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Molecular mechanism of signal transduction by reactive oxygen species

Research Project

Project/Area Number 21390097
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionKumamoto University

Principal Investigator

AKAIKE Takaaki  熊本大学, 大学院・生命科学研究部, 教授 (20231798)

Co-Investigator(Kenkyū-buntansha) FUJII Shigemoto  熊本大学, 大学院・生命科学研究部, 助教 (00325333)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords活性酸素 / シグナル伝達 / 酸化ストレス / 8-nitro-cGMP / S-グアニル化 / 8-nitra-cGMP
Research Abstract

8-Nitro-cGMP is involved in reactive oxygen species-mediated signaling via protein S-guanylation. Here we identified several particular S-guanylated proteins(e. g., H-Ras etc.) occurring in cells and their involvement in various cellular signaling functions. We also revealed that endogenously produced hydrogen sulfide regulates protein S-guanylation in cells.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (175 results)

All 2012 2011 2010 2009 Other

All Journal Article (59 results) (of which Peer Reviewed: 39 results) Presentation (100 results) Book (9 results) Remarks (7 results)

  • [Journal Article] Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration2012

    • Author(s)
      Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, and Akaike T
    • Journal Title

      Nature Chem Biol

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anks4b, a novel target of HNF4α interacts with GRP78 and regulates endoplasmic reticulum stress-induced apoptosis in pancreaticβ-cells2012

    • Author(s)
      Sato Y, Hatta M, Karim MF, Sawa T, Wei FY, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, and Yamagata K
    • Journal Title

      J Biol Chem

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complete genome sequence of Helicobacter cinaedi strain PAGU611, isolated in a case of human bacteremia2012

    • Author(s)
      Goto T, Ogura Y, Hirakawa H, Tomida J, Morita Y, Akaike T, Hayashi T, and Kawamura Y
    • Journal Title

      J Bacteriol

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] S-Guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents2012

    • Author(s)
      Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, and Otagiri M
    • Journal Title

      J Pharm Sci

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential association of Helicobacter cinaedi with atrial arrhythmia and atherosclerosis2012

    • Author(s)
      Khan S, Okamoto T, Enomoto K, Sakashita N, Oyama K, Fujii S, Sawa T, Takeya M, Ogawa H, Yamabe H, and Akaike T
    • Journal Title

      Microbiol Immunol

      Volume: 56 Pages: 145-154

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation by mitochondrial superoxide and NADPH oxidase of cell formation of nitrated cyclic GMP : potential implications for ROS signaling2012

    • Author(s)
      Ahmed KA, Sawa T, Ihara H, Kasamatsu S, Yoshitake J, Okamoto T, Fujii S, and Akaike T
    • Journal Title

      Biochem J

      Volume: 441 Pages: 719-730

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 基礎の基礎細胞工学2012

    • Author(s)
      赤池孝章
    • Journal Title

      特集「活性酸素シグナル制御とレドックスホメオスタシス」

      Volume: 31(2) Pages: 134-137

    • Related Report
      2011 Final Research Report
  • [Journal Article] ニトロ化環状ヌクレオチドによるタンパク質S.グアニル化を介する酸化ストレス適応応答の分子機序2012

    • Author(s)
      藤井重元, 赤池孝章
    • Journal Title

      生化学

      Volume: 84(2) Pages: 124-128

    • NAID

      10030346449

    • Related Report
      2011 Final Research Report
  • [Journal Article] Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP : potential implications for ROS signalling2012

    • Author(s)
      Ahmed KA., et al
    • Journal Title

      Biochem J

      Volume: 441 Issue: 2 Pages: 719-730

    • DOI

      10.1042/bj20111130

    • NAID

      120004875062

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新・活性酸素中毒2012

    • Author(s)
      赤池孝章
    • Journal Title

      ファルマシア

      Volume: 48 Pages: 1-1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 基礎の基礎2012

    • Author(s)
      赤池孝章
    • Journal Title

      細胞工学

      Volume: 31 Pages: 134-137

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ニトロ化環状ヌクレオチドによるタンパク質S-グアニル化を介する酸化ストレス適応応答の分子機序2012

    • Author(s)
      藤井重元、赤池孝章
    • Journal Title

      生化学

      Volume: 84 Pages: 124-128

    • NAID

      10030346449

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frontiers in nitric oxide and redox signaling2011

    • Author(s)
      Akaike T, van der Vliet A, and Eaton P
    • Journal Title

      Nitric Oxide

      Volume: 25 Pages: 57-58

    • NAID

      120004058207

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3', 5'-cyclic monophosphate formed in glia cells2011

    • Author(s)
      Ihara H, Ahmed KA, Ida T, Kasamatsu S, Kunieda K, Okamoto T, Sawa T, and Akaike T
    • Journal Title

      Nitric Oxide

      Volume: 25 Pages: 169-175

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nucleotides function as endogenous chemical sensors for oxidative stress signaling2011

    • Author(s)
      Ihara H, Sawa T, Nakabeppu Y, and Akaike T
    • Journal Title

      J Clin Biochem Nutr

      Volume: 48 Pages: 1-7

    • NAID

      130004879228

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Midbrain dopaminergic neurons utilize nitric oxide/cyclic GMP signaling to recruit ERK that links retinoic acid receptor stimulation to up-regulation of BDNF2011

    • Author(s)
      Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike T, Shudo K, and Katsuki H
    • Journal Title

      J Neurochem

      Volume: 116 Pages: 323-333

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular responses to 8-nitro-cyclic GMP in nondiabetic and diabetic mice2011

    • Author(s)
      Tokutomi Y, Kataoka K, Yamamoto E, Nakamura T, Hisato F, Nako H, Toyama K, Dong YF, Ahmed KA, Sawa T, Akaike T, and Kim-Mitsuyama S
    • Journal Title

      Br J Pharmacol

      Volume: 162 Pages: 1884-1893

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides2011

    • Author(s)
      Ahmed KA, Sawa T, and Akaike T
    • Journal Title

      Amino Acids

      Volume: 41 Pages: 123-130

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile2011

    • Author(s)
      Sawa T, Ihara H, and Akaike T
    • Journal Title

      Curr Top Med Chem

      Volume: 11 Pages: 1854-1860

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detoxification of methylmercury by hydrogen sulfide-producing enzyme in mammalian cells2011

    • Author(s)
      Yoshida E, Toyama T, Shinkai Y, Sawa T, Akaike T, and Kumagai Y
    • Journal Title

      Chem. Res. Toxicol

      Volume: 24 Pages: 1633-1635

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 活性酸素・一酸化窒素によるニトロ化シグナルと抗炎症作用2011

    • Author(s)
      澤智裕, 小野勝彦, 赤池孝章
    • Journal Title

      感染・炎症・免疫

      Volume: 41 Pages: 12-19

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 植物精油citralのインフルエンザウイルス感染能抑制効果について2011

    • Author(s)
      今吉理恵子, 岡本竜哉, 永尾潤一, 長環, 松永勝政, 赤池孝章, 上西秀則
    • Journal Title

      医学と生物学

      Volume: 155 Pages: 489-494

    • Related Report
      2011 Final Research Report
  • [Journal Article] 喫煙と酸化ストレス: Oxidative stress induced by cigarette smoking2011

    • Author(s)
      岡本竜哉, 居原秀, 赤池孝章
    • Journal Title

      最新精神医学

      Volume: 16 Pages: 431-439

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Frontiers in nitric oxide and redox signaling2011

    • Author(s)
      Akaike T., et al
    • Journal Title

      Nitric Oxide

      Volume: 25 Issue: 2 Pages: 57-58

    • DOI

      10.1016/j.niox.2011.04.015

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice2011

    • Author(s)
      Tokutomi Y., et al
    • Journal Title

      Br J Pharmabol

      Volume: 162 Issue: 8 Pages: 1884-1893

    • DOI

      10.1111/j.1476-5381.2011.01201.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant Effect of a Nitrated Cyclic Nucleotide Functioning as an Endogenous Electrophile2011

    • Author(s)
      Sawa T., et al
    • Journal Title

      Curr Top Med Chem

      Volume: 11 Pages: 1854-1860

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detoxification of methylmercury by hydrogen sulfide-producing enzyme in Mammalian cells2011

    • Author(s)
      Yoshida E, Toyama T (equalcontributor), Shinkai Y, Sawa T, Akaike T, Kumagai Y
    • Journal Title

      Chemical Research in Toxicology

      Volume: 24 Issue: 10 Pages: 1633-1635

    • DOI

      10.1021/tx200394g

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular uptake mechanisms and responses to NO transferred from mono- and poly-S-nitrosated human serum albumin2011

    • Author(s)
      Yu Ishima., et al
    • Journal Title

      Free Radical Research

      Volume: 45 Issue: 10 Pages: 1196-1206

    • DOI

      10.3109/10715762.2011.606814

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular responses to 8-nitro-cyclic GMP in nondiabetic and diabetic mice2011

    • Author(s)
      Tokutomi Y., et al
    • Journal Title

      Br J Pharmacol

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response2010

    • Author(s)
      Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahmed KA, Ishima Y, Motohashi H, Yamamoto M, and Akaike T
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 23970-23984

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new paradigm for antimicrobial host defense mediated by a nitrated cyclic nucleotide2010

    • Author(s)
      Okamoto T, Khan S, Oyama K, Fujii S, Sawa T, and Akaike T
    • Journal Title

      J Clin Biochem Nutr

      Volume: 46 Pages: 14-19

    • NAID

      130004466590

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles2010

    • Author(s)
      Sawa T, Arimoto H, and Akaike T
    • Journal Title

      Bioconjugate Chem

      Volume: 21 Pages: 1121-1129

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell signaling mediated by nitrated cyclic guanine nucleotide2010

    • Author(s)
      Akaike T, Fujii S, Sawa T, and Ihara H
    • Journal Title

      Nitric Oxide

      Volume: 23 Pages: 166-174

    • NAID

      120002772115

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-step preparation of S-nitrosated human serum albumin with high biological activities2010

    • Author(s)
      Ishima Y, Hiroyama S, Kragh-Hansen U, Maruyama T, Sawa T, Akaike T, Kai T and Otagiri M
    • Journal Title

      Nitric Oxide

      Volume: 23 Pages: 121-127

    • NAID

      120002971552

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 8-Nitro-cGMPの発見と生理機能の解明2010

    • Author(s)
      藤井重元, 澤智裕, 赤池孝章
    • Journal Title

      化学と生物

      Volume: 48 Pages: 22-27

    • NAID

      10026437376

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 毒性説から脱した活性酸素研究-シグナル分子としての活躍-2010

    • Author(s)
      澤智裕, 赤池孝章
    • Journal Title

      現代化学

      Volume: 469 Pages: 34-38

    • NAID

      40016994933

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Nitric oxide(NO)およびNO関連物質2010

    • Author(s)
      岡本竜哉, 澤智裕, 赤池孝章
    • Journal Title

      日本臨床

      Volume: 982 Pages: 839-842

    • Related Report
      2011 Final Research Report
  • [Journal Article] 呼吸器疾患における酸化ストレスと制御シグナルの分子基盤: Molecular mechanisms of nitric oxide-and reactive oxygen species-mediated signalings in the respiratory diseases2010

    • Author(s)
      岡本竜哉, 赤池孝章
    • Journal Title

      呼吸

      Volume: 29 Pages: 859-866

    • Related Report
      2011 Final Research Report
  • [Journal Article] 新興感染症原因菌-Helicobacter cinaedi2010

    • Author(s)
      河村好章, 赤池孝章
    • Journal Title

      日本医事新報

      Volume: 4514 Pages: 59-62

    • Related Report
      2011 Final Research Report
  • [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides2010

    • Author(s)
      Ahmed K.A., et al
    • Journal Title

      Amino Acids

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of redox signaling involving chemical conjugation of protein thiols by nitricoxide and electrophiles2010

    • Author(s)
      Sawa T., et al
    • Journal Title

      Bioconjugate Chem

      Volume: 21 Pages: 1121-1129

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile2010

    • Author(s)
      Sawa T., et al
    • Journal Title

      Current Topics Med Chem

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 呼吸器疾患における酸化ストレスと制御シグナルの分子基盤:Molecular mechanisms of nitric oxide-and reactive oxygen species-mediated signalings in the respiratory diseases2010

    • Author(s)
      岡本竜哉, 他
    • Journal Title

      呼吸

      Volume: 29 Pages: 859-866

    • Related Report
      2010 Annual Research Report
  • [Journal Article] A new paradigm for antimicrobial host defense mediated by a nitrated cyclic nucleotide2010

    • Author(s)
      Okamoto T., et al
    • Journal Title

      J Clin Biochem Nutr 46

      Pages: 14-19

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular signaling mediated by nitrated cyclic nucleotides2010

    • Author(s)
      Akaike T., et al
    • Journal Title

      Nitric Oxide (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles2010

    • Author(s)
      Sawa T., et al
    • Journal Title

      Bioconjug Chem (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitronucleotides2010

    • Author(s)
      Ahmed KA., et al
    • Journal Title

      Amino Acids (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 毒性説から脱した活性酸素研究-シグナル分子としての活躍-2010

    • Author(s)
      澤智裕, 他
    • Journal Title

      現代化学 469

      Pages: 34-38

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 8-Nitro-cGMPの発見と生理機能の解明2010

    • Author(s)
      藤井重元, 他
    • Journal Title

      化学と生物 48

      Pages: 22-27

    • NAID

      10026437376

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Cytoprotective function of heme oxygenase-1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis2009

    • Author(s)
      Zaki MH, Fujii S, Okamoto T, Islam S, Khan S, Ahmed KA, Sawa T, and Akaike T
    • Journal Title

      J Immnol

      Volume: 182 Pages: 3746-3756

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] NOによる細胞内感染防御の新しい展開-New paradigm of host defense against intracellular pathogens by nitric oxide2009

    • Author(s)
      赤池孝章, 岡本竜哉, Zaki MH, 藤井重元, 澤智裕
    • Journal Title

      Nihon Hansenbyo Gakkai Zasshi

      Volume: 78 Pages: 41-47

    • Related Report
      2011 Final Research Report
  • [Journal Article] 活性酸素・NOによる感染防御シグナルの新展開-Antimicrobial signaling mediated by reactive oxygen species and NO2009

    • Author(s)
      岡本竜哉, 澤智裕, 藤井重元, 赤池孝章
    • Journal Title

      細胞

      Volume: 41 Pages: 51-55

    • Related Report
      2011 Final Research Report
  • [Journal Article] 活性酸素のシグナル伝達機能-その生理機能の再発見と酸化ストレス研究の新展開2009

    • Author(s)
      赤池孝章
    • Journal Title

      実験医学

      Pages: 2320-2329

    • Related Report
      2011 Final Research Report
  • [Journal Article] チオール基の修飾による活性酸素のセンサー機能制御2009

    • Author(s)
      澤智裕, 有本博一, 赤池孝章
    • Journal Title

      実験医学

      Pages: 2341-2347

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytoprotective function of heme oxygenase-1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis2009

    • Author(s)
      Zaki MM., et al
    • Journal Title

      J Immnol 182

      Pages: 3746-3756

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 活性酸素のシグナル伝達機能-その生理機能の再発見と酸化ストレス研究の新展開2009

    • Author(s)
      赤池孝章, 他
    • Journal Title

      実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス 27

      Pages: 2320-2329

    • Related Report
      2009 Annual Research Report
  • [Journal Article] チオール基の修飾による活性酸素のセンサー機能制御2009

    • Author(s)
      澤智裕, 他
    • Journal Title

      実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス 27

      Pages: 2341-2347

    • Related Report
      2009 Annual Research Report
  • [Journal Article] NOによる細胞内感染防御の新しい展開-New paradigm of host defense against intracellular pathogens by nitric oxide2009

    • Author(s)
      赤池孝章, 他
    • Journal Title

      日本ハンセン病学会雑誌 78

      Pages: 41-47

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 活性酸素・NOによる感染防御シグナルの新展開-Antimicrobial signaling mediated by reactive oxygen species and NO2009

    • Author(s)
      岡本竜哉, 他
    • Journal Title

      細胞 41

      Pages: 51-55

    • Related Report
      2009 Annual Research Report
  • [Presentation] トップジャーナル七転び八起き2012

    • Author(s)
      赤池孝章
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール(長崎)(招待講演)
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 硫化水素の抗酸化機能と酸化ストレスバイオマーカー2012

    • Author(s)
      藤井重元、赤池孝章
    • Organizer
      第8回呼吸器バイオマーカー研究会
    • Place of Presentation
      東京、都市センターホテル
    • Year and Date
      2012-03-10
    • Related Report
      2011 Final Research Report
  • [Presentation] トップジャーナル七転び八起き2012

    • Author(s)
      赤池孝章
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎、長崎ブリックホール
    • Related Report
      2011 Final Research Report
  • [Presentation] Cellular signaling mediated by nitrated cyclic nucleotides and its regulation by hydrogen sulfide2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 23^<rd> Annual Meeting of the Korean Society for Molecular and Cellular Biology
    • Place of Presentation
      COEX(ソウル韓国)(招待講演)
    • Year and Date
      2011-10-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] ROS and electrophilic cellular signaling regulated by hydrogen sulfide2011

    • Author(s)
      赤池孝章, 他
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)(招待講演)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Antimicrobial cell signaling mediated by nitrated cyclic nucleotide2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      第84回日本細菌学会総会
    • Place of Presentation
      札幌コンベンションセンター(札幌)(招待講演)
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内因性硫化水素イオンによるROS・親電子シグナル制御2011

    • Author(s)
      赤池孝章
    • Organizer
      第2回Molecular Cardiovascular Conference II
    • Place of Presentation
      ホテルピアノ(北海道キロロ)(招待講演)
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生体内ガス分子と活性酸素による多次元シグナルネットワーク2011

    • Author(s)
      赤池孝章
    • Organizer
      第8回Heme Oxygenase研究フォーラム
    • Place of Presentation
      京都、京都府立医科大学青蓮会館
    • Year and Date
      2011-08-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 生体内ガス分子と活性酸素による多次元シグナルネットワーク2011

    • Author(s)
      赤池孝章
    • Organizer
      第8回Heme Oxygenase研究フォーラム
    • Place of Presentation
      京都府立医科大学・青蓮会館(京都)(招待講演)
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Protein S-guanylation and its unique regulation mechanisms involving cysteine metabolism2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      12th International congress on amino acids, peptides and proteins
    • Place of Presentation
      Beijing International Convention Center(北京)
    • Year and Date
      2011-08-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 親電子シグナルと硫化水素2011

    • Author(s)
      赤池孝章
    • Organizer
      九州大学生体防御医学研究所共同利用研究集会
    • Place of Presentation
      福岡、九州大学
    • Year and Date
      2011-07-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 親電子シグナルと硫化水素.九州大学生体防御医学研究所共同利用2011

    • Author(s)
      赤池孝章
    • Organizer
      九州大学生体防御医学研究所共同利用研究集会
    • Place of Presentation
      九州大学生体防御医学研究所会議室(福岡)(招待講演)
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内因性硫化水素イオンによる親電子シグナル制御2011

    • Author(s)
      赤池孝章
    • Organizer
      64回日本酸化ストレス学会学術集会
    • Place of Presentation
      ルスツリゾートホテル&コンベンション(北海道留寿都)(招待講演)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cellular signaling mediated by nitrated cyclic nucleotide and regulated by hydrogen sulfide.5th International Conference on cGMP2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      第5回cGMP国際会議
    • Place of Presentation
      Lowengebaude, (Halle, Germany)(招待講演)
    • Year and Date
      2011-06-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 活性酸素シグナル伝達と加齢2011

    • Author(s)
      赤池孝章
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      国立京都国際会館(京都)(招待講演)
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Electrophilic cellular signaling regulated by H_2 S-medaited sulfhydration2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      第11回日本NO学会総会
    • Place of Presentation
      昭和薬科大学(東京都町田市)
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cellular signaling by nitrated cyclic nucleotides and regulation of its biological effects2011

    • Author(s)
      Akaike T.
    • Organizer
      Gordon Research Conferemce on Nitric Oxide : Understanding the Biology and Chemistry of Its Formation, Action, and Signaling
    • Place of Presentation
      Four Points Sheraton/Holiday Inn Express (Ventura, CA)
    • Year and Date
      2011-02-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cell signaling mediated by nitrated cyclic guanine nucleotide2011

    • Author(s)
      Akaike T.
    • Organizer
      International Symposium on Free Radical Research : Contribution to Medicine
    • Place of Presentation
      Hyatt Regency Kyoto(京都市)
    • Year and Date
      2011-01-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] ROS and electrophilic cellular signaling regulated by hydrogen sulfide2011

    • Author(s)
      赤池孝章、澤智裕、西田基宏
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都、国立京都国際会館
    • Related Report
      2011 Final Research Report
  • [Presentation] Antimicrobial cell signaling mediated by nitrated cyclic nucleotide2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      XIII International Congress of Bacteriology and Applied Microbiology, 第84回日本細菌学会総会
    • Place of Presentation
      Sapporo, Sapporo Convention Center
    • Related Report
      2011 Final Research Report
  • [Presentation] 内因性硫化水素イオンによるROS・親電子シグナル制御2011

    • Author(s)
      赤池孝章
    • Organizer
      第2回Molecular Cardiovascular Conference II
    • Place of Presentation
      北海道、キロロ"ホテルピアノ
    • Related Report
      2011 Final Research Report
  • [Presentation] Protein S-guanylation and its unique regulation mechanisms involving cysteine metabolism2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      12th International congress on amino acids, peptides and proteins
    • Place of Presentation
      Beijing China
    • Related Report
      2011 Final Research Report
  • [Presentation] 内因性硫化水素イオンによる親電子シグナル制御2011

    • Author(s)
      赤池孝章
    • Organizer
      第64回日本酸化ストレス学会学術集会
    • Place of Presentation
      留寿都、北海道ルスツリゾートホテル & コンベンション
    • Related Report
      2011 Final Research Report
  • [Presentation] Cellular signaling mediated by nitrated cyclic nucleotide and regulated by hydrogen sulfide2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      5th International Conference on cGMP
    • Place of Presentation
      Halle, Germany
    • Related Report
      2011 Final Research Report
  • [Presentation] 活性酸素シグナル伝達と加齢2011

    • Author(s)
      赤池孝章
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都、国立京都国際会館
    • Related Report
      2011 Final Research Report
  • [Presentation] Electrophilic cellular signaling regulated by H_2S-medaited sulfhydration2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      第11回日本NO学会学術集会
    • Place of Presentation
      東京町田、昭和薬科大学
    • Related Report
      2011 Final Research Report
  • [Presentation] Cellular signaling by nitrated cyclic nucleotides and regulation of its biological effects2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      Gordon Research Conferemce on Nitric Oxide : Understanding the Biology and Chemistry of Its Formation, Action, and Signaling
    • Place of Presentation
      Ventura, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Cell signaling mediated by nitrated cyclic guanine nucleotide2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      International Symposium on Free Radical Research : ontribution to Medicine
    • Place of Presentation
      京都、ハイアットリージェンシー京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 核酸分子の化学修飾による活性酸素シグナルのケミカルセンシング2010

    • Author(s)
      澤智裕, 他
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      ポートアイランド(神戸市)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] NOによる抗酸化応答の新展開2010

    • Author(s)
      澤智裕, 他
    • Organizer
      第27回臨床フリーラジカル会議
    • Place of Presentation
      京都・烟河(京都市)
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Glyceraldehyde 3-phosphate dehydrogenaseの基質依存的な酸化的不活性化2010

    • Author(s)
      小野勝彦, 他
    • Organizer
      第63回日本酸化ストレス学会学術集会
    • Place of Presentation
      神奈川県民ホール(横浜市)
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細胞内における8-nitro-cGMP生成メカニズムの解析2010

    • Author(s)
      吉武淳, 他
    • Organizer
      第63回日本酸化ストレス学会学術集会
    • Place of Presentation
      神奈川県民ホール(横浜市)
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Critical roles of nitric oxide signaling via 8-nitro-cGMP-induced protein S-guanylation in antioxidant adaptive responses2010

    • Author(s)
      Shigemoto Fujii, Tomohiro Sawa, Hideshi Ihara, Takaaki Akaike
    • Organizer
      The 26th Kumamoto Medical Bioscience Symposium
    • Place of Presentation
      熊本、熊本大学
    • Year and Date
      2010-06-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Critical roles of nitric oxide signaling via 8-nitro-cGMP-induced protein S-guanylation in antioxidant adaptive responses2010

    • Author(s)
      Fujii S, et al
    • Organizer
      The 26th Kumamoto Medical Bioscience Symposium
    • Place of Presentation
      山崎記念館(熊本市)
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chemical basis for mechanism of 8-nitroguanosine 3',5'-cyclic monophosohate formation in cells2010

    • Author(s)
      Ahmed K.A., et al
    • Organizer
      6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Detection of protein-bound 3-nitrotyrosine in plasma from pediatric patients with fulminant ARDS and avian influenza infection2010

    • Author(s)
      Okamoto T., et al
    • Organizer
      6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Guanine nitration and oxidative stress responses during influenza virus pneumonia in mice2010

    • Author(s)
      Khan S., et al
    • Organizer
      6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nitration of 3',5'-cyclic guanylic acid, a bacterial signaling molecule2010

    • Author(s)
      Ono K., et al
    • Organizer
      6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Estrogen receptor-dependent or-independent suppression of NO production and 8-nitroguanosine formation by endocrine-disrupting chemicals2010

    • Author(s)
      Yoshitake J., et al
    • Organizer
      6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Proteomic identification for sulfhydryl modifications of mitochondrial proteins by 8-nitroguanosine 3',5'-cyclic monophosphate2010

    • Author(s)
      Rahaman M.M., et al
    • Organizer
      6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Activation mechanism of cGMP-dependent protein kinase by a nitrated derivative of cGMP2010

    • Author(s)
      Oyama K., et al
    • Organizer
      6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Protein S-guanylation : a new post-translational regulation for redox signaling2010

    • Author(s)
      Akaike T.
    • Organizer
      The 20th World Congress of the International Society for Heart Research 2010 Kyoto
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-05-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] A New Paradigm for Antimicrobial Host Defense Mediated by NO and ROS : A Critical Role of Nitrated Nucleotides2010

    • Author(s)
      赤池孝章
    • Organizer
      第83回 日本細菌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] ニトロ化環状ヌクレオチドによる蛋白質S-グアニル化を介するcGMP依存性プロテインキナーゼの活性化2010

    • Author(s)
      藤井重元, 他
    • Organizer
      第83回 日本細菌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Possible association of Helicobacter cinaedi with arrhythmia and atherosclerosis2010

    • Author(s)
      岡本竜哉, 他
    • Organizer
      第83回 日本細菌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Helicobacter cinaedi-related cardiovascular diseases and atherosclerosis2010

    • Author(s)
      岡本竜哉, 他
    • Organizer
      第10回日韓国際微生物学シンポジウム
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] ROS signaling in animal cells2010

    • Author(s)
      赤池孝章
    • Organizer
      第51回日本植物生理学会年会
    • Place of Presentation
      熊本大学 黒髪北キャンパス
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] NO・活性酸素のヌクレオチドセンサーと親電子シグナル形成2010

    • Author(s)
      赤池孝章
    • Organizer
      第83回 日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] A unique signal transduction of NO and ROS iated by cGMP-dependent protein kinase activated via S-guanylation2010

    • Author(s)
      Ahmed KA., et al.
    • Organizer
      第26回 臨床フリーラジカル会議
    • Place of Presentation
      琵琶湖ホテル(大津市)
    • Year and Date
      2010-01-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] ニトロ化環状ヌクレオチドによる蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機序2010

    • Author(s)
      藤井重元、澤智裕、居原秀、Kit I. Tong、井田智章、岡本竜哉、Khandaker Ahtesham Ahmed、本橋ほづみ、山本雅之、赤池孝章
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸、神戸国際展示場
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of Keap1 S-guanylation in the antioxidant adaptive response in C6 glioma cells2010

    • Author(s)
      Shigemoto Fujii, Tomohiro Sawa, Hideshi Ihara, Tomoaki Ida, Tatsuya Okamoto, Hozumi Motohashi, Masayuki Yamamoto, Takaaki Akaike
    • Organizer
      6th International Conference on Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Kyoto, Kyoto International Conference Center
    • Related Report
      2011 Final Research Report
  • [Presentation] Protein S-guanylation : a new post-translational regulation for redox signaling2010

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 20th World Congress of the International Society for Heart Research
    • Place of Presentation
      京都、国立京都国際会館
    • Related Report
      2011 Final Research Report
  • [Presentation] ニトロ化環状ヌクレオチドによる蛋白質S-グアニル化を介するcGMP依存性プロテインキナーゼの活性化2010

    • Author(s)
      藤井重元、他
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] A new paradigm for antimicrobial host defense mediated by NO and ROS : A critical role of nitrated nucleotides2010

    • Author(s)
      Takaaki Akaike
    • Organizer
      第83回日本細菌学会総会International Symposium
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] ROS signaling in animal cells2010

    • Author(s)
      Takaaki Akaike
    • Organizer
      第51回日本植物生理学会年会
    • Place of Presentation
      熊本大学
    • Related Report
      2011 Final Research Report
  • [Presentation] NO・活性酸素のヌクレオチドセンサーと親電子シグナル形成2010

    • Author(s)
      赤池孝章
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪、大阪国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] New NO signaling via 8-nitro-cGMP formation and protein S-guanylation2009

    • Author(s)
      赤池孝章
    • Organizer
      5^<th> Joint Meeting of the Societies for Free Radical Research Australasia and Japan
    • Place of Presentation
      University of Sydney, Sydney, Australia
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] A unique activating mechanism of cGMP-dependent protein kinase by a nitrated derivative of cGMP2009

    • Author(s)
      小山耕太, 他
    • Organizer
      5^<th> Joint Meeting of the Societies for Free Radical Research Australasia and Japan
    • Place of Presentation
      University of Sydney, Sydney, Australia
    • Year and Date
      2009-12-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 活性酸素による新しい翻訳後修飾と親電子シグナル2009

    • Author(s)
      赤池孝章
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白質研究所講堂
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] An emerging pathogen, Helicobacter cinaedi : Possible association with arrhythmia and atherosclerosis2009

    • Author(s)
      Khan S., et al.
    • Organizer
      第25回熊本医学生物科学シンポジウム
    • Place of Presentation
      熊本大学山崎記念館(熊本市)
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] A unique activating mechanism of cGMP-dependent protein kinase by a nitrated derivative of cGMP2009

    • Author(s)
      Ahmed KA., et al.
    • Organizer
      第25回熊本医学生物科学シンポジウム
    • Place of Presentation
      熊本大学山崎記念館(熊本市)
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] An emerging pathogen, Helicobacter cinaedi : Possible association with atherosclerosis2009

    • Author(s)
      Khan S., et al.
    • Organizer
      第3回 細菌学・若手コロセウム
    • Place of Presentation
      シーガイアサンホテルフェニックス(宮崎市)
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新興感染症菌ヘリコバクター・シネディの血清診断法の確立と感染疫学への応用2009

    • Author(s)
      小山耕太, 他
    • Organizer
      第3回 細菌学・若手コロセウム
    • Place of Presentation
      シーガイアサンホテルフェニックス(宮崎市)
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] NOと活性酸素による酸化ストレス適応応答2009

    • Author(s)
      赤池孝章, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] ニトロ化環状ヌクレオチドによる蛋白質S-グアニル化を介したcGMP依存性プロテインキナーゼの活性化機構2009

    • Author(s)
      澤智裕, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞内S-グアニル化蛋白質の同定と蛋白質S-グアニル化の生理機能の解明2009

    • Author(s)
      藤井重元, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細菌シグナル分子3',5'-cyclic diguanylic acid のニトロ化2009

    • Author(s)
      小野勝彦, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chemical basis of 8-nitroguanosine 3',5'-cyclic monophosphate formation in cells2009

    • Author(s)
      Ahmed KA., et al.
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 活性酸素シグナル研究の新展開2009

    • Author(s)
      赤池孝章
    • Organizer
      第13回 Molecular Cardiovascular Conference
    • Place of Presentation
      キロロ ホテルピアノ(北海道)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] サルモネラ感染におけるニトロ化環状ヌクレオチドを介するNO誘導性生体防御機構2009

    • Author(s)
      藤井重元, 他
    • Organizer
      第62回 日本細菌学会九州支部総会
    • Place of Presentation
      佐賀大学医学部(佐賀市)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] An emerging pathogen, Helicobacter cinaedi : Possible association with atherosclerosis2009

    • Author(s)
      Khan S., et al.
    • Organizer
      第62回 日本細菌学会九州支部総会
    • Place of Presentation
      佐賀大学医学部(佐賀市)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新興感染症菌ヘリコバクター・シネディの血清診断法の確立と感染疫学への応用2009

    • Author(s)
      小山耕太, 他
    • Organizer
      第62回 日本細菌学会九州支部総会
    • Place of Presentation
      佐賀大学医学部(佐賀市)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] インフルエンザウイルス肺炎における8-ニトロ-cGMPの生成を介した酸化ストレス応答の分子メカニズム2009

    • Author(s)
      岡本竜哉, 他
    • Organizer
      第46回 日本ウイルス学会九州支部総会
    • Place of Presentation
      佐賀大学医学部(佐賀市)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nitric oxide and electrophilic signaling mediated via 8-nitro-cGMP2009

    • Author(s)
      赤池孝章
    • Organizer
      SFRR International Free Radical School in Japan 2009
    • Place of Presentation
      上越国際スキーリゾート
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機序2009

    • Author(s)
      藤井重元, 他
    • Organizer
      第6回 Heme Oxygenase 研究フォーラム
    • Place of Presentation
      京都府立医科大学(京都市)
    • Year and Date
      2009-08-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機序2009

    • Author(s)
      藤井重元、澤智裕、岡本竜哉、居原秀、井田智章、Kit I. Tong、本橋ほづみ、山本雅之、赤池孝章
    • Organizer
      第6回Heme Oxygenase研究フォーラム
    • Place of Presentation
      京都、京都府立大学青蓮会館
    • Year and Date
      2009-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] インフルエンザウイルス肺炎における 8-ニトロ-cGMPの生成を介した酸化ストレス応答の分子メカニズム2009

    • Author(s)
      岡本竜哉, 他
    • Organizer
      第20回 日本生体防御学会
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] SNO化血液製剤の薬理活性解析と臨床応用2009

    • Author(s)
      丸山徹, 他
    • Organizer
      レドックス生命科学第170委員会第21回研究会
    • Place of Presentation
      ホテルグリーンピア南阿蘇(熊本)
    • Year and Date
      2009-07-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新興感染症菌ヘリコバクター・シネディと院内感染2009

    • Author(s)
      岡本竜哉, 他
    • Organizer
      第2回 感染病態研究フロンティア
    • Place of Presentation
      江陽グランドホテル(仙台市)
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Impairment of NO-dependent host defense via degradation of 8-nitro-cGMP induced by group A Streptococcus2009

    • Author(s)
      Ahmed KA., et al.
    • Organizer
      第18回 Lancefield レンサ球菌研究会
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 活性酸素による新しい翻訳後修飾とシグナル伝達機能の解明2009

    • Author(s)
      赤池孝章
    • Organizer
      科学技術振興調整費先端融合領域イノベーション創出拠点の形成第1回公開シンポジウム
    • Place of Presentation
      横浜、横浜市立大学
    • Year and Date
      2009-06-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 活性酸素による新しい翻訳後修飾とシグナル伝達機能の解明2009

    • Author(s)
      赤池孝章, 他
    • Organizer
      科学技術振興調整費先端融合領域イノベーション創出拠点の形成 第1回公開シンポジウム
    • Place of Presentation
      港区民文化センターひまわりの郷(横浜市)
    • Year and Date
      2009-06-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 活性酸素とNOによる親電子シグナル伝達2009

    • Author(s)
      赤池孝章, 他
    • Organizer
      第62回日本酸化ストレス学会学術集会
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] S-グアニル化を介した protein kinase G の新規な活性化機構2009

    • Author(s)
      澤智裕, 他
    • Organizer
      第62回日本酸化ストレス学会学術集会
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞内S-グアニル化蛋白質の同定とS-グアニル化制御機構の解明2009

    • Author(s)
      藤井重元, 他
    • Organizer
      第62回日本酸化ストレス学会学術集会
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 8-ニトログアノシン3',5'-環状1リン酸による蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機構2009

    • Author(s)
      藤井重元, 他
    • Organizer
      第9回 日本NO学会総会
    • Place of Presentation
      グランシップ(静岡市)
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] インフルエンザウイルス肺炎における 8-ニトロ-cGMPの生成を介した酸化ストレス応答の分子メカニズム2009

    • Author(s)
      岡本竜哉, 他
    • Organizer
      第9回 日本NO学会総会
    • Place of Presentation
      グランシップ(静岡市)
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] S-Guanylation proteomics : unique post-translational modification of thiols dependent on nitric oxide and reactive oxygen species2009

    • Author(s)
      澤智裕, 他
    • Organizer
      第9回 日本NO学会総会
    • Place of Presentation
      グランシップ(静岡市)
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nitration of guanosine 3',5'-cyclic monophosphate by nitric oxide and reactive oxigen species2009

    • Author(s)
      Ahmed KA., et al.
    • Organizer
      第9回 日本NO学会総会
    • Place of Presentation
      グランシップ(静岡市)
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Host defense function of 8-nitro-cGMP during murine salmonellosis2009

    • Author(s)
      Khan S., et al.
    • Organizer
      第9回 日本NO学会総会
    • Place of Presentation
      グランシップ(静岡市)
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細菌シグナル分子3',5'-cyclic diguanylic acid のニトロ化2009

    • Author(s)
      小山耕太, 他
    • Organizer
      第9回 日本NO学会総会
    • Place of Presentation
      グランシップ(静岡市)
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] New NO signaling via 8-nitro-cGMP formation and protein S-guanylation2009

    • Author(s)
      Takaaki Akaike
    • Organizer
      5th Joint Meeting of the Societies for Free Radical Research Australasia and Japan
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2011 Final Research Report
  • [Presentation] 活性酸素による新しい翻訳後修飾と親電子シグナル2009

    • Author(s)
      赤池孝章
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪府吹田市、大阪大学
    • Related Report
      2011 Final Research Report
  • [Presentation] NOと活性酸素による酸化ストレス適応応答2009

    • Author(s)
      赤池孝章
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸、神戸ポートアイランド
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞内S-グアニル化蛋白質の同定と蛋白質S-グアニル化の生理機能の解明2009

    • Author(s)
      藤井重元、澤智裕、岡本竜哉、三浦高、岩本典子、熊谷嘉人、赤池孝章
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸、神戸ポートアイランド
    • Related Report
      2011 Final Research Report
  • [Presentation] 活性酸素シグナル研究の新展開2009

    • Author(s)
      赤池孝章
    • Organizer
      第13回Molecular Cardiovascular Conference
    • Place of Presentation
      北海道、キロロ"ホテルピアノ"
    • Related Report
      2011 Final Research Report
  • [Presentation] Nitric oxide and electrophilic signaling mediated via 8-nitro-cGMP2009

    • Author(s)
      Takaaki Akaike
    • Organizer
      SFRR International Free Radical School in Japan 2009
    • Place of Presentation
      新潟、上越国際スキーリゾート
    • Related Report
      2011 Final Research Report
  • [Presentation] 活性酸素とNOによる親電子シグナル伝達2009

    • Author(s)
      赤池孝章
    • Organizer
      活性酸素とNOによる親電子シグナル伝達
    • Place of Presentation
      福岡、九州大学百年講堂
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞内S-グアニル化蛋白質の同定とS-グアニル化制御機構の解明2009

    • Author(s)
      藤井重元、澤智裕、岡本竜哉、三浦高、岩本典子、熊谷嘉人、赤池孝章
    • Organizer
      第62回日本酸化ストレス学会学術集会
    • Place of Presentation
      福岡、九州大学百年講堂
    • Related Report
      2011 Final Research Report
  • [Presentation] 8-ニトログアノシン3', 5'-環状1リン酸による蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機構2009

    • Author(s)
      藤井重元、赤池孝章
    • Organizer
      第9回日本NO学会学術集会
    • Place of Presentation
      静岡、グランシップ
    • Related Report
      2011 Final Research Report
  • [Book] Antioxidant adaptive response of malignant glioma related to antitumor treatment. In Novel Therapeutic Concepts in Targeting Glioma2011

    • Author(s)
      Sawa T, Akaike T
    • Publisher
      InTech
    • Related Report
      2011 Final Research Report
  • [Book] 一酸化窒素nitric oxide/NO2011

    • Author(s)
      澤智裕、赤池孝章
    • Total Pages
      39
    • Publisher
      朝倉書店
    • Related Report
      2011 Final Research Report
  • [Book] 活性酸素reactive oxygen species(ROS)2011

    • Author(s)
      澤智裕、赤池孝章
    • Total Pages
      109
    • Publisher
      朝倉書店
    • Related Report
      2011 Final Research Report
  • [Book] Antioxidant adaptive response of malignant glioma related to resistance to antitumor treatment.In Novel Therapeutic Concepts in Targeting Glioma (eds., Fans Farassati), p.247-2622011

    • Author(s)
      Sawa, T., Akaike T
    • Total Pages
      15
    • Publisher
      InTech (Open Access Company)
    • Related Report
      2011 Annual Research Report
  • [Book] 免疫の事典(桂義元,河本宏,小安重夫,山本一彦編)一酸化窒素nitric oxide/NO.p.392011

    • Author(s)
      澤智裕, 赤池孝章
    • Total Pages
      1
    • Publisher
      朝倉書店
    • Related Report
      2011 Annual Research Report
  • [Book] 免疫の事典(桂義元,河本宏,小安重夫,山本一彦編)活性酸素reactive oxygen species (ROS).p.1092011

    • Author(s)
      澤智裕, 赤池孝章
    • Total Pages
      1
    • Publisher
      朝倉書店
    • Related Report
      2011 Annual Research Report
  • [Book] Nitric Oxide Synthase Inhibitors : From Animal Studies to Clinical Implications2011

    • Author(s)
      Okamoto T., et al
    • Publisher
      Nitric oxide-mediated host immune response and microbial pathogenesis(in press)
    • Related Report
      2010 Annual Research Report
  • [Book] 日本臨床増刊号 広範囲血液・尿化学検査,免疫学的検査-42010

    • Author(s)
      岡本竜哉, 他
    • Publisher
      Nitric oxide(NO)およびNO関連物質
    • Related Report
      2010 Annual Research Report
  • [Book] Nitric Oxide Synthase Inhibitors : From Animal Studies to Clinical Implications2010

    • Author(s)
      Okamoto T., et al
    • Publisher
      Nitric oxide-mediated host immune response and microbial pathogenesis(in press)
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://kumadai-bisei.com/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://ros-signal.jp/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://kumadai-bisei.com/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.ros-signal.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://kumadai-bisei.com/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.ros-signal.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://kumadai-bisei.com/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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