Post-translational histnoe modification and transcriptional regulation.
| Project/Area Number |
21390085
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
ITO Takashi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (90306275)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Takeya 長崎大学, 大学院・医歯薬学総合研究科, 助教 (50363502)
MIZUSAKI Hirofumi 長崎大学, 大学院・医歯薬学総合研究科, 助教 (40467957)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | DNA高次構浩 / アセチル化 / エピジェネティクス / クロマチン / ヌクレオソーム / ヒストン / ユビキチン化 / リン酸化 / 遺伝子転写 / H2A / 脱ユビキチン化 / 転写開始 / 高次構造 / USP21 / クロストーク |
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| Research Abstract |
The genome of the eukaryote is packaged into chromatin, which permits dynamic and broad-ranging changes related to many important biological phenomena. Diverse posttranslational modifications of the core histones occur, often on the tail domains and related to transcriptional regulation. In this project we identified that histone H2A ubiquitylation inhibits histone H3K4 methylation resulting in transcriptional repression. Thus we clarified the role of histone modification and chromatin structure, which related to transcriptional regulation.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel2011
Author(s)
Shindo, H., Yasui, K., Yamamoto, K., Honma, K., Yui, K., Kohno, T., Ma, Y., Chua, K. J., Kubo, Y., Aihara, H., Ito T, Nagayasu T, Matsuyama T, Hayashi H
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Journal Title
Cytokine
Volume: 56
Pages: 564-572
NAID
Related Report
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[Journal Article] A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor.2010
Author(s)
Sawatsubashi, S., Murata, T., Lim, J., Fujiki, R., Ito, S., Suzuki, E., Tanabe, M., Zhao, Y., Kimura, S., Fujiyama, S., Ueda, T., Umetsu, D., Ito, T., Takeyama, K., Kato, S.
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Journal Title
Genes Dev 24
Pages: 159-170
Related Report
Peer Reviewed
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