| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Research Abstract |
Faconi anemia(FA) is a hereditary disorder characterized by progressive bone marrow failure, increased incidence of cancer, and deficiency of DNA repair driven by the ubiquitin system. In this study, we have clarified a role of checkpoint kinase ATR in triggering DNA damage-induced activation of theFA DNA repair pathway. Furthermore, we have discovered that some FA proteins promote association of essential ATR interacter ATRIP to chromatin.
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