MAINTENANCE OF PROTEIN HOMEOSTASIS REGULATED BY HEAT SHOCK FACTOR
| Project/Area Number |
21390095
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Yamaguchi University |
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Principal Investigator |
NAKAI Akira 山口大学, 大学院・医学系研究科, 教授 (60252516)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Mitsuaki 山口大学, 大学院・医学系研究科, 講師 (80359900)
TAKH Ryousuke 山口大学, 大学院・医学系研究科, 助教 (00419558)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 熱ショック / 蛋白質 / ホメオスタシス / 転写 / フォールディング / 分解 / ポリグルタミン / マウス / 転写因子 / ミスフォールディング病 / 熱ショック蛋白質 / 神経変性疾患 |
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| Research Abstract |
Cellular protein homeostasis(proteostasis) capacity, or buffering capacity of protein misfolding, is related with aging and aging-associated protein misfolding diseases. One of prominent mechanisms of the maintenance of proteostasis capacity is the heat shock response, which is regulated mainly at the level of transcription by heat shock factor(HSF). In this research project, we first demonstrate that HSF1 controls proteostasis capacity by regulating not only heat shock proteins(HSPs), which facilitate protein folding, but also non-HSP proteins with diverse function including protein degradation.
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Report
(4 results)
Research Products
(125 results)
