Sperm-specific mechanism that induces the gross chromosomal rearrangements

• Project/Area Number: 21390101
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human genetics
• Research Institution: Fujita Health University
• Principal Investigator: KURAHASHI Hiroki 藤田保健衛生大学, 総合医科学研究所, 教授 (30243215)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 染色体転座 / 切断点 / 回文配列 / パリンドローム / 十字架型DNA / 非B型DNA / 染色体再構成 / 染色体構造異常

Research Abstract

Gross chromosomal rearrangements(GCRs) are often generated by illegitimate repair between two DNA breakages at regions with nucleotide sequences that potentially adopt a non-B DNA structure. We previously established a plasmid-based model system that recapitulates palindrome-mediated recurrent translocations in humans, and demonstrated that cruciform DNA is required for the rearrangements. In this study, we show that two sequential reactions that cleave the cruciform structures induce the translocation : GEN1-mediated resolution that cleaves diagonally at the four-way junction of the cruciform, and Artemis-mediated opening of the subsequently formed hairpin ends. These two intrinsic pathways that normally fulfill vital functions independently, Holliday junction resolution in homologous recombination and coding joint formation in rearrangement of antigen-receptor genes, act upon the unusual DNA conformation in concert and lead to these recurrent GCRs in humans.

Research Products

• [Journal Article] Molecular basis of maternal age-related increase in oocyte aneuploidy (2012)
  • Author(s): Kurahashi H, Tsutsumi M, Nishiyama S, Kogo H, Inagaki H, Ohye T
  • Journal Title: Congenit Anom (Kyoto) Volume: 52 Issue: 1 Pages: 8-15
  • DOI: 10.1111/j.1741-4520.2011.00350.x
  • Peer Reviewed
• [Journal Article] Mechanism of complex gross chromosomal rearrangements : A commentary on Concomitant microduplications of MECP2 and ATRX in male patients with severe mental retardation (2012)
  • Author(s): Kurahashi H, Ohye T, Inagaki H, Kogo H, Tsutsumi M
  • Journal Title: J Hum Genet Volume: 57 Issue: 2 Pages: 81-83
  • DOI: 10.1038/jhg.2011.143
  • NAID: 10030711395
  • Peer Reviewed
• [Journal Article] DNA secondary structure is influenced by genetic variation and alters susceptibility to de novo translocation (2011)
  • Author(s): Kato T, Inagaki H, Tong M, Kogo H, Ohye T, Yamada K, Tsutsumi M, Emanuel BS, Kurahashi H
  • Journal Title: Mol Cytoenet Volume: 4 Pages: 18-18
  • Peer Reviewed
• [Journal Article] Characterization of a novel mouse gene encoding an SYCP3-like protein that re-localizes from the XY body to the nucleolus during prophase of male meiosis I (2011)
  • Author(s): Tsutsumi M, Kogo H, Kowa-Sugiyama H, Inagaki H, Ohye T, Kurahashi H
  • Journal Title: Biol Reprod Volume: 85 Issue: 1 Pages: 165-171
  • DOI: 10.1095/biolreprod.110.087270
  • Peer Reviewed
• [Journal Article] Pathogenic exon-trapping by SVA retrotransposon and rescue in Fukuyama muscular dystrophy (2011)
  • Author(s): Taniguchi-Ikeda M, Kobayashi K, Kanagawa M, Yu CC, Mori K, Oda T, Kuga A, Kurahashi H, Akman HO, DiMauro S, Kaji R, Yokota T, Takeda S, Toda T
  • Journal Title: Nature Volume: 478 Issue: 7367 Pages: 127-131
  • DOI: 10.1038/nature10456
  • Peer Reviewed
• [Journal Article] A rare synaptonemal complex protein 3 gene variant in unexplained female infertility (2011)
  • Author(s): Nishiyama S, Kishi T, Kato T, Suzuki M, Bolor H, Udagawa Y, Kurahashi H
  • Journal Title: Mol Hum Reprod Volume: 17 Issue: 4 Pages: 266-271
  • DOI: 10.1093/molehr/gaq098
  • Peer Reviewed
• [Journal Article] Polymorphism in annexin A5 gene promoter in Japanese women with recurrent pregnancy loss (2011)
  • Author(s): Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Markoff A, Yanagihara I, Udagawa Y, Kurahashi H
  • Journal Title: Mol Hum Reprod Volume: 17 Issue: 7 Pages: 447-452
  • DOI: 10.1093/molehr/gar008
  • Peer Reviewed
• [Journal Article] DNA secondary structure is influenced by genetic variation and alters susceptibility to de novo translocation (2011)
  • Author(s): Kato T, Inagaki H, Tong M, Kogo H, Ohye T, Yamada K, Tsutsumi M, Emanuel BS, Kurahashi H
  • Journal Title: Mol Cytogenet Volume: 4 Issue: 1 Pages: 18-18
  • DOI: 10.1186/1755-8166-4-18
  • Peer Reviewed
• [Journal Article] Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction (2011)
  • Author(s): Nishizawa H, Ota S, Suzuki M, Kato T, Sekiya T, Kurahashi H, Udagawa Y
  • Journal Title: Reprod Biol Endocrinol Volume: 9 Issue: 1 Pages: 107-107
  • DOI: 10.1186/1477-7827-9-107
  • Peer Reviewed
• [Journal Article] Impact of indoleamine 2,3-dioxygenase on the antioxidant system in the placentas of severely pre-eclamptic patients (2011)
  • Author(s): Nishizawa H, Suzuki M, Pryor-Koishi K, Sekiya T, Tada S, Kurahashi H, Udagawa Y
  • Journal Title: Syst Biol Reprod Med Volume: 57 Issue: 4 Pages: 174-178
  • DOI: 10.3109/19396368.2011.587590
  • Peer Reviewed
• [Journal Article] Global gene expression profiling in early-stage polycystic kidney disease in the Han : SPRD Cy rat identifies a role for RXR signaling (2011)
  • Author(s): Kugita M, Nishii K, Morita M, Yoshihara D, Kowa-Sugiyama H, Yamada K, Yamaguchi T, Wallace DP, Calvet JP, Kurahashi H, Nagao S
  • Journal Title: Am J Physiol Renal Physiol Volume: 300 Issue: 1 Pages: F177-F188
  • DOI: 10.1152/ajprenal.00470.2010
  • Peer Reviewed
• [Journal Article] PPAR-{gamma} agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease (2011)
  • Author(s): Yoshihara D, Kurahashi H, Morita M, Kugita M, Hiki Y, Aukema HM, Yamaguchi T, Calvet JP, Wallace DP, Nagao S
  • Journal Title: Am J Physiol Renal Physiol Volume: 300 Issue: 2 Pages: F465-F474
  • DOI: 10.1152/ajprenal.00460.2010
  • Peer Reviewed
• [Journal Article] Lack of Association between Orexin Receptor Genes Polymorphisms and Obstructive Sleep Apnea Syndrome in Japanese (2011)
  • Author(s): Ahmed WA, Mori T, Nishimura Y, Kitanaka T, Kato T, Bhardwaj KA, Kurahashi H, Suzuki K
  • Journal Title: Sleep Biol Rhythms Volume: 9 Pages: 73-77
  • Peer Reviewed
• [Journal Article] Polymorphism in annexin A5 gene promoter in Japanese women with recurrent pregnancy loss. (2011)
  • Author(s): Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Markoff A, Yanagihara I, Udagawa Y, Kurahashi H.
  • Journal Title: Mol Hum Reprod Volume: (In press)
  • Peer Reviewed
• [Journal Article] A rare synaptonemal complex protein 3 gene variant is associated with unexplained female infertility. (2011)
  • Author(s): Nishiyama S, Kishi T, Kato T, Suzuki M, Bolor H, Udagawa Y, Kurahashi H.
  • Journal Title: Mol Hum Reprod Volume: (In press)
  • Peer Reviewed
• [Journal Article] Global gene expression profiling in early-stage polycystic kidney disease in the Han : SPRD Cy rat identifies a role for RXR signaling. (2011)
  • Author(s): Kugita M, Nishii K, Morita M, Yoshihara D, Kowa-Sugiyama H, Yamada K, Yamaguchi T, Wallace DP, Calvet JP, Kurahashi H, Nagao S.
  • Journal Title: Am J Physiol Renal Physiol Volume: (In press)
  • Peer Reviewed
• [Journal Article] PPAR-{gamma} agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. (2011)
  • Author(s): Yoshihara D, Kurahashi H, Morita M, Kugita M, Hiki Y, Aukema HM, Yamaguchi T, Calvet JP, Wallace DP, Nagao S.
  • Journal Title: Am J Physiol Renal Physiol Volume: (In press)
  • Peer Reviewed
• [Journal Article] Paternal origin of the de novo constitutional t(11 ; 22)(q23 ; q11) (2010)
  • Author(s): Ohye T, Inagaki H, Kogo H, Tsutsumi M, Kato T, Tong M, Macville M, Medne L, Zackai EH, Emanuel BS, Kurahashi H
  • Journal Title: Eur J Hum Genet Volume: 18(7) Pages: 783-7
  • Peer Reviewed
• [Journal Article] Polymorphisms of the 22q11.2 breakpoint region influence the frequency of de novo constitutional t(11 ; 22) s in sperm (2010)
  • Author(s): Tong M, Kato T, Yamada K, Inagaki H, Kogo H, Ohye T, Tsutsumi M, Wang J, Emanuel BS, Kurahashi H
  • Journal Title: Hum Mol Genet Volume: 19(13) Pages: 2630-7
  • Peer Reviewed
• [Journal Article] A new palindrome-mediated recurrent translocation with 3 : 1 meiotic non-disjunction : the t(8 ; 22)(q24.13 ; q11.21) (2010)
  • Author(s): Sheridan MB, Kato T, Haldeman-Englert C, Jalali GR, Milunsky JM, Zou Y, Klaes R, Gimelli S, Gemmill RM, Drabkin HA, Hacker AM, Brown J, Tomkins D, Shaikh TH, Kurahashi H, Zackai EH, Emanuel BS
  • Journal Title: Am J Hum Genet Volume: 87(2) Pages: 209-18
  • Peer Reviewed
• [Journal Article] The constitutional t(11 ; 22): implications for a novel mechanism responsible for gross chromosomal rearrangement (2010)
  • Author(s): Kurahashi H, Inagaki H, Kogo H, Ohye T, Tsutsumi M, Kato T, Tong M, Emanuel BS
  • Journal Title: Clin Genet Volume: 78(4) Pages: 299-309
  • Peer Reviewed
• [Journal Article] Paternal origin of the de novo constitutional t(11;22)(q23;q11). (2010)
  • Author(s): Ohye T, Inagaki H, Kogo H, Tsutsumi M, Kato T, Tong M, Macville M, Medne L, Zackai EH, Emanuel BS, Kurahashi H.
  • Journal Title: Eur J Hum Genet Volume: 18 Pages: 783-7
  • Peer Reviewed
• [Journal Article] Polymorphisms of the 22q11.2 breakpoint region influence the frequency of de novo constitutional t(11;22)s in sperm. (2010)
  • Author(s): Tong M, Kato T, Yamada K, Inagaki H, Kogo H, Ohye T, Tsutsumi M, Wang J, Emanuel BS, Kurahashi H.
  • Journal Title: Hum Mol Genet Volume: 19 Pages: 2630-7
  • Peer Reviewed
• [Journal Article] A new palindrome -mediated recurrent translocation with 3:1 meiotic non-disjunction : the t(8;22)(q24.13 ; q11.21). (2010)
  • Author(s): Sheridan MB, Kato T, Haldem an-Englert C, Jalali GR, Milunsky JM, Zou Y, Klaes R, Gimelli S, Gemmill RM, Drabkin HA, Hacker AM, Brown J, Tomkins D, Shaikh TH, Kurahashi H, Zackai EH, Emanuel BS.
  • Journal Title: Am J Hum Genet Volume: 87 Pages: 209-18
  • Peer Reviewed
• [Journal Article] The constitutional t(11;22) : implications for a novel mechanism responsible for gross chromosomal rearrangement. (2010)
  • Author(s): Kurahashi H, Inagaki H, Kogo H, Ohye T, Tsutsumi M, Kato T, Tong M, Emanuel BS.
  • Journal Title: Clin Genet Volume: 78 Pages: 299-309
  • Peer Reviewed
• [Journal Article] Screening of genes involved in chromosome segregation during meiosis I : towards the identification of genes responsible for infertility in humans. (2010)
  • Author(s): Kogo H, Kowa-Sugiyama H, Yamada K, Bolor H, Tsutsumi M, Ohye T, Inagaki H, Taniguchi M, Tada T, Kurahashi H.
  • Journal Title: J Hum Genet Volume: 55 Pages: 293-9
  • NAID: 10030734983
  • Peer Reviewed
• [Journal Article] CD9 gene variations are not associated with female infertility in humans. (2010)
  • Author(s): Nishiyama S, Kishi T, Kato T, Suzuki M, Nishizawa H, Pryor-Koishi K, Sawada T, Nishiyama Y, Iwata N, Udagawa Y, Kurahashi H.
  • Journal Title: Gynecol Obstet Invest Volume: 69 Pages: 116-21
  • Peer Reviewed
• [Journal Article] Genetic variation in the indoleamine 2,3-dioxygenase gene in pre-eclampsia. (2010)
  • Author(s): Nishizawa H, Kato T, Ohta S, Nishiyama S, Pryor-Koishi K, Suzuki M, Tsutsumi M, Inagaki H, Kurahashi H, Udagawa Y.
  • Journal Title: Am J Reprod Immunol Volume: 64 Pages: 68-76
  • Peer Reviewed
• [Journal Article] Genetic variation in the indoleamine 2,3-dioxygenase gene in pre-eclampsia (Reply). (2010)
  • Author(s): Nishizawa H, Kurahashi H.
  • Journal Title: Am J Reprod Immunol Volume: 64 Pages: 317-317
  • Peer Reviewed
• [Journal Article] Polycystic kidney disease in Han : SPRD Cy rats is associated with elevated expression and mislocalization of SamCystin. (2010)
  • Author(s): Nagao S, Morita M, Kugita M, Yoshihara D, Yamaguchi T, Kurahashi H, Calvet JP, Wallace DP.
  • Journal Title: Am J Physiol Renal Physiol Volume: 299
  • Peer Reviewed
• [Journal Article] Urinary neutrophil gelatinase-associated lipocalin is a potential non-invasive marker for renal scarring in patients with vesicoureteral reflux. (2010)
  • Author(s): Ichino M, Kusaka M, Kuroyanagi Y, Mori T, Morooka M, Sasaki H, Shiroki R, Shishido S, Kurahashi H, Hoshinaga K.
  • Journal Title: J Urol Volume: 183 Pages: 2001-7
  • Peer Reviewed
• [Journal Article] Serum tissue inhibitor of metalloproteinases 1 (TIMP-1) predicts organ recovery from delayed graft function after kidney transplantation from donors after cardiac death. (2010)
  • Author(s): Kusaka M, Kuroyanagi Y, Ichino M, Sasaki H, Maruyama T, Hayakawa K, Shiroki R, Sugitani A, Kurahashi H, Hoshinaga K.
  • Journal Title: Cell Transplant Volume: 19 Pages: 723-9
  • Peer Reviewed
• [Journal Article] Correlation of axillary osmidrosis to a SNP in the ABCC11 gene determined by the smart-amplification process (SMAP). (2010)
  • Author(s): Inoue Y, Mori T, Sakurai A, Mitani Y, Toyoda Y, Ishikawa T, Hayashizaki Y, Yoshimura Y, Kurahashi H, Sakai Y.
  • Journal Title: J Plast Reconstr Aesthet Surg Volume: 63 Pages: 1369-74
  • Peer Reviewed
• [Journal Article] Angiotensin converting enzyme 2 gene expression increased compensatory for left ventricular remodeling in patients with end-stage heart failure. (2010)
  • Author(s): Ohtsuki M, Morimoto S, Izawa H, Ismail TF, Ishibashi-Ueda H, Kato Y, Horii T, Isomura T, Suma H, Nomura M, Hishida H, Kurahashi H, Ozaki Y.
  • Journal Title: Int J Cardiol Volume: 145 Pages: 333-4
  • Peer Reviewed
• [Journal Article] CD9 gene variations are not associated with female infertility in humans (2010)
  • Author(s): Nishiyama S, Kishi T, Kato T, Suzuki M, Nishizawa H, Pryor-Koishi K, Sawada T, Nishiyama Y, Iwata N, Udagawa Y, Kurahashi H
  • Journal Title: Gynecologic and Obstetric Investigation 69 Pages: 116-121
  • Peer Reviewed
• [Journal Article] Chromosomal instability mediated by non-B DNA : Cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans (2009)
  • Author(s): Inagaki H, Ohye T, Kogo H, Kato T, Bolor H, Taniguchi M, Shaikh TH, Emanuel BS, Kurahashi H
  • Journal Title: Genome Res Volume: 19(2) Pages: 191-198
  • Peer Reviewed
• [Journal Article] Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells (2009)
  • Author(s): Kurahashi H, Inagaki H, Kato T, Hosoba E, Kogo H, Ohye T, Tsutsumi M, Bolor H, Tong M, Emanuel BS
  • Journal Title: Hum Mol Genet Volume: 18(18) Pages: 3397-3406
  • Peer Reviewed
• [Journal Article] Recent advance in our understanding of the molecular nature of chromosomal abnormalities (2009)
  • Author(s): Kurahashi H, Bolor H, Kato T, Kogo H, Tsutsumi M, Inagaki H, Ohye T
  • Journal Title: J Hum Genet Volume: 54(5) Pages: 253-260
  • NAID: 10030730167
  • Peer Reviewed
• [Journal Article] Mutations of the SYCP3 gene in women with recurrent pregnancy loss (2009)
  • Author(s): Bolor H, Mori T, Nishiyama S, Ito Y, Hosoba E, Inagaki H, Kogo H, Ohye T, Makiko T, Kato T, Tong M, Nishizawa H, Pryor-Koishi K, Kitaoka E, Sawada T, Nishiyama Y, Udagawa Y, Kurahashi H
  • Journal Title: American Journal of Human Genetics 84 Pages: 14-20
  • Peer Reviewed
• [Journal Article] Chromosomal instability mediated by non-B DNA : Cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans (2009)
  • Author(s): Inagaki H, Ohye T, Kogo H, Kato T, Bolor H, Taniguchi M, Shaikh TH, Emanuel BS, Kurahashi H
  • Journal Title: Genome Research 19 Pages: 191-198
  • Peer Reviewed
• [Journal Article] Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells (2009)
  • Author(s): Kurahashi H, Inagaki H, Kato T, Hosoba E, Kogo H, Ohye T, Tsutsumi M, Bolor H, Tong M, Emanuel BS
  • Journal Title: Human Molecular Genetics 18 Pages: 3397-3406
  • Peer Reviewed
• [Journal Article] Recent advance in our understanding of the molecular nature of chromosomal abnormalities (2009)
  • Author(s): Kurahashi H, Bolor H, Kato T, Kogo H, Tsutsumi M, Inagaki H, Ohye T
  • Journal Title: Journal of Human Genetics 54 Pages: 253-260
  • NAID: 10030730167
  • Peer Reviewed
• [Journal Article] Analysis of nitric oxide metabolism as a placental or maternal factor underlying the etiology of pre-eclampsia (2009)
  • Author(s): Nishizawa H, Pryor-Koishi K, Suzuki M, Kato T, Sekiya T, Tada S, Kurahashi H, Udagawa Y
  • Journal Title: Gynecologic and Obstetric Investigation 68 Pages: 239-247
  • Peer Reviewed
• [Journal Article] Increased urinary neutrophil gelatinase-associated lipocalin levels in a rat model of upper urinary tract infection (2009)
  • Author(s): Ichino M, Kuroyanagi Y, Kusaka M, Mori T, Ishikawa K, Shiroki R, Kurahashi H, Hoshinaga K
  • Journal Title: Journal of Urology 181 Pages: 2326-2331
  • Peer Reviewed
• [Journal Article] Global expression profiles in 1-hour biopsy specimens of human kidney transplantation from donors after cardiac death (2009)
  • Author(s): Kusaka M, Kuroyanagi Y, Mori T, Nagaoka K, Sasaki H, Maruyama T, Hayakawa K, Shiroki R, Kurahashi H, Hoshinaga K
  • Journal Title: Cell Transplantation 18 Pages: 647-656
  • Peer Reviewed
• [Journal Article] Chromosomal translocations and palindromic AT-rich repeats
  • Author(s): Kato T, Kurahashi H, Emanuel BS
  • Journal Title: Curr Opin Genet Dev. Volume: (In press)
  • Peer Reviewed
• [Journal Article] HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes
  • Author(s): Kogo H, Tsutsumi M, Ohye T, Inagaki H, Abe T, Kurahashi H
  • Journal Title: Genes Cells Volume: (In press)
  • Peer Reviewed
• [Journal Article] A Functional variation in the hypocretin neuropeptide precursor gene may be associated with obstructive sleep apnea syndrome in Japan
  • Author(s): Ahmed WA, Tsutsumi M, Nakata S, Mori T, Nishimura Y, Fujisawa T, Kato I, Nakashima M, Kurahashi H, Suzuki K
  • Journal Title: Laryngoscope Volume: (In press)
  • Peer Reviewed
• [Journal Article] Serum neutrophil gelatinase-associated lipocalin during the early postoperative period predicts the recovery of graft function after kidney transplantation from donors after cardiac death
  • Author(s): Kusaka M, Iwamatsu F, Kuroyanagi Y, Nakaya M, Ichino M, Marubashi S, Nagano H, Shiroki R, Kurahashi H, Hoshinaga K
  • Journal Title: J Urol Volume: (In press)
  • Peer Reviewed
• [Presentation] Mechanism of recurrent translocation t(11 ; 22) initiated by cruciform conformation of palindromic sequences (2011)
  • Author(s): Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H
  • Organizer: The 12th International Congress of Human Genetics
  • Place of Presentation: Montreal, Canada
• [Presentation] Identification of a novel palindrome mediated translocation associated with the t(3 ; 8) of hereditary renal cancer (2011)
  • Author(s): Kato T, Sheridan MB, Hacker AM, Inagaki H, Glover TW, Plon SE, Drabkin HA, Gemmill RM, Kurahashi H, Emanuel BS
  • Organizer: The 12th International Congress of Human Genetics
  • Place of Presentation: Montreal, Canada
• [Presentation] GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans (2011)
  • Author(s): Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H
  • Organizer: Kyestone Symposia : Functional consequences of structural variation in the genome
  • Place of Presentation: Steamboat Springs, USA
• [Presentation] Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss (2011)
  • Author(s): Kurahashi H, Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Negi R, Markoff A, Yanagihara I, Udagawa, Y
  • Organizer: European Society of Human Genetics Conference 2011
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss (2011)
  • Author(s): Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama s, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Markoff A, Yanagihara I, Udagawa Y, Kurahashi H
  • Organizer: 59th Annual Clinical Meeting, ACOG
  • Place of Presentation: Washington DC, USA
• [Presentation] Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss (2011)
  • Author(s): Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Markoff A, Yanagihara I, Udagawa Y, Kurahashi H
  • Organizer: 27th Annual Meeting of ESHRE-Stockholm 2011
  • Place of Presentation: Stockholm, Sweden
• [Presentation] Mechanism of recurrent translocation t(11;22) initiated by cruciform conformation of palindromic sequences (2011)
  • Author(s): Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H
  • Organizer: The 12th International Congress of Human Genetics
  • Place of Presentation: Montreal, Canada
• [Presentation] Identification of a recombination hotspot sequence at the breakpoint region of the 22q11 deletion using a yeast model (2011)
  • Author(s): Ohye T, Inagaki H, Kogo H, Tsutsumi M, Emanuel BS, Kurahashi H
  • Organizer: The 12th International Congress of Human Genetics
  • Place of Presentation: Montreal, Canada
• [Presentation] HORMAD1-deficiency causes azoospermia in males and pregnancy loss in females (2011)
  • Author(s): Kogo H, Tsutsumi M, Ohye T, Inagaki H, Kurahashi H
  • Organizer: The 12th International Congress of Human Genetics
  • Place of Presentation: Montreal, Canada
• [Presentation] Identification of a novel palindrome mediated translocation associated with the t(3;8) of hereditary renal cancer (2011)
  • Author(s): Kato T, Sheridan MB, Hacker AM, Inagaki H, Glover TW, Plon SE, Drabkin HA, Gemmill RM, Kurahashi H, Emanuel BS
  • Organizer: The 12th International Congress of Human Genetics
  • Place of Presentation: Montreal, Canada
• [Presentation] Mutation in the SYCP3 gene identified in a woman with recurrent pregnancy loss affect the synaptonemal complex conformation at meiotic prophase I (2011)
  • Author(s): Tsutsumi M, Kogo H, Inagaki H, Ohye T, Kurahashi H
  • Organizer: The 12th International Congress of Human Genetics
  • Place of Presentation: Montreal, Canada
• [Presentation] HORMAD1-dependent synapsis checkpoint in mammalian meiosis (2011)
  • Author(s): Kogo H, Tsutsumi M, Ohye T, Inagaki H, Kurahashi H
  • Organizer: 2011 FASEB Summer Research Conferences, Genetic Recombination & Genome Rearrangements
  • Place of Presentation: Steamboat Spring, USA
• [Presentation] PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease (2011)
  • Author(s): Yoshihara D, Kurahashi H, Morita M, Kugita M, Hiki Y, Aukema HM, Yamaguchi T, Calvet JP, Wallace DP, Nagao S
  • Organizer: World Congress of Nephrology 2011
  • Place of Presentation: Vancouver, Canada
• [Presentation] Global gene expression profiling in kidneys of PPAR-gamma agonist-treated PCK rats, an orthologous model of human ARPKD (2011)
  • Author(s): Yoshihara D, Kugita M, Kurahashi H, Morita M, Hiki Y, Yamaguchi T, Aukema HM, Wallace DP, Calvet JP, Toyohara T, Abe T, Nagao S
  • Organizer: American Society of Nephrology 44th Annual Meetine & Scientific Exposition
  • Place of Presentation: Philadelphia, PA USA
• [Presentation] GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans. (2011)
  • Author(s): Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H.
  • Organizer: Keystone Symposia : Functional Consequences of Structural Variation in the Genome
  • Place of Presentation: Steamboat Springs, Colorado, USA
• [Presentation] GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans (2010)
  • Author(s): Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H
  • Organizer: The American Society of Human Genetics 60th Annual Meeting
  • Place of Presentation: Washington DC, USA
• [Presentation] GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans (2010)
  • Author(s): Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H
  • Organizer: The 7th 3R Symposium
  • Place of Presentation: Toyama, Japan
• [Presentation] Palindrome-mediated chromosomal translocation in humans. (2010)
  • Author(s): Kurahashi H
  • Organizer: FASEB Summer Research Conferences. Biological Impact of Alternatively Structured DNA
  • Place of Presentation: Colorado, USA
• [Presentation] Paternal origin of the de novo constitutional t(11 ; 22)(q23 ; q11) (2010)
  • Author(s): Ohye T, Inagaki H, Kogo H, Tsutsumi M, Kato T, Tong M, Macville MVE, Medne L, Zackai EH, Emanuel BS, Kurahashi H
  • Organizer: European Society of Human Genetics Conference 2010
  • Place of Presentation: Gothenburg, Sweden
• [Presentation] Palindrome-mediated chromosomal translocation in humans. (2010)
  • Author(s): Kurahashi H.
  • Organizer: FASEB Summer Research Conferences. Biological Impact of Alternatively Structured DNA.
  • Place of Presentation: Steamboat Springs, Colorado, USA(招待講演)
• [Presentation] Mutation of the SYCP3 gene in women with recurrent pregnancy loss. (2010)
  • Author(s): Kurahashi H, Tsutsumi M, Egusa H, Nishiyama S, Suzuki M, Kogo H, Inagaki H, Ohye T.
  • Organizer: International Symposium on Epigenome Network, Development and Reprogramming of Germ Cells.
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Paternal origin of the de novo constitutional t(11;22) (q23;q11). (2010)
  • Author(s): Ohye T, Inagaki H, Kogo H, Tsutsumi M, Kato T, Tong M, Macville MVE, Medne L, Zackai EH, Emanuel BS, Kurahashi H.
  • Organizer: European Society of Human Genetics Conference 2010.
  • Place of Presentation: Gothenburg, Sweden
• [Presentation] GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans. (2010)
  • Author(s): Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H.
  • Organizer: The 7th 3R Symposium
  • Place of Presentation: Toyama, Japan
• [Presentation] GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans. (2010)
  • Author(s): Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H.
  • Organizer: The American Society of Human Genetics 60th Annual Meeting
  • Place of Presentation: Washington DC, USA
• [Presentation] Parental origin of de novo t(11 ; 22)(q23 ; q11) (2009)
  • Author(s): Ohye T, Inagaki H, Kogo H, Tsutsumi M, Kato T, Tong M, Macville MV, Medne L, Zackai EH, Emanuel BS, Kurahashi H
  • Organizer: 59th annual meeting of American Society of Human Genetics
  • Place of Presentation: Hawai, USA
• [Presentation] Two successive cleavages in palindrome-mediated translocation (2009)
  • Author(s): Kurahashi H, Inagaki H, Kato T, Ohye T, Kogo H, Shaikh TH, Emanuel BS
  • Organizer: Genome Instability and DNA Repair
  • Place of Presentation: Taos, USA
• [Presentation] Mutations of the SYCP3 gene in women with recurrent pregnancy loss (2009)
  • Author(s): Kurahashi H, Bolor H, Mori T, Nishiyama S, Inagaki H, Kogo H, Tsutsumi M, Ohye T
  • Organizer: European Society of Human Genetics conference 2009
  • Place of Presentation: Vienna, Austria
• [Presentation] Parental origin of de novo t(11;22)(q23;q11) (2009)
  • Author(s): Kurahashi H, Inagaki H, Kato T, Ohye T, Kogo H, Shaikh TH, Emanuel BS
  • Organizer: 59th annual meeting of American Society of Human Genetics
  • Place of Presentation: Honolulu, Hawai, USA
• [Book] Cruciform DNA. Encyclopedia of Genetics, 2nd Edition
  • Author(s): Inagaki H, Kurahashi H
  • Publisher: Elsevier(in press)
• [Remarks] 藤田保健衛生大学・総合医科学研究所
  • URL: http://www.fujita-hu.ac.jp/ICMS/
• [Remarks] 分子遺伝学研究部門
  • URL: http://www.fujita-hu.ac.jp/~genome/mg/
• [Remarks]
  • URL: http://www.fujita-hu.ac.jp/~genome/mg/