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Molecular Mechanisms to Regulate The Metabolism of Water and Electrolytes

Research Project

Project/Area Number 21390096
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionKochi University

Principal Investigator

HONKE Koichi  高知大学, 教育研究部・医療学系, 教授 (80190263)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords代謝異常学 / 水・電解質代謝 / アンジオテンシン / アンドステロン合成酵素 / カルシニューリン / 遺伝子発現調節 / スルファチド / バソプレシン / アクアポリン / アルドステロン合成酵素 / 腎尿細管機能 / サルファタイド / アルドステロン / シグナル伝達
Research Abstract

Aiming at elucidation of molecular regulatory mechanisms underlying the reabsorption of water and electrolytes on the distal tubules and collecting ducts of the nephron, we demonstrated calcineurin is involved in the signaling pathway dictating the angiotensin II-dependent aldosteron secretion. Further, we found that deficiency of the mascurin gene causes depletion of the antidiuretic hormone(vasopressin). Finally, amounts of urine and water intake were increased when a high salt concentration of water was given to the sulfated glycolipid-deficient mice. However expression levels and membrane localizations of aquaporin and Na^+, K^+-ATPase were not deteriorated.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2012 2011 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (6 results) Book (3 results)

  • [Journal Article] A proteomics approach to the cell-surface interactome using the enzyme-mediated activation of radical sources reaction2012

    • Author(s)
      Jiang S, Kotani N, Ohnishi T, Miyagawa-Yamguchi A, Tsuda M, Yamashita R, Ishiura Y, Honke K
    • Journal Title

      Proteomics

      Volume: 12 Issue: 1 Pages: 54-62

    • DOI

      10.1002/pmic.201100551

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The enzyme-mediated activation of radical source reaction : a new approach to identify partners of a given molecule in membrane microdomains2011

    • Author(s)
      Honke K, Kotani N
    • Journal Title

      J. Neurochem

      Volume: 116 Issue: 5 Pages: 690-695

    • DOI

      10.1111/j.1471-4159.2010.07027.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporally-regulated interaction betweenβ1 integrin and ErbB4 that is involved in fibronectin-dependent cell migration2011

    • Author(s)
      Yamashita R, Kotani N, Ishiura Y, Higashiyama S, Honke K
    • Journal Title

      J. Biochem

      Volume: 149 Issue: 3 Pages: 347-355

    • DOI

      10.1093/jb/mvq148

    • NAID

      10030584133

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hollingsworth MA : Overexpression of GalNAc-transferase GalNAc-T3 promotes pancreatic cancer cell growth2011

    • Author(s)
      Taniuchi K, Cerny RL, Tanouchi A, Kohno K, Kotani N, Honke K, Saibara T
    • Journal Title

      Oncogene

      Volume: 30 Issue: 49 Pages: 4843-4854

    • DOI

      10.1038/onc.2011.194

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new approach to identify partners of a given molecule in membrane domains.2011

    • Author(s)
      Honke K, Kotani N
    • Journal Title

      J.Neurochem.

      Volume: 116 Pages: 690-695

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcineurin mediates the angiotensin II-induced aldosterone synthesis in theadrenal glands by upregulation of transcription of the CYP11B2 gene2010

    • Author(s)
      Yamashiro T, Kuge H, Zhang J, Honke K
    • Journal Title

      J. Biochem

      Volume: 148 Issue: 1 Pages: 115-123

    • DOI

      10.1093/jb/mvq037

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anomalous expression of Thy1(CD90) in B-cell lymphoma cells and proliferation inhibition by anti-Thy1 antibody treatment2010

    • Author(s)
      Ishiura Y, Kotani N, Yamashita R, Yamamoto H, Kozutsumi Y, Honke K
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 396 Pages: 329-334

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2010.04.092

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcineurin mediates the angiotensin II-induced aldosterone synthesis in theadrenal glands by upregulation of transcription of the CYP11B2 gene2010

    • Author(s)
      Yamashiro T, Kuge H, Zhang J, Honke K
    • Journal Title

      J.Biochem.

      Volume: 148 Pages: 115-123

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anomalous Expression of Thy1 (CD90) in B-Cell Lymphoma Cells and Proliferation Inhibition by Anti-Thy1 Antibody Treatment.2010

    • Author(s)
      Ishiura Y, Kotani N, et al.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 396 Pages: 329-334

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcineurin mediates the angiotensin II-induced aldosterone synthesis in the adrenal glands by upregulation of transcription of the CYP11B2 gene2010

    • Author(s)
      Yamashiro T, Kuge H, Zhang J, Honke K
    • Journal Title

      J.Biochem. (印刷中)

    • NAID

      10027877322

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Honke K, Taniguchi N
    • Journal Title

      The Sugar Code.Fundamentals of Glycosciences(Wiley-VCH Verlag GmbH & Co.KGaA)

      Pages: 385-401

    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of molecular clustering on the living cell membrane2011

    • Author(s)
      Honke K, Miyagawa-Yamaguchi A, Kotani N
    • Organizer
      Glycobiology Japan-Netherland Joint Seminar 2011
    • Place of Presentation
      名古屋大学
    • Year and Date
      2011-10-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of molecular clustering on the living cell membrane2011

    • Author(s)
      Honke K, Miyagawa-Yamaguchi A, Kotani N
    • Organizer
      Glycobiology Japan-Netherland Joint Seminar 2011
    • Place of Presentation
      名古屋大学(招待講演)
    • Year and Date
      2011-10-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 硫酸化糖鎖の生理機能2011

    • Author(s)
      本家孝一
    • Organizer
      遺伝子・デリバリー研究会第11回夏期セミナー
    • Place of Presentation
      高知三翠園
    • Year and Date
      2011-08-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 硫酸化糖鎖の生理機能2011

    • Author(s)
      本家孝一
    • Organizer
      遺伝子・デリバリー研究会第11回夏期セミナー
    • Place of Presentation
      高知三翠園(招待講演)
    • Year and Date
      2011-08-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functions of glycoconjugates in the membrane microdomains in development2010

    • Author(s)
      Honke K, Yamashita T
    • Organizer
      The 28th Naito Conference on" Glycan expression and regulation[ I]"
    • Place of Presentation
      Shonan, Kanagawa, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Functions of glycoconjugates in the membrane microdomains in development.2010

    • Author(s)
      Honke K, Yamashita T
    • Organizer
      The 28th Naito Conference on "Glycan expression and regulation [I]"
    • Place of Presentation
      Shonan, Kanagawa, Japan
    • Related Report
      2010 Annual Research Report
  • [Book] 脂質2011

    • Author(s)
      本家孝一
    • Publisher
      メジカルビュー社
    • Related Report
      2011 Final Research Report
  • [Book] カラーイラストで学ぶ集中講義生化学2011

    • Author(s)
      鈴木敬一郎、本家孝一、大河原知水、藤原範子
    • Publisher
      メジカルビュー社
    • Related Report
      2010 Annual Research Report
  • [Book] Animal models to delineate glycan functionality2009

    • Author(s)
      Honke K, Taniguchi N
    • Publisher
      Wiley-VCH Verlag GmbH & Co. KGaA
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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