Molecular basis study on PACAP gene as a risk factor for schizophrenia
Project/Area Number |
21390069
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General pharmacology
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Research Institution | Osaka University |
Principal Investigator |
BABA Akemichi 大阪大学, 大学院・薬学研究科, 名誉教授 (70107100)
|
Co-Investigator(Kenkyū-buntansha) |
SHINTANI Norihito 大阪大学, 大学院・薬学研究科, 准教授 (10335367)
HAYATA Atsuko 大阪大学, 連合小児発達学研究科, 助教 (70390812)
HASHIMOTO Hitoshi 大阪大学, 大学院・薬学研究科, 教授 (30240849)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
|
Keywords | 精神疾患・障害 / 統合失調症 / 神経ペプチドPACAP / 遺伝子改変マウス / 環境因子 / 疾患モデル / セロトニン / スパイン / PACAP / 脆弱因子 / 疾患マウスモデル / 精神疾患 |
Research Abstract |
Clinical studies suggest that environmental factors, besides genetic factors, play a key role in etiology of many psychiatric disorders. This study demonstrated that schizophrenia-related behaviors in mice lacking PACAP are highly infuluenced by the environmental factors during the early stages of development. In this mutant, we also found abnormalities in the 5-HT2A receptor function and the hippocampal neuron maturation, suggesting possible involvement of these dysfunctions in the development of schizophrenia-related behaviors in mice lacking PACAP.
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Report
(4 results)
Research Products
(95 results)
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[Journal Article] Baba A PACAP centrally mediates emotional stress-induced corticosterone responses in mice2011
Author(s)
Tsukiyama N, Saida Y, Kakuda M, Shintani N, Hayata A, Morita Y, Tanida M, Tajiri M, Hazama K, Ogata K, Hashimoto H
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Journal Title
Stress
Volume: 14(4)
Pages: 368-375
Related Report
Peer Reviewed
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[Journal Article] Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal neurogenesis2011
Author(s)
Ago Y, Yoneyama M, Ishihama T, Kataoka S, Kawada K, Tanaka T, Ogita K, Shintani N, Hashimoto H, Baba A, Takuma K, Matsuda T
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Journal Title
Neuroscience
Volume: 172
Pages: 554-561
Related Report
Peer Reviewed
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[Journal Article] Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission2011
Author(s)
Ago Y, Araki R, Yano K, Hiramatsu N, Kawasaki T, Chaki S, Nakazato A, Onoe H, Hashimoto H, Baba A, Takuma K, Matsuda T
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Journal Title
Psychopharmacology (Berl)
Volume: 217(3)
Issue: 3
Pages: 443-52
DOI
Related Report
Peer Reviewed
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[Journal Article] PACAP centrally mediates emotional stress-induced corticosterone responses in mice2011
Author(s)
Tsukiyama N, Saida Y Kakuda M, Shintani N, Hayata A, Morita Y, Tanida M, Tajiri M, Hazama K, Ogata K, Hashimoto H, Baba A
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Journal Title
Stress
Volume: 14(4)
Issue: 4
Pages: 368-375
DOI
Related Report
Peer Reviewed
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[Journal Article] Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice.2011
Author(s)
Kawasaki T, Ago Y, Yano K, Araki R, Washida Y, Onoe H, Chaki S, Nakazato A, Hashimoto H, Baba A, Takuma K, Matsuda T.
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Journal Title
Neuropharmacology
Volume: 60
Pages: 397-404
Related Report
Peer Reviewed
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[Journal Article] Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal neurogenesis.2011
Author(s)
Ago Y, Yoneyama M, Ishihama T, Kataoka S, Kawada K, Tanaka T, Ogita K, Shintani N, Hashimoto H, Baba A, Takuma K, Matsuda T.
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Journal Title
Neuroscience
Volume: 172
Pages: 554-61
Related Report
Peer Reviewed
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[Journal Article] Possible association between the pituitary adenylate cyclase-activating polypeptide(PACAP) gene and major depressive disorder2010
Author(s)
Hashimoto R, Hashimoto H, Shintani N, Ohi K, Hori H, Saitoh O, Kosuga A, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Baba A, Takeda M, Kunugi H.
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Journal Title
Neurosci Lett
Volume: 14 ; 468(3)
Pages: 300-302
Related Report
Peer Reviewed
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[Journal Article] Depression-like behavior in the forced swimming test in PACAP-deficient mice : amelioration by the atypical antipsychotic risperidone2009
Author(s)
Hashimoto H, Hashimoto R, Shintani N, Tanaka K, Yamamoto A, Hatanaka M, Guo X, Morita Y, Tanida M, Nagai K, Takeda M, Baba A.
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Journal Title
J Neurochem
Volume: 110(2)
Pages: 595-602
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[Presentation] Possible Implication of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Schizophrenia : Regulation of Spine Formation and Genetic Association2010
Author(s)
Hashimoto H, Meltzer H, Hashimoto R, Jayathilake K, Takano-Hayata A, Ogata K, Shintani N, Takeda M, Baba A
Organizer
The ACNP 49th Annual Meeting
Place of Presentation
Miami Beach, Florida, USA
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[Presentation] 海馬歯状回でのstathmin1の増加は異常な軸索伸展を惹起するIncreased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations2010
Author(s)
山田浩平, 松崎伸介, 服部剛志, 桑原隆亮, 谷口学, 橋本均, 新谷紀人, 馬場明道, 熊本奈都子, 山田和男, 吉川武男, 片山泰一, 遠山正彌
Organizer
Neuro2010 第33回日本神経科学大会 第53回日本神経化学会大会 第20回日本神経回路学会大会 合同大会
Place of Presentation
神戸
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