The role of IRF transcription factor family in inflammation-associated tumorigenesis
| Project/Area Number |
21390089
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MAEDA Shin 横浜市立大学, 医学研究科, 教授 (40415956)
YANAI Hideyuki 東京大学, 医学研究科, 助教 (70431765)
HOTTA Chie 横浜市立大学, 医学研究科, 助教 (80363810)
KUROTAKI Daisuke 横浜市立大学, 医学研究科, 助教 (10568455)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 転写因子 / 癌 / 免疫学 / 遺伝子 / 細胞・組織 / 発現制御 |
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| Research Abstract |
A role for chronic inflammation in tumorigenesis is now generally accepted, and nuclear factorκ-B(NF-κB) has been implicated in the cause or exacerbation of inflammation-induced cancers. The present study demonstrates that the interferon regulatory factor(IRF) transcription factor family, which can be activated simultaneously with NF-κB by innate immune stimuli, possesses tumor-suppressing abilities in inflammation-induced cancers.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development2011
Author(s)
Yamamoto M, Kato T, Hotta C, Nishiyama A, Kurotaki D, Yoshinari M, Takami M, Ichino M, Nakazawa M, Matsuyama T, Kamijo R, Kitagawa S, Ozato K, Tamura T
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Interferon regulatory factor 8 regulates bone metabolism by suppressing osteoclastogenesis2009
Author(s)
Zhao B, Takami M, Yamada A, Wang X, Koga T, Hu X, Tamura T, Ozato K, Choi Y, Ivashkiv LB, Takayanagi H, Kamijo R
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Journal Title
Nat. Med
Volume: 15
Pages: 1066-1071
Related Report
Peer Reviewed
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[Journal Article] A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA2009
Author(s)
Choi MK, Wang Z, Ban T, Yanai H, Lu Y, Koshiba R, Nakaima Y, Hangai S, Savitsky D, Nakasato M, Negishi H, Takeuchi O, Honda K, Akira S, Tamura T, Taniguchi T
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 106
Pages: 17870-7875
Related Report
Peer Reviewed
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[Journal Article] HMGB proteins function as universal sentinels for nucleic acid-mediated innate immune responses2009
Author(s)
Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, Nakasato M, Lu Y, Hangai S, Koshiba R, Savitsky D, Ronfani R, Akira S, Bianchi ME, Honda K, Tamura T, Kodama T, Taniguchi T
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Journal Title
Nature
Volume: 462
Pages: 99-103
Related Report
Peer Reviewed
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[Presentation] The transcription factor IRF8 rescues the dendritic cell development impaired by p210 Bcr/Abl2011
Author(s)
Watanabe T, Hotta C, Sato GR, Yamamoto M, Fujita H, Sakai R, Fujisawa S, Nishiyama A, Aihara M, Ishigatsubo Y, Tamura T
Organizer
第34回日本分子生物学会年会口演
Place of Presentation
横浜
Year and Date
2011-12-14
Related Report
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[Presentation] A shared role of transcription factors IRF4 and IRF8 in myeloid cell development2010
Author(s)
Yamamoto M, Kato T, Ichino M, Hotta C, Nakazawa M, Takami M, Matsuyama T, Kamijo R, Kitagawa S, Ozato K, Tamura T
Organizer
14th International Congress of Immunologyワークショップ
Place of Presentation
神戸
Year and Date
2010-08-24
Related Report
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[Presentation] Interferon regulatory factor 8(IRF-8)による骨恒常性の調節2009
Author(s)
高見正道, 趙宝紅, 山田篤, 王九虎谷, 古賀貴子, ヒュウシアオユ, 田村智彦, オザトケイコ, 催容源, ライオネルイワシキフ, 高柳広, 上條竜太郎
Organizer
第32回日本分子生物学学会年会ワークショップ
Place of Presentation
横浜
Year and Date
2009-12-10
Related Report
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