| Project/Area Number |
21390075
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
AKIYAMA Tetsu 東京大学, 分子細胞生物学研究所, 教授 (70150745)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tsutomu 東京大学, 分子細胞生物学研究所, 講師 (30302798)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
|---|
| Keywords | 細胞内情報伝達 / 分子神経生物学 / 神経可塑性 / シグナル伝達 / 脳・神経 / スパイン / RICS/PX-RICS / NMDA受容体 / CaMKII / 14-3-3 / GABARAP / シナグル伝達 / 14-3-3ζ/θ / ニューロン / 樹状突起 / RICS / PX-RIGS / N-cadherin / β-catenin |
|---|
| Research Abstract |
Postsynaptic protein RICS is thought to serve as a link between excitatory signaling and synaptic adhesion. In this research project, we showed that, by using hippocampal neurons of RICS knockout mice, RICS functions downstream of NMDA/CaMKII signaling and upstream of Cdc42/JNK signaling. We also demonstrated that PX-RICS, a splicing variant of RICS, is localized to the spine apparatus together with its cargos(N-cadherin,β-catenin), linkers(GABARAP, 14-3-3) and motors(dynein, dynactin). These findings suggest that PX-RICS-dependent trafficking system works in dendrites and/or dendritic spines.
|
