Role of stress response for differentiation and maturation of hematop oietic cells

• Project/Area Number: 21390074
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Tohoku University
• Principal Investigator: MOTOHASHI Hozumi 東北大学, 大学院・医学系研究科, 准教授 (00282351)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: 転写因子 / 巨核球 / 血小板 / 細胞分化

Research Abstract

This study aimed at clarifying how metabolic and oxidative stresses influence the proliferation and differentiation of hematopoietic cells from the viewpoint of CNC-Maf transcription factors. I found that NF-E2 p45 antagonize with Nrf2 and promotes the terminal differentiation of megakaryocytes resulting in the increase of intracellular reactive oxygen species. I also found that NF-E2 p45 directly activates the genes encoding the factors involved in the platelet function. In tumor-bearing mice, expression of NF-E2 p45 and its target genes was robustly increased

Research Products

• [Journal Article] Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma (2012)
  • Author(s): Inoue D, Suzuki T, Mitsuishi Y, Miki Y, Suzuki S, Sugawara S, Watanabe M, Sakudara A, Endo C, Uruno A, Sasano H, Nakagawa T, Satoh K, Tanaka N, Kubo H, Motohashi H*, and Yamamoto M*.
  • Journal Title: Cancer Sci Volume: 103 Pages: 760-766
• [Journal Article] Embryonic lethality and fetal liver apoptosis in mice lacking all three small maf proteins (2012)
  • Author(s): Yamsazaki H, Katsuoka F, Motohashi H, Engel JD and Yamamoto M.
  • Journal Title: Mol Cell Biol Volume: 32 Pages: 808-816
• [Journal Article] 酸化ストレスシグナルとKeap1-Nrf2システムの役割 (2012)
  • Author(s): 村上昌平、本橋ほづみ.
  • Journal Title: 細胞工学 Volume: 31 Pages: 144-149
• [Journal Article] Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins (2012)
  • Author(s): Yamazaki H, Katsuoka F, Motohashi H, Engel JD, Yamamoto M
  • Journal Title: Mol Cell Biol Volume: 32 Issue: 4 Pages: 808-816
  • DOI: 10.1128/mcb.06543-11
  • Peer Reviewed
• [Journal Article] The Keap1-Nrf2 system as an in vivo sensor for electrophiles (2012)
  • Author(s): Uruno A, Motohashi H
  • Journal Title: Nitric Oxide Volume: 25 Issue: 2 Pages: 153-160
  • DOI: 10.1016/j.niox.2011.02.007
  • Peer Reviewed
• [Journal Article] Inducible disruption of autophagy in the lung causes airway hyper-responsiveness (2011)
  • Author(s): Inoue D, Kubo H, Taguchi K, Suzuki T, Komatsu M, Motohashi H*, and Yamamoto M*.
  • Journal Title: Biochem Biophys Res Commun Volume: 405 Pages: 13-18
• [Journal Article] Molecular determinants for small Maf protein control of platelet production (2011)
  • Author(s): Motohashi H*, Fujita R, Takayama M, Inoue A, Katsuoka F, Bresnick EH and Yamamoto M.
  • Journal Title: Mol Cell Biol Volume: 31 Pages: 151-162
• [Journal Article] The Keap1-Nrf2 system as an in vivo sensor for electrophiles (2011)
  • Author(s): Uruno A and Motohashi H.
  • Journal Title: Nitric Oxide Volume: 25 Pages: 153-160
• [Journal Article] Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution (2011)
  • Author(s): Taguchi K, Motohashi H and Yamamoto M.
  • Journal Title: Genes Cells Volume: 16 Pages: 123-140
• [Journal Article] The critical role of nitric oxide signalling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response (2010)
  • Author(s): Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahtesham AK, Ishima Y, Motohashi H, Yamamoto M and Akaike T.
  • Journal Title: J Biol Chem Volume: 285 Pages: 23970-23984
• [Journal Article] Genetic analysis of cytoprotective functions supported by graded expression of Keap1 (2010)
  • Author(s): Taguchi K, Maher JM, Suzuki T, Kawatani Y, Motohashi H, and Yamamoto M.
  • Journal Title: Mol Cell Biol Volume: 30 Pages: 3016-3026
• [Journal Article] Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis (2010)
  • Author(s): Takayama M, Fujita R, Suzuki M, Okuyama R, Aiba S, Motohashi H*, and Yamamoto M.
  • Journal Title: Mol Cell Biol Volume: 30 Pages: 2668-2680
• [Journal Article] The selective autophagy substrate p62 activates the stress response transcription factor Nrf2 through inactivation of Keap1 (2010)
  • Author(s): Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou Y.-S., Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S.-i., Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K and Yamamoto M.
  • Journal Title: Nat Cell Biol Volume: 12 Pages: 213-223
• [Journal Article] NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation (2010)
  • Author(s): Motohashi H*, Kimura M, Fujita R, Inoue A, Pan X, Takayama M, Katsuoka F, Aburatani H, Bresnick EH and Yamamoto M.
  • Journal Title: Blood Volume: 115 Pages: 677-686
  • NAID: 40019431698
• [Journal Article] MafB as a type I interferon rheostat (2010)
  • Author(s): Motohashi H and Igarashi K.
  • Journal Title: Nature Immunol Volume: 11 Pages: 695-696
• [Journal Article] 酸化ストレスと呼吸器疾患 (2010)
  • Author(s): 井上大輔、本橋ほづみ、山本雅之
  • Journal Title: 分子呼吸病 Volume: 14(1) Pages: 6-7
• [Journal Article] Genetic analysis of hierarchical regulation for Gatal and NF-E2 p45 gene expression in megakaryopoiesis. (2010)
  • Author(s): Takayama M, Fujita R, Suzuki M, Okuyama R, Aiba S, Motohashi H, Yamamoto M.
  • Journal Title: Mol Cell Biol (印刷中)
  • Peer Reviewed
• [Journal Article] The selective autophagy substrate p62 activates the stress response transcription factor Nrf2 through inactivation of Keap1. (2010)
  • Author(s): Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou Y.-S., Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S.-i., Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M.
  • Journal Title: Nat Cell Biol 12 Pages: 213-223
  • Peer Reviewed
• [Journal Article] NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation. (2010)
  • Author(s): Motohashi H, Kimura M, Fujita R, Inoue A, Pan X, Takayama M, Katsuoka F, Aburatani H, Bresnick EH, Yamamoto M.
  • Journal Title: Blood 115 Pages: 677-686
  • NAID: 40019431698
  • Peer Reviewed
• [Journal Article] Structural basis of alternative DNA recognition by Maf transcription factors (2009)
  • Author(s): Kurokawa H, Motohashi H, Sueno S, Kimura M, Takagawa H, Kanno Y, Yamamoto M, and Tanaka T.
  • Journal Title: Mol Cell Biol Volume: 29 Pages: 6232-6244
• [Journal Article] 巨核球分化過程におけるストレス応答とその調節機構 (2009)
  • Author(s): 本橋ほづみ.
  • Journal Title: 生化学 Volume: 81(6) Pages: 511-519
  • NAID: 10025188147
• [Journal Article] Structural basis of alternative DNA recognition by Maf transcription factors. (2009)
  • Author(s): Kurokawa H, Motohashi H, Sueno S, Kimura M, Takagawa H, Kanno Y, Yamamoto M, Tanaka T.
  • Journal Title: Mol Cell Biol 23 Pages: 6232-6244
  • Peer Reviewed
• [Journal Article] Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-γ production in mice but does not suppress T_h2-cytokine production or antibody production (2009)
  • Author(s): Nohara, K., Suzuki, T., Ao, K., Murai, H., Miyamoto, Y., Inouye, K., Pan, X., Motohashi, H., Fujii-Kuriyama, Y., Yamamoto, M., Tohyama, C.
  • Journal Title: Int Immunol 21 Pages: 769-777
  • NAID: 10025387030
  • Peer Reviewed
• [Presentation] MafG C-terminal region contains a nuclear matrix targeting signal and confers competence for transcriptionalregulation in megakaryocytes (2012)
  • Author(s): Hozumi Motohashi
  • Organizer: The 27th RBC-NIRS International symposium"Chromatin dynamics and epigenetic memory in DNA damage response"
  • Place of Presentation: Co-op Inn Kyoto, Kyoto
• [Presentation] Nrf2 activates the pentose phosphate pathway and glutamine consumption in metabolic reprogramming (2012)
  • Author(s): Yoichiro Mitsuishi, Keiko Taguchi, Hiroyuki Aburatani, Masayuki Yamamoto, Hozumi Motohashi
  • Organizer: Keystone Symposium on Cancer and Metabolism
  • Place of Presentation: Fairmont Banff Spring, Banff, Canada
• [Presentation] がん細胞における酸化ストレス応答と代謝リプログラミング (2011)
  • Author(s): 本橋ほづみ
  • Organizer: 第12回WAKOつくばフォーラム転写と代謝のクロストーク:病態バイオロジーの新展開
  • Place of Presentation: 筑波和光ホールつくば
  • Year and Date: 2011-11-29
• [Presentation] 環境応答の分子機構とその破綻による炎症性病態形成 (2011)
  • Author(s): 本橋ほづみ
  • Organizer: 日本耳科学会聴覚生理研究会特別講演
  • Place of Presentation: 沖縄コンベンションセンター宜野湾市
  • Year and Date: 2011-11-26
• [Presentation] 環境応答の分子機構とその破綻による炎症性病態形成 (2011)
  • Author(s): 本橋ほづみ
  • Organizer: 日本耳科学会聴覚生理研究会
  • Place of Presentation: 沖縄コンベンションセンター宜野湾市
  • Year and Date: 2011-11-26
• [Presentation] 細胞増殖における酸化ストレス応答機構の役割 (2011)
  • Author(s): 本橋ほづみ
  • Organizer: 千里ライフサイエンスセミナー「ストレス応答の分子メカニズム」
  • Place of Presentation: 千里ライフサイエンスセンタービル大阪
  • Year and Date: 2011-11-14
• [Presentation] 増殖細胞におけるストレス応答と代謝制御のクロストーク (2011)
  • Author(s): 本橋ほづみ
  • Organizer: 「転写代謝システム」キックオフミーティング
  • Place of Presentation: 大手町サンケイプラザ東京
  • Year and Date: 2011-10-19
• [Presentation] Nrf2 activates the pentose phosphate pathway and glutamine consumption in proliferating cells (2011)
  • Author(s): Hozumi Motohashi
  • Organizer: 第11回日本NO学会学術集会
  • Place of Presentation: シンポジウム昭和薬科大学、町田
• [Presentation] Keap1 degradation by autophagy for the maintenance of redox homeostasis (2011)
  • Author(s): Nanako Fujikawa, Keiko Taguchi, Hozumi Motohashi and Masayuki Yamamoto
  • Organizer: 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine
  • Place of Presentation: Hotel Rodos Palace, Rhodes Island, Greece
• [Presentation] Nrf2 activates the pentose phosphate pathway and glutamine consumption in proliferating cells (2011)
  • Author(s): Yoichiro Mitsuishi, Keiko Taguchi, Masayuki Yamamoto, and Hozumi Motohashi
  • Organizer: 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine
  • Place of Presentation: Hotel Rodos Palace, Rhodes Island, Greece (oral presentation)
• [Presentation] 転写因子NF-E2 p45による血小板機能制御メカニズムの解明 (2011)
  • Author(s): 藤田理恵、辻本昌理子、油谷浩幸、本橋ほづみ、山本雅之
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(一般講演2T14p-6、ポスター2P-0461)
• [Presentation] 転写因子Nrf2はペントースリン酸経路とグルタミン代謝を制御して細胞増殖に貢献する (2011)
  • Author(s): 光石陽一郎、田口恵子、油谷浩幸、貫和敏博、本橋ほづみ、山本雅之
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(一般講演2T16p-12、ポスター2P-0542)
• [Presentation] Regulation of platelet function by NF-E2 p45 (2011)
  • Author(s): Rie Fujita, Mariko Takayama, Hozumi Motohashi, Masayuki Yamamoto
  • Organizer: Gordon Research Conference on Cell Bioligy of Megakaryocytes & Platelets
  • Place of Presentation: Galveston, Texas
• [Presentation] The Nrf2-Keap1 stress response pathway : Moleculear basis of adaptive responses and pathogenesis (2011)
  • Author(s): Yamamoto M, Kurokawa H, Suzuki T, Taguchi K, and Motohashi H.
  • Organizer: Anniversary annual meeting & ToxExpo
  • Place of Presentation: Washington, DC
• [Presentation] Transcription factor Nrf2 drives the pentosew phosphate pathway and glutamine consumption in proliferating cells (2011)
  • Author(s): Yoichiro Mitsuishi, Keiko Taguchi, Hozumi Motohashi, Masayuki Yamamoto
  • Organizer: Discovery on Target ; Cancer Cell Metabolism as Drug Target
  • Place of Presentation: Park Plaza Hotel & Towers, Boston, MA, USA
• [Presentation] Nrf2 activates the pentose phosphate pathway and glutamine consumption in proliferating cells (2011)
  • Author(s): Yoichiro Mitsuishi, Keiko Taguchi, Masayuki Yamamolo, Hozumi Motohashi
  • Organizer: 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine
  • Place of Presentation: Hotel Rodos Palace, Rhodes Island, Greece
• [Presentation] 転写因子NF-E2 p45による血小板機能制御メカニズムの解明 (2011)
  • Author(s): 藤田理恵、辻本昌理子、油谷浩幸、本橋ほづみ、山本雅之
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館、京都
• [Presentation] 転写因子Nrf2はペントースリン酸経路とグルタミン代謝を制御して細胞増殖に貢献する (2011)
  • Author(s): 光石陽一郎、田口恵子、油谷浩幸、貫和敏博、本橋ほづみ、山本雅之
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館、京都
• [Presentation] MafG C-terminal region contains a nuclear matrix targeting signal and confers competence for transcriptional regulation in megakaryocytes (2011)
  • Author(s): Hozumi Motohashi
  • Organizer: The 27th RBC-NIRS International symposium "Chromatin dynamics and epigenetic memory in DNA damage response"
  • Place of Presentation: Co-op Inn Kyoto, Kyoto
• [Presentation] Nrf2 activates the pentose phosphate pathway and glutamine consumption in proliferating cells (2011)
  • Author(s): 本橋ほづみ
  • Organizer: 第11回日本NO学会学術集会シンポジウム
  • Place of Presentation: 昭和薬科大学、町田
• [Presentation] Rie Fujita, Hironori Satoh, Hiroyuki Aburatani, Masayuki Yamamoto. Stress response of megakaryocytes alters inherent reactivity of platelets (2010)
  • Author(s): Hozumi Motohashi
  • Organizer: BMB2010第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(シンポジウム4S4-5)
  • Year and Date: 2010-07-10
• [Presentation] Stress response mechanisms by Keap1-Nrf2 regulatory system. Institut de Radiobiologie Cellulaire et Moleculaire (2010)
  • Author(s): Hozumi Motohashi
  • Organizer: Commissariate a l' Energie Atomique (CEA)
  • Place of Presentation: Fontenay-aux-Roses, France
  • Year and Date: 2010-02-09
• [Presentation] Modulation of megakaryocytic gene expression by electrophiles as a potential anti-platelet therapy (2010)
  • Author(s): Hozumi Motohashi
  • Organizer: INSERM
  • Place of Presentation: Institut Gustave Roussy, Villejuif, France
  • Year and Date: 2010-02-08
• [Presentation] Electrophiles as potential anti-platelet reagents through modulation of gene expression in megakaryocytes (2010)
  • Author(s): Hozumi Motohashi
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto International Conference Center (ICC Kyoto)
• [Presentation] Regulation of platelet reactivity by transcription factor NF-E2 p45 in megakaryocytes (2010)
  • Author(s): 藤田理恵、高山昌理子、本橋ほづみ、山本雅之
  • Organizer: BMB2010第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(ポスター2P-0549)
• [Presentation] Gemininは造血幹細胞の維持と巨核球の分化を制御する (2010)
  • Author(s): 中野星児、佐々木陽丞、本橋ほづみ、中山啓子
  • Organizer: BMB2010第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(一般講演3T5-11、ポスター3P-0899)
• [Presentation] ニトロ化環状ヌクレオチドによるタンパク質S-グアニル化を介する酸化ストレス適応応答の分子機序 (2010)
  • Author(s): 藤井重元、澤智裕、居原秀、Kit I Tong、井田智章、岡本竜哉、Ahmed Khandaker Ahtesham、本橋ほづみ、山本雅之、赤池孝章
  • Organizer: BMB2010第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(一般講演2T9-9、ポスター2P-0156)
• [Presentation] Analysis of the Role of Nrf2-Keap1 System in Hematopoietic Stem Cell (2010)
  • Author(s): Shohei Murakami, Hozumi Motohashi, Masayuki Yamamoto
  • Organizer: 9th Japanese Biochemical Society (JBS)Bio-Frontier Symposium 2010/5th International Symposium on GATA factors
  • Place of Presentation: Gonryo-Hall, Sendai
• [Presentation] Functional Roles of NF-E2 p45 in the Regulation of Platelet Activity (2010)
  • Author(s): Rie Fujita, Mariko Takayama-Tsujimoto, Hozumi Motohashi, Masayuki Yamamoto
  • Organizer: 9th Japanese Biochemical Society (JBS)Bio-Frontier Symposium 2010/5th International Symposium on GATA factors
  • Place of Presentation: Gonryo-Hall, Sendai
• [Presentation] Embryonic lethality and fetal liver hypoplasia in mice lacking all three small Maf proteins (2010)
  • Author(s): Fumiki Katsuoka, Hiromi Yamazaki, Hozumi Motohashi, James Douglas Engel, Masayuki Yamamoto
  • Organizer: 9th Japanese Biochemical Society (JBS)Bio-Frontier Symposium 2010/5th International Symposium on GATA factors
  • Place of Presentation: Gonryo-Hall, Sendai
• [Presentation] Hereditary persistence of fetal hemoglobin and the HBS1L-MYB locus (2010)
  • Author(s): Mikiko Suzuki, Harumi Y. Mukai, Hozumi Motohashi, James Douglas Engel, Masayuki Yamamoto
  • Organizer: 9th Japanese Biochemical Society (JBS)Bio-Frontier Symposium 2010/5th International Symposium on GATA factors
  • Place of Presentation: Gonryo-Hall, Sendai
• [Presentation] 転写因子Nrf2はヒト肺線癌細胞株A549でosteopontinの発現を増加させる (2010)
  • Author(s): 光石陽一郎, 本橋ほづみ, 貫和敏博, 山本雅之
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪国際会議場・リーガロイヤルホテル大阪. 大阪
• [Presentation] 巨核球分化と酸化ストレス応答 (2009)
  • Author(s): 本橋ほづみ
  • Organizer: 東京大学先端科学技術研究センター
  • Place of Presentation: エピゲノミクスセミナー東京
  • Year and Date: 2009-11-20
• [Presentation] マウス胎生期における小 Maf 群因子の機能 (2009)
  • Author(s): 勝岡史城、中山博未、本橋ほづみ、Engel JD、山本雅之
  • Organizer: 日本生化学会東北支部第75回例会・シンポジウム
  • Place of Presentation: 東北大学、仙台
  • Year and Date: 2009-05-09
• [Presentation] Modulation of megakaryocytic gene expression by electrophiles as a potential anti-platelet therapy (2009)
  • Author(s): Hozumi Motohashi
  • Organizer: NAPA 2009
  • Place of Presentation: Jeju, Korea
• [Presentation] 生体におけるKeap1/Nrf2制御系の機能貢献と応答機構 (2009)
  • Author(s): 本橋ほづみ、藤田理恵、鈴木隆史、Kit T. Tong、黒河博文、山本雅之
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 九州大学百年講堂
• [Presentation] Identification of the target genes of transcription factor NF-E2 p45 in megakaryocytes (2009)
  • Author(s): 藤田理恵, 本橋ほづみ, 油谷浩幸, 山本雅之
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] TGF-beta suppresses transcription of Heme Oxigenase-1 through induction of MafK and Bach1 (2009)
  • Author(s): 沖田結花里, 鴨志田敦, 鈴木裕之, 伊東健, 本橋ほづみ, 五十嵐和彦, 山本雅之, 加藤光保
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Nrf2 is degraded by Keap1-independent proteasome pathway in the absende of small Maf proteins (2009)
  • Author(s): 勝岡史城, 中山博未, 本橋ほづみ, 山本雅之
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] NF-E2 p45 N-terminal Region Is Essential for Transactivation Mediating Thrombogenesis (2009)
  • Author(s): Mariko Takayama, Rie Fujita, Hozumi Motohashi, Masayuki Yamamoto
  • Organizer: Tohoku University Global COE for Conquest of Signal Transduction Diseases with"Network Medicine"
  • Place of Presentation: Sendai
• [Presentation] Nrf2 is degraded by Keap1-independent degradation pathway in the absence of small Maf proteins (2009)
  • Author(s): Fumiki Katsuoka, Hozumi Motohashi, Hiromi Nakayama, Masayuki Yamamoto
  • Organizer: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
  • Place of Presentation: Tokyo
• [Presentation] マウス胎生期における小Maf群因子の機能 (2009)
  • Author(s): 中山博未, 勝岡史城, 本橋ほづみ, 山本雅之
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 血小板形成における転写因子NF-E2 p45 N末端領域の重要性 (2009)
  • Author(s): 高山昌理子, 井上あい, 藤田理恵, 本橋ほづみ, 山本雅之
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Double-edged Sword of the Nrf2-Keap1 Stress Response System ; Carcinogenesis and Cancer Chemoprevention (2009)
  • Author(s): Masayuki Yamamoto, Tatsuhiro Shibata, Ohta Tsutomu, Kit Tong, Hirofumi Kurokawa, Takafumi Suzuki, Keiko Taguchi, and Hozumi Motohashi
  • Organizer: 第68回日本癌学会学術総会シンポジウム
  • Place of Presentation: パシフィコ横浜
• [Presentation] MafG C-terminal region contains a nuclear matrix targeting signal and confers competence for transcriptional regulation (2009)
  • Author(s): Hozumi Motohashi, Mariko Takayama, Rie Fujita, Ai Inoue, Fumiki Katsuoka, and Masayuki Yamamoto
  • Organizer: The 24th NAITO Conference on Nuclear Dynamics and RNA[II]
  • Place of Presentation: Sapporo, Japan
• [Presentation] Identification of the target genes of transcription factor NF-E2 p45 in megakaryocytes. (2009)
  • Author(s): 藤田理恵, 本橋ほづみ, 油谷浩幸, 山本雅之
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] TGF-beta suppresses transcription of Heme Oxigenase-1 through induction of MafK and Bach1. (2009)
  • Author(s): 沖田結花里, 鴨志田敦, 鈴木裕之, 伊東健, 本橋ほづみ, 五十嵐和彦, 山本雅之, 加藤光保
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] NF-E2 p45 N-terminal Region Is Essential for Transactivation Mediating Thrombogenesis. (2009)
  • Author(s): Mariko Takayama, Rie Fujita, Hozumi Motohashi, Masayuki Yamamoto
  • Organizer: Tohoku University Global COE for Conquest of Signal Transduction Diseases with "Network Medicine"
  • Place of Presentation: Gonryo-kaikan, Sendai
• [Presentation] Nrf2 is degraded by Keap1-independent degradation pathway in the absence of small Maf proteins. (2009)
  • Author(s): Fumiki Katsuoka, Hozumi Motohashi, Hiromi Nakayama, Masayuki Yamamoto
  • Organizer: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
  • Place of Presentation: University of Tokyo, Tokyo
• [Presentation] マウス胎生期における小Maf群因子の機能 (2009)
  • Author(s): 中山博未, 勝岡史城, 本橋ほづみ, 山本雅之
  • Organizer: 第82回日本生化学会大会.
  • Place of Presentation: 神戸ポートアイランド.
• [Presentation] 血小板形成における転写因子NF-E2 p45 N末端領域の重要性. (2009)
  • Author(s): 高山昌理子, 井上あい, 藤田理恵, 本橋ほづみ, 山本雅之
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Double-edged Sword of the Nrf2-Keap1 Stress Response System ; Carcinogenesis and Cancer Chemoprevention. (2009)
  • Author(s): Masayuki Yamamoto, Tatsuhiro Shibata, Ohta Tsutomu, Kit Tong, Hirofumi Kurokawa, Takafumi Suzuki, Keiko Taguchi, Hozumi Motohashi
  • Organizer: 第68回日本癌学会学術総会シンポジウム
  • Place of Presentation: パシフィコ横浜
• [Book] Survival Strategy and Disease Pathogenesis According to the Nrf2-Small Maf Heterodimer. Oxidative Stress in Vertebrates and Invertebrates. Wiley-Blackwell (2011)
  • Author(s): Morita M and Motohashi H.