The role of IRF transcription factor family in inflammation-associated tumorigenesis

• Project/Area Number: 21390089
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Yokohama City University
• Principal Investigator: TAMURA Tomohiko 横浜市立大学, 医学研究科, 教授 (50285144)
• Co-Investigator(Renkei-kenkyūsha): MAEDA Shin 横浜市立大学, 医学研究科, 教授 (40415956) ; YANAI Hideyuki 東京大学, 医学研究科, 助教 (70431765) ; HOTTA Chie 横浜市立大学, 医学研究科, 助教 (80363810) ; KUROTAKI Daisuke 横浜市立大学, 医学研究科, 助教 (10568455)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 転写因子 / 癌 / 免疫学 / 遺伝子 / 細胞・組織 / 発現制御

Research Abstract

A role for chronic inflammation in tumorigenesis is now generally accepted, and nuclear factorκ-B(NF-κB) has been implicated in the cause or exacerbation of inflammation-induced cancers. The present study demonstrates that the interferon regulatory factor(IRF) transcription factor family, which can be activated simultaneously with NF-κB by innate immune stimuli, possesses tumor-suppressing abilities in inflammation-induced cancers.

Research Products

• [Journal Article] IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype (2012)
  • Author(s): Masuda T, Tsuda M, Yoshinaga R, Tozaki-Saitoh H, Ozato K, Tamura T, Inoue K
  • Journal Title: Cell Reports Volume: 1 Pages: 334-340
  • Peer Reviewed
• [Journal Article] Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development (2011)
  • Author(s): Yamamoto M, Kato T, Hotta C, Nishiyama A, Kurotaki D, Yoshinari M, Takami M, Ichino M, Nakazawa M, Matsuyama T, Kamijo R, Kitagawa S, Ozato K, Tamura T
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Journal Article] Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development (2011)
  • Author(s): Yamamoto M, et al
  • Journal Title: PLoS ONE Volume: 6 Issue: 10 Pages: e25812-e25812
  • DOI: 10.1371/journal.pone.0025812
  • Peer Reviewed
• [Journal Article] Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus (2010)
  • Author(s): Savitsky DA, Yanai H, Tamura T, Taniguchi T, Honda K
  • Journal Title: Proc Natl Acad Sci USA Volume: 1072 Pages: 10154-10159
  • Peer Reviewed
• [Journal Article] Regulation of immunity and oncogenesis by the IRF transcription factor family (2010)
  • Author(s): Savitsky D, Tamura T, Yanai H, Taniguchi T
  • Journal Title: Cancer Immunol Immunother Volume: 59 Pages: 489-510
  • Peer Reviewed
• [Journal Article] 治らない炎症が引き起こす疾患の分子機構 (2010)
  • Author(s): 市野素英, 堀田千絵, 田村智彦
  • Journal Title: 細胞工学 Volume: 29 Pages: 793-798
• [Journal Article] Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus (2010)
  • Author(s): Savitsky D, et al
  • Journal Title: Proc Natl Acad Sci USA Volume: VOL.107 Pages: 10154-10159
  • Peer Reviewed
• [Journal Article] Regulation of immunity and oncogenesis by the IRF transcription factorfamily (2010)
  • Author(s): Savitsky D, Tamura T, Yanai H, Taniguchi T
  • Journal Title: Cancer Immunol Immunother Volume: VOL.59 Pages: 489-510
  • Peer Reviewed
• [Journal Article] Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene (2009)
  • Author(s): Nakajima A, Nishimura K, Nakaima Y, Oh T, Noguchi S, Taniguchi T, Tamura T
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 106 Pages: 12448-12452
  • Peer Reviewed
• [Journal Article] Interferon regulatory factor 8 regulates bone metabolism by suppressing osteoclastogenesis (2009)
  • Author(s): Zhao B, Takami M, Yamada A, Wang X, Koga T, Hu X, Tamura T, Ozato K, Choi Y, Ivashkiv LB, Takayanagi H, Kamijo R
  • Journal Title: Nat. Med Volume: 15 Pages: 1066-1071
  • Peer Reviewed
• [Journal Article] A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA (2009)
  • Author(s): Choi MK, Wang Z, Ban T, Yanai H, Lu Y, Koshiba R, Nakaima Y, Hangai S, Savitsky D, Nakasato M, Negishi H, Takeuchi O, Honda K, Akira S, Tamura T, Taniguchi T
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 106 Pages: 17870-7875
  • Peer Reviewed
• [Journal Article] HMGB proteins function as universal sentinels for nucleic acid-mediated innate immune responses (2009)
  • Author(s): Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, Nakasato M, Lu Y, Hangai S, Koshiba R, Savitsky D, Ronfani R, Akira S, Bianchi ME, Honda K, Tamura T, Kodama T, Taniguchi T
  • Journal Title: Nature Volume: 462 Pages: 99-103
  • Peer Reviewed
• [Journal Article] Regulation of the cytosolic DNA-sensing system in innate immunity ; A current view (2009)
  • Author(s): Yanai H, Savitsky D, Tamura T, Taniguchi T
  • Journal Title: Curr. Opin. Immunol Volume: 21 Pages: 17-22
  • Peer Reviewed
• [Journal Article] Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene (2009)
  • Author(s): Nakajima A, et al
  • Journal Title: Proc Natl Acad Sci USA VOL.106 Pages: 12448-12452
  • Peer Reviewed
• [Journal Article] HMGB proteins function as universal sentinels for nucleic acid-mediated innate immune responses (2009)
  • Author(s): Yanai H, et al
  • Journal Title: Nature VOL.462 Pages: 99-103
  • Peer Reviewed
• [Journal Article] A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA (2009)
  • Author(s): Choi MK, et al
  • Journal Title: Proc Natl Acad Sci USA VOL.106 Pages: 17870-17875
  • Peer Reviewed
• [Presentation] 骨髄系細胞分化でのIRF8とIRF4の機能 (2012)
  • Author(s): 加藤隆幸、山本道雄、堀田千絵、西山晃、高見正道、松山俊文、上條竜太郎、北川誠一、尾里啓子、田村智彦
  • Organizer: 第89回日本生理学会大会口演
  • Place of Presentation: 松本
  • Year and Date: 2012-03-31
• [Presentation] IRF8 physically interacts with C/EBPα to inhibit the generation of granulocyte-macrophage progenitors and neutrophils (2011)
  • Author(s): Tamura T, Yamamoto M, Osato N, Kurotaki D, Uno K, Nakazawa M, Nishiyama A, Ozato K
  • Organizer: 第34回日本分子生物学会年会ワークショップ
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-15
• [Presentation] IRF8 physically interacts with C/EBPa to inhibit the generation of granulocyte-macrophage progenitors and neutrophils (2011)
  • Author(s): Tamura T, et al
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-12-15
• [Presentation] The transcription factor IRF8 rescues the dendritic cell development impaired by p210 Bcr/Abl (2011)
  • Author(s): Watanabe T, Hotta C, Sato GR, Yamamoto M, Fujita H, Sakai R, Fujisawa S, Nishiyama A, Aihara M, Ishigatsubo Y, Tamura T
  • Organizer: 第34回日本分子生物学会年会口演
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-14
• [Presentation] The transcription factor IRF8 rescues the dendritic cell development impaired by p210 Bcr/Abl (2011)
  • Author(s): Watanabe T, et al
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-12-14
• [Presentation] Regulation of the development of monocyte subsets by interferon regulatory factor 8 (2011)
  • Author(s): Kurotaki D, Ichino M, Nishiyama A, Sato G, Yamamoto M, Ozato K, Tamura T
  • Organizer: 第40回日本免疫学会学術総会ワークショップ
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] Regulation of the development of monocyte subsets by interferon regulatory factor 8 (2011)
  • Author(s): Kurotaki D, et al
  • Organizer: 第40回日本免疫学会学術総会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-28
• [Presentation] Interferon stimulation causes diverse changes in chromatin to regulate transcription (2011)
  • Author(s): Ozato K, Sarai N, Patel M, Debrosse M, Tamura T, Ura K
  • Organizer: 9th Joint Meeting of the International Society for Interferon and Cytokine Research(ISICR) and the International Cytokine Society(ICS)口演
  • Place of Presentation: フィレンツェ、イタリア
  • Year and Date: 2011-10-12
• [Presentation] Selective regulation of monocyte subsets by the transcription factor Interferon Regulatory Factor 8 (2011)
  • Author(s): Kurotaki D, Ichino M, Nishiyama A, Sato G, Yamamoto M, Ozato K, Tamura T
  • Organizer: 9th Joint Meeting of the International Society for Interferon and Cytokine Research(ISICR) and the International Cytokine Society(ICS)ポスター
  • Place of Presentation: フィレンツェ、イタリア
  • Year and Date: 2011-10-11
• [Presentation] Interferon regulatory factor-8は、神経損傷後に見られる脊髄ミクログリアの過活動状態への移行に重要な転写因子である (2011)
  • Author(s): 増田隆博, 津田誠, 吉永遼平, 齊藤秀俊, 田村智彦, 井上和秀
  • Organizer: 第54回日本神経化学会大会口演
  • Place of Presentation: 加賀
  • Year and Date: 2011-09-28
• [Presentation] IRF8 transcription factor directs microglia to be a hyperactive phenotype driving neuropathic pain (2011)
  • Author(s): Masuda T, Tsuda M, Yoshinaga R, Tozaki-Saitoh H, Tamura T, Inoue K
  • Organizer: 10th Euroglia Meeting on Glial Cells in Health and Diseasesポスター
  • Place of Presentation: プラハ、チェコ
  • Year and Date: 2011-09-17
• [Presentation] マラリアにおける樹状細胞分化の異常と転写因子IRFファミリー (2011)
  • Author(s): 市野素英、堀田千絵、田村智彦
  • Organizer: 第80回日本寄生虫学会口演
  • Place of Presentation: 東京
  • Year and Date: 2011-07-18
• [Presentation] Interferon regulatory factor-8はミクログリア由来疼痛関連分子の発現を誘導する転写因子である (2010)
  • Author(s): 増田隆博, 津田誠, 吉永遼平, 田村智彦, 井上和秀
  • Organizer: Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会ならびに第20回日本神経回路学会大会)口演
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] A shared role of transcription factors IRF4 and IRF8 in myeloid cell development (2010)
  • Author(s): Yamamoto M, Kato T, Ichino M, Hotta C, Nakazawa M, Takami M, Matsuyama T, Kamijo R, Kitagawa S, Ozato K, Tamura T
  • Organizer: 14th International Congress of Immunologyワークショップ
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-24
• [Presentation] A shared role of transcription factors IRF4 and IRF8 in myeloid cell development (2010)
  • Author(s): Yamamoto M, et al
  • Organizer: 14th International Congress of Immunology (Workshop)
  • Place of Presentation: Kobe Convention Center Complex (Kobe)
  • Year and Date: 2010-08-24
• [Presentation] 神経障害性疼痛におけるinterferon regulatory factor-8の役割 (2010)
  • Author(s): 増田隆博, 津田誠, 吉永遼平, 田村智彦, 井上和秀
  • Organizer: 第83回日本薬理学会年会口演
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-18
• [Presentation] A shared role of transcription factors IRF4 and IRF8 in myeloid cell development (2009)
  • Author(s): 加藤隆幸、北川誠一、尾里啓子、田村智彦
  • Organizer: 第32回日本分子生物学学会年会ワークショップ
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] Interferon regulatory factor 8(IRF-8)による骨恒常性の調節 (2009)
  • Author(s): 高見正道, 趙宝紅, 山田篤, 王九虎谷, 古賀貴子, ヒュウシアオユ, 田村智彦, オザトケイコ, 催容源, ライオネルイワシキフ, 高柳広, 上條竜太郎
  • Organizer: 第32回日本分子生物学学会年会ワークショップ
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] Cell type-dependent pro-apoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene (2009)
  • Author(s): 中島啓, 西村啓士郎, 仲井真優佳奈, 王智彦, 谷口維紹, 田村智彦
  • Organizer: 第32回日本分子生物学学会年会ポスター
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] A shared role of transcription factors IRF4 and IRF8 in myeloid cell development (2009)
  • Author(s): 加藤隆幸, ら
  • Organizer: 第32回日本分子生物学学会年会(ワークショップ)
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-12-10
• [Remarks]