Function of Inducible Transcriptional Regulators in Regulation of Inflammatory Reactions in Homeostasis and Its Dysregulation.
Project/Area Number |
21390088
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pathological medical chemistry
|
Research Institution | Tohoku University |
Principal Investigator |
MUTA Tatsushi 東北大学, 大学院・生命科学研究科, 教授 (60222337)
|
Co-Investigator(Renkei-kenkyūsha) |
OHBA Tomoyuki 東北大学, 大学院・生命科学研究科, 助教 (80380666)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
Keywords | 分子病態学 / IκB-ζ / 核内IκBファミリー / 慢性炎症 / シェーグレン症候群 / アポトーシス / 上皮細胞 / B細胞 / 自己免疫疾患 / 遺伝子 / 細胞・組織 / シグナル伝達 / 発現制御 / 免疫学 / 炎症 / NF-κB |
Research Abstract |
IκB-ζ gene-deficient mice spontaneously develop chronic inflammation around eyes. In this study, we analyzed the chronic inflammation of the mutant mice. We revealed that the inflammation was caused by an autoimmune disease resembling human Sjogren's syndrome, that although lymphocytes were required for the development of the inflammation, IκB-ζ-deficiency in epithelial cells, but not abnormality of the lymphocytes was the main causes of the disease, and that enhanced apoptosis was induced in IκB-ζ-deficient lacrimal glands, which resulted in activation of autoreactive lymphocytes. These results will greatly contribute to the understanding of pathogenic mechanism and development of therapy for Sjogren's syndrome.
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Report
(4 results)
Research Products
(80 results)
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[Journal Article] Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in intramolecular disulfide bond, proteolytic cleavage, and RNA-sensing2013
Author(s)
Kanno A, Yamamoto C, Onji M, Fukui R, Saitoh SI, Motoi Y, Shibata T, Matsumoto F, Muta T, Miyake K
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Journal Title
Int Immunol.
Volume: 25
Issue: 7
Pages: 413-422
DOI
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Peer Reviewed
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[Journal Article] IκBζ regulates T_H17 development bycooperating with ROR nuclear receptors2010
Author(s)
Okamoto K, Iwai Y, Oh-Hora M, Yamamoto M, Morio T, Aoki K, Ohya K, Jetten AM, Akira S, Muta T, Takayanagi H
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Journal Title
Nature
Volume: 464(7293)
Issue: 7293
Pages: 1381-5
DOI
Related Report
Peer Reviewed
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[Presentation] Chemokine Induction in Macrophages as a Response to Necrotic Cells2011
Author(s)
Kimura, T., Watanabe, E., Hanihara, F., Ohba, T., and ○Muta, T.
Organizer
Toll2011 Meeting-Decoding InnateImmunity (Poster)
Place of Presentation
Riva del Garda, Italy
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[Presentation] Analysis on the Pathogenesis of Chronic Skin Inflammation that Spontaneously Develops in IκB-ζ Gene-deficient Mice2010
Author(s)
Okuma, A., Ohba, T., Ono, M., Shibuya, S., Aiba, S., and Muta, T
Organizer
14th International Congress of Immunology (Poster)
Place of Presentation
Kobe, Japan
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