Roles of receptors for lipid mediators in inflammation and immunity
Project/Area Number |
21390083
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General medical chemistry
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
OKUNO Toshiaki 九州大学, 大学院・医学研究院, 助教 (60361466)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
|
Keywords | ロイコトリエンB4 / Gタンパク質共役型受容体 / マクロファージ / 骨粗霧症 / 多発性硬化症 / 炎症性腸疾患 / 生理活性脂質 / 12-ヒドロキシトリエン酸 / 樹状細胞 / サイトカイン / ケラチノサイト / 細胞移動 / 細胞障害性T細胞 |
Research Abstract |
BLT1-deficient mice exhibited milder symptoms in models of osteoporosis, multiple sclerosis and spinal injury, suggesting the possible application of BLT1 antagonists in these diseases. We established BLT2-deficient mice, and found that BLT2 protects intestinal inflammation by enhancing the barrier functions of colon epithelial cells. We established a system to measure 12-HHT, a BLT2 ligand in combination of liquid chromatography and mass spectrometry.
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Report
(4 results)
Research Products
(110 results)
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[Journal Article] A high affinity monoclonal antibody against the FLAG tag useful for Gprotein coupled receptor study2012
Author(s)
Sasaki, F., Okuno, T., Saeki, K, NTul, L, Onohara, N., Kate, H, Shimizu, T. and Yokomizo, T.
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Journal Title
Anal. Bloc hem
Volume: 425
Pages: 157-165
Related Report
Peer Reviewed
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[Journal Article] Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions2011
Author(s)
Back, M, Dahlen, S. E., Drazen, J. M., Evans, J. F., Serhan, C. N., Shimizu, T., Yokomizo, T. and Rovati, G. E.
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Journal Title
Pharmacol
Volume: Rev. 63
Pages: 539-584
Related Report
Peer Reviewed
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[Journal Article] Shimizu, T. and Miyano, M Expression, purification and characterization of leukotriene B(4) receptor, BLTl in Pichia pastoris2010
Author(s)
ort, T., Sate, Y., Takahashi, N., Takio, K, Yokomizo, T., Nakamura, M
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Journal Title
Protein Expr. Purif
Volume: 72
Pages: 66-74
Related Report
Peer Reviewed
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[Journal Article] Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis2010
Author(s)
Iizuka, Y., Okuno, T., Saeki, K, Uozaki, H., Okada, S., Misaka, T., Sate, T., Ton, H., Fukayama, M, Takeda, N., Kita, Y., Shimizu, T., Nakamura, M and Yokomizo, T.
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Journal Title
FASEB J
Volume: 24
Pages: 4678-4690
Related Report
Peer Reviewed
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[Journal Article] The leukotriene B4 receptor, BLTl, is required for the induction of experimental autoimmune encephalomyelitis2010
Author(s)
Kihara, Y., Yokomizo, T., Kunita, A., Morishita, Y., Fukayama, M., Ishii, S. and Shimizu, T.
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 394
Pages: 673-678
Related Report
Peer Reviewed
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[Journal Article] The LTB4-BLTl axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury2010
Author(s)
Saiwai, H, Ohkawa, Y., Yamada, H, Kumamaru, H, Harada, A., Okano, H, Yokomizo, T., Iwamoto, Y. and Okada, S.
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Journal Title
Am. J. Pathol
Volume: 176
Pages: 2352-2366
Related Report
Peer Reviewed
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[Journal Article] Identification of a novel marker for dendritic cell maturation, mouse transmembrane protein 1232010
Author(s)
Takekoshi, T., Tada, Y., Watanabe, T., Sugaya, M, Hoashi, T., Komine, M., Kawashima, T., Shimizu, T., Hall, C. S., Asahina, A., Yokomizo, T., Sate, S. and Tamaki, K
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Journal Title
J. Biol. Chem
Volume: 285
Pages: 31876-31884
Related Report
Peer Reviewed
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[Journal Article] Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene B4 receptor 12010
Author(s)
Toda, A., Terawaki, K, Yamazaki, S., Saeki, K, Shimizu, T. and Yokomizo, T.
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Journal Title
Biochimie
Volume: 92
Pages: 682-691
Related Report
Peer Reviewed
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[Journal Article] CDiobearing fibroblast inhibits matrigel invasive potency of interleukinlalpha-producing squamous cell carcinoma by diminishing substance P te ve is in the tumor micro e nviro nine ht2010
Author(s)
Xie, L., Moroi, Y., Tsuji, G., Lin, M, Hayashida, S., Takahara, M, Fukagawa, S., Takeuchi, S., Shah, B., Nakahara, T., Uchi, H, Yokomizo, T. and Furue, M.
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Journal Title
Cancer Sci
Volume: 101
Pages: 2570-2578
Related Report
Peer Reviewed
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[Journal Article] Aromatic D-amino acids act as c he mo attractant factors for human leukocytes through a G proteincoupled receptor, GPR109B2009
Author(s)
Irukayama-Tomobe, Y., Tanaka, H, Yokomizo, T., HashidateYoshida, T., Yanagisawa, M and Sakurai, T.
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Journal Title
Proc. Natl. Acad. Sci. U. S. A.
Volume: 106
Pages: 3930-3934
Related Report
Peer Reviewed
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[Journal Article] Transcriptional regulation of human G2A in monocytes/macrophages : involvement of c/EBPs, Runx and Pu. 12009
Author(s)
Murakami, N., Hashidate, T., Harayama, T., Yokomizo, T., Shimizu, T. and Nakamura, M.
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Journal Title
Genes Cells
Volume: 14
Pages: 1441-1455
Related Report
Peer Reviewed
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[Journal Article] Helix 8 of le ukotrie ne B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum2009
Author(s)
Yasuda, D., Okuno, T., Yokomizo, T., Hori, T., Hirota, N., Hashidate, T., 1Vliyano, M, Shimizu, T. and Nakamura, M.
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Journal Title
FASEB J.
Volume: 23
Pages: 1470-1481
Related Report
Peer Reviewed
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