Molecular mechanism of signal transduction by reactive oxygen species

• Project/Area Number: 21390097
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Kumamoto University
• Principal Investigator: AKAIKE Takaaki 熊本大学, 大学院・生命科学研究部, 教授 (20231798)
• Co-Investigator(Kenkyū-buntansha): FUJII Shigemoto 熊本大学, 大学院・生命科学研究部, 助教 (00325333)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 活性酸素 / シグナル伝達 / 酸化ストレス / 8-nitro-cGMP / S-グアニル化 / 8-nitra-cGMP

Research Abstract

8-Nitro-cGMP is involved in reactive oxygen species-mediated signaling via protein S-guanylation. Here we identified several particular S-guanylated proteins(e. g., H-Ras etc.) occurring in cells and their involvement in various cellular signaling functions. We also revealed that endogenously produced hydrogen sulfide regulates protein S-guanylation in cells.

Research Products

• [Journal Article] Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration (2012)
  • Author(s): Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, and Akaike T
  • Journal Title: Nature Chem Biol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Anks4b, a novel target of HNF4α interacts with GRP78 and regulates endoplasmic reticulum stress-induced apoptosis in pancreaticβ-cells (2012)
  • Author(s): Sato Y, Hatta M, Karim MF, Sawa T, Wei FY, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, and Yamagata K
  • Journal Title: J Biol Chem Volume: (in press)
  • Peer Reviewed
• [Journal Article] Complete genome sequence of Helicobacter cinaedi strain PAGU611, isolated in a case of human bacteremia (2012)
  • Author(s): Goto T, Ogura Y, Hirakawa H, Tomida J, Morita Y, Akaike T, Hayashi T, and Kawamura Y
  • Journal Title: J Bacteriol Volume: (in press)
  • Peer Reviewed
• [Journal Article] S-Guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents (2012)
  • Author(s): Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, and Otagiri M
  • Journal Title: J Pharm Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] Potential association of Helicobacter cinaedi with atrial arrhythmia and atherosclerosis (2012)
  • Author(s): Khan S, Okamoto T, Enomoto K, Sakashita N, Oyama K, Fujii S, Sawa T, Takeya M, Ogawa H, Yamabe H, and Akaike T
  • Journal Title: Microbiol Immunol Volume: 56 Pages: 145-154
  • Peer Reviewed
• [Journal Article] Regulation by mitochondrial superoxide and NADPH oxidase of cell formation of nitrated cyclic GMP : potential implications for ROS signaling (2012)
  • Author(s): Ahmed KA, Sawa T, Ihara H, Kasamatsu S, Yoshitake J, Okamoto T, Fujii S, and Akaike T
  • Journal Title: Biochem J Volume: 441 Pages: 719-730
  • Peer Reviewed
• [Journal Article] 基礎の基礎細胞工学 (2012)
  • Author(s): 赤池孝章
  • Journal Title: 特集「活性酸素シグナル制御とレドックスホメオスタシス」 Volume: 31(2) Pages: 134-137
• [Journal Article] ニトロ化環状ヌクレオチドによるタンパク質S.グアニル化を介する酸化ストレス適応応答の分子機序 (2012)
  • Author(s): 藤井重元, 赤池孝章
  • Journal Title: 生化学 Volume: 84(2) Pages: 124-128
  • NAID: 10030346449
• [Journal Article] Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP : potential implications for ROS signalling (2012)
  • Author(s): Ahmed KA., et al
  • Journal Title: Biochem J Volume: 441 Issue: 2 Pages: 719-730
  • DOI: 10.1042/bj20111130
  • NAID: 120004875062
  • Peer Reviewed
• [Journal Article] 新・活性酸素中毒 (2012)
  • Author(s): 赤池孝章
  • Journal Title: ファルマシア Volume: 48 Pages: 1-1
  • Peer Reviewed
• [Journal Article] 基礎の基礎 (2012)
  • Author(s): 赤池孝章
  • Journal Title: 細胞工学 Volume: 31 Pages: 134-137
  • Peer Reviewed
• [Journal Article] ニトロ化環状ヌクレオチドによるタンパク質S-グアニル化を介する酸化ストレス適応応答の分子機序 (2012)
  • Author(s): 藤井重元、赤池孝章
  • Journal Title: 生化学 Volume: 84 Pages: 124-128
  • NAID: 10030346449
  • Peer Reviewed
• [Journal Article] Frontiers in nitric oxide and redox signaling (2011)
  • Author(s): Akaike T, van der Vliet A, and Eaton P
  • Journal Title: Nitric Oxide Volume: 25 Pages: 57-58
  • NAID: 120004058207
  • Peer Reviewed
• [Journal Article] Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3', 5'-cyclic monophosphate formed in glia cells (2011)
  • Author(s): Ihara H, Ahmed KA, Ida T, Kasamatsu S, Kunieda K, Okamoto T, Sawa T, and Akaike T
  • Journal Title: Nitric Oxide Volume: 25 Pages: 169-175
  • Peer Reviewed
• [Journal Article] Nucleotides function as endogenous chemical sensors for oxidative stress signaling (2011)
  • Author(s): Ihara H, Sawa T, Nakabeppu Y, and Akaike T
  • Journal Title: J Clin Biochem Nutr Volume: 48 Pages: 1-7
  • NAID: 130004879228
  • Peer Reviewed
• [Journal Article] Midbrain dopaminergic neurons utilize nitric oxide/cyclic GMP signaling to recruit ERK that links retinoic acid receptor stimulation to up-regulation of BDNF (2011)
  • Author(s): Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike T, Shudo K, and Katsuki H
  • Journal Title: J Neurochem Volume: 116 Pages: 323-333
  • Peer Reviewed
• [Journal Article] Vascular responses to 8-nitro-cyclic GMP in nondiabetic and diabetic mice (2011)
  • Author(s): Tokutomi Y, Kataoka K, Yamamoto E, Nakamura T, Hisato F, Nako H, Toyama K, Dong YF, Ahmed KA, Sawa T, Akaike T, and Kim-Mitsuyama S
  • Journal Title: Br J Pharmacol Volume: 162 Pages: 1884-1893
  • Peer Reviewed
• [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides (2011)
  • Author(s): Ahmed KA, Sawa T, and Akaike T
  • Journal Title: Amino Acids Volume: 41 Pages: 123-130
  • Peer Reviewed
• [Journal Article] Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile (2011)
  • Author(s): Sawa T, Ihara H, and Akaike T
  • Journal Title: Curr Top Med Chem Volume: 11 Pages: 1854-1860
  • Peer Reviewed
• [Journal Article] Detoxification of methylmercury by hydrogen sulfide-producing enzyme in mammalian cells (2011)
  • Author(s): Yoshida E, Toyama T, Shinkai Y, Sawa T, Akaike T, and Kumagai Y
  • Journal Title: Chem. Res. Toxicol Volume: 24 Pages: 1633-1635
  • Peer Reviewed
• [Journal Article] 活性酸素・一酸化窒素によるニトロ化シグナルと抗炎症作用 (2011)
  • Author(s): 澤智裕, 小野勝彦, 赤池孝章
  • Journal Title: 感染・炎症・免疫 Volume: 41 Pages: 12-19
• [Journal Article] 植物精油citralのインフルエンザウイルス感染能抑制効果について (2011)
  • Author(s): 今吉理恵子, 岡本竜哉, 永尾潤一, 長環, 松永勝政, 赤池孝章, 上西秀則
  • Journal Title: 医学と生物学 Volume: 155 Pages: 489-494
• [Journal Article] 喫煙と酸化ストレス: Oxidative stress induced by cigarette smoking (2011)
  • Author(s): 岡本竜哉, 居原秀, 赤池孝章
  • Journal Title: 最新精神医学 Volume: 16 Pages: 431-439
• [Journal Article] Frontiers in nitric oxide and redox signaling (2011)
  • Author(s): Akaike T., et al
  • Journal Title: Nitric Oxide Volume: 25 Issue: 2 Pages: 57-58
  • DOI: 10.1016/j.niox.2011.04.015
  • Peer Reviewed
• [Journal Article] Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice (2011)
  • Author(s): Tokutomi Y., et al
  • Journal Title: Br J Pharmabol Volume: 162 Issue: 8 Pages: 1884-1893
  • DOI: 10.1111/j.1476-5381.2011.01201.x
  • Peer Reviewed
• [Journal Article] Antioxidant Effect of a Nitrated Cyclic Nucleotide Functioning as an Endogenous Electrophile (2011)
  • Author(s): Sawa T., et al
  • Journal Title: Curr Top Med Chem Volume: 11 Pages: 1854-1860
  • Peer Reviewed
• [Journal Article] Detoxification of methylmercury by hydrogen sulfide-producing enzyme in Mammalian cells (2011)
  • Author(s): Yoshida E, Toyama T (equalcontributor), Shinkai Y, Sawa T, Akaike T, Kumagai Y
  • Journal Title: Chemical Research in Toxicology Volume: 24 Issue: 10 Pages: 1633-1635
  • DOI: 10.1021/tx200394g
  • Peer Reviewed
• [Journal Article] Cellular uptake mechanisms and responses to NO transferred from mono- and poly-S-nitrosated human serum albumin (2011)
  • Author(s): Yu Ishima., et al
  • Journal Title: Free Radical Research Volume: 45 Issue: 10 Pages: 1196-1206
  • DOI: 10.3109/10715762.2011.606814
  • Peer Reviewed
• [Journal Article] Vascular responses to 8-nitro-cyclic GMP in nondiabetic and diabetic mice (2011)
  • Author(s): Tokutomi Y., et al
  • Journal Title: Br J Pharmacol Volume: (in press)
  • Peer Reviewed
• [Journal Article] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response (2010)
  • Author(s): Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahmed KA, Ishima Y, Motohashi H, Yamamoto M, and Akaike T
  • Journal Title: J Biol Chem Volume: 285 Pages: 23970-23984
  • Peer Reviewed
• [Journal Article] A new paradigm for antimicrobial host defense mediated by a nitrated cyclic nucleotide (2010)
  • Author(s): Okamoto T, Khan S, Oyama K, Fujii S, Sawa T, and Akaike T
  • Journal Title: J Clin Biochem Nutr Volume: 46 Pages: 14-19
  • NAID: 130004466590
  • Peer Reviewed
• [Journal Article] Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles (2010)
  • Author(s): Sawa T, Arimoto H, and Akaike T
  • Journal Title: Bioconjugate Chem Volume: 21 Pages: 1121-1129
  • Peer Reviewed
• [Journal Article] Cell signaling mediated by nitrated cyclic guanine nucleotide (2010)
  • Author(s): Akaike T, Fujii S, Sawa T, and Ihara H
  • Journal Title: Nitric Oxide Volume: 23 Pages: 166-174
  • NAID: 120002772115
  • Peer Reviewed
• [Journal Article] One-step preparation of S-nitrosated human serum albumin with high biological activities (2010)
  • Author(s): Ishima Y, Hiroyama S, Kragh-Hansen U, Maruyama T, Sawa T, Akaike T, Kai T and Otagiri M
  • Journal Title: Nitric Oxide Volume: 23 Pages: 121-127
  • NAID: 120002971552
  • Peer Reviewed
• [Journal Article] 8-Nitro-cGMPの発見と生理機能の解明 (2010)
  • Author(s): 藤井重元, 澤智裕, 赤池孝章
  • Journal Title: 化学と生物 Volume: 48 Pages: 22-27
  • NAID: 10026437376
• [Journal Article] 毒性説から脱した活性酸素研究-シグナル分子としての活躍- (2010)
  • Author(s): 澤智裕, 赤池孝章
  • Journal Title: 現代化学 Volume: 469 Pages: 34-38
  • NAID: 40016994933
• [Journal Article] Nitric oxide(NO)およびNO関連物質 (2010)
  • Author(s): 岡本竜哉, 澤智裕, 赤池孝章
  • Journal Title: 日本臨床 Volume: 982 Pages: 839-842
• [Journal Article] 呼吸器疾患における酸化ストレスと制御シグナルの分子基盤: Molecular mechanisms of nitric oxide-and reactive oxygen species-mediated signalings in the respiratory diseases (2010)
  • Author(s): 岡本竜哉, 赤池孝章
  • Journal Title: 呼吸 Volume: 29 Pages: 859-866
• [Journal Article] 新興感染症原因菌-Helicobacter cinaedi (2010)
  • Author(s): 河村好章, 赤池孝章
  • Journal Title: 日本医事新報 Volume: 4514 Pages: 59-62
• [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides (2010)
  • Author(s): Ahmed K.A., et al
  • Journal Title: Amino Acids Volume: (in press)
  • Peer Reviewed
• [Journal Article] Regulation of redox signaling involving chemical conjugation of protein thiols by nitricoxide and electrophiles (2010)
  • Author(s): Sawa T., et al
  • Journal Title: Bioconjugate Chem Volume: 21 Pages: 1121-1129
  • Peer Reviewed
• [Journal Article] Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile (2010)
  • Author(s): Sawa T., et al
  • Journal Title: Current Topics Med Chem Volume: (in press)
  • Peer Reviewed
• [Journal Article] 呼吸器疾患における酸化ストレスと制御シグナルの分子基盤:Molecular mechanisms of nitric oxide-and reactive oxygen species-mediated signalings in the respiratory diseases (2010)
  • Author(s): 岡本竜哉, 他
  • Journal Title: 呼吸 Volume: 29 Pages: 859-866
• [Journal Article] A new paradigm for antimicrobial host defense mediated by a nitrated cyclic nucleotide (2010)
  • Author(s): Okamoto T., et al
  • Journal Title: J Clin Biochem Nutr 46 Pages: 14-19
  • Peer Reviewed
• [Journal Article] Cellular signaling mediated by nitrated cyclic nucleotides (2010)
  • Author(s): Akaike T., et al
  • Journal Title: Nitric Oxide (in press)
  • Peer Reviewed
• [Journal Article] Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles (2010)
  • Author(s): Sawa T., et al
  • Journal Title: Bioconjug Chem (in press)
  • Peer Reviewed
• [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitronucleotides (2010)
  • Author(s): Ahmed KA., et al
  • Journal Title: Amino Acids (in press)
  • Peer Reviewed
• [Journal Article] 毒性説から脱した活性酸素研究-シグナル分子としての活躍- (2010)
  • Author(s): 澤智裕, 他
  • Journal Title: 現代化学 469 Pages: 34-38
• [Journal Article] 8-Nitro-cGMPの発見と生理機能の解明 (2010)
  • Author(s): 藤井重元, 他
  • Journal Title: 化学と生物 48 Pages: 22-27
  • NAID: 10026437376
• [Journal Article] Cytoprotective function of heme oxygenase-1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis (2009)
  • Author(s): Zaki MH, Fujii S, Okamoto T, Islam S, Khan S, Ahmed KA, Sawa T, and Akaike T
  • Journal Title: J Immnol Volume: 182 Pages: 3746-3756
  • Peer Reviewed
• [Journal Article] NOによる細胞内感染防御の新しい展開-New paradigm of host defense against intracellular pathogens by nitric oxide (2009)
  • Author(s): 赤池孝章, 岡本竜哉, Zaki MH, 藤井重元, 澤智裕
  • Journal Title: Nihon Hansenbyo Gakkai Zasshi Volume: 78 Pages: 41-47
• [Journal Article] 活性酸素・NOによる感染防御シグナルの新展開-Antimicrobial signaling mediated by reactive oxygen species and NO (2009)
  • Author(s): 岡本竜哉, 澤智裕, 藤井重元, 赤池孝章
  • Journal Title: 細胞 Volume: 41 Pages: 51-55
• [Journal Article] 活性酸素のシグナル伝達機能-その生理機能の再発見と酸化ストレス研究の新展開 (2009)
  • Author(s): 赤池孝章
  • Journal Title: 実験医学 Pages: 2320-2329
• [Journal Article] チオール基の修飾による活性酸素のセンサー機能制御 (2009)
  • Author(s): 澤智裕, 有本博一, 赤池孝章
  • Journal Title: 実験医学 Pages: 2341-2347
  • Peer Reviewed
• [Journal Article] Cytoprotective function of heme oxygenase-1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis (2009)
  • Author(s): Zaki MM., et al
  • Journal Title: J Immnol 182 Pages: 3746-3756
  • Peer Reviewed
• [Journal Article] 活性酸素のシグナル伝達機能-その生理機能の再発見と酸化ストレス研究の新展開 (2009)
  • Author(s): 赤池孝章, 他
  • Journal Title: 実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス 27 Pages: 2320-2329
• [Journal Article] チオール基の修飾による活性酸素のセンサー機能制御 (2009)
  • Author(s): 澤智裕, 他
  • Journal Title: 実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス 27 Pages: 2341-2347
• [Journal Article] NOによる細胞内感染防御の新しい展開-New paradigm of host defense against intracellular pathogens by nitric oxide (2009)
  • Author(s): 赤池孝章, 他
  • Journal Title: 日本ハンセン病学会雑誌 78 Pages: 41-47
• [Journal Article] 活性酸素・NOによる感染防御シグナルの新展開-Antimicrobial signaling mediated by reactive oxygen species and NO (2009)
  • Author(s): 岡本竜哉, 他
  • Journal Title: 細胞 41 Pages: 51-55
• [Presentation] トップジャーナル七転び八起き (2012)
  • Author(s): 赤池孝章
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎ブリックホール(長崎)(招待講演)
  • Year and Date: 2012-03-27
• [Presentation] 硫化水素の抗酸化機能と酸化ストレスバイオマーカー (2012)
  • Author(s): 藤井重元、赤池孝章
  • Organizer: 第8回呼吸器バイオマーカー研究会
  • Place of Presentation: 東京、都市センターホテル
  • Year and Date: 2012-03-10
• [Presentation] トップジャーナル七転び八起き (2012)
  • Author(s): 赤池孝章
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎、長崎ブリックホール
• [Presentation] Cellular signaling mediated by nitrated cyclic nucleotides and its regulation by hydrogen sulfide (2011)
  • Author(s): Takaaki Akaike
  • Organizer: The 23^<rd> Annual Meeting of the Korean Society for Molecular and Cellular Biology
  • Place of Presentation: COEX(ソウル韓国)(招待講演)
  • Year and Date: 2011-10-06
• [Presentation] ROS and electrophilic cellular signaling regulated by hydrogen sulfide (2011)
  • Author(s): 赤池孝章, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都)(招待講演)
  • Year and Date: 2011-09-21
• [Presentation] Antimicrobial cell signaling mediated by nitrated cyclic nucleotide (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 第84回日本細菌学会総会
  • Place of Presentation: 札幌コンベンションセンター(札幌)(招待講演)
  • Year and Date: 2011-09-06
• [Presentation] 内因性硫化水素イオンによるROS・親電子シグナル制御 (2011)
  • Author(s): 赤池孝章
  • Organizer: 第2回Molecular Cardiovascular Conference II
  • Place of Presentation: ホテルピアノ(北海道キロロ)(招待講演)
  • Year and Date: 2011-09-02
• [Presentation] 生体内ガス分子と活性酸素による多次元シグナルネットワーク (2011)
  • Author(s): 赤池孝章
  • Organizer: 第8回Heme Oxygenase研究フォーラム
  • Place of Presentation: 京都、京都府立医科大学青蓮会館
  • Year and Date: 2011-08-26
• [Presentation] 生体内ガス分子と活性酸素による多次元シグナルネットワーク (2011)
  • Author(s): 赤池孝章
  • Organizer: 第8回Heme Oxygenase研究フォーラム
  • Place of Presentation: 京都府立医科大学・青蓮会館(京都)(招待講演)
  • Year and Date: 2011-08-26
• [Presentation] Protein S-guanylation and its unique regulation mechanisms involving cysteine metabolism (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 12th International congress on amino acids, peptides and proteins
  • Place of Presentation: Beijing International Convention Center(北京)
  • Year and Date: 2011-08-01
• [Presentation] 親電子シグナルと硫化水素 (2011)
  • Author(s): 赤池孝章
  • Organizer: 九州大学生体防御医学研究所共同利用研究集会
  • Place of Presentation: 福岡、九州大学
  • Year and Date: 2011-07-22
• [Presentation] 親電子シグナルと硫化水素.九州大学生体防御医学研究所共同利用 (2011)
  • Author(s): 赤池孝章
  • Organizer: 九州大学生体防御医学研究所共同利用研究集会
  • Place of Presentation: 九州大学生体防御医学研究所会議室(福岡)(招待講演)
  • Year and Date: 2011-07-22
• [Presentation] 内因性硫化水素イオンによる親電子シグナル制御 (2011)
  • Author(s): 赤池孝章
  • Organizer: 64回日本酸化ストレス学会学術集会
  • Place of Presentation: ルスツリゾートホテル&コンベンション(北海道留寿都)(招待講演)
  • Year and Date: 2011-07-02
• [Presentation] Cellular signaling mediated by nitrated cyclic nucleotide and regulated by hydrogen sulfide.5th International Conference on cGMP (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 第5回cGMP国際会議
  • Place of Presentation: Lowengebaude, (Halle, Germany)(招待講演)
  • Year and Date: 2011-06-23
• [Presentation] 活性酸素シグナル伝達と加齢 (2011)
  • Author(s): 赤池孝章
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 国立京都国際会館(京都)(招待講演)
  • Year and Date: 2011-05-27
• [Presentation] Electrophilic cellular signaling regulated by H_2 S-medaited sulfhydration (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 第11回日本NO学会総会
  • Place of Presentation: 昭和薬科大学(東京都町田市)
  • Year and Date: 2011-05-13
• [Presentation] Cellular signaling by nitrated cyclic nucleotides and regulation of its biological effects (2011)
  • Author(s): Akaike T.
  • Organizer: Gordon Research Conferemce on Nitric Oxide : Understanding the Biology and Chemistry of Its Formation, Action, and Signaling
  • Place of Presentation: Four Points Sheraton/Holiday Inn Express (Ventura, CA)
  • Year and Date: 2011-02-17
• [Presentation] Cell signaling mediated by nitrated cyclic guanine nucleotide (2011)
  • Author(s): Akaike T.
  • Organizer: International Symposium on Free Radical Research : Contribution to Medicine
  • Place of Presentation: Hyatt Regency Kyoto(京都市)
  • Year and Date: 2011-01-21
• [Presentation] ROS and electrophilic cellular signaling regulated by hydrogen sulfide (2011)
  • Author(s): 赤池孝章、澤智裕、西田基宏
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都、国立京都国際会館
• [Presentation] Antimicrobial cell signaling mediated by nitrated cyclic nucleotide (2011)
  • Author(s): Takaaki Akaike
  • Organizer: XIII International Congress of Bacteriology and Applied Microbiology, 第84回日本細菌学会総会
  • Place of Presentation: Sapporo, Sapporo Convention Center
• [Presentation] 内因性硫化水素イオンによるROS・親電子シグナル制御 (2011)
  • Author(s): 赤池孝章
  • Organizer: 第2回Molecular Cardiovascular Conference II
  • Place of Presentation: 北海道、キロロ"ホテルピアノ
• [Presentation] Protein S-guanylation and its unique regulation mechanisms involving cysteine metabolism (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 12th International congress on amino acids, peptides and proteins
  • Place of Presentation: Beijing China
• [Presentation] 内因性硫化水素イオンによる親電子シグナル制御 (2011)
  • Author(s): 赤池孝章
  • Organizer: 第64回日本酸化ストレス学会学術集会
  • Place of Presentation: 留寿都、北海道ルスツリゾートホテル & コンベンション
• [Presentation] Cellular signaling mediated by nitrated cyclic nucleotide and regulated by hydrogen sulfide (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 5th International Conference on cGMP
  • Place of Presentation: Halle, Germany
• [Presentation] 活性酸素シグナル伝達と加齢 (2011)
  • Author(s): 赤池孝章
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 京都、国立京都国際会館
• [Presentation] Electrophilic cellular signaling regulated by H_2S-medaited sulfhydration (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 第11回日本NO学会学術集会
  • Place of Presentation: 東京町田、昭和薬科大学
• [Presentation] Cellular signaling by nitrated cyclic nucleotides and regulation of its biological effects (2011)
  • Author(s): Takaaki Akaike
  • Organizer: Gordon Research Conferemce on Nitric Oxide : Understanding the Biology and Chemistry of Its Formation, Action, and Signaling
  • Place of Presentation: Ventura, USA
• [Presentation] Cell signaling mediated by nitrated cyclic guanine nucleotide (2011)
  • Author(s): Takaaki Akaike
  • Organizer: International Symposium on Free Radical Research : ontribution to Medicine
  • Place of Presentation: 京都、ハイアットリージェンシー京都
• [Presentation] 核酸分子の化学修飾による活性酸素シグナルのケミカルセンシング (2010)
  • Author(s): 澤智裕, 他
  • Organizer: 第83回日本生化学会大会
  • Place of Presentation: ポートアイランド(神戸市)
  • Year and Date: 2010-12-07
• [Presentation] NOによる抗酸化応答の新展開 (2010)
  • Author(s): 澤智裕, 他
  • Organizer: 第27回臨床フリーラジカル会議
  • Place of Presentation: 京都・烟河(京都市)
  • Year and Date: 2010-12-04
• [Presentation] Glyceraldehyde 3-phosphate dehydrogenaseの基質依存的な酸化的不活性化 (2010)
  • Author(s): 小野勝彦, 他
  • Organizer: 第63回日本酸化ストレス学会学術集会
  • Place of Presentation: 神奈川県民ホール(横浜市)
  • Year and Date: 2010-06-24
• [Presentation] 細胞内における8-nitro-cGMP生成メカニズムの解析 (2010)
  • Author(s): 吉武淳, 他
  • Organizer: 第63回日本酸化ストレス学会学術集会
  • Place of Presentation: 神奈川県民ホール(横浜市)
  • Year and Date: 2010-06-24
• [Presentation] Critical roles of nitric oxide signaling via 8-nitro-cGMP-induced protein S-guanylation in antioxidant adaptive responses (2010)
  • Author(s): Shigemoto Fujii, Tomohiro Sawa, Hideshi Ihara, Takaaki Akaike
  • Organizer: The 26th Kumamoto Medical Bioscience Symposium
  • Place of Presentation: 熊本、熊本大学
  • Year and Date: 2010-06-19
• [Presentation] Critical roles of nitric oxide signaling via 8-nitro-cGMP-induced protein S-guanylation in antioxidant adaptive responses (2010)
  • Author(s): Fujii S, et al
  • Organizer: The 26th Kumamoto Medical Bioscience Symposium
  • Place of Presentation: 山崎記念館(熊本市)
  • Year and Date: 2010-06-19
• [Presentation] Chemical basis for mechanism of 8-nitroguanosine 3',5'-cyclic monophosohate formation in cells (2010)
  • Author(s): Ahmed K.A., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Detection of protein-bound 3-nitrotyrosine in plasma from pediatric patients with fulminant ARDS and avian influenza infection (2010)
  • Author(s): Okamoto T., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Guanine nitration and oxidative stress responses during influenza virus pneumonia in mice (2010)
  • Author(s): Khan S., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Nitration of 3',5'-cyclic guanylic acid, a bacterial signaling molecule (2010)
  • Author(s): Ono K., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Estrogen receptor-dependent or-independent suppression of NO production and 8-nitroguanosine formation by endocrine-disrupting chemicals (2010)
  • Author(s): Yoshitake J., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Proteomic identification for sulfhydryl modifications of mitochondrial proteins by 8-nitroguanosine 3',5'-cyclic monophosphate (2010)
  • Author(s): Rahaman M.M., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Activation mechanism of cGMP-dependent protein kinase by a nitrated derivative of cGMP (2010)
  • Author(s): Oyama K., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Protein S-guanylation : a new post-translational regulation for redox signaling (2010)
  • Author(s): Akaike T.
  • Organizer: The 20th World Congress of the International Society for Heart Research 2010 Kyoto
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-05-14
• [Presentation] A New Paradigm for Antimicrobial Host Defense Mediated by NO and ROS : A Critical Role of Nitrated Nucleotides (2010)
  • Author(s): 赤池孝章
  • Organizer: 第83回 日本細菌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2010-03-27
• [Presentation] ニトロ化環状ヌクレオチドによる蛋白質S-グアニル化を介するcGMP依存性プロテインキナーゼの活性化 (2010)
  • Author(s): 藤井重元, 他
  • Organizer: 第83回 日本細菌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2010-03-27
• [Presentation] Possible association of Helicobacter cinaedi with arrhythmia and atherosclerosis (2010)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第83回 日本細菌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2010-03-27
• [Presentation] Helicobacter cinaedi-related cardiovascular diseases and atherosclerosis (2010)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第10回日韓国際微生物学シンポジウム
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2010-03-26
• [Presentation] ROS signaling in animal cells (2010)
  • Author(s): 赤池孝章
  • Organizer: 第51回日本植物生理学会年会
  • Place of Presentation: 熊本大学 黒髪北キャンパス
  • Year and Date: 2010-03-18
• [Presentation] NO・活性酸素のヌクレオチドセンサーと親電子シグナル形成 (2010)
  • Author(s): 赤池孝章
  • Organizer: 第83回 日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2010-03-16
• [Presentation] A unique signal transduction of NO and ROS iated by cGMP-dependent protein kinase activated via S-guanylation (2010)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第26回 臨床フリーラジカル会議
  • Place of Presentation: 琵琶湖ホテル(大津市)
  • Year and Date: 2010-01-29
• [Presentation] ニトロ化環状ヌクレオチドによる蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機序 (2010)
  • Author(s): 藤井重元、澤智裕、居原秀、Kit I. Tong、井田智章、岡本竜哉、Khandaker Ahtesham Ahmed、本橋ほづみ、山本雅之、赤池孝章
  • Organizer: 第83回日本生化学会大会
  • Place of Presentation: 神戸、神戸国際展示場
• [Presentation] Role of Keap1 S-guanylation in the antioxidant adaptive response in C6 glioma cells (2010)
  • Author(s): Shigemoto Fujii, Tomohiro Sawa, Hideshi Ihara, Tomoaki Ida, Tatsuya Okamoto, Hozumi Motohashi, Masayuki Yamamoto, Takaaki Akaike
  • Organizer: 6th International Conference on Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto, Kyoto International Conference Center
• [Presentation] Protein S-guanylation : a new post-translational regulation for redox signaling (2010)
  • Author(s): Takaaki Akaike
  • Organizer: The 20th World Congress of the International Society for Heart Research
  • Place of Presentation: 京都、国立京都国際会館
• [Presentation] ニトロ化環状ヌクレオチドによる蛋白質S-グアニル化を介するcGMP依存性プロテインキナーゼの活性化 (2010)
  • Author(s): 藤井重元、他
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: 横浜、パシフィコ横浜
• [Presentation] A new paradigm for antimicrobial host defense mediated by NO and ROS : A critical role of nitrated nucleotides (2010)
  • Author(s): Takaaki Akaike
  • Organizer: 第83回日本細菌学会総会International Symposium
  • Place of Presentation: 横浜、パシフィコ横浜
• [Presentation] ROS signaling in animal cells (2010)
  • Author(s): Takaaki Akaike
  • Organizer: 第51回日本植物生理学会年会
  • Place of Presentation: 熊本大学
• [Presentation] NO・活性酸素のヌクレオチドセンサーと親電子シグナル形成 (2010)
  • Author(s): 赤池孝章
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪、大阪国際会議場
• [Presentation] New NO signaling via 8-nitro-cGMP formation and protein S-guanylation (2009)
  • Author(s): 赤池孝章
  • Organizer: 5^<th> Joint Meeting of the Societies for Free Radical Research Australasia and Japan
  • Place of Presentation: University of Sydney, Sydney, Australia
  • Year and Date: 2009-12-04
• [Presentation] A unique activating mechanism of cGMP-dependent protein kinase by a nitrated derivative of cGMP (2009)
  • Author(s): 小山耕太, 他
  • Organizer: 5^<th> Joint Meeting of the Societies for Free Radical Research Australasia and Japan
  • Place of Presentation: University of Sydney, Sydney, Australia
  • Year and Date: 2009-12-01
• [Presentation] 活性酸素による新しい翻訳後修飾と親電子シグナル (2009)
  • Author(s): 赤池孝章
  • Organizer: 大阪大学蛋白質研究所セミナー
  • Place of Presentation: 大阪大学蛋白質研究所講堂
  • Year and Date: 2009-11-27
• [Presentation] An emerging pathogen, Helicobacter cinaedi : Possible association with arrhythmia and atherosclerosis (2009)
  • Author(s): Khan S., et al.
  • Organizer: 第25回熊本医学生物科学シンポジウム
  • Place of Presentation: 熊本大学山崎記念館(熊本市)
  • Year and Date: 2009-11-12
• [Presentation] A unique activating mechanism of cGMP-dependent protein kinase by a nitrated derivative of cGMP (2009)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第25回熊本医学生物科学シンポジウム
  • Place of Presentation: 熊本大学山崎記念館(熊本市)
  • Year and Date: 2009-11-12
• [Presentation] An emerging pathogen, Helicobacter cinaedi : Possible association with atherosclerosis (2009)
  • Author(s): Khan S., et al.
  • Organizer: 第3回 細菌学・若手コロセウム
  • Place of Presentation: シーガイアサンホテルフェニックス(宮崎市)
  • Year and Date: 2009-10-26
• [Presentation] 新興感染症菌ヘリコバクター・シネディの血清診断法の確立と感染疫学への応用 (2009)
  • Author(s): 小山耕太, 他
  • Organizer: 第3回 細菌学・若手コロセウム
  • Place of Presentation: シーガイアサンホテルフェニックス(宮崎市)
  • Year and Date: 2009-10-26
• [Presentation] NOと活性酸素による酸化ストレス適応応答 (2009)
  • Author(s): 赤池孝章, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] ニトロ化環状ヌクレオチドによる蛋白質S-グアニル化を介したcGMP依存性プロテインキナーゼの活性化機構 (2009)
  • Author(s): 澤智裕, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] 細胞内S-グアニル化蛋白質の同定と蛋白質S-グアニル化の生理機能の解明 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] 細菌シグナル分子3',5'-cyclic diguanylic acid のニトロ化 (2009)
  • Author(s): 小野勝彦, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] Chemical basis of 8-nitroguanosine 3',5'-cyclic monophosphate formation in cells (2009)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] 活性酸素シグナル研究の新展開 (2009)
  • Author(s): 赤池孝章
  • Organizer: 第13回 Molecular Cardiovascular Conference
  • Place of Presentation: キロロ ホテルピアノ(北海道)
  • Year and Date: 2009-09-04
• [Presentation] サルモネラ感染におけるニトロ化環状ヌクレオチドを介するNO誘導性生体防御機構 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第62回 日本細菌学会九州支部総会
  • Place of Presentation: 佐賀大学医学部(佐賀市)
  • Year and Date: 2009-09-04
• [Presentation] An emerging pathogen, Helicobacter cinaedi : Possible association with atherosclerosis (2009)
  • Author(s): Khan S., et al.
  • Organizer: 第62回 日本細菌学会九州支部総会
  • Place of Presentation: 佐賀大学医学部(佐賀市)
  • Year and Date: 2009-09-04
• [Presentation] 新興感染症菌ヘリコバクター・シネディの血清診断法の確立と感染疫学への応用 (2009)
  • Author(s): 小山耕太, 他
  • Organizer: 第62回 日本細菌学会九州支部総会
  • Place of Presentation: 佐賀大学医学部(佐賀市)
  • Year and Date: 2009-09-04
• [Presentation] インフルエンザウイルス肺炎における8-ニトロ-cGMPの生成を介した酸化ストレス応答の分子メカニズム (2009)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第46回 日本ウイルス学会九州支部総会
  • Place of Presentation: 佐賀大学医学部(佐賀市)
  • Year and Date: 2009-09-04
• [Presentation] Nitric oxide and electrophilic signaling mediated via 8-nitro-cGMP (2009)
  • Author(s): 赤池孝章
  • Organizer: SFRR International Free Radical School in Japan 2009
  • Place of Presentation: 上越国際スキーリゾート
  • Year and Date: 2009-09-03
• [Presentation] 蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機序 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第6回 Heme Oxygenase 研究フォーラム
  • Place of Presentation: 京都府立医科大学(京都市)
  • Year and Date: 2009-08-31
• [Presentation] 蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機序 (2009)
  • Author(s): 藤井重元、澤智裕、岡本竜哉、居原秀、井田智章、Kit I. Tong、本橋ほづみ、山本雅之、赤池孝章
  • Organizer: 第6回Heme Oxygenase研究フォーラム
  • Place of Presentation: 京都、京都府立大学青蓮会館
  • Year and Date: 2009-08-28
• [Presentation] インフルエンザウイルス肺炎における 8-ニトロ-cGMPの生成を介した酸化ストレス応答の分子メカニズム (2009)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第20回 日本生体防御学会
  • Place of Presentation: 東京医科歯科大学(東京都)
  • Year and Date: 2009-07-25
• [Presentation] SNO化血液製剤の薬理活性解析と臨床応用 (2009)
  • Author(s): 丸山徹, 他
  • Organizer: レドックス生命科学第170委員会第21回研究会
  • Place of Presentation: ホテルグリーンピア南阿蘇(熊本)
  • Year and Date: 2009-07-16
• [Presentation] 新興感染症菌ヘリコバクター・シネディと院内感染 (2009)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第2回 感染病態研究フロンティア
  • Place of Presentation: 江陽グランドホテル(仙台市)
  • Year and Date: 2009-07-04
• [Presentation] Impairment of NO-dependent host defense via degradation of 8-nitro-cGMP induced by group A Streptococcus (2009)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第18回 Lancefield レンサ球菌研究会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2009-06-26
• [Presentation] 活性酸素による新しい翻訳後修飾とシグナル伝達機能の解明 (2009)
  • Author(s): 赤池孝章
  • Organizer: 科学技術振興調整費先端融合領域イノベーション創出拠点の形成第1回公開シンポジウム
  • Place of Presentation: 横浜、横浜市立大学
  • Year and Date: 2009-06-19
• [Presentation] 活性酸素による新しい翻訳後修飾とシグナル伝達機能の解明 (2009)
  • Author(s): 赤池孝章, 他
  • Organizer: 科学技術振興調整費先端融合領域イノベーション創出拠点の形成 第1回公開シンポジウム
  • Place of Presentation: 港区民文化センターひまわりの郷(横浜市)
  • Year and Date: 2009-06-19
• [Presentation] 活性酸素とNOによる親電子シグナル伝達 (2009)
  • Author(s): 赤池孝章, 他
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2009-06-11
• [Presentation] S-グアニル化を介した protein kinase G の新規な活性化機構 (2009)
  • Author(s): 澤智裕, 他
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2009-06-11
• [Presentation] 細胞内S-グアニル化蛋白質の同定とS-グアニル化制御機構の解明 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2009-06-11
• [Presentation] 8-ニトログアノシン3',5'-環状1リン酸による蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機構 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第9回 日本NO学会総会
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] インフルエンザウイルス肺炎における 8-ニトロ-cGMPの生成を介した酸化ストレス応答の分子メカニズム (2009)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第9回 日本NO学会総会
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] S-Guanylation proteomics : unique post-translational modification of thiols dependent on nitric oxide and reactive oxygen species (2009)
  • Author(s): 澤智裕, 他
  • Organizer: 第9回 日本NO学会総会
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] Nitration of guanosine 3',5'-cyclic monophosphate by nitric oxide and reactive oxigen species (2009)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第9回 日本NO学会総会
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] Host defense function of 8-nitro-cGMP during murine salmonellosis (2009)
  • Author(s): Khan S., et al.
  • Organizer: 第9回 日本NO学会総会
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] 細菌シグナル分子3',5'-cyclic diguanylic acid のニトロ化 (2009)
  • Author(s): 小山耕太, 他
  • Organizer: 第9回 日本NO学会総会
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] New NO signaling via 8-nitro-cGMP formation and protein S-guanylation (2009)
  • Author(s): Takaaki Akaike
  • Organizer: 5th Joint Meeting of the Societies for Free Radical Research Australasia and Japan
  • Place of Presentation: Sydney, Australia
• [Presentation] 活性酸素による新しい翻訳後修飾と親電子シグナル (2009)
  • Author(s): 赤池孝章
  • Organizer: 大阪大学蛋白質研究所セミナー
  • Place of Presentation: 大阪府吹田市、大阪大学
• [Presentation] NOと活性酸素による酸化ストレス適応応答 (2009)
  • Author(s): 赤池孝章
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸、神戸ポートアイランド
• [Presentation] 細胞内S-グアニル化蛋白質の同定と蛋白質S-グアニル化の生理機能の解明 (2009)
  • Author(s): 藤井重元、澤智裕、岡本竜哉、三浦高、岩本典子、熊谷嘉人、赤池孝章
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸、神戸ポートアイランド
• [Presentation] 活性酸素シグナル研究の新展開 (2009)
  • Author(s): 赤池孝章
  • Organizer: 第13回Molecular Cardiovascular Conference
  • Place of Presentation: 北海道、キロロ"ホテルピアノ"
• [Presentation] Nitric oxide and electrophilic signaling mediated via 8-nitro-cGMP (2009)
  • Author(s): Takaaki Akaike
  • Organizer: SFRR International Free Radical School in Japan 2009
  • Place of Presentation: 新潟、上越国際スキーリゾート
• [Presentation] 活性酸素とNOによる親電子シグナル伝達 (2009)
  • Author(s): 赤池孝章
  • Organizer: 活性酸素とNOによる親電子シグナル伝達
  • Place of Presentation: 福岡、九州大学百年講堂
• [Presentation] 細胞内S-グアニル化蛋白質の同定とS-グアニル化制御機構の解明 (2009)
  • Author(s): 藤井重元、澤智裕、岡本竜哉、三浦高、岩本典子、熊谷嘉人、赤池孝章
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 福岡、九州大学百年講堂
• [Presentation] 8-ニトログアノシン3', 5'-環状1リン酸による蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機構 (2009)
  • Author(s): 藤井重元、赤池孝章
  • Organizer: 第9回日本NO学会学術集会
  • Place of Presentation: 静岡、グランシップ
• [Book] Antioxidant adaptive response of malignant glioma related to antitumor treatment. In Novel Therapeutic Concepts in Targeting Glioma (2011)
  • Author(s): Sawa T, Akaike T
  • Publisher: InTech
• [Book] 一酸化窒素nitric oxide/NO (2011)
  • Author(s): 澤智裕、赤池孝章
  • Total Pages: 39
  • Publisher: 朝倉書店
• [Book] 活性酸素reactive oxygen species(ROS) (2011)
  • Author(s): 澤智裕、赤池孝章
  • Total Pages: 109
  • Publisher: 朝倉書店
• [Book] Antioxidant adaptive response of malignant glioma related to resistance to antitumor treatment.In Novel Therapeutic Concepts in Targeting Glioma (eds., Fans Farassati), p.247-262 (2011)
  • Author(s): Sawa, T., Akaike T
  • Total Pages: 15
  • Publisher: InTech (Open Access Company)
• [Book] 免疫の事典(桂義元,河本宏,小安重夫,山本一彦編)一酸化窒素nitric oxide/NO.p.39 (2011)
  • Author(s): 澤智裕, 赤池孝章
  • Total Pages: 1
  • Publisher: 朝倉書店
• [Book] 免疫の事典(桂義元,河本宏,小安重夫,山本一彦編)活性酸素reactive oxygen species (ROS).p.109 (2011)
  • Author(s): 澤智裕, 赤池孝章
  • Total Pages: 1
  • Publisher: 朝倉書店
• [Book] Nitric Oxide Synthase Inhibitors : From Animal Studies to Clinical Implications (2011)
  • Author(s): Okamoto T., et al
  • Publisher: Nitric oxide-mediated host immune response and microbial pathogenesis(in press)
• [Book] 日本臨床増刊号 広範囲血液・尿化学検査,免疫学的検査-4 (2010)
  • Author(s): 岡本竜哉, 他
  • Publisher: Nitric oxide(NO)およびNO関連物質
• [Book] Nitric Oxide Synthase Inhibitors : From Animal Studies to Clinical Implications (2010)
  • Author(s): Okamoto T., et al
  • Publisher: Nitric oxide-mediated host immune response and microbial pathogenesis(in press)
• [Remarks]
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• [Remarks]
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• [Remarks]
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• [Remarks]
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• [Remarks]
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• [Remarks]
  • URL: http://www.ros-signal.jp/
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