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Regulation of the ubiquitin system by checkpoint kinases in response to stalled replication forks

Research Project

Project/Area Number 21390094
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionKyoto University

Principal Investigator

TAKATA Minoru  京都大学, 放射線生物研究センター, 教授 (30281728)

Co-Investigator(Kenkyū-buntansha) ITAYA Akiko  京都大学, 放射線生物研究センター, 研究員 (50535812)
TOMIDA Junya  京都大学, 放射線生物研究センター, 研究員 (50511367)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywordsファンコニ貧血 / チェックポイントキナーゼ / リン酸化 / モノユビキチン化 / FANCD2 / FANC1 / FANCL / FANCI / コア複合体
Research Abstract

Faconi anemia(FA) is a hereditary disorder characterized by progressive bone marrow failure, increased incidence of cancer, and deficiency of DNA repair driven by the ubiquitin system. In this study, we have clarified a role of checkpoint kinase ATR in triggering DNA damage-induced activation of theFA DNA repair pathway. Furthermore, we have discovered that some FA proteins promote association of essential ATR interacter ATRIP to chromatin.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (78 results)

All 2012 2011 2010 2009 Other

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (51 results) Book (2 results) Remarks (3 results)

  • [Journal Article] DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI2012

    • Author(s)
      Koichi Sato. Kazue Toda, Masamichi Ishiai, Minora Takata, Hitoshi Kurumizaka
    • Journal Title

      Nucleic Acids Research

      Volume: 40 Issue: 10 Pages: 4553-4561

    • DOI

      10.1093/nar/gks053

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ATR-Chkl signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity2012

    • Author(s)
      Fujinaka Y, Matsuoka K, Iimori M, Tuul M, Sakasai R, Yoshinaga K, Saeki H, Morita M, Kakeji Y, Gillespie DA, Yamamoto KI, Takata M, Kitao H, Maehara Y
    • Journal Title

      DNA Repair

      Volume: 1(3) Issue: 3 Pages: 247-58

    • DOI

      10.1016/j.dnarep.2011.11.005

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ATR-ATRIP Kinase Complex Triggers Activation of the Fanconi Anemia DNA Repair Pathway2012

    • Author(s)
      Tomoko Shigechi, Junya Tomida, Koichi Sato, Masahiko Kobayashi, John K.Eykelenboom, Fabio Pessina, Yanbin Zhang, Emi Uchida, Masamichi Ishiai, Noel F.Lowndes, Kenichi Yamamoto, Hitoshi Kurumizaka, Yoshihiko Maehara, Minoru Takata
    • Journal Title

      Cancer Research

      Volume: 72 Issue: 5 Pages: 1149-1156

    • DOI

      10.1158/0008-5472.can-11-2904

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of the DNA repair-defective mutants in DT40 cells2012

    • Author(s)
      Ishiai M, Uchida E, Takata M
    • Journal Title

      Methods Mol Biol

      Volume: (in press)

    • NAID

      120004996387

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway2011

    • Author(s)
      Rosado IV, Langevin F, Crossan GP, Takata M, Patel KJ
    • Journal Title

      Nat Struct Mol Biol

      Volume: 18(12) Issue: 12 Pages: 1432-4

    • DOI

      10.1038/nsmb.2173

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predisposition to cancer caused by genetic and functional defects of Mammalian atad52011

    • Author(s)
      Bell DW, Sikdar N, Lee KY, Price J C, Chatterjee R, Park HD, Fox J, Ishiai M, Rudd ML, Pollock LM, Fogoros SK, Mohamed H, Hanigan CL ; NISC Comparative Sequencing Program, Zhang S, Cruz P, Renaud G, Hansen NF, Cherukuri PF, Borate B, McManus KJ, Stoepel J
    • Journal Title

      PLoS Genet

      Volume: 7(8) Issue: 8 Pages: e1002245-e1002245

    • DOI

      10.1371/journal.pgen.1002245

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct Inhibition of TNF-α Promoter Activity by Fanconi Anemia Prote in FANCD22011

    • Author(s)
      Nobuko Matsushita, Yujiro Endo, Koichi Sato, Hitoshi Kurumizaka, Takayuki Yamashita, Minoru Takata, Shigeru Yanagi
    • Journal Title

      PLoS One

      Volume: 6(電子媒体による発表) Issue: 8 Pages: e23324-e23324

    • DOI

      10.1371/journal.pone.0023324

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of SNM1 family nucleases in etoposide-induced apoptosis2011

    • Author(s)
      Hosono, Y., Abe, T., Ishiai, M., Takata, M., Enomoto, T., Seki, M.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 410 Issue: 3 Pages: 568-573

    • DOI

      10.1016/j.bbrc.2011.06.027

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] FancJ/Bripl helicase protects against genomic losses and gains in vertebrate cells2011

    • Author(s)
      Kitao H, Nanda I, Sugino RP, Kinomura A, Yamazoe M, Arakawa H, Schmid M, Innan H, Hiom K, Takata M
    • Journal Title

      Genes to Cells

      Volume: 16(6) Pages: 714-27

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation2011

    • Author(s)
      Guervilly JH, Renaud E, Takata M, Rosselli F
    • Journal Title

      Hum Mol Genet

      Volume: 20(11) Issue: 11 Pages: 2171-81

    • DOI

      10.1093/hmg/ddr103

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway2011

    • Author(s)
      Yamamoto KN, Kobayashi S, Tsuda M, Kurumizaka H, Takata M, Kono K, Jiricny J, Takeda S, Hirota K
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 108 Issue: 16 Pages: 6492-6496

    • DOI

      10.1073/pnas.1018487108

    • NAID

      120003072120

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fanconi anemia : a disorder defective in the DNA damage response2011

    • Author(s)
      Kitao H, Takata M
    • Journal Title

      Int J Hematol

      Volume: 93(4) Issue: 4 Pages: 417-24

    • DOI

      10.1007/s12185-011-0832-9

    • NAID

      10029534160

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents2010

    • Author(s)
      azunori Yoshikiyo, Katja Kratz, Kouji Hirota, Kana Nishihara, Minoru Takata, Hitoshi Kurumizaka, Satoshi Horimoto, Shunichi Takeda and Josef Jiricny.
    • Journal Title

      PNAS

      Volume: 107(50) Issue: 50 Pages: 21553-7

    • DOI

      10.1073/pnas.1011081107

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents.2010

    • Author(s)
      Yoshikiyo K, Kratz K, Hirota K, Nishihara K, Takata M, Kurumizaka H, Horimoto S, Takeda S, Jiricny J.
    • Journal Title

      Proc.Natl.Acad.Sci.USA.2010

      Volume: 107 Pages: 21553-21557

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemopreventive effects of gefitinib on nonsmoking-related lung tumorigenesis in activating epidermal growth factor receptor transgenic mice2009

    • Author(s)
      Ohashi K, Takigawa N, Osawa M, Ichihara E, Takeda H, Kubo T, Hirano S, Yoshino T, Takata M, Tanimoto M, Kiura K.
    • Journal Title

      Cancer Res

      Volume: 69(17) Issue: 17 Pages: 7088-95

    • DOI

      10.1158/0008-5472.can-08-4205

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Fanconi anemia pathway : Insights from somatic cell genetics using DT40 cell line2009

    • Author(s)
      Takata M, Ishiai M, Kitao H
    • Journal Title

      Invited review Mutat Res

      Volume: 668(1-2) Issue: 1-2 Pages: 92-102

    • DOI

      10.1016/j.mrfmmm.2008.12.012

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Fanconi anemia pathway : Insights from somatic cell genetics using DT40 cell line2009

    • Author(s)
      Takata M, Ishiai M, Kitao H
    • Journal Title

      Mutat Res 668

      Pages: 92-102

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemopreventive effects of gefitinib on nonsmoking-related lung tumorigenesis in activating epidermal growth factor receptor transgenic mice2009

    • Author(s)
      Ohashi K, Takigawa N, Osawa M, Ichihara E, Takeda H, Kubo T, Hirano S, Yoshino T, Takata M, Tanimoto M, Kiura K.
    • Journal Title

      Can Res 69

      Pages: 7088-95

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation.

    • Author(s)
      Guervilly JH, Renaud E, Takata M, Rosselli F.
    • Journal Title

      Hum.Mol.Genet.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.

    • Author(s)
      Yamamoto KY, Kobayashi S, Kurumizaka H, Takata M, Kono K, Jiricny J, Takeda S, Hirota K.
    • Journal Title

      Proc.Natl Acad.Sci.USA.

      Volume: (in press)

    • NAID

      120003072120

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells.

    • Author(s)
      Kitao H, Nanda I, Sugino RP, Kinomura A, Yamazoe M, Arakawa H, Schmid M, Innan H, Hiom K, Takata M.
    • Journal Title

      Genes Cells

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fanconi anemia : a disorder defective in the DNA damage response."Progress in Hematology review series"

    • Author(s)
      Kitao H, Takata M.
    • Journal Title

      Int.J.Hematol.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] DNA損傷への応答メカニズムと疾患2012

    • Author(s)
      高田穣
    • Organizer
      第ll回分子予防環境医学研究会シンポジウムオーガナイザー & 演者
    • Place of Presentation
      倉敷市
    • Year and Date
      2012-01-27
    • Related Report
      2011 Final Research Report
  • [Presentation] DNA損傷への応答メカニズムと疾患2012

    • Author(s)
      高田穣
    • Organizer
      第11回分子予防環境医学研究会
    • Place of Presentation
      倉敷市市民会館(倉敷市)(招待講演)
    • Year and Date
      2012-01-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] The Sugahara Memorial International Symposium on Prospective Topics and Charm of Radiation Biology2012

    • Author(s)
      Minoru Takata
    • Organizer
      Fanconi anemia and the DNA damage response
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] Fanconi anemia and the DNA damage response2012

    • Author(s)
      Minoru Takata
    • Organizer
      The Sugahara Memorial International Symposium
    • Place of Presentation
      稲盛ホール(京都市)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] International session for DNA repair and related subjects2011

    • Author(s)
      Takata, M
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸商工会議所会館(神戸市)(招待講演)
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 特別企画プログラム東京ビッグサイト2011

    • Author(s)
      高田穣
    • Organizer
      第28回日本医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射線被曝医療2011

    • Author(s)
      高田穣
    • Organizer
      第28回日本医学会総会講演会特別企画プログラム
    • Place of Presentation
      東京ビッグサイト(東京都)(招待講演)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] ファンコニ貧血DNA修復経路の中心タンパク質FANCD2はヌクレオソームアセンブリー活性を示す2011

    • Author(s)
      石合正道、佐藤浩一、高田穣、胡桃坂仁志
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Related Report
      2011 Final Research Report
  • [Presentation] ファンコニ貧血コア複合体によるATR-ATRIPキナーゼのクロマチン動態制御2011

    • Author(s)
      高田穣、冨田純也、板谷(内田)亜希子、茂地智子、海野純也、前原善彦、石合正道
    • Organizer
      第70回日本癌学会学術総会シンポジウム
    • Place of Presentation
      名古屋市
    • Related Report
      2011 Final Research Report
  • [Presentation] 複製ストレスによるFA経路の活性化には、ATRIP-ATRキナーゼが必須である2011

    • Author(s)
      茂地智子、冨田純也、佐藤浩一、海野純也、小林昌彦、山本健一、石合正道、胡桃坂仁志、前原善彦、高田穣
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      古屋市
    • Related Report
      2011 Final Research Report
  • [Presentation] An Absolute Requirement of ATRIP-ATR Kinase in Replication Stress-induced Triggering of the FA Pathway Activation2011

    • Author(s)
      T. Shigechi, J. Tomida, K. Sato, Y. Zhang, E. Uchida, J. Eykelenbo, N. Lowndes, H. Kurumizaka, Y. Maehara, M. Takata
    • Organizer
      23rd ANNUAL Fanconi Anemia Research Fund SCIENTIFIC SYMPOSIUM
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Final Research Report
  • [Presentation] Inhibition of NHEJ Reveals Distinct Roles for FANCG in the Repair of Interstrand Crosslinks and DNA Strand Breaks2011

    • Author(s)
      J. B. Wilson, J. K. Lingley, F. A. Makki, A. M. Alandwani, K. Lee, Y. Xiao, M. Takata, G. M. Kupfer, N. J. Jones
    • Organizer
      23rd ANNUAL Fanconi Anemia Research Fund SCIENTIFIC SYMPOSIUM
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Final Research Report
  • [Presentation] ファンコニ貧血蛋白質FANCD2/FANCI結合タンパク質のプロテオーム解析2011

    • Author(s)
      海野純也、板谷(内田)亜希子、冨田純也、井倉毅、高田穣
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸市
    • Related Report
      2011 Final Research Report
  • [Presentation] 複製ストレスによるファンコニ貧血経路の活性化には、ATR-ATRIPキナーゼ複合体が必須である2011

    • Author(s)
      茂地智子、冨田純也、佐藤浩一、小林昌彦、内田恵美、山本健一、胡桃坂仁志、前原善彦、高田穣
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸市
    • Related Report
      2011 Final Research Report
  • [Presentation] ファンコニ貧血とDNA損傷シグナリン」ポジウム[Internationa session for DNA repair and related subjects2011

    • Author(s)
      Takata, M
    • Organizer
      H放射線影響学会
    • Place of Presentation
      神戸市
    • Related Report
      2011 Final Research Report
  • [Presentation] Genome Dynamics : molecular network in maintenance and conversion:molecularnetworkinmaintenanceandconversion2011

    • Author(s)
      高田穣
    • Organizer
      日本分子生物学会第34回年会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular mechanisms of the Fanconi anemia pathway.2011

    • Author(s)
      Masamichi Ishiai, Junya Tomida, Tomoko Shigechi, Akiko Itaya, Emi Uchida, Junya Unno, Minoru Takata
    • Organizer
      日本分子生物学会第34回年会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Final Research Report
  • [Presentation] リン酸化プロテオミクスを用いた新規DNA損傷初期応答キナーゼの探索2011

    • Author(s)
      足立淳、鳴海良平、佐野聖三、久家貴寿、白水崇、松本雅記、中山敬一、井倉正枝、井倉毅、高田穣、朝長毅
    • Organizer
      日本分子生物学会第34回年会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Final Research Report
  • [Presentation] Mass spectrometric analysis identifiles factors associated with the Fanconi anemia proteins FANCD2 and FANCI2011

    • Author(s)
      unya Unno, Akiko Itaya, Junya Tomida, Tsuyoshi Ikura, Minoru Takata
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Final Research Report
  • [Presentation] Homologous recombinational repair and Chk1-mediated S-phase arrest protect cells from 5-FU cytotoxicity repair and Chkl-mediated S-phase arrest protect cells from2011

    • Author(s)
      Hiroyuki Kitao, Yoshihiko Fujinaka, Kazuaki Matsuoka, Makoto Iimori, Munkhbold Tuul, Ryo Sakasai, Ken-ichi Yamamoto, Minoru Takata, Yoshihiko Kakeji, Yoshihiko Maehara
    • Organizer
      日本分子生物学会第34回年会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Final Research Report
  • [Presentation] ファンコニ貧血蛋白FANCD2によるNF-kappaB転写制御機構の解析2011

    • Author(s)
      松下暢子、菊間啓太、太田莉英子、もたい龍介、徳山郷±、高田穣、胡桃坂仁志、山下孝之、稲留涼子、柳茂
    • Organizer
      日本分子生物学会第34回年会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Final Research Report
  • [Presentation] Histone chaperone activity of the FANCD2-FANCI complex and its importance in repair of interstrand DNA crosslinks by the Fanconi anemia pathway2011

    • Author(s)
      oichi Sato, Masamichi Ishiai, Kazue Toda, Satoshi Furukoshi, Akihisa Osakabe, Hiroaki Tachiwana, Yoshimasa Takizawa, Wataru Kagawa, Hiroyuki Kitao, Naoshi Dohmae, Chikashi Obuse, Hiroshi Kimura, Minoru Takata, Hitoshi Kurumizaka
    • Organizer
      日本分子生物学会第34回年会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Final Research Report
  • [Presentation] Robust stimulation of the FANCD2 monoubiquitination by three-way brached DNAs2011

    • Author(s)
      Kazue Toda, Koichi Sato, Masamichi Ishiai, Minoru Takata, Hitoshi Kurumizaka
    • Organizer
      日本生物学会第34回年会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Final Research Report
  • [Presentation] Mcm8 and Mcm9 form a novel complex involved in resistance to DNA crosslinking agents2011

    • Author(s)
      Kohei Nishimura, Masamichi Ishiai, Tatsuo Fukagawa, Minoru Takata, Haruhiko Takisawa, Masato Kanemaki
    • Organizer
      日本生物学会第34回年会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Final Research Report
  • [Presentation] ATR-ATRIP kinase complex is responsible for triggering of the FA pathway2011

    • Author(s)
      Tomoko Shigechi, Junya Tomida, Koichi Sato, Masahiko Kobayashi, John Eykelenboom, Pessina Fabio, Zhang Yanbin, Emi Uchida, Masamichi Ishiai, Noel Lowndes, Kenichi Yamamoto, Hitoshi Kurumizaka, Yoshihiko Maehara, Minoru Takata
    • Organizer
      日本生物学会第34回年会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Final Research Report
  • [Presentation] Fanconi anemia and the DNA damage signaling2011

    • Author(s)
      Minoru Takata
    • Organizer
      7th RBC-NIRS International Symposium
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] Fanconi貧血原因遺伝子餌艦η2及びE郡01一の機能解析2011

    • Author(s)
      佐藤浩一, 石合正道, 戸田和江, 古越聡, 越坂部晃永, 立和名博昭, 堂前直, 小布施力史, 木村宏, 高田穣, 胡桃坂仁志
    • Organizer
      第9回核ダイナミクス研究会
    • Place of Presentation
      伊豆市
    • Related Report
      2011 Final Research Report
  • [Presentation] ファンコニ貧血コア複合体によるATR-ATRIPキナーゼのクロマチン動態制御2011

    • Author(s)
      高田穣、冨田純也、板谷(内田)亜希子、茂地智子、海野純也、前原善彦、石合正道
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] An Absolute Requirement of ATRIP-ATR Kinase in Replication stress-induced Triggering of the FA Pathway Activation2011

    • Author(s)
      T.Shigechi, J.Tomida, K.Sato, Y.Zhang, E.Uchida, J.Eykelenbo, N.Lowndes, H.Kurumizaka, Y.Maehara, M.Takata
    • Organizer
      23rd ANNUAL Fanconi Anemia Research Fund SCIENTIFIC SYMPOSIUM
    • Place of Presentation
      Princesa Sofia Hotel(スペイン)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genome Dynamics : molecular network in maintenance and conversion2011

    • Author(s)
      高田穣
    • Organizer
      日本分子生物学会第34回年会
    • Place of Presentation
      パシフィコ横浜(横浜市)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular mechanisms of the Fanconi anemia pathway2011

    • Author(s)
      Masamicni Ishiai, Junya Tomida, Tomoko Shigechi, Akiko Itaya, Emi Uchida, Junya Unno, Minoru Takata
    • Organizer
      日本分子生物学会第34回年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA損傷応答シグナルにおけるクロマチン動態とエピジェネティクス制御2011

    • Author(s)
      Minoru Takata
    • Organizer
      27th RBC-NIRS International Symposium
    • Place of Presentation
      コープイン京都(京都市)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 発がんとDNA損傷応答の分子メカニズム2010

    • Author(s)
      高田穣
    • Organizer
      肺がん分子病態研究会
    • Year and Date
      2010-09-11
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Activation mechanisms of the Fanconi anemia pathway via ATR signaling2010

    • Author(s)
      高田穣
    • Organizer
      放射線生物若手の会(原子炉実験所
    • Year and Date
      2010-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] リン酸化・モノユビキチン化によるファンコニ貧血・DNA修復経路の活性化メカニズム2010

    • Author(s)
      石合正道, 冨田純也, 茂地智子, 板谷亜希子, 高田穣
    • Organizer
      第9回核ダイナミクス研究会
    • Place of Presentation
      伊豆市
    • Related Report
      2011 Final Research Report
  • [Presentation] FAAP20 is Required for Normal Activation of the Fanconi Anemia-associated DNA Damage Response Pathway2010

    • Author(s)
      Z. Yan, R. Guo, W. Shen, D. FoxIII, A. B. Oostra, M. Takata, D. Schindler, H. oatlin, J. de Winter, W. Wang.
    • Organizer
      22nd Fanconi Anemia Research Fund Scientific Symposium
    • Place of Presentation
      Minnesota(USA)
    • Related Report
      2011 Final Research Report
  • [Presentation] FANCG Functions Independently of the FA Core Complex in Homologous Recombination Repair of Phleomycin-induced DNA Damage2010

    • Author(s)
      N. J. Jones, A. Aladwani, Y. Xiao, V. S. Mysore, G. M. Kupfer, M. Takata, J. B. Wilson
    • Organizer
      22nd Fanconi Anemia Research Fund Scientific Symposium
    • Place of Presentation
      Minnesota(USA)
    • Related Report
      2011 Final Research Report
  • [Presentation] DNA損傷応答におけるファンコニ貧血経路の活性化メカニズム2010

    • Author(s)
      冨田純也、板谷亜希子、内田恵美、茂地智子、井倉正枝、胡桃坂仁志、井倉毅、石合正道、高田穣
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      ワークショップ京都
    • Related Report
      2011 Final Research Report
  • [Presentation] Artemisの核内動態制御機構の解析2010

    • Author(s)
      石合正道、島弘季、田代聡、高田穣
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      ワークショップ京都市
    • Related Report
      2011 Final Research Report
  • [Presentation] FANCI phosphorylation by ATR kinase proceeds in a Rad17/TopBP1-independent manner2010

    • Author(s)
      Junya Tomida, Akiko Itaya, Emi Uchida, Tomoko Shigechi, Masahiko Kobayashi, Ken-ichi Yamamoto, Masae Ikura, Tsuyoshi Ikura, Agata Smogorzewska, Masamichi Ishiai, Minoru Takata
    • Organizer
      第33回年会日本生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] DNAダメージにおけるArtemisの核内動態制御2010

    • Author(s)
      石合正道、島弘季、田代聡、高田穣
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Related Report
      2011 Final Research Report
  • [Presentation] Gene targeting : vector design and construction EMBO practical course2010

    • Author(s)
      Minoru Takata
    • Organizer
      EMBO practical course
    • Related Report
      2011 Final Research Report
  • [Presentation] How we can achieve disruption of the genes essential for cell viability in DT40 cells?2010

    • Author(s)
      Minoru Takata
    • Organizer
      EMBO practical course
    • Place of Presentation
      Ireland
    • Related Report
      2011 Final Research Report
  • [Presentation] Activation mechanisms of the Fanconi anemia pathway2010

    • Author(s)
      Minoru Takata
    • Organizer
      Traute Schroeder-Kurth Symposium at the University of Wu rzburg
    • Place of Presentation
      Gemmany
    • Related Report
      2011 Final Research Report
  • [Presentation] The DT40 cell line as a model genetic system2010

    • Author(s)
      Takata M.
    • Organizer
      EMBO Practical Course
    • Place of Presentation
      Galway, Ireland(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Activation mechanisms of the Fanconi anemia pathway2010

    • Author(s)
      Takata M.
    • Organizer
      Preventing genomic instability, neoplasia and premature ageing emerging role of the Fanconi anemia- BRCA caretaker network.Traute Schroeder-Kurth Symposium.
    • Place of Presentation
      Wurburg, Germany(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel role of the FA core complex in FANCI phosphorylation, an important switch in the FA pathway2009

    • Author(s)
      Minom Takata, Junva Tomida, Tomoko Shigechi, Hiroyuki Kitao, Akiko Itava, Masamichi Ishiai
    • Organizer
      Twenty-first Annual Fanconi Anemia Research Fund Scientific Symposium
    • Related Report
      2011 Final Research Report
  • [Presentation] A novel role of the FA core complex in FANCI phosphorylation, an important switch in the FA pathway2009

    • Author(s)
      Minoru Takata, Junya Tomida, Tomoko Shigechi, Hiroyuki Kitao, Akiko Itaya, Masamichi Ishiai
    • Organizer
      Twenty-first Annual Fanconi Anemia Research Fund Scientific Symposium
    • Place of Presentation
      Baltimore, MA, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] REGULATION OF CROSS-LINK REPAIR THROUGH THE FANCONI ANEMIA PATHWAY2009

    • Author(s)
      Minoru Takata, Junya Tomida, Akiko Itaya, Tomoko Shigechi, Masamichi Ishiai
    • Organizer
      The Fortieth International Symposium of the Princess Takamatsu Cancer Research Fund
    • Place of Presentation
      Tokyo
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高発がん遺伝病ファンコニ貧血の分子メカニズム2009

    • Author(s)
      高田穣
    • Organizer
      第71回 日本血液学会学術集会 シンポジウム「小児血液腫瘍の発症リスクと先天異常」
    • Place of Presentation
      京都市 国際会館
    • Related Report
      2009 Annual Research Report
  • [Presentation] DNA damage signaling in the Fanconi anemia pathogenesis2009

    • Author(s)
      高田穣
    • Organizer
      第51回 小児血液学会 血液プレジデンシャルシンポジウム「DNA damage response and hemato logical disorder」
    • Place of Presentation
      千葉 東京ベイホテル東急
    • Related Report
      2009 Annual Research Report
  • [Book] Evaluation of Homologous Recombinational Repair in Chicken B Lymphoma Cell Line, DT40. Methods Mol Biol2011

    • Author(s)
      Kitao H, Hirano S, Takata M
    • Total Pages
      745
    • Related Report
      2011 Final Research Report
  • [Book] Establishment of the DNA repair-defective mutants in DT40 cells. Methods Mol Biol

    • Author(s)
      Ishiai M, Uchida E, and Takata M
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.rbc.kyoto-u.ac.jp/Late_Effect/Site_1/Welcome.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.rbc.kyoto-u.ac.jp/Late_Effect/Site_1/Welcome.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.rbc.kyoto-u.ac.jp/Late_Effect/Site_1/Welcome.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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