Functional redundancy and hierarchy of glycosphingolipids in the architectures and regulations of lipid rafts in vivo

• Project/Area Number: 21390076
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Nagoya University
• Principal Investigator: KOICHI Furukawa 名古屋大学, 大学院・医学系研究科, 教授 (80211530)
• Co-Investigator(Renkei-kenkyūsha): JIRO Usukura 名古屋大学, 大学院・工学系研究科, 教授 (30143415) ; AKIHIRO Kusumi 京都大学, 再生医科学研究所, 教授 (50169992)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: ガングリオシド / ノックアウト / 炎症 / 神経変性 / ニューロン / 脂質ラフト / グリア / ミクログリア / Wisp2 / アポトーシス / スフィンゴ糖脂質 / 小脳 / 補体

Research Abstract

Using various knockout mice lacking synthetic enzyme genes responsible for the synthesis of gangliosides, we analyzed abnormal phenotypes of the mutamt mice. Analysis of the changes in the composition and chemical structures of glycolipids was performed, and comparison of architectures and dynamic features of lipid rafts among those mutant mice was also done. Consequently, abnormal rafts depending on the degree of the defects of gangliosides were elucidated. Furthermore, roles of gangliosides in the regulation of signals and of complements in lipid rafts were also clarified.

Research Products

• [Journal Article] Molecular mechanisms for the regulation of nervous systems with glycosphingolipids (2011)
  • Author(s): Furukawa K, Ohmi Y, Ohkawa Y, Tokuda N, Tajima O, Furukawa K
  • Journal Title: Seikagaku Volume: 83(3) Pages: 169-173
  • NAID: 10029067618
  • Peer Reviewed
• [Journal Article] Involvement of NGF in the rat model of persistent muscle pain associated with taut band (2011)
  • Author(s): Hayashi K, Ozaki N, Kawakita K, Itoh K, Mizumura K, Furukawa K, Yasui M, Hori K, Yi SQ, Yamaguchi T, Sugiura Y
  • Journal Title: J Pain. Volume: 12(10) Pages: 1059-1068
  • Peer Reviewed
• [Journal Article] Wisp2/CCN5up-regulated in the central nervous system of GM3-only mice facilitates neurite formation in Neuro2a cells via integrin-Akt signaling (2011)
  • Author(s): Ohkawa Y, Ohmi Y, Tajima O, Yamauchi Y, Furukawa K, Furukawa K
  • Journal Title: Biochem Biophys Res Commun Volume: 411(3) Pages: 483-489
  • Peer Reviewed
• [Journal Article] C9-R95X Polymorphism in Patients with Neovascular Age-Related Macular Degeneration (2011)
  • Author(s): Nishiguchi KM, Yasuma TR, Tomida D, Nakamura M, Ishikawa K, Kikuchi M, Ohmi Y, Niwa T, Hamajima N, Furukawa K, Terasaki H
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 53(1) Pages: 508-12
  • Peer Reviewed
• [Journal Article] Impairedhippo campal long-term potentiation and failure of learning inβ1 4-N-acetylgalactosaminy l transferasegene transgenic mice. (2011)
  • Author(s): Ikarashi K, Fujiwara H, Yamazaki Y, Goto J, Kaneko K, Kato H, Fujii S, Sasaki H, Fukumoto S, Furukawa K, Waki H, Furukawa K
  • Journal Title: Glycobiology Volume: 21(10) Pages: 1373-81
  • Peer Reviewed
• [Journal Article] Regulatory mechanisms of nervous systems with glycosphingolipids. (2011)
  • Author(s): Koichi Furukawa, Yuhsuke Ohmi, YukiOhkawa, Noriyo Tokuda, Yuji Kondo, Orie Tajima, Keiko Furukawa
  • Journal Title: Neurochem Res Volume: 36(9) Pages: 1578-1586
  • Peer Reviewed
• [Journal Article] Neuromuscular synaptic transmission in agedganglioside-deficient mice (2011)
  • Author(s): Zitman FM, Todorov B, Verschuuren JJ, JacobsBC, Furukawa K, Furukawa K, Willison HJ, Plomp JJ
  • Journal Title: Neurobiol Aging Volume: 32(1) Pages: 157-67
  • Peer Reviewed
• [Journal Article] Gangliosides are essential in the protection of inflammation and neurodegeneration viamaintenance of lipid rafts : elucidation by a series of ganglioside-deficient mutant mice (2011)
  • Author(s): Ohmi Y, Tajima O, Ohkawa Y, Yamauchi Y, Sugiura Y, Furukawa K, Furukawa K.
  • Journal Title: J Neurochem Volume: 116(5) Pages: 926-935
  • Peer Reviewed
• [Journal Article] Gangliosides are essential in the protection of inflammation and neuro degeneration via maintenance of lipid rafts: elucidation by a series of ganglioside-deficient mutant mice (2011)
  • Author(s): Ohmi, Y., Tajima, O., Ohkawa, Y., Sugiura, Y., Furukawa, K., Furukawa, K.
  • Journal Title: J.Neurochem. Volume: 116 Issue: 5 Pages: 926-935
  • DOI: 10.1111/j.1471-4159.2010.07067.x
  • Peer Reviewed
• [Journal Article] Functional activation of Src family kinase Yes is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3 (2011)
  • Author(s): Hamamura, K., Tsuji, M., Hotta, H., Ohkawa, Y., Takahashi, M., Shibuya, H., Nakashima, H., Yamauchi, Y., Hashimoto, N., Hattori, H., Ueda, M., Furukawa, K., Furukawa. K
  • Journal Title: J.Biol.Chem. Volume: 286 Issue: 21 Pages: 18526-37
  • DOI: 10.1074/jbc.m110.164798
  • Peer Reviewed
• [Journal Article] Wisp2/CCN5 up-regulated in the central nervous system of GM3-only mice facilitates neurite formation in Neuro2a cells via integrin-Akt signaling (2011)
  • Author(s): Ohkawa, Y., Ohmi, Y, Tajima, O., Yamauchi, Y, Furukawa, K., Furukawa' K
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 411 Issue: 3 Pages: 483-489
  • DOI: 10.1016/j.bbrc.2011.06.118
  • Peer Reviewed
• [Journal Article] Gangliosides are essential in the protection of inflammation and neuro degeneration via maintenance of lipid rafts : elucidation by a series of ganglioside-deficient mutant mice. (2011)
  • Author(s): Ohmi, Y., Tajima, O., Ohkawa, Y., Sugiura, Y., Furukawa, K., Furukawa, K
  • Journal Title: J.Neurochem. Volume: 116 Pages: 926-935
  • Peer Reviewed
• [Journal Article] Developmental stage-dependent expression of analpha2, 8-trisialic acid unit on glycoproteins in mouse brain (2010)
  • Author(s): Inoko E, Nishiura Y, Tanaka H, Takahashi T, Furukawa K, Kitajima K, Sato C
  • Journal Title: Glycobiology Volume: 20(7) Pages: 916-928
  • Peer Reviewed
• [Journal Article] Anti-GD1a antibodies activate complement and calpain to injure distal motor nodes of Ranvier in mice (2010)
  • Author(s): McGonigal R, Rowan EG, Greenshields KN, Halstead SK, Humphreys PD, Rother RP, Furukawa K, Willison HJ
  • Journal Title: Brain Volume: 133(Pt7) Pages: 1944-1960
  • Peer Reviewed
• [Journal Article] Dysfunction of muscarinic acetylcholine receptors as asubstantial basis for progressive neurological deterioration in GM3-only mice (2010)
  • Author(s): Tajima O, Egashira N, Ohmi Y, Fukue Y, Mishima K, Iwasaki K, Fujiwara M, Sugiura Y, Furukawa K
  • Journal Title: Behav Brain Res Volume: 206(1) Pages: 101-108
  • Peer Reviewed
• [Journal Article] To talganglioside ablation at mouse motor nerveterminals alters neurotransmitter release level (2010)
  • Author(s): Zitman FM, Todorov B, Furukawa K, Furukawa K, Willison HJ, Plomp JJ
  • Journal Title: Synapse Volume: 64(4) Pages: 335-338
  • Peer Reviewed
• [Journal Article] Ganglioside GD3 enhances adhesion signals and augments malignant properties of melanoma cells by recruiting integrins to glycolipid-enriched microdomains. (2010)
  • Author(s): Ohkawa, Y., Miyazaki, S., Ha-mamura, H., Ohmi, Y., Yama-uchi, Y., Furukawa, K., et al.
  • Journal Title: J.Biol. Chem. Volume: 285 Pages: 27213-27223
  • Peer Reviewed
• [Journal Article] Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice. (2010)
  • Author(s): Tajima, O., Egashira, N., Ohmi, Y., Fukue, Y., Mishima, K., Iwasaki, K., Fujiwara, M., Sugi-ura, Y., Furukawa, K., et al.
  • Journal Title: Behav. Brain Res Volume: 206 Pages: 101-108
  • Peer Reviewed
• [Journal Article] Ganglioside GD3 enhances adhesion signals and augments malignant properties of melanoma cells by recruiting integrins to glycolipid-enriched microdomains. (2010)
  • Author(s): Ohkawa, Y., Miyazaki, S., Ha-mamura, H., Ohmi, Y., Yamauchi, Y., Furukawa, K., et al.
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 27213-27223
  • Peer Reviewed
• [Journal Article] Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice. (2010)
  • Author(s): Tajima, O., Egashira, N., Ohmi, Y., Fukue, Y., Mishima, K., Iwasaki, K., Fujiwara, M., Sugiura, Y., Furukawa, K., et al.
  • Journal Title: Behav.Brain Res. Volume: 206 Pages: 101-108
  • Peer Reviewed
• [Journal Article] Glycosphingoliids in neural differentiation (2009)
  • Author(s): Furukawa K, Ohmi Y, Tokuda N, Furukawa K, Tajima O
  • Journal Title: Seitai no Kagaku Volume: 60(3) Pages: 187-193
  • Peer Reviewed
• [Journal Article] Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues (2009)
  • Author(s): Ohmi Y, Tajima O, Ohkawa Y, Mori A, Sugiura Y, Furukawa K
  • Journal Title: Proc Natl Acad Sci U S A Volume: 106(52) Pages: 22405-10
  • Peer Reviewed
• [Journal Article] The neuropathic potential of anti-GM1 autoantibodies is regulated by the localglycolipid environment in mice (2009)
  • Author(s): Greenshields KN, Halstead SK, Zitman FM, Rinaldi S, Brennan KM, O' Leary C, Chamberlain LH, Easton A, Roxburgh J, PedianiJ, Furukawa K, Furukawa K, Goodyear CS, Plomp JJ, Willison HJ
  • Journal Title: J Clin Invest. Volume: 119(3) Pages: 595-610
  • Peer Reviewed
• [Journal Article] Gangliosides determine the amyloid pathology of Alzheimer's disease (2009)
  • Author(s): Oikawa N, Yamaguchi H, Ogino K, Taki T, Yuyama K, Yamamoto N, Shin RW, Furukawa K, Yanagisawa K
  • Journal Title: Neuroreport Volume: 20(12) Pages: 1043-6
  • Peer Reviewed
• [Journal Article] In vitro analysis of glial cell function in ganglioside-deficient mice (2009)
  • Author(s): Edina Silajdzic, Hugh J. Willison, KoichiFurukawa, and Susan C. Barnett
  • Journal Title: J Neurosci Res Volume: 87(11) Pages: 2467-83
  • Peer Reviewed
• [Journal Article] Glycocon jugate glycosy ltransferases (2009)
  • Author(s): Furukawa K, Tsuchida A, Okajima T, Furukawa K.
  • Journal Title: Glycocon J Volume: 26(8) Pages: 987-998
  • Peer Reviewed
• [Journal Article] Reduced motor and sensory functions and emotional response inGM3-only mice : emeregence from early stage of life and exacerbation with aging (2009)
  • Author(s): Tajima O, Egashira N, Ohmi Y, Fukue Y, Mishima K, Iwasaki M, Fujiwara M, Sugiura Y, Furukawa K, Furukawa K.
  • Journal Title: Behav Brain Res Volume: 198(1) Pages: 74-82
  • Peer Reviewed
• [Presentation] The Niemann-Pick type C protein NPC1 regulates trafficking of disease-associated gangliosides from the lysosome to the plasma membrane (2011)
  • Author(s): Yoshio Yamauchi, Kosuke Yoshida, Ta YuanChang, Keiko Furukawa
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] 糖鎖科学の統合的展開をめざす先端的・国際的研究拠点の形成 (2011)
  • Author(s): 古川鋼一、若槻壮市、加藤晃一
  • Organizer: 第9回糖鎖科学コンソーシアムシンポジウム
  • Place of Presentation: 名古屋
• [Presentation] Wisp2/CCN5 up-regulated in spinal cord of GM3-only mice facilitates neurite formation in Neuro2a cells via integrin-Akt signaling. (2011)
  • Author(s): 大川祐樹、大海雄介、田島織絵、金子慶、岩沢太司、山内祥生、古川圭子、古川鋼一
  • Organizer: 第84回日本生化学会大会合同大会
  • Place of Presentation: 京都
• [Presentation] Roles of gangliosides on the maintenance of integrity of lipid rafts (2011)
  • Author(s): 大海雄介、田島織絵、大川祐樹、山内祥生、古川圭子、古川鋼一
  • Organizer: 第84回日本生化学会大会合同大会
  • Place of Presentation: 京都
• [Presentation] Wisp2/CCN5 up-regulated in spinal cord of GM3-only mice facilitates neurite formation inNeuro2a cells via integrin-Akt signaling (2011)
  • Author(s): 大川祐樹、大海雄介、田島織絵、金子慶、岩沢太司、山内祥生、古川圭子、古川鋼一
  • Organizer: 第84回日本生化学会大会合同大会
  • Place of Presentation: 京都
• [Presentation] Gut abnormalities during postnatal developmentin GM3-only mice (2011)
  • Author(s): 田島織絵、藤田雄輝、大海雄介、大川祐樹、古川圭子、古川鋼一
  • Organizer: 第84回日本生化学会大会合同大会
  • Place of Presentation: 京都
• [Presentation] Essential roles of gangliosides in the protection of inflammation and neurodegeneration via the regulation of lipid rafts : elucidation by a series of ganglioside deficient mice (2011)
  • Author(s): K. Furukawa, Y. Ohmi, O. Tajima, Y. Ohkawa, Y. Yamauchi, K. Furukawa
  • Organizer: 21st International Synposium on Glycoconjugates
  • Place of Presentation: Vienna, Austria
• [Presentation] Molecular mechanisms for the growth disorders in GM3-only mice (2011)
  • Author(s): O. Tajima, Y. Fujita, Y. Ohmi, Y. Ohkawa, K. Furukawa, K. Furukawa
  • Organizer: 21st International Synposium on Glycoconjugates
  • Place of Presentation: Vienna, Austria
• [Presentation] 病理学におけるグライコーム研究.神経・筋、感染症、がん、再生医学.医学における糖鎖研究の重要性 (2011)
  • Author(s): 古川鋼一
  • Organizer: 第8回日本病理学会2011カンファレンス松本
  • Place of Presentation: 松本
• [Presentation] GM3 onlyマウスの中枢神経系で高度発現するWisp2/CCN5の機能解析 (2011)
  • Author(s): 大川祐樹、大海雄介、田島織絵、金子慶、岩沢太司、山内祥生、古川圭子、古川鋼一
  • Organizer: 第30回日本糖質学会年会
  • Place of Presentation: 長岡
• [Presentation] Regulatory mechanisms of malignant phenotypes of human cancers by tumor-associated carbohydrate antigens in the microdomains (2011)
  • Author(s): 古川鋼一
  • Organizer: The 31^<st> Naito Conference [Glycan Expression and Regulation [II] : Metabolites, Stress Response, Microdomains, and Beyond]
  • Place of Presentation: 札幌(シャトレーゼガトーキングダムサッポロ)
• [Presentation] Essential Roles of Gangliosides in the Regulation of Lipid Rafts in Nervous Tissues (2010)
  • Author(s): Koichi Furukawa, Yuhsuke Ohmi, Orie Tajima, Yuki Ohkawa, Keiko Furukawa
  • Organizer: GlycoT 2010 Tokyo 7^<th> International Symposium on Glycosyl-transferases
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2010-07-08
• [Presentation] Endosome/lysosome and Small Molecules that Stimulates Their Transport to the Plasma Membrane in Niemamm-Pick Type CCells (2010)
  • Author(s): Yoshio Yamauchi, Kosuke Yoshida, Ta-YuanChang, Koichi Furukawa
  • Organizer: GlycoT 2010 Tokyo 7^<th> International Symposium on Glycosyltransferases
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2010-07-08
• [Presentation] Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues (2010)
  • Author(s): Koichi Furukawa, et al
  • Organizer: 4th ISN Special Neurochemistry Conference "Membrane Domains in CNS physiology and pathology"
  • Place of Presentation: Erice (Trapani), Sicily, Italy
  • Year and Date: 2010-05-23
• [Presentation] Lysosomal accumulation of disease-associatedgangliosides and small molecules that stimulate their lysosome-to-plasma membrane transport inNiemamm-Pick type C cells (2010)
  • Author(s): Yoshio Yamauchi, Kosuke Yoshida, Ta YuanChang, Keiko Furukawa, Koichi Furukawa
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] Lysosomal accumulation of disease-associatedgangliosides and small molecules that stimulatetheir lysosome-to-plasma membrane transport in Niemamm-Pick type C cells (2010)
  • Author(s): Yoshio Yamauchi, Kosuke Yoshida, Ta YuanChang, Keiko Furukawa, Koichi Furukawa
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] GM3 only miceの脊髄における神経変性機構の解明 (2010)
  • Author(s): 大海雄介、田島織絵、大川祐樹、古川圭子、古川鋼一
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] GM3 onlyマウスの中枢神経系におけるCCN5/Wisp2遺伝子の機能解析 (2010)
  • Author(s): 大川祐樹、大海雄介、田島織絵、稲垣邦江、徳田典代、古川圭子、古川鋼一
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] 糖鎖変異マウスにおける成長障害の分子メカニズム (2010)
  • Author(s): 田島織絵、藤田雄輝、大海雄介、大川祐樹、古川圭子、古川鋼一
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] ABC transporterABCA1 facilitates bidirectional sterol movement and modulates the regulatory sterol signals (2010)
  • Author(s): Yoshio Yamauchi, Maximillian A. Rogers, Sumiko Abe-Dohmae, Shinji Yokoyama, KoichiFurukawa, and Ta-Yuan Chang
  • Organizer: 第42回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 岐阜
• [Presentation] Gangliosides play pivotalroles in the regulation of complement systems andin the maintenance of integrity in nerve tissues (2010)
  • Author(s): Koichi Furukawa
  • Organizer: 4^<th> ISN Special Neurochemistry Conference
  • Place of Presentation: Sicily, Italy
• [Presentation] Disruption of GM2/GD2synthase gene resulted in overt expression of 9-O-acetyl GD3 irrespective of TIS21 (2010)
  • Author(s): K. Furukawa, W. Aixingjueluo, T. Kasama, Y. Ohkawa, M. Yoshihara, Y. Ohmi, O. Tajima, A. Suzumura, K. Furukawa
  • Organizer: 4^<th> ISN Special Neurochemistry Conference
  • Place of Presentation: Sicily, Italy
• [Presentation] 遺伝子改変動物から学んだ新たな糖鎖機能と疾患メカニズムオーガナイザー (2009)
  • Author(s): 古川鋼一、北爪しのぶ
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Neurodegeneration due to ganglioside deficiencyis caused via inflammatory reaction based on complement activation (2009)
  • Author(s): 古川鋼一、大海雄介、田島織絵、大川祐樹、古川圭子
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Roles of gangliosides in the regulation of lipid rafts. Glycosylation in Cell Biology (2009)
  • Author(s): Yuhsuke Ohmi, Orie Tajima, Yuki Ohkawa, Atsushi Mori, Kunie Inagaki, Keiko Furukawa, Koichi Furukawa
  • Organizer: 20^<th> Joint Glycobiology Meeting Cologne & Satellite Core-to-Core Meeting of the Japanese and German Societies
  • Place of Presentation: Cologne, Germany
• [Presentation] 糖鎖の持つユニークな生化学的活性と疾患:スフィンゴ糖脂質による脂質ラフトの制御とその破綻 (2009)
  • Author(s): 古川鋼一、大海雄介、濱村和紀、古川圭子
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] マウス新生仔脳局在A2B5エピトープ含有糖タンパク質のシアロ糖鎖の特徴と生合成 (2009)
  • Author(s): 猪子恵未、西浦祐二、田中浩士、高橋孝志、古川鋼一、北島健、佐藤ちひろ
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 糖鎖欠損マウスにおける進行性神経機能障害の基盤としてのアセチルコリン受容体異常 (2009)
  • Author(s): 田島織絵、江頭伸昭、大海雄介、福江善彦、三島健一、岩崎克典、藤原道弘、杉浦康夫、古川圭子、古川鋼一
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 日本糖鎖科学コンソーシアムのデータベース (2009)
  • Author(s): 鹿内俊秀、新間陽一、鈴木芳典、藤田典昭、梶裕之、佐藤隆、栂谷内晶、亀山昭彦、舘野浩章、平林淳、奥田修二郎、川嵜敏祐、高橋禮子、加藤晃一、古川鋼一、八杉悦子、西島正弘、木下聖子、西原祥子、山田一作、水野正盛、白井孝、加藤雅樹、山口芳樹、萩谷恵理子、吉田圭一、谷口直之、成松久
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 細胞膜ミクロドメインの健常性維持と機能における酸性糖脂質の役割 (2009)
  • Author(s): 古川鋼一、大海雄介、田島織絵、大川祐樹、徳田典代、古川圭子
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 高山
• [Presentation] GM3 onlyマウスの神経変性における補体の役割 (2009)
  • Author(s): 大海雄介、田島織絵、大川祐樹、徳田典代、古川圭子、古川鋼一
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 高山
• [Book] グロボ系糖脂質欠損マウスモデル動物実験マニュアル生物機能モデルと新しいリソース・リサーチツール(小幡裕一他編) (2011)
  • Author(s): 古川鋼一、近藤裕史、奥田徹哉、古川圭子
  • Publisher: Life-Science Information Center
• [Book] 生物機能モデルと新しいリソース・リサーチツール「ガングリオシド合成酵素」 (2011)
  • Author(s): 古川鋼一、大海雄介その, 他4名
  • Total Pages: 671
  • Publisher: エル・アイ・シー
• [Book] 生物機能モデルと新しいリソース・リサーチツール「ガングリオシド合成酵素」 (2011)
  • Author(s): 古川鋼一, 大海雄介, その他4名
  • Total Pages: 671
  • Publisher: エル・アイ・シー
• [Remarks]
  • URL: http://www.glycomics.ne.jp/news1201.html
• [Remarks]
  • URL: http://www.glycomics.ne.jp/news1201.html
• [Patent(Industrial Property Rights)] グロボトリアオシルセラミドを特異的に認識する果モノクローナル抗体及びその作製法 (2010)
  • Inventor(s): 古川鋼一, ら5名
  • Industrial Property Rights Holder: 名古屋大学(株)GPバイオサイエンス
  • Industrial Property Number: 2010-197639
  • Filing Date: 2010-09-03