Activity-dependent regulation of spine morphology by RICS/PX-RICS
| Project/Area Number |
21390075
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AKIYAMA Tetsu 東京大学, 分子細胞生物学研究所, 教授 (70150745)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tsutomu 東京大学, 分子細胞生物学研究所, 講師 (30302798)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 細胞内情報伝達 / 分子神経生物学 / 神経可塑性 / シグナル伝達 / 脳・神経 / スパイン / RICS/PX-RICS / NMDA受容体 / CaMKII / 14-3-3 / GABARAP / シナグル伝達 / 14-3-3ζ/θ / ニューロン / 樹状突起 / RICS / PX-RIGS / N-cadherin / β-catenin |
|---|
| Research Abstract |
Postsynaptic protein RICS is thought to serve as a link between excitatory signaling and synaptic adhesion. In this research project, we showed that, by using hippocampal neurons of RICS knockout mice, RICS functions downstream of NMDA/CaMKII signaling and upstream of Cdc42/JNK signaling. We also demonstrated that PX-RICS, a splicing variant of RICS, is localized to the spine apparatus together with its cargos(N-cadherin,β-catenin), linkers(GABARAP, 14-3-3) and motors(dynein, dynactin). These findings suggest that PX-RICS-dependent trafficking system works in dendrites and/or dendritic spines.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of sam682011
Author(s)
Morishita EC, Murayama K, Kato-Murayama M, Ishizuka-Katsura Y, Tomabechi Y, Hayashi T, Terada T, Handa N, Shirouzu M, Akiyama T, Yokoyama S
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Journal Title
Structure
Volume: 19
Issue: 10
Pages: 1496-1508
DOI
Related Report
Peer Reviewed
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[Journal Article] The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas2010
Author(s)
Niimi R, Matsumine A, Iino T, Murata T, Shintani K, Nakazora S, Nakamura T, Uehara Y, Kusuzaki K, Akiyama T, Uchida A
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Journal Title
Oncol Rep
Volume: 23
Issue: 3
Pages: 631-638
DOI
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Peer Reviewed
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[Journal Article] Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+mice with natural ligands2009
Author(s)
Kawajiri K, Kobayashi Y, Ohtake F, Ikuta T, Matsushima Y, Mimura J, Pettersson S, Pollenz RS, Sakaki T, Hirokawa T, Akiyama T, Kurosumi M, Poellinger L, Kato S, Fujii-Kuriyama Y
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Journal Title
Proc Natl Acad Sci USA
Volume: 106
Issue: 32
Pages: 13481-13486
DOI
Related Report
Peer Reviewed
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