| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Research Abstract |
IκB-ζ gene-deficient mice spontaneously develop chronic inflammation around eyes. In this study, we analyzed the chronic inflammation of the mutant mice. We revealed that the inflammation was caused by an autoimmune disease resembling human Sjogren's syndrome, that although lymphocytes were required for the development of the inflammation, IκB-ζ-deficiency in epithelial cells, but not abnormality of the lymphocytes was the main causes of the disease, and that enhanced apoptosis was induced in IκB-ζ-deficient lacrimal glands, which resulted in activation of autoreactive lymphocytes. These results will greatly contribute to the understanding of pathogenic mechanism and development of therapy for Sjogren's syndrome.
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