| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Research Abstract |
Cellular protein homeostasis(proteostasis) capacity, or buffering capacity of protein misfolding, is related with aging and aging-associated protein misfolding diseases. One of prominent mechanisms of the maintenance of proteostasis capacity is the heat shock response, which is regulated mainly at the level of transcription by heat shock factor(HSF). In this research project, we first demonstrate that HSF1 controls proteostasis capacity by regulating not only heat shock proteins(HSPs), which facilitate protein folding, but also non-HSP proteins with diverse function including protein degradation.
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