Role of hypothalamic AMP kinase in food intake and metabolic regulation in lean and obese animals

• Project/Area Number: 21390067
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: MINOKOSHI Yasuhiko 生理学研究所, 発達生理学研究系, 教授 (10200099)
• Co-Investigator(Renkei-kenkyūsha): OKAMOTO Shiki 生理学研究所, 発達生理学研究系, 助教 (40342919) ; SHIUCHI Tetsuya 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (70372729)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2009: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
• Keywords: 生理学 / 栄養学 / 生体分子 / 摂食行動 / 肥満 / 代謝

Research Abstract

AMP kinase(AMPK) has been known to be a "metabolic sensor". Here, we found that AMPK in the paraventricular hypothalamus regulates food selection behavior for carbohydrate and fat diets via fatty acid oxidation in the nucleus.

Research Products

• [Journal Article] Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice (2011)
  • Author(s): Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori Y, Yada T, Minokoshi Y & Tominaga M
  • Journal Title: Diabetes Volume: 60 Issue: 1 Pages: 119-126
  • DOI: 10.2337/db10-0276
  • Peer Reviewed
• [Journal Article] Decreased intake of sucrose solutions in orexin knockout mice (2011)
  • Author(s): Matsuo E, Mochizuki A, Nakayama K, Nakamura S, Yamamoto T, Shioda S, Sakurai T, Yanagisawa M, Shiuchi T, Minokoshi Y, Inoue T
  • Journal Title: J Mol Neurosci Volume: 43 Issue: 2 Pages: 217-224
  • DOI: 10.1007/s12031-010-9475-1
  • Peer Reviewed
• [Journal Article] An enzymatic photometric assay for 2-deoxyglucose uptake in insulin-responsive tissues and 3T3-L1 adipocytes (2011)
  • Author(s): Saito K, Lee S, Shiuchi T, Toda C, Kamijo M, Inagaki-Ohara K, Okamoto S, Minokoshi Y
  • Journal Title: Analytical Biochem Volume: 412 Issue: 1 Pages: 9-17
  • DOI: 10.1016/j.ab.2011.01.022
  • Peer Reviewed
• [Journal Article] DNA methylation of intronic enhancers directs tissue-specific expression of Steroidogenic Factor 1/Adrenal 4 Binding Protein (SF-1/Ad4BP) (2011)
  • Author(s): Erling A.Hoivik, et al
  • Journal Title: Endocrinology Volume: 152 Issue: 5 Pages: 2100-2112
  • DOI: 10.1210/en.2010-1305
  • Peer Reviewed
• [Journal Article] PDK1-Foxo1 in Agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure (2011)
  • Author(s): Cao Y, Nakata M, Okamoto S, Takano E, Yada T, Minokoshi Y, Hirata Y, Nakajima K, Iskandar K, Hayashi Y, Ogawa W, Barsh GS, Hosoda H, Kangawa K, Itoh H, Noda T, Kasuga M, Nakae J
  • Journal Title: PLoS ONE Volume: 6 Issue: 4 Pages: 2100-2112
  • DOI: 10.1371/journal.pone.0018324
  • Peer Reviewed
• [Journal Article] Role of central leptin signaling in the starvation-induced alteration of B cell development (2011)
  • Author(s): M. Tanaka, T. Suganami, M. Kim-Saijo, C. Toda, M. Tsuiji, K. Ochi, Y. Kamei, Y. Minokoshi, Y. Ogawa
  • Journal Title: J. Neurosci. Volume: 31 Issue: 23 Pages: 8373-8380
  • DOI: 10.1523/jneurosci.6562-10.2011
  • Peer Reviewed
• [Journal Article] Structural basis for compound C inhibition of the human AMP-activated protein kinaseα2 subunit kinase domain (2011)
  • Author(s): Handa N, Takagi T, Saijo S, Kishishita S, Takaya D, Toyama M, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y, Yokoyam S
  • Journal Title: Acta Crystallogr D Biol Crystallogr Volume: 67 Issue: 5 Pages: 480-487
  • DOI: 10.1107/s0907444911010201
  • Peer Reviewed
• [Journal Article] Crystal structure of the Ca2+/Calmodulin-dependent protein kinase in complex with the inhibitor STO-609 (2011)
  • Author(s): Kukimoto-Nino M, Yamauchi T, Okada Iwabu M, Iwabu M, Kadowaki T
  • Journal Title: J. Biol. Chem. Volume: 286 Issue: 25 Pages: 22570-22579
  • DOI: 10.1074/jbc.m111.251710
  • Peer Reviewed
• [Journal Article] Metabolic adaptation of mice in a cool environment (2010)
  • Author(s): Uchida K, Shiuchi T, Inada H, Minokoshi Y, Tominaga, M
  • Journal Title: Pflugers Arch Volume: 459 Issue: 5 Pages: 765-774
  • DOI: 10.1007/s00424-010-0795-3
  • Peer Reviewed
• [Journal Article] Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide (2010)
  • Author(s): Sasaki T, Kim HJ, Kobayashi M, Kitamura YI, Yokota-Hashimoto H, Shiuchi T, Minokoshi Y, Kitamura T
  • Journal Title: Endocrinology Volume: 151 Issue: 6 Pages: 2556-2566
  • DOI: 10.1210/en.2009-1319
  • Peer Reviewed
• [Journal Article] CXCL14 deficiency in mice attenuates obesity and inhibits feeding behavior in a novel environment (2010)
  • Author(s): Tanegashima K, Okamoto S, Nakayama Y, Taya C, Shitara H, Ishii R, Yonekawa H, Minokoshi Y, Hara T
  • Journal Title: PLoS One Volume: 5 Issue: 4 Pages: e10321-e10321
  • DOI: 10.1371/journal.pone.0010321
  • Peer Reviewed
• [Journal Article] A liver-derived secretory protein, Selenoprotein P, causes insulin resistance (2010)
  • Author(s): Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim H-J, Lee I-K, Minokoshi Y, Saito Y
  • Journal Title: Cell Metabolism Volume: 12 Issue: 5 Pages: 483-495
  • DOI: 10.1016/j.cmet.2010.09.015
  • NAID: 120002661942
  • Peer Reviewed
• [Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistanee. (2010)
  • Author(s): Misu H, Minokoshi Y, Hara T, 他
  • Journal Title: Cell Metabolism Volume: 12 Pages: 483-495
  • Peer Reviewed
• [Journal Article] CXCL14 deficiency in mice attenuates obesity and inhibits feeding behavior in a novel environment. (2010)
  • Author(s): Tanegashima K, Takamura T, Minokoshi Y, Kaneko S, 他
  • Journal Title: PLoS ONE Volume: 5
  • Peer Reviewed
• [Journal Article] Induction of hypothalamic Sirtl leads to cessation of feeding via agouti-related peptide. (2010)
  • Author(s): Sasaki T, Minokoshi Y, Kitamura T, 他
  • Journal Title: Endocrinology Volume: 151 Pages: 2556-2566
  • Peer Reviewed
• [Journal Article] Metabolic adaptation of mice in a cool environment. (2010)
  • Author(s): Uchida K, Minokoshi Y, Tominaga M, 他
  • Journal Title: Pflugers Archiv Volume: 459 Pages: 765-774
  • Peer Reviewed
• [Journal Article] Lack of TRPM2 impaired insulin secretion and glucose metabolisms inmice. (2010)
  • Author(s): Uchida K, Minokoshi Y, Tominaga M, 他
  • Journal Title: Diabetes Volume: 60 Pages: 119-126
  • Peer Reviewed
• [Journal Article] 脳におけるエネルギー感受機構とAMPK (2010)
  • Author(s): 箕越靖彦
  • Journal Title: 実験医学 増刊号 Volume: 28 Pages: 836-842
• [Journal Article] Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues (2009)
  • Author(s): Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB
  • Journal Title: Mol Cell Biol Volume: 29 Issue: 16 Pages: 4563-4573
  • DOI: 10.1128/mcb.01914-08
  • Peer Reviewed
• [Journal Article] Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues (2009)
  • Author(s): Toda C, Shiuchi T, Lee S, Yamato-Esaki M, Fujino Y, Suzuki A, Okamoto S, Minokoshi Y
  • Journal Title: Diabetes Volume: 58 Issue: 12 Pages: 2757-2765
  • DOI: 10.2337/db09-0638
  • Peer Reviewed
• [Journal Article] Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system (2009)
  • Author(s): Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Bachman ES, Kim Y-B, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y
  • Journal Title: Cell Metabolism Volume: 10 Issue: 6 Pages: 466-480
  • DOI: 10.1016/j.cmet.2009.09.013
  • Peer Reviewed
• [Journal Article] Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system (2009)
  • Author(s): Shiuchi T, Minokoshi Y, 他
  • Journal Title: Cell Metabolism 10 Pages: 466-480
  • Peer Reviewed
• [Journal Article] Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues (2009)
  • Author(s): Toda C, Minokoshi Y, 他
  • Journal Title: Diabetes 58 Pages: 2757-2765
  • Peer Reviewed
• [Journal Article] Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues (2009)
  • Author(s): Xue B, Minokoshi Y, 他
  • Journal Title: Molecular and Cellular Biology 29 Pages: 4563-4573
  • Peer Reviewed
• [Journal Article] 摂食調節シグナルとしての視床下部AMPK/mTORと細胞内代謝 (2009)
  • Author(s): 箕越靖彦
  • Journal Title: 実験医学増刊号 27 Pages: 1099-1104
• [Journal Article] 視床下部における摂食・代謝調節作用とAMPキナーゼ (2009)
  • Author(s): 箕越靖彦
  • Journal Title: 肥満研究 15 Pages: 20-28
  • Peer Reviewed
• [Journal Article] 視床下部における食欲制御 (2009)
  • Author(s): 岡本士毅、箕越靖彦
  • Journal Title: 細胞工学 28 Pages: 812-816
• [Journal Article] 視床下部による血糖レベルの調節 (2009)
  • Author(s): 志内哲也、箕越靖彦
  • Journal Title: 体育の科学 59 Pages: 457-464
• [Journal Article] AMPキナーゼと糖・エネルギー代謝調節 (2009)
  • Author(s): 鈴木敦、箕越靖彦
  • Journal Title: アディポサイエンス 6 Pages: 33-39
• [Presentation] AMP-kinase in the paraventricular hypothalamus regulates food selection behavior in mice (2012)
  • Author(s): Okamoto S, Minokoshi Y
  • Organizer: The 89th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Matsumoto Bunka Kaikan, Matsumoto
  • Year and Date: 2012-03-31
• [Presentation] Hypothalamic and sympathetic control of muscle metabolism (2011)
  • Author(s): Minokoshi Y, Shiuchi T
  • Organizer: FASEB Summer Research Conferences "Glucose transporters, signaling, and Diabetes"
  • Place of Presentation: Snowmass Village Conference Center, Snowmass Village, Colorado, USA
  • Year and Date: 2011-08-14
• [Presentation] Hypothalamic and sympathetic control of muscle metabolism (2011)
  • Author(s): Minokoshi Y, Shiuchi T
  • Organizer: FASEB Summer Research Conferences "Glucose transporters, signaling, and Diabetes"
  • Place of Presentation: Snowmass Village (Colorado, USA)
  • Year and Date: 2011-08-14
• [Presentation] 視床下部AMPKによるエネルギー代謝調節機構 (2011)
  • Author(s): 箕越靖彦
  • Organizer: 第30回成長ホルモン成長因子セミナー
  • Place of Presentation: 新宿住友ホール、新宿区、東京都
  • Year and Date: 2011-06-10
• [Presentation] 視床下部AMPKによるエネルギー代謝調節機構 (2011)
  • Author(s): 箕越靖彦
  • Organizer: 第30回成長ホルモン成長因子セミナー
  • Place of Presentation: 新宿住友ホール(東京都)
  • Year and Date: 2011-06-10
• [Presentation] 視床下部AMPキナーゼによる摂食調節機構 (2011)
  • Author(s): 箕越靖彦
  • Organizer: 日本分子生物学会第10回春季シンポジウム
  • Place of Presentation: 石川県立音楽堂交流ホール、金沢市、石川県
  • Year and Date: 2011-05-25
• [Presentation] 食から肥満とやせのなぞを探る～摂食と代謝調節の脳内機構～、市民公開講座「考えよう!食と健康」 (2010)
  • Author(s): 箕越靖彦
  • Organizer: 日本栄養改善学会中国支部主催
  • Place of Presentation: 県立広島大学、広島市、広島県
  • Year and Date: 2010-12-11
• [Presentation] 食から肥満とやせのなぞを探る～摂食と代謝調節の脳内機構～ (2010)
  • Author(s): 箕越靖彦
  • Organizer: 市民公開講座「考えよう!食と健康」日本栄養改善学会中国支部主催
  • Place of Presentation: 県立広島大学(広島)
  • Year and Date: 2010-12-11
• [Presentation] Regulatory role of hypothalamic AMP-kinase in calorie intake and food preference (2010)
  • Author(s): Minokoshi Y, Okamoto S
  • Organizer: The FASEB Summer Research Conference
  • Place of Presentation: Otsu Prince Hotel, Otsu, Shiga
  • Year and Date: 2010-10-07
• [Presentation] Regulatory role of hypothalamic AMP-kinase in calorie intake and food preference. (2010)
  • Author(s): Minokoshi Y, Okamoto S
  • Organizer: The FASEB Summer Research Conference.
  • Place of Presentation: Otsu Prince Hotel(滋賀)
  • Year and Date: 2010-10-07
• [Presentation] 肥満マウスの食餌嗜好性に及ぼす視床下部室傍核AMPキナーゼの調節作用 (2010)
  • Author(s): 岡本士毅、箕越靖彦
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ、前橋市、群馬県
  • Year and Date: 2010-10-01
• [Presentation] 肥満マウスの食餌嗜好性に及ぼす視床下部室傍核AMPキナーゼの調節作用 (2010)
  • Author(s): 岡本士毅、箕越靖彦
  • Organizer: 第31回日本肥満学会、シンポジウム
  • Place of Presentation: 前橋テルサ(群馬)
  • Year and Date: 2010-10-01
• [Presentation] Regulatory role of AMP-kinase in the paraventricular hypothalamus in calorie intake and food preference (2010)
  • Author(s): Minokoshi Y, Okamoto S
  • Organizer: 11th International Congress on Obesity. Satellite Symposium
  • Place of Presentation: Clarion Hotel, Stockholm, Sweden
  • Year and Date: 2010-07-10
• [Presentation] Role of he paraventricular hypothalamic AMP kinase in food selection behavior (2010)
  • Author(s): Minokoshi Y, Okamoto S
  • Organizer: The 87th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Morioka Shimin-Bunka Hole,盛岡市,岩手県
  • Year and Date: 2010-05-21
• [Presentation] Role of the paravelltricular hypothalamic AMP kinase in food selection behavior. (2010)
  • Author(s): Minokoshi Y, Okamoto S
  • Organizer: The 87th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 盛岡市民文化ホール(岩手)
  • Year and Date: 2010-05-21
• [Presentation] 摂食・代謝調節の脳内機構と栄養環境との相互作用 (2010)
  • Author(s): 箕越靖彦
  • Organizer: 脳科学研究教育センターシンポジウム
  • Place of Presentation: 北海道大学、札幌市、北海道
  • Year and Date: 2010-04-07
• [Presentation] 摂食・代謝調節の脳内機構と栄養環境との相互作用 (2010)
  • Author(s): 箕越靖彦
  • Organizer: 脳科学研究教育センターシンポジウム
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2010-04-07
• [Presentation] Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system (2010)
  • Author(s): Minokoshi Y, Shiuchi T
  • Organizer: ICE2010 15^<th> International Congress of Endocrinology Official Satellite Symposium Neuroendocrine Functions of GPCRs
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2010-03-31
• [Presentation] Role of hypothalamic AMP kinase in food selection behavior (2010)
  • Author(s): Minokoshi Y, Okamoto S
  • Organizer: ICE2010 14th International Congress of Endocrinology, Symposium AMP kinase
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2010-03-30
• [Presentation] Regulatory role of leptin in glucose metabolism in peripheral tissues (2010)
  • Author(s): 箕越靖彦
  • Organizer: ICE2010 15^<th> International Congress of Endocrinology Official Satellite Symposium Obesity and Metabolic Syndrome
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2010-03-30
• [Presentation] Role of hypothalamic AMP kinase in food selection behavior. (2010)
  • Author(s): Minokoshi Y, Okamoto S
  • Organizer: ICE2010 14^<th> International Congress of Endocrinology
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2010-03-27
• [Presentation] Neural regulation of energy homeostasis (2010)
  • Author(s): 箕越靖彦
  • Organizer: Danish-Japanese Joint Workshop. "Molecular Diabetology"
  • Place of Presentation: Comwell Hotel Osterport, Copenhagen, Denmark
  • Year and Date: 2010-03-24
• [Presentation] 視床下部AMPキナーゼによる摂食調節機構 (2010)
  • Author(s): 箕越靖彦
  • Organizer: 第83回日本薬理学会年会、シンポジウム
  • Place of Presentation: 大阪国際会議場、大阪市、大阪府
  • Year and Date: 2010-03-17
• [Presentation] 食欲の生理学 (2010)
  • Author(s): 箕越靖彦
  • Organizer: 第14回安藤百福賞記念講演会
  • Place of Presentation: ホテルニューオータニ、東京都
  • Year and Date: 2010-03-10
• [Presentation] 視床下部AMPキナーゼによるエネルギー代謝調節機構 (2010)
  • Author(s): 箕越靖彦
  • Organizer: ミニリトリート若手研究報告会「ストレスと栄養クラスター」
  • Place of Presentation: ウエスティンホテル淡路、淡路市、兵庫県
  • Year and Date: 2010-02-19
• [Presentation] 視床下部オレキシンによる骨格筋での糖代謝調節作用と動機づけ摂食行動との作用連関 (2010)
  • Author(s): 志内哲也、箕越靖彦
  • Organizer: 生理学研究所研究会「中枢・末梢臓器連関による摂食、エネルギー代謝調節」
  • Place of Presentation: 岡崎カンファレンスセンター、岡崎市、愛知県
  • Year and Date: 2010-02-13
• [Presentation] Regulatory role of AMP-kinase in the paraventricular hypothalamus in calorie intake and food preference. (2010)
  • Author(s): Minokoshi Y, Okamoto S
  • Organizer: 11th International Congress on Obesity Satellite Symposium
  • Place of Presentation: Clarion Hotel, Stcockholm(Sweden)
• [Presentation] 末梢組織でのグルコース取り込み促進作用に及ぼす視床下部レプチンーメラノコルチンシステムの調節作用 (2009)
  • Author(s): 戸田知得、箕越靖彦
  • Organizer: 第80回メタボリック症候群(生活習慣病)研究会
  • Place of Presentation: 東京ステーションホテル、東京都
  • Year and Date: 2009-12-05
• [Presentation] Regulatory role of AMP-kinase in the paraventricular hypothalamus in calorie intake and food preference (2009)
  • Author(s): Minokoshi Y, Okamoto S
  • Organizer: The 25th Kumamoto Medical Bioscience Symposium. "New Progress in Diabetes Research : From Basic Research to Clinical Trials"
  • Place of Presentation: ANA Hotel Kumamoto New Sky, Kumamoto
  • Year and Date: 2009-11-13
• [Presentation] 視床下部オレキシンー交感神経系による骨格筋でのグルコース夜謝調節作用 (2009)
  • Author(s): 志内哲也、箕越靖彦
  • Organizer: 第62回日本自律神経学会総会、ジンポジウム
  • Place of Presentation: ダイワロイネットホテル、和歌山市、和歌山県
  • Year and Date: 2009-11-06
• [Presentation] Role of the hypothalamic AMP kinase in food intake and preference regulation (2009)
  • Author(s): Minokoshi Y, Okamoto S
  • Organizer: 3^<rd> KU/YU-NIPS International Collaborative Symposium
  • Place of Presentation: Korea Univ, Seoul, Korea
  • Year and Date: 2009-10-31
• [Presentation] 骨格筋でのグルコース代謝に及ぼす視床下部オレキシンの調節作用 (2009)
  • Author(s): 箕越靖彦、志内哲也, 他
  • Organizer: 第30回日本肥満学会、シンポジウム
  • Place of Presentation: アクトシティ浜松、浜松市、静岡県
  • Year and Date: 2009-10-10
• [Presentation] 中枢性摂食調節におけるFoxO1とSirt1の役割 (2009)
  • Author(s): 北村忠弘、佐々木努、箕越靖彦
  • Organizer: 第30回日本肥満学会、シンポジウム
  • Place of Presentation: アクトシティ浜松、浜松市、静岡県
  • Year and Date: 2009-10-10
• [Presentation] Sirt1の視床下部における摂食行動・エネルギー代謝制御機構の解明 (2009)
  • Author(s): 佐々木努、箕越靖彦、北村忠弘
  • Organizer: 第30回日本肥満学会、シンポジウム
  • Place of Presentation: アクトシティ浜松、浜松市、静岡県
  • Year and Date: 2009-10-10
• [Presentation] レプチンによる末梢組織でのグルコース取り込み促進作用に及ぼす視床下部腹内側核の調節作用 (2009)
  • Author(s): 戸田知得、箕越靖彦, 他
  • Organizer: 第30回日本肥満学会
  • Place of Presentation: アクトシティ浜松、浜松市、静岡県
  • Year and Date: 2009-10-09
• [Presentation] 視床下部室傍核AMPキナーゼによる食餌嗜好性の調節作用とその異常 (2009)
  • Author(s): 岡本士毅、箕越靖彦, 他
  • Organizer: 第30回日本肥満学会、シンポジウム
  • Place of Presentation: アクトシティ浜松、浜松市、静岡県
  • Year and Date: 2009-10-09
• [Presentation] Role of hypothalamic AMPK in the regulation of food intake and energy homeostasis (2009)
  • Author(s): Minokoshi Y, Okamoto S
  • Organizer: Satellite Symposium of the 9^<th> International Symposium on VIP, PACAP and Related Peptides
  • Place of Presentation: Yakushima Iwasaki Hotel, Yakushima, Kagoshima
  • Year and Date: 2009-10-03
• [Presentation] レプチンによる末梢組織での糖取り込みに及ぼす視床下部腹内側核の役割 (2009)
  • Author(s): 戸田知得、箕越靖彦, 他
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場、名古屋市、愛知県
  • Year and Date: 2009-09-16
• [Presentation] Paraventricular hypothalamic AMPK regulates macronutrient selection of carbohydrate and fat diets (2009)
  • Author(s): Okamoto S, Minokoshi Y
  • Organizer: 第32回日本神経科学大会、シンポジウム
  • Place of Presentation: 名古屋国際会議場、名古屋市、愛知県
  • Year and Date: 2009-09-16
• [Presentation] 視床下部室傍核AMPキナーゼと脂肪酸代謝を介する食餌嗜好性調節機構 (2009)
  • Author(s): 箕越靖彦
  • Organizer: 第36回日本神経内分泌学会、シンポジウム
  • Place of Presentation: 北九州市国際会議場、北九州市、福岡県
  • Year and Date: 2009-09-04
• [Presentation] Orexins enhance glucose metabolism in skeletal muscle via mediobasal hypothalamus-sympathetic nerve and beta2-adrenergic pathway (2009)
  • Author(s): Shiuchi T, Minokoshi Y, 他
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2009-07-30
• [Presentation] Paraventricular hypothalamic AMPK regulates macronutrient selection of carbohydrate and fat diets (2009)
  • Author(s): Okamoto S, Minokoshi Y, 他
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2009-07-30
• [Presentation] AMPK family member ARK5 is essential for white adipose tissue hypertrophy in response to high-fat diet feeding (2009)
  • Author(s): Suzuki A, Minokoshi Y, 他
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2009-07-29
• [Presentation] BNDF is a novel adipokine that suppresses plasminogen activato rinhibitor-1(PAI-1)mRNA expression in adipocytes through TrkB-T1 receptor (2009)
  • Author(s): Lee S, Minokoshi Y, 他
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2009-07-28
• [Presentation] 視床下部室傍核AMPキナーゼによる食餌嗜好性調節機構 (2009)
  • Author(s): 箕越靖彦
  • Organizer: 第63回日本栄養・食糧学会大会、シンポジウム「中枢と末梢を結ぶ摂食調節機構」
  • Place of Presentation: 長崎市茂里町ブリックホール、長崎市、長崎県
  • Year and Date: 2009-05-20
• [Presentation] 視床下部室傍核AMPキナーゼによる食餌嗜好性調節機構 (2009)
  • Author(s): 箕越靖彦
  • Organizer: 第63回日本栄養・食糧学会大会、シンポジウム「中枢と末梢を結ぶ摂食調節機構」
  • Place of Presentation: 長崎ブリックホール、長崎市、長崎県
  • Year and Date: 2009-05-20
• [Presentation] Role of a novel protein phosphatase CIPP in leptin-induced suppression of AMPK activity in the arcuate hypothalamus (2009)
  • Author(s): Minokoshi Y
  • Organizer: 2009 Nanjing Symposium on Obesity & Diabetes
  • Place of Presentation: Nanjing University, Nanjing, China
  • Year and Date: 2009-05-16
• [Presentation] Role of a novel protein phosphatase CIPP in leptin-induced suppression of AMPK activity in the arcuate hypothalamus (2009)
  • Author(s): 箕越靖彦
  • Organizer: 2009 Nanjing Symposium on Obesity & Diabetes
  • Place of Presentation: Nanjing Univ, Nanjing, China
  • Year and Date: 2009-05-16
• [Presentation] Regulatory role of AMP-kinase in the paraventricular hypothalamus in calorie intake and food preference (2009)
  • Author(s): Minokoshi Y
  • Organizer: NRL International Mini-Symposium "A Recent Progress in the Research of Obesity and Related Metabolic Disorder"
  • Place of Presentation: Asan Medial Center, Seoul, Korea
  • Year and Date: 2009-05-14
• [Presentation] Regulatory role of AMP-kinase in the paraventricular hypothalamus in calorie intake and food preference (2009)
  • Author(s): 箕越靖彦
  • Organizer: NRL International Mini-Symposium "A Recent Progress in the Research of Obesity and Related Metabolic Disorder"
  • Place of Presentation: Asan Medical Center, Seoul, Korea
  • Year and Date: 2009-05-14
• [Presentation] 視床下部AMPキナーゼによる食餌嗜好性の調節作用 (2009)
  • Author(s): 岡本士毅、箕越靖彦
  • Organizer: 第82回日本内分泌学会
  • Place of Presentation: 群馬県民会館、前橋市、群馬県
  • Year and Date: 2009-04-24
• [Book] 糖尿病ナビゲーター(第二版)AMPキナーゼ (2010)
  • Author(s): 鈴木敦、箕越靖彦
  • Publisher: 株式会社メディカルレビュー社(東京)
• [Remarks]
  • URL: http://www.nips.ac.jp/endocrlin/
• [Remarks]
  • URL: http://www.nips.ac.jp/endocrlin/
• [Remarks]
  • URL: http://www.nips.ac.jp/endoerlin/
• [Remarks]
  • URL: http://www.nips.ac.jp/endoclin/