis by cycloheximide2012

    • Author(s)
      Nishide, S.Y., Ono, D., Yamada, Y., Honma, S., Honma, K.
    • Journal Title

      Eur.J.Neurosci.

      Volume: 35 Issue: 2 Pages: 291-299

    • DOI

      10.1111/j.1460-9568.2011.07952.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of basic helix-loop-helix transcription factors Dec1 and Dec2 by RORα and their roles in adipogenesis2012

    • Author(s)
      Ozaki N, Noshiro M, Kawamoto T, Nakashima A, Honda K, Fukuzaki-Dohi U, Honma S, Fujimoto K, Tanimoto K, Tanne K and Kato, Y
    • Journal Title

      Genes Cells

      Volume: 17 Pages: 109-21

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of basic helix-loop-helix transcription factors Dec1 and Dec2 by RORα and their roles in adipogenesis.2012

    • Author(s)
      Ozaki N
    • Journal Title

      Genes to Cells

      Volume: 17 Issue: 2 Pages: 107-121

    • DOI

      10.1111/j.1365-2443.2011.01574.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Light responsiveness of clock genes, Per1 and Per2, in the olfactory bulb of mice2011

    • Author(s)
      Hamada T, Homna S, Honma K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 409 Issue: 4 Pages: 727-731

    • DOI

      10.1016/j.bbrc.2011.05.076

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physical exercise accelerates re-entrainment of human sleep-wake cycle but not of plasma melatonin rhythm to 8 h phase-advanced sleep schedule2011

    • Author(s)
      YamanakaY, Hashimoto S, Tanahashi Y, Nishide S, Honma S, and Honma K
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 298

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of circadian rhythm andlight-induced suppression of pineal melatonin levels in Cry1 and Cry2 double-deficient mice2010

    • Author(s)
      Yamanaka Y, Suzuki Y, Todo T, Honma K andHonma S
    • Journal Title

      Genes to Cells

      Volume: 15 Issue: 10 Pages: 1063-1071

    • DOI

      10.1111/j.1365-2443.2010.01443.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multichannel perfusion culture bioluminescence reporter system for long-term detection in living cells2010

    • Author(s)
      Watanabe T, Enomoto T, Takahashi M, Honma S, Honma K, Ohmiya Y
    • Journal Title

      Anal. Biochem

      Volume: 402 Issue: 1 Pages: 107-109

    • DOI

      10.1016/j.ab.2010.03.014

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-sustained circadian rhythm in cultured humanmononuclear cells isolated from peripheral blood2010

    • Author(s)
      Ebisawa T, Numazawa K, Shimada H, IzutsubH, Sasaki T, Kato N, Tokunaga K, Akio Mori A, Honma K, Honma S, Shibata S
    • Journal Title

      Neurosci Res

      Volume: 66 Issue: 2 Pages: 223-227

    • DOI

      10.1016/j.neures.2009.10.007

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-sustained circadian rhythm in cultured human mononuclear cells isolated from peripheral blood2010

    • Author(s)
      Ebisawa T
    • Journal Title

      Neurosci Res

      Volume: 66 Pages: 223-227

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of circadian rhythm and light-induced suppression of pineal melatonin levels in Cry1 and Cry2 double-deficient mice2010

    • Author(s)
      Yamanaka Y
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 298

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multichannel perfusion culture bioluminescence reporter system for long-term detection in livins cells2010

    • Author(s)
      Watanabe T
    • Journal Title

      Anal.Biochem.

      Volume: 402 Pages: 107-109

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of circadian rhythm and light-induced suppression of pineal melatonin levels in Cry1 and Cry2 double-deficient mice2010

    • Author(s)
      Yamanaka Y
    • Journal Title

      Genes to Cells

      Volume: 15 Pages: 1063-1071

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生物時計のイメージング2010

    • Author(s)
      本間さと
    • Journal Title

      自律神経

      Volume: 47 Pages: 102-106

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 体のリズムを統合する脳の時計機能2010

    • Author(s)
      本間さと
    • Journal Title

      ビオフィリア

      Volume: 6 Pages: 13-19

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Physical exercise accelerates re-entrainment of human sleep-wake cycle but not of plasma melatonin rhythm to 8 h phase-advanced sleep schedule.2010

    • Author(s)
      Yamanaka, Y.
    • Journal Title

      Am.J.Physiol.Regul.Integ.Comp.Physiol.

      Volume: 298

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The liver X receptors (LXRα and LXRβ) are potent regulators for hepatic Dec1 expression2009

    • Author(s)
      Noshiro M, Usui E, Kawamoto T, Sato F, Nakashima A, Ueshima T, Honda K, Fujimoto K, Honma S, Honma K, Makishima M and Kato Y
    • Journal Title

      Genes to Cells

      Volume: 14 Pages: 29-40

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The liver X receptors (LXR α and LXR β) are potent regulators for hepatic Dec 1 expression2009

    • Author(s)
      Noshiro, M.
    • Journal Title

      Genes to Cells

      Volume: 14 Pages: 29-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-sustained circadian rhythm in cultured human mononuclear cells isolated from peripheral blood.2009

    • Author(s)
      Ebisawa, S.
    • Journal Title

      Neurosci Res.

      Volume: 66 Pages: 223-227

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The SCN-independent clocks, methamphetamine and food restriction.2009

    • Author(s)
      Honma, K.
    • Journal Title

      Eur.J.Neurosci

      Volume: 30 Pages: 1707-1717

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 睡眠障害の時間治療2009

    • Author(s)
      山仲勇二郎
    • Journal Title

      医療ジャーナル

      Volume: 145 Pages: 107-112

    • Related Report
      2009 Annual Research Report
  • [Presentation] Monitoring the circadian clock'stick; multiple hands for multiple functions2012

    • Author(s)
      Honma S
    • Organizer
      4th International Symposium on Photonic Bioimaging
    • Place of Presentation
      Hokkaido University Conference Center
    • Related Report
      2011 Final Research Report
  • [Presentation] Multi-oscillator System of Mammalian Circadian Clock2012

    • Author(s)
      Honma S. Natsubori A, Honma K
    • Organizer
      Symposium "Molecular and cellular mechanisms of circadian clock and sleep", Asian Society for Sleep Research
    • Place of Presentation
      Taipei International Convention Center, Taiwan
    • Related Report
      2011 Final Research Report
  • [Presentation] Suprachiasmatic nucleus output couplings. Suprachiasmatic Structure Workshop2012

    • Author(s)
      Honma S
    • Organizer
      Society for Research on Biological Rhythms Biannual meeting 2012
    • Place of Presentation
      Sandestin Golf and Beach Resort, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Signal integration of circadian neuronal networks2012

    • Author(s)
      Honma S
    • Organizer
      Society for Research on Biological Rhythms Biannual Meeting 2012
    • Place of Presentation
      Sandestin Golf and Beach Resort, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Continuous monitoring of circadian clock' s tick in the suprachiasmatic neurons2012

    • Author(s)
      Honma S
    • Organizer
      International Syposium on Frontiers in Sleep and Biological Rhythms' Research
    • Place of Presentation
      Dokuz Eylul University Izmir,Turkey
    • Related Report
      2011 Final Research Report
  • [Presentation] Continuous monitoring of circadian clock’ s tick in the suprachiasmatic neurons.2012

    • Author(s)
      Honma S
    • Organizer
      International Syposium on Frontiers in Sleep and Biological Rhythms’ Research
    • Place of Presentation
      International Syposium on Frontiers in Sleep and Biological Rhythms’ Research,Turkey
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 生物時計の発達と睡眠覚醒リズム:時間生物学の小児科学への応用2012

    • Author(s)
      本間 さと
    • Organizer
      第54回日本小児神経学会
    • Place of Presentation
      札幌ロイトンホテル(札幌市)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Signal integration of circadian neuronal networks.2012

    • Author(s)
      Honma S
    • Organizer
      Society for Research on Biological Rhythms Biannual meeting
    • Place of Presentation
      Sandestin Resort, Destin, FL,USA
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Suprachiasmatic nucleus output couplings.2012

    • Author(s)
      Honma S
    • Organizer
      Society for Research on Biological Rhythms Biannual meeting
    • Place of Presentation
      Sandestin Resort, Destin, FL,USA
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 覚醒マウスにおける時計遺伝子発現の4Dイメージング2012

    • Author(s)
      浜田 俊幸
    • Organizer
      第2回睡眠研究会
    • Place of Presentation
      名古屋大学シンポジオン(名古屋市)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 中枢時計の発達と時計遺伝子機能2012

    • Author(s)
      小野 大輔
    • Organizer
      第19回日本時間生物学会学術大会
    • Place of Presentation
      北海道大学学術交流会館(札幌市)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 母仔同調因子としての環境温:in vivoにおける視交叉上核の温度感受性2012

    • Author(s)
      吉川 朋子
    • Organizer
      第19回日本時間生物学会学術大会
    • Place of Presentation
      北海道大学学術交流会館(札幌市)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Monitoring the circadian clock’s tick; multiple hands for multiple functions2012

    • Author(s)
      Honma S
    • Organizer
      4th International Symposium on Photonic Bioimaging
    • Place of Presentation
      Hokkaido University Conference Center, Sapporo
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 時計遺伝子と生物時計の発達2012

    • Author(s)
      本間 さと
    • Organizer
      日本小児神経学会第42回小児神経学セミナー
    • Place of Presentation
      湘南国際村(逗子市)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Cellular rhythms and oscillatory networks in the suprachiasmatic nucleus2011

    • Author(s)
      Honma S
    • Organizer
      Workshop: Emergence of circadian rhythms from the central pacemaker and beyond
    • Place of Presentation
      Institute of Theoretical Biology, Humboldt University, Germany
    • Year and Date
      2011-08-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Single cell neuronal clocks and regional pacemakers in the suprachiasmatic nucleus2011

    • Author(s)
      Honma, S
    • Organizer
      International Symposium on Photonic Bioimaging
    • Place of Presentation
      Keio Plaza Hotel, Sapporo
    • Related Report
      2011 Final Research Report
  • [Presentation] Mammalian circadian clocks detecting morning light and evening lights2011

    • Author(s)
      Honma S, Yoshikawa T and Honma K
    • Organizer
      6th World congress of the World Sleep Federation
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] Animal models of human sleep-wake cycle: non-SCN circadian behavior rhythms in rodents2011

    • Author(s)
      Kameyama A, Honma S., Honma K
    • Organizer
      6th World congress of the World Sleep Federation
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] Effect of scheduled physical exercise on re-entrainment of human circadian rhythms to 8 h advanced sleep schedule in isolation facility2011

    • Author(s)
      Yamanaka Y, Hashimoto S, Honma S. and Honma K
    • Organizer
      6th World Congress of the World Sleep Federation
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] Suprachiasmatic nucleus: cellular clocks and networks2011

    • Author(s)
      Honma S
    • Organizer
      12th Congress of European Society for Biological Rhythm
    • Place of Presentation
      Oxford, UK
    • Related Report
      2011 Final Research Report
  • [Presentation] Network vs single neuronal rhythms in the SCN.2011

    • Author(s)
      Honma S
    • Organizer
      Symposium:Molecular and network properties of the suprachiasmatic nucleus, the 3rd World Congress of Chronobiology
    • Place of Presentation
      Cultural Center BUAP, Puebra, Mexico
    • Related Report
      2011 Final Research Report
  • [Presentation] Panel Discussion "Neurophysiology and humoral regulation of sleep"2010

    • Author(s)
      Honma S. and Honma K. Animal model of human sleep-wake rhythm
    • Organizer
      The 11th Congress of Turkish Sleep Society
    • Place of Presentation
      Maritim Pine Beach Resort, Antalya, Turkey
    • Related Report
      2011 Final Research Report
  • [Presentation] Assessing multi-oscillator mammalian clock using mice with clock gene mutation2010

    • Author(s)
      Honma S
    • Organizer
      Lorenz Center Workshop, Assembling multi-cellular Circadian Pacemaker
    • Place of Presentation
      Lorenz Center, Leiden, The Netherlands
    • Related Report
      2011 Final Research Report
  • [Presentation] ssing multi-oscillator mammalian clock using mice with clock gene mutati2010

    • Author(s)
      Honma S.
    • Organizer
      Lorenz Center Workshop
    • Place of Presentation
      Leiden, Neherland(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Animal model of human sleep-wake rhythm2010

    • Author(s)
      Honma S
    • Organizer
      e 11th Congress of Turkish Sleep Society
    • Place of Presentation
      Antalya, Turkey(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 行動リズムと時計遺伝子機能2010

    • Author(s)
      本間さと
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡市民文化ホール(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vivo bioluminescence reporter gene imaging in the mouse brain2010

    • Author(s)
      Hamada T
    • Organizer
      8th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      Hokkaido University, Sappor
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vivo bioluminescence reporter gene imaging of the olfactory bulb in the mouse brain2010

    • Author(s)
      Hamada T
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      Kyoto International Conference Center、Kyoto
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体リズムのイメージング2009

    • Author(s)
      本間さと
    • Organizer
      第62回日本自律神経学会
    • Place of Presentation
      ダイワロイネットホテル、和歌山 (招待講演)
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Seasonality in sleep and wakefulness.2009

    • Author(s)
      Honma, S.
    • Organizer
      The 6^<th> Congress of Asian Sleep Research Society.
    • Place of Presentation
      Osaka Convention Center, Osaka (招待講演)
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] ホルモン分泌と生物時計機構:生物発光レポーターとその応用2009

    • Author(s)
      本間さと
    • Organizer
      第9回日本内分泌学会北海道地方会
    • Place of Presentation
      かでる2.7、札幌 (招待講演)
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生存戦略としての生物時計-その分子・細胞メカニズム2009

    • Author(s)
      本間さと
    • Organizer
      第4回体温調節・温度受容研究会
    • Place of Presentation
      岡崎カンファレンスセンター、岡崎 (招待講演)
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Non-photic time cues and animal life : photic cue is not almighty. Symposium on "Entrainment by non-photic time cues2009

    • Author(s)
      Honma, S.
    • Organizer
      IX th European Congress on Biological Rhythms
    • Place of Presentation
      University of Strasbourg, Sttasboug, France (招待講演)
    • Year and Date
      2009-08-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Clock for all seasons composed of functionally heterogenous SCN cells.2009

    • Author(s)
      Honma, S.
    • Organizer
      International Symposium on Biological Rhythms
    • Place of Presentation
      Hokkaido University Conference Center, Sapporo (招待講演)
    • Year and Date
      2009-08-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Clock mechanisms in mammals encoding photoperiods.2009

    • Author(s)
      Honma, S.
    • Organizer
      International Congress of Physiological Societies(IUPS)2009
    • Place of Presentation
      International Conference Center, Kyoto (招待講演)
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Photic regulation of phase and tau ; adaptive role of a kinase in the SCN2009

    • Author(s)
      Honma, S.
    • Organizer
      Gordon Conference on Chronobiology
    • Place of Presentation
      Slave Regina Collage, New Port, RI, USA (招待講演)
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rapid shift of social schedule induces an internal desynchronization between sleep-wake cycle and plasma melatonin rhythms2009

    • Author(s)
      Yamanaka Y, Hashimoto S, Nakamura K, Tanahashi Y, Nishide S, Yamada Y, Honma S and Honma
    • Organizer
      The 1st ASRS Summit and Symposium of Asia Oceania Sleep Research and Sleep
    • Place of Presentation
      Medicine in Okinawa Bankoku Sniryokan, Okinawa
    • Related Report
      2011 Final Research Report
  • [Presentation] Seasonality in sleep and wakefulness2009

    • Author(s)
      Honma S, Yoshikawa T, and Honma,K
    • Organizer
      The6th Congress of Asian Sleep Research Society
    • Place of Presentation
      Osaka Convention Center, Osakka
    • Related Report
      2011 Final Research Report
  • [Presentation] Circadian firing rhythms in Cry1/Cry2 double-deficient mice in the cultured suprachiasmatic nucleus2009

    • Author(s)
      Ono D, Honma S, and Honma K
    • Organizer
      IXth European Congress on Biological Rhythms, Univ
    • Place of Presentation
      Strasbourg, Strasbourg, France
    • Related Report
      2011 Final Research Report
  • [Presentation] Nonphotic time cues phase-dependently accelerate phase-shifts of mouse peripheral clocks2009

    • Author(s)
      Yamanaka Y, Honma S, and Honma K
    • Organizer
      IXth European Congress on Biological Rhythms, Univ
    • Place of Presentation
      Strasbourg, Strasbourg, France
    • Related Report
      2011 Final Research Report
  • [Presentation] Non-photic time cues and animal life: photic cue is not almighty. IXth European Congress on Biological Rhythms, Univ2009

    • Author(s)
      Honma S
    • Organizer
      Strasbourg
    • Place of Presentation
      Strasbourg, France
    • Related Report
      2011 Final Research Report
  • [Presentation] Clock for all seasons composed of functionally heterogenous SCN cells2009

    • Author(s)
      Honma S. Yoshikawa T, and Honma,K
    • Organizer
      International Symposium on Biological Rhythms
    • Place of Presentation
      Hokkaido University Conference Hall, Sapporo
    • Related Report
      2011 Final Research Report
  • [Presentation] Clock mechanisms in mammals encoding photoperiods2009

    • Author(s)
      Honma S, Yoshikawa T, Tokumaru N, and Honma,K
    • Organizer
      IUPS 2009
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] Photic regulation of phase and tau; adaptive role of a kinase in the SCN2009

    • Author(s)
      Honma S
    • Organizer
      Gordon Conference on Chronobiology, Salve Regina Collage
    • Place of Presentation
      New Port, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Bioluminescence imaging for assessing heterogeneous cell functions in the central circadian clock2009

    • Author(s)
      Honma S
    • Organizer
      the 3rd Symposium for Research Center for Cooperative Projects of Hokkaido University Graduate School of Medicine, Hokkaido Univ
    • Place of Presentation
      Conference Center, Sapporo
    • Related Report
      2011 Final Research Report
  • [Book] 中枢時計の分子生物学 DOJIN SCIENCE SERIES 02「時間生物学」2012

    • Author(s)
      本間さと
    • Publisher
      海老原史樹文、吉村崇(編)化学同人
    • Related Report
      2011 Final Research Report
  • [Book] DOJIN SCIENCE SERIES 02 時間生物学2012

    • Author(s)
      本間 さと
    • Publisher
      科学同人
    • Related Report
      2011 Annual Research Report
  • [Book] 株式会社シナジー2012

    • Author(s)
      山仲 勇二郎
    • Publisher
      脳とこころのプライマリケア 第5巻 意識と睡眠
    • Related Report
      2011 Annual Research Report
  • [Book] 嗅球の体内時計と嗅覚刺激の作用、体内時計の科学と産業応用2011

    • Author(s)
      浜田俊幸、本間さと、本間研一
    • Publisher
      柴田重信監修、シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Book] Tamaki N. Kuge Y eds "Molecular Imaging for Integrated Medical Therapy and Drug Development" Springer, Tokyo2010

    • Author(s)
      Honma S, Yoshikawa T, Nishide S, Ono D and Honma K
    • Publisher
      Bioluminescent imaging for assessing heterogeneous cell functions in the mammalian central circadian clock
    • Related Report
      2011 Final Research Report
  • [Book] 環境応答-概日リズムからだと光の事典2010

    • Author(s)
      本間さと
    • Publisher
      太陽紫外線防御研究委員会編集朝倉書店
    • Related Report
      2011 Final Research Report
  • [Book] からだと光の事典2010

    • Author(s)
      本間さと
    • Total Pages
      421
    • Publisher
      朝倉書店
    • Related Report
      2010 Annual Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development2010

    • Author(s)
      Honma, S.
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report
  • [Book] Editor-in-Chief: LR. Squire, New Encyclopedia of Neuroscience, Elsevier2009

    • Author(s)
      Honma S and Honma K
    • Publisher
      Single cell neuronal circadian clocks
    • Related Report
      2011 Final Research Report
  • [Book] 視交叉上核と光周性光周性の分子生物学2009

    • Author(s)
      吉川朋子、本間さと
    • Publisher
      海老原史樹文,伊澤毅編シュプリンガー・ジャパン、東京
    • Related Report
      2011 Final Research Report
  • [Book] 睡眠学2009

    • Author(s)
      本間さと
    • Publisher
      朝倉書店
    • Related Report
      2009 Annual Research Report
  • [Book] 光周性の分子生物学2009

    • Author(s)
      吉川朋子
    • Publisher
      シュプリンガー・ジャパン
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.hucc.hokudai.ac.jp/~a10071/

    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] ターゲット位置追跡装置およびターゲット発光検出装置2010

    • Inventor(s)
      石川正純、浜田俊幸、本間研一、本間さと、ケネス・リー・サザーランド
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Number
      2010-245624
    • Filing Date
      2010-11-01
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] ターゲット位置追跡装置およびターゲット発光検出装置2010

    • Inventor(s)
      俊幸, 本間研一, 本間さと, K.サザーランド
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Number
      2010-245624
    • Filing Date
      2010-11-01
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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