Phys i o I og i ca I f unct i on and regu I atory mechan i sm of Fhodl and Fhod3, proteins that regulate actin filaments

• Project/Area Number: 21390084
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kyushu University
• Principal Investigator: SUMIMOTO Hideki 九州大学, 医学研究院, 教授 (30179303)
• Co-Investigator(Kenkyū-buntansha): TAKEYA Ryu 九州大学, 大学院・医学研究院, 講師 (50335981)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: 細胞骨格 / アクチン / formin / Fhod / 筋細胞

Research Abstract

Fhod3, a member of formin family proteins that play pivotal roles in actin filament assembly, plays a crucial role in organization of the sarcomere(the contractile unit of myofibrils) in cultured cardiomyocytes. Indeed Fhod3-gene-deficient mice are embryonic lethal due to defective myofibrillogenesis at an early stage of heart development. Thus Fhod3 is a protein essential for cardiogenesis.

Research Products

• [Journal Article] Assessment of the role for Rho family GTPases in NADPH oxidase activation (2012)
  • Author(s): Miyano K, and Sumimoto H.
  • Journal Title: Methods Mol. Biol Volume: 827 Pages: 195-212
  • Peer Reviewed
• [Journal Article] Noxa1 as a moderate activator of Nox2-based NADPH oxidase (2012)
  • Author(s): Kawano M, Miyamoto K, Kaito Y, Sumimoto H, Tamura M.
  • Journal Title: Arch Biochem Biophys Volume: 519 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Blockade of inflammatory responses by a smallmolecule inhibitor of the Rac activator DOCK2 (2012)
  • Author(s): Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saitoh N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H, Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, and Fukui Y.
  • Journal Title: Chem. Biol Volume: 19 Pages: 488-497
  • Peer Reviewed
• [Journal Article] Expression and subcellular localization of mammalian formin Fhod3 in the embryonic and adultheart (2012)
  • Author(s): Kan-o M, Takeya R, Taniguchi K, Tanoue Y, Tominaga R, and Sumimoto H.
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] and Shimada, I. Atypical membraneembedded PI(3, 4) P2 binding site on p47p"ーX PX domain revealed by NMR (2012)
  • Author(s): Stampoulis, P., Ueda, T., Matsumoto, M., Terasawa, H., Miyano, K., Sumimoto, H.
  • Journal Title: J. Biol. Chem Volume: 287
  • Peer Reviewed
• [Journal Article] Assessment of the role for Rho family GTPases in NADPHoxidase activation (2012)
  • Author(s): Miyano K, Sumimoto H
  • Journal Title: Methods Mol. Biol Volume: 827 Pages: 195-212
  • DOI: 10.1007/978-1-61779-442-1_14
  • ISBN: 9781617794414, 9781617794421
  • Peer Reviewed
• [Journal Article] Noxa1 as a moderate activator of Nox2-based NADPH oxidase (2012)
  • Author(s): Kawano M, Miyamoto K, Kaito Y, Sumimoto H, Tamura M
  • Journal Title: Arch. Biochem. Biophys Volume: 519 Issue: 1 Pages: 1-7
  • DOI: 10.1016/j.abb.2011.12.025
  • Peer Reviewed
• [Journal Article] Blockade of inflammatory responses by a small-molecule inhibitor of the Racactivator DOCK2 (2012)
  • Author(s): Nishikimi, A., et al
  • Journal Title: Chem.Biol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Expression and subcellular localization of mammalian formin Fhod3 in the embryonic and adultheart (2012)
  • Author(s): Kan-o M, Takeya R, Taniguchi K, Tanoue Y, Tominaga R, and Sumimoto H
  • Journal Title: PLoS One Volume: 7 Issue: 4 Pages: 34765-34765
  • DOI: 10.1371/journal.pone.0034765
  • Peer Reviewed
• [Journal Article] Atypical membrane-embedded p47^<phox> PI(3,4)P_2 binding site on PX domain revealed by NMR (2012)
  • Author(s): Stampoulis P, Ueda T, Matsumoto M, Terasawa H, Miyano K, Sumimoto H, and Shimada I
  • Journal Title: J. Biol. Chem Volume: 287 Issue: 21 Pages: 17848-17859
  • DOI: 10.1074/jbc.m111.332874
  • Peer Reviewed
• [Journal Article] Polarity proteins Beml and Cdc24 are components of the filamentous fungal NADPH oxidase complex (2011)
  • Author(s): Takemoto D, Kamakura S, Saikia S, Becker Y, Wrenn R, Tanaka A, Sumimoto H, and Scott B.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108 Pages: 2861-2866
  • Peer Reviewed
• [Journal Article] Selectively induced apoptosis in human neutrophils in the presence of oxidative phenoxazines, 2-amino-4, 4 a dihydryo4 a 71I-phenoxazine-3-one and 2aminophenoxazine-3-one preceded by decrease of intracellular pH, depolarization of the mitochondria and inh (2011)
  • Author(s): Tabuchi T, Che X.-F, Hiraishi K, Adachi M, Miyano K, Sumimoto H, Tabuchi T, Miyazawa K, and Tomoda A.
  • Journal Title: J. Pharmacol. Sci Volume: 117 Pages: 139-148
  • Peer Reviewed
• [Journal Article] Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-nriched protein(LGN) (2011)
  • Author(s): Yuzawa S, Kamakura S, Iwakiri Y, Hayase J, and Sumimoto H.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108 Pages: 19210-19215
  • Peer Reviewed
• [Journal Article] Polarity proteins Bem1 and Cdc24 are components of the filamentous fungal NADPH oxidasecomplex (2011)
  • Author(s): Takemoto D, Kamakura S, Saikia S, Becker Y, Wrenn R, Tanaka A, Sumimoto H, and Scott B
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108 Issue: 7 Pages: 2861-2866
  • DOI: 10.1073/pnas.1017309108
  • Peer Reviewed
• [Journal Article] Selectively Induced Apoptosis in Human Neutrophils in the Presence of Oxidative Phenoxazines, 2-Amino-4,4<I>&alpha;</I>-dihydryo-4<I>&alpha;</I>-7<I>H</I>-phenoxazine-3-one and 2-Aminophenoxazine-3-one, Preceded by Decrease of Intracellular pH, Depolarization of the Mitochondria, and Inhibition of Superoxide Generation (2011)
  • Author(s): Tabuchi T, Ch, X-F, Hiraishi K, Adachi M, Miyano K, Sumimoto H , Tabuchi T, Miyazawa K, and Tomoda A
  • Journal Title: Journal of Pharmacological Sciences Volume: 117 Issue: 3 Pages: 139-148
  • DOI: 10.1254/jphs.11134FP
  • NAID: 10030453178
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein(LGN) (2011)
  • Author(s): Yuzawa S, Kamakura S, Iwakiri Y, Hayase J, and Sumimoto H
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108 Issue: 48 Pages: 19210-19215
  • DOI: 10.1073/pnas.1110951108
  • Peer Reviewed
• [Journal Article] Polarity proteins Bem1 and Cdc24 are components of the filamentous fungal NADPH oxidase complex. (2011)
  • Author(s): Takemoto, D., Kamakura, S., Saikia, S., Becker, Y., Wrenn, R., Tanaka, A., Sumimoto, H., Scott, B.
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 108 Pages: 2861-2866
  • Peer Reviewed
• [Journal Article] Assessment of the Role for Rho family GTPases in NADPH oxidase activation (2011)
  • Author(s): Miyano, K., Sumimoto, H.
  • Journal Title: Methods Mol.Biol. Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Membrane phospholipid metabolism during phagocytosis in human neutrophils (2010)
  • Author(s): Minakami R, Maehara Y, Kamakura S, Kumano 0, Miyano K, Sumimoto H.
  • Journal Title: Genes Cells Volume: 15 Pages: 409-423
  • Peer Reviewed
• [Journal Article] Pertussis toxin upregulates angiotensin type 1 receptors through Toll-like receptor 4mediated Rac activation (2010)
  • Author(s): Nishida M, Suda R, Nagamatsu Y, Tanabe S, Onohara N, Nakaya M, Kanaho Y, Shibata T, Uchida K, Sumimoto H, Sato Y, Kurose H.
  • Journal Title: J. Biol. Chem Volume: 285 Pages: 15268-15277
  • Peer Reviewed
• [Journal Article] A Conserved Region between the TPR and Activation Domains of p67phox Participates in Activation of the Phagocyte NADPH Oxidase. (2010)
  • Author(s): Maehara Y, Miyano K, Yuzawa S, Akimoto R, Takeya R, and Sumimoto H.
  • Journal Title: J. Biol. Chem Volume: 41 Pages: 31435-31445
  • Peer Reviewed
• [Journal Article] Effects of F/G-actin ratio and actin turn-over rate on NADPH oxidase activity in microglia (2010)
  • Author(s): Rasmussen I, Pedersen L. H, Byg L, Suzuki K, Sumimoto H, and Vilhardt F.
  • Journal Title: BMC Immunol Volume: 11 Pages: 44-44
  • Peer Reviewed
• [Journal Article] Leukotriene B4 augments and restores FcgRs-dependent phagocytosis in macrophages (2010)
  • Author(s): Okamoto F, Saeki K, Sumimoto H, Yamasaki S, and Yokomizo T.
  • Journal Title: J. Biol. Chem Volume: 285 Pages: 41113-41121
  • Peer Reviewed
• [Journal Article] Membrane phospholipid metabolism during phagocytosis in human neutrophils. (2010)
  • Author(s): Minakami, R., Maehara, Y., Kamakura, S., Kumano, O., Miyano, K., Sumimoto, H.
  • Journal Title: Genes Cells Volume: 15 Pages: 409-423
  • Peer Reviewed
• [Journal Article] Pertussis toxin upregulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation. (2010)
  • Author(s): Nishida, M., Suda, R., Nagamatsu, Y., Tanabe, S., Onohara, N., Nakaya, M., Kanaho, Y., Shibata, T., Uchida, K., Sumimoto, H., Sato, Y., Kurose, H.
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 15268-15277
  • Peer Reviewed
• [Journal Article] Effects of F/G-actin ratio and actin turn-over rate on NADPH oxidase activity in microglia. (2010)
  • Author(s): Rasmussen, I., Pedersen, L.H., Byg, L, Suzuki, K., Sumimoto, H., Vilhardt, F.
  • Journal Title: BMC Immunol. Volume: 11 Pages: 44-44
  • Peer Reviewed
• [Journal Article] A conserved region between the TPR and activation domains of p67^<phox> participates in activation of the phagocyte NADPH oxidase. (2010)
  • Author(s): Maehara, Y., Miyano, K., Yuzawa, S., Akimoto, R., Takeya, R., Sumimoto, H.
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 31435-31445
  • Peer Reviewed
• [Journal Article] Leukotriene B_4 augments and restores FcgRs-dependent phagocytosis in macrophages. (2010)
  • Author(s): Okamoto, F., Saeki, K., Sumimoto, H., Yamasaki, S., Yokomizo, T.
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 41113-41121
  • Peer Reviewed
• [Journal Article] 外敵侵入に備えるNADPHオキシダーゼ (2010)
  • Author(s): 住本英樹
  • Journal Title: 外科と代謝・栄養 Volume: 44 Pages: 213-217
  • NAID: 10026699858
  • Peer Reviewed
• [Journal Article] Membrane phospholipid metabolism during phagocytosis in human neutrophils (2010)
  • Author(s): Minakami, R., et al.
  • Journal Title: Genes Cells (印刷中)
  • Peer Reviewed
• [Journal Article] Pertussis toxin upregulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation (2010)
  • Author(s): Nishida, M., et al.
  • Journal Title: J. Biol. Chem. (印刷中)
  • Peer Reviewed
• [Journal Article] Mammalian form in Fhods regulates actin assembly and sarcomereorganization in striated muscles (2009)
  • Author(s): Taniguchi K, Takeya R, Suetsugu S, Kan-o M, Narusawa M, Shiose A, Tominaga R, and Sumimoto H.
  • Journal Title: J. Biol. Chem Volume: 284 Pages: 29873-29881
  • Peer Reviewed
• [Journal Article] Mammalian formin Fhod3 regulates actin assembly and sarcomere organization in striated muscles (2009)
  • Author(s): Taniguchi K, Takeya R, Suetsugu S, Kan-o M, Narusawa M, Shiose A, Tominaga R, and Sumimoto H.
  • Journal Title: J. Biol. Chem Volume: 284 Pages: 29873-29881
  • Peer Reviewed
• [Journal Article] A regionN-terminal to the tandem SH3 domain ofP47phox plays a crucial role in activationof the phagocyte NADPH oxidase (2009)
  • Author(s): Taura M, Miyano K, Minakami R, KamakuraS, Takeya R, Sumimoto H.
  • Journal Title: Biochem J. Volume: 419 Pages: 329-338
  • Peer Reviewed
• [Journal Article] NMR structure of theheterodimer of Beml and Cdc24 PBI domainsfrom Saccharomyces cerevisiae (2009)
  • Author(s): Ogura K, Tandai T, Yoshinaga S, Kobashigawa Y, Kumeta H, Ito T, Sumimoto旦, Inagaki F.
  • Journal Title: J Biochem. Volume: 146 Pages: 317-325
  • Peer Reviewed
• [Journal Article] The insert region of the Rac GTPases isdispensable for activation ofsuperoxide-producing NADPH oxidases. (2009)
  • Author(s): Miyano K, Koga H, Minakami R, Sumimoto H.
  • Journal Title: Biochem J. Volume: 422 Pages: 373-382
  • Peer Reviewed
• [Journal Article] The domain organization of p67p'ーX, a protein required for activation of the superoxideproducing NADPH oxidase in phagocytes (2009)
  • Author(s): Yuzawa S, Miyano K, Honbou K, Inagaki F, and Sumimoto H.
  • Journal Title: J. Innate Immun Volume: 1 Pages: 543-555
  • Peer Reviewed
• [Journal Article] Mammalian formin Fhod3 regulates actin assembly and sarcomere organization in striated muscles (2009)
  • Author(s): Taniguchi, K., et al.
  • Journal Title: J. Biol. Chem. 284 Pages: 29873-29881
  • Peer Reviewed
• [Journal Article] A region N-terminal to the tandem SH3 domain of p47_<phox> plays a plays a crucial role in activation of the phagocyte NADPH oxidase (2009)
  • Author(s): Taura, M., et al.
  • Journal Title: Biochem. J. 419 Pages: 329-338
  • Peer Reviewed
• [Journal Article] The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases (2009)
  • Author(s): Miyano, K., et al.
  • Journal Title: Biochem J. 422 Pages: 373-382
  • Peer Reviewed
• [Journal Article] Role for the first SH3 domain of p67_<phox> in activation of superoxide-producing NADPH oxidases (2009)
  • Author(s): Maehara, Y., et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 379 Pages: 589-593
  • Peer Reviewed
• [Journal Article] The domain organization of p67_<phox>, a protein require or activation of the superoxide-producing NADPH oxidase in phagocytes (2009)
  • Author(s): Yuzawa, S., et al.
  • Journal Title: J. Innate Immun. 1 Pages: 543-555
  • Peer Reviewed
• [Journal Article] NMR structure of the heterodimer of Bem1 and Cdc24 PB1 domains from Saccharomyces cerevisiae (2009)
  • Author(s): Ogura., K., et al.
  • Journal Title: J. Biochem. 146 Pages: 317-325
  • Peer Reviewed
• [Journal Article] 活性酸素生成酵素NADPHオキシダーゼの構造と活性化機構 (2009)
  • Author(s): 住本英樹
  • Journal Title: 蛋白質 核酸 酵素 54 Pages: 1690-1695
• [Journal Article] 活性酸素シグナル生成系の制御機構 (2009)
  • Author(s): 住本英樹
  • Journal Title: 実験医学 27 Pages: 2328-2335
• [Presentation] Transcriptional Regulation by IKB and the NF-KB p50 subunit (2012)
  • Author(s): Son Yamazaki and Hideki Sumimoto.
  • Organizer: Keystone Symposia on Molecular and Cellular Biology
  • Place of Presentation: Whistler, CANADA
• [Presentation] 感染防御時の好中球による活性酸素生成の分子機構[招待講演]第85回日本細菌学会総会 (2012)
  • Author(s): 住本英樹
  • Organizer: ワークショップ「感染防御応答の多次元シグナルネットワーク」
  • Place of Presentation: 長崎
• [Presentation] Mechanism for cell polarization during chemotaxis of neutrophils (2012)
  • Author(s): Sumimoto, H.
  • Organizer: The 21st Hot Spring Harbor Symposium jointly with 9th Global COE International Symposium : Cell Migration in Biology and Medicine
  • Place of Presentation: 福岡(invited speaker)
• [Presentation] ワークショップ「感染防御応答の多次元シグナルネットワーク」感染防御時の好中球による活性酸素生成の分子機構 (2012)
  • Author(s): 住本英樹
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎(招待講演)
• [Presentation] 食細胞と非食細胞NADPHオキシダーゼの活性酸素生成活性の制御領域について (2011)
  • Author(s): 宮野佳,住本英樹
  • Organizer: 第22回日本生体防御学会学術総会
  • Place of Presentation: 那覇
• [Presentation] Structure and regulation of Nox family NADPH oxidases that deliberately produce reactive oxygen species[ invited speaker] (2011)
  • Author(s): Sumimoto, H., and Miyano, K.
  • Organizer: The 17th International Symposium on Flavins and Flavoproteins
  • Place of Presentation: Berkeley, USA
• [Presentation] The Nox family NADPH oxidases involved in host defense and signal transduction[ invited speaker] (2011)
  • Author(s): Sumimoto, H., and Miyano, K.
  • Organizer: The 13th International Congress of Bacteriology and Applied Microbiology : Symposium" ROS signaling in hostbacteria stress responses"
  • Place of Presentation: Sapporo, Japan
• [Presentation] form in相同蛋白質Fhodsのマウス胎仔、成獣、およびヒト心筋サルコメアにおける局在 (2011)
  • Author(s): 神尾明君,武谷立,田ノ上禎久,富永隆治,住本英樹
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
• [Presentation] 新規Par6結合タンバク質による上皮細胞極性の制御機構 (2011)
  • Author(s): 早瀬純也,鎌倉幸子,岩切優子,山口佳洋,伊崎智子,伊藤隆司,住本英樹
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] 新規NuMA結合タンパク質による分裂期染色体の整列調節機構 (2011)
  • Author(s): 岩切優子,鎌倉幸子,住本英樹
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] form in相同蛋白質Fhodsの心筋サルコメアにおける局在と機能 (2011)
  • Author(s): 神尾明君,武谷立,田ノ上禎久,富永隆治,住本英樹
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] 細胞極性関連タンパク質InscuteableとLGNとの複合体のX線結晶構造解析 (2011)
  • Author(s): 湯澤聡,鎌倉幸子,岩切優子,早瀬純也,住本英樹
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] 抗菌タンパク質をコードする遺伝子の転写誘導におけるNF一κBとグルココルチコイド受容体(GR)の協調作用 (2011)
  • Author(s): 山崎創,住本英樹
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Structure and regulation of Nox family NADPH oxidases that deliberately produce reactive oxygen species (2011)
  • Author(s): Sumimoto, H., Miyano, K.
  • Organizer: The 17th International Symposium on Flavins and Flavoproteins
  • Place of Presentation: Berkeley, USA(invited speaker)
• [Presentation] The Nox family NADPH oxidases involved in host defense and signal transduction (2011)
  • Author(s): Sumimoto, H., Miyano, K.
  • Organizer: The 13th International Congress of Bacteriology and Applied Microbiology : Symposium "ROS signaling in host-bacteria stress responses"
  • Place of Presentation: 札幌(invited speaker)
• [Presentation] formin相同蛋白質Fhod3のマウス胎仔、成獣、およびヒト心筋サルコメアにおける局在 (2011)
  • Author(s): 神尾明君, 武谷立, 田ノ上禎久, 富永隆治, 住本英樹
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
• [Presentation] 生体防御に重要な食細胞・非食細胞に発現する活性酸素生成酵素NADPHオキシダーゼの活性制御領域について (2011)
  • Author(s): 宮野佳, 住本英樹
  • Organizer: 第17回MPO研究会
  • Place of Presentation: 熊本
• [Presentation] 新規Par6結合タンパク質による上皮細胞極性の制御機構 (2011)
  • Author(s): 早瀬純也, 鎌倉幸子, 岩切優子, 山口佳洋, 伊崎智子, 伊藤隆司, 住本英樹
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] formin相同蛋白質Fhod3の心筋サルコメアにおける局在と機能 (2011)
  • Author(s): 神尾明君, 武谷立, 田ノ上禎久, 富永隆治, 住本英樹
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] 抗菌タンパク質をコードする遺伝子の転写誘導におけるNF-κBとグルココルチコイド受容体(GR)の協調作用 (2011)
  • Author(s): 山崎創, 住本英樹
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] 活性酸素と病気: NADPHオキシダーゼの役割 (2010)
  • Author(s): 住本英樹
  • Organizer: 日本臨床検査自動化学会・第24回春期セミナー
  • Place of Presentation: 福岡
  • Year and Date: 2010-04-03
• [Presentation] 活性酸素と病気:NADPHオキシダーゼの役割 (2010)
  • Author(s): 住本英樹
  • Organizer: 日本臨床検査自動化学会・第24回春期セミナー
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2010-04-03
• [Presentation] レドックスシグナリングと活性酸素生成の調節機構 (2010)
  • Author(s): 住本英樹
  • Organizer: ワンキャンパスプロジェクトグローバルFUプログラムバイオストレス応答の制御機構研究教育拠点「lnternationalSymposiumofLifeSciences」
  • Place of Presentation: 福岡
  • Year and Date: 2010-03-23
• [Presentation] レドックスシグナリングと活性酸素生成の調節機構 (2010)
  • Author(s): 住本英樹
  • Organizer: 福岡大学国際生命科学シンポジウム「International Symposium of Life Sciences」
  • Place of Presentation: 福岡
  • Year and Date: 2010-03-23
• [Presentation] 食作用時の活性酸素生成酵素NADPHオキシダーゼの活性化機構 (2010)
  • Author(s): 住本英樹
  • Organizer: 生理学研究所研究会「食食細胞機能のイメージング」
  • Place of Presentation: 岡崎
• [Presentation] RolefortheN-terminaltransmembrane and C-terminal cytosolic moieties of Nox-family NADPH oxidases (2010)
  • Author(s): Miyano, K., Sumimoto, H.
  • Organizer: Gordon Research Conference(Nox Family NADPH Oxidases) Les Diablerets
  • Place of Presentation: the Switzerland
• [Presentation] [invited speaker] Interaction of Nox-family oxidases with p22phox and soluble regulatory proteins (2010)
  • Author(s): Sumimoto, H.
  • Organizer: Gordon Research Conference(Nox FamilyNADPH Oxidases). Les Diablerets
  • Place of Presentation: the Switzerland
• [Presentation] 生体防御に重要な活性酸素生成酵素NADPHオキシダーゼの活性化機構 (2010)
  • Author(s): 宮野佳,住本英樹
  • Organizer: 第21回日本生体防御学会学術総会
  • Place of Presentation: 仙台
• [Presentation] 活性酸素生成型NADPHオキシダーゼ(Nox)ファミリーの活性化における膜貫通領域と細胞質領域の役割 (2010)
  • Author(s): 宮野佳,住本英樹
  • Organizer: BMB2oio(第33回日本分子生物学会年会・第83回日本生化学会大会)
  • Place of Presentation: 神戸
• [Presentation] LPSとグルココルチコイドによる相乗的な遺伝子発現における核タンパク質1κB一ζの役割 (2010)
  • Author(s): 山暗創,住本英樹
  • Organizer: BMB2oio(第33回日本分子生物学会年会・第83回日本生化学会大会)
  • Place of Presentation: 神戸
• [Presentation] Interaction of Nox-family oxidases with p22phox and soluble regulatory proteins. (2010)
  • Author(s): Sumimoto, H.
  • Organizer: Gordon Research Conference (Nox Family NADPH Oxidases)
  • Place of Presentation: Les Diablerets, the Switzerland(invited speaker)
• [Presentation] 生体防御に重要な活性酸素生成酵素NADPHオキシダーゼの活性化機構 (2010)
  • Author(s): 宮野佳, 住本英樹
  • Organizer: 第21回日本生体防御学会学術総会
  • Place of Presentation: 仙台(招待講演)
• [Presentation] LPSとグルココルチコイドによる相乗的な遺伝子発現における核タンパク質IκB-ζの役割 (2010)
  • Author(s): 山崎創, 住本英樹
  • Organizer: BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会)
  • Place of Presentation: 神戸
• [Presentation] 活性酸素生成型NADPHオキシダーゼ(Nox)ファミリーの活性化における膜貫通領域と細胞質領域の役割 (2010)
  • Author(s): 宮野佳, 住本英樹
  • Organizer: BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会)
  • Place of Presentation: 神戸
• [Presentation] 食作用時の活性酸素生成酵素NADPHオキシダーゼの活性化機構 (2010)
  • Author(s): 住本英樹
  • Organizer: 生理学研究所研究会「貪食細胞機能のイメージング」
  • Place of Presentation: 岡崎
• [Presentation] スーパーオキシド生成酵素NADPHオキシダーゼの活性化因子p67phoxの作用機構の解明 (2009)
  • Author(s): 宮野佳,前原優一,湯澤聡,住本英樹
  • Organizer: 平成21年度日本生化学会九州支部例会
  • Place of Presentation: 福岡
• [Presentation] 発現誘導型核タンパク質IkB-zを介した標的遺伝子の発現調節 (2009)
  • Author(s): 山崎創,住本英樹
  • Organizer: 平成21年度日本生化学会九州支部例会
  • Place of Presentation: 福岡
• [Presentation] formin相同蛋白質FHOD3の活性制御機i構の解明 (2009)
  • Author(s): 成澤慈,武谷立,住本英樹
  • Organizer: 平成21年度日本生化学会九州支部例会
  • Place of Presentation: 福岡
• [Presentation] formin相同蛋白質FHOD3の筋細胞における生理的役割 (2009)
  • Author(s): 武谷立,谷口賢一郎,住本英樹
  • Organizer: 平成21年度日本生化学会九州支部例会
  • Place of Presentation: 福岡
• [Presentation] シンポジウム「外科侵襲下の酸素の役割」外敵侵入に備えるNADPHオキシダーゼ (2009)
  • Author(s): 住本英樹
  • Organizer: 日本外科代謝栄養学会第46回学術集会
  • Place of Presentation: 東京
• [Presentation] Roleofthedomainorganizationofp67ph°XinNox2activation (2009)
  • Author(s): 湯澤聡,宮野佳,本坊和也,稲垣冬彦,住本英樹
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] Theinsert region of the Rae GTPases is dispensable for activation of superoxide・producing NADPH osidases (2009)
  • Author(s): 宮野佳,古賀博文,水上令子,住杢_墓樹
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] Gene regulation by the inducible nuclear protein IkappaB-zeta and NFKappaB p50 subunit (2009)
  • Author(s): 山崎創,住本英樹
  • Organizer: 化学会大会
  • Place of Presentation: 神戸
• [Presentation] 食細胞による活性酸素生成機構 (2009)
  • Author(s): 住本英樹
  • Organizer: 大阪大学蛋白質研究所セミナー「活性酸素のシグナル伝達」
  • Place of Presentation: 大阪
• [Presentation] Rae-dependent activation of superoxideproducing NADPH oxidases does not require its insert region (2009)
  • Author(s): 宮野佳,古賀博文,水上令子,住杢_墓樹
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Gene Regulation by the Nuclear NFkappaB-zeta complex in Macrophages and Fibroblasts (2009)
  • Author(s): 山暗創,住本英樹
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Regulation of actin assembly and sarcomere organization in cardiomyocytes by the formin homology protein Fhod3 (2009)
  • Author(s): 谷口賢一郎,武谷立,末次志郎,神尾明君,成澤慈,塩瀬明,富永隆治,住本英樹
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] The domain organization of p67phox, a protein required for activation of the superoxideproducing NADPH oxidase in phagocytes (2009)
  • Author(s): 湯澤聡,宮野佳,本坊和也,稲垣冬彦,住本英樹
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] 外敵侵入に備えるNADPHオキシダーゼ (2009)
  • Author(s): 住本英樹
  • Organizer: 日本外科代謝栄養学会 第46回学術集会シンポジウム「外科侵襲下の酸素の役割」
  • Place of Presentation: 東京
• [Presentation] スーパーオキシド生成酵素NADPHオキシダーセの活性化因子p67_<phox>の作用機構の解明 (2009)
  • Author(s): 宮野佳, 前原優一, 湯澤聡, 住本英樹
  • Organizer: 平成21年度日本生化学会九州支部例会
  • Place of Presentation: 福岡
• [Presentation] formin相同蛋白質FHOD3の活性制御機構の解明 (2009)
  • Author(s): 成澤慈, 武谷立, 住本英樹
  • Organizer: 平成21年度日本生化学会九州支部例会
  • Place of Presentation: 福岡
• [Presentation] Role of the domain organization of p67_<phox> in Nox2 activation. (2009)
  • Author(s): 湯澤聡, 宮野佳, 本坊和也, 稲垣冬彦, 住本英樹
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] The insert region of the Rae GTPases is dispensable for activation of superoxide-producing NADPH osidases (2009)
  • Author(s): 宮野佳, 古賀博文, 水上令子, 住本英樹
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] Gene regulation by the inducible nuclear protein IkappaB-zeta and NF-KappaB p50 subunit (2009)
  • Author(s): 山崎創, 住本英樹
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 食細胞による活性酸素生成機構 (2009)
  • Author(s): 住本英樹
  • Organizer: 大阪大学蛋白質研究所セミナー「活性酸素のシグナル伝達」
  • Place of Presentation: 吹田
• [Presentation] Rac-dependent activation of superoxide-producing NADPH oxidases does not require its insert region (2009)
  • Author(s): 宮野佳, 古賀博文, 水上令子, 住本英樹
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Gene Regulation by the Nuclear NF-kappaB-zeta complex in Macrophages and Fibroblasts (2009)
  • Author(s): 山崎創, 住本英樹
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] The domain organization of p67_<phox>, a protein required for activation of the superoxide-producing NADPH oxidase in phagocytes (2009)
  • Author(s): 湯澤聡, 宮野佳, 本坊和也, 稲垣冬彦, 住本英樹
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Book] In Free Radical Biology in Digestive Diseases (Front.Gastrointest.Res., vol.29, Yoshikavva, T., Suematsu, M., & Naito, Y., eds.) (2011)
  • Author(s): Sumimoto, H., Minakami, R., Miyano, K.
  • Total Pages: 176
  • Publisher: Basel, S.Karger AG
• [Book] In Free Radical Biology in Digestive Diseases (Frontiers of Gastrointestinal Research Vol.29) (2011)
  • Author(s): Sumimoto, H., Minakami, R., Miyano, K.
  • Total Pages: 176
  • Publisher: S.Karger AG
• [Book] The Nox Family of NADPH Osidases that deliberately Produce Reactive Oxygen Species In Free Radical Biology in Digestive Diseases (2010)
  • Author(s): Sumimoto H, Minakami R, Miyano K.