| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Research Abstract |
We have elucidated that ZFAT is indispensable for mouse embryonic development and a critical transcription factor for primitive hematopoiesis in the regulation of Tal1 in blood islands through the analysis of Zfat-deficient mice. In addition, using T-cell specific conditional Zfat-deficient mice we have reported that ZFAT is crucial for peripheral T cell homeostasis and its T cell receptor-mediated responses. Furthermore, we have demonstrated that Tespa1 is a MAM-associated molecule and critically involved in Ca2+ signaling in T cells, and also identified several independent risk loci for Graves’ disease within the MHC region in the Japanese population.
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