Analysis of genes encoding secretory and membrane protein by CAST method and microRNA regulation in esophago-gastric cancer and its clinical application

• Project/Area Number: 21390105
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Hiroshima University
• Principal Investigator: YASUI Wataru 広島大学, 大学院・医歯薬学総合研究科, 教授 (40191118)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 胃癌 / 食道扁平上皮癌 / 膜蛋白・分泌蛋白 / CAST法 / microRNA / 診断・治療 / 消化管癌 / 分泌蛋白 / 膜蛋白 / 診断

Research Abstract

CAST method was carried out on esophago-gastric cancers and identified DSC2, TSPAN8, TM9SF3, etc. as possible therapeutic target. By microRNA microarray, several microRNAs were identified as diagnostic marker. miR-148a and miR-143 were found to participate in invasion and morphogenesis. New development of diagnosis and therapeutics using novel markers is expected

Research Products

• [Journal Article] Upregulation of HOXAio in gastric cancer with the intestinal mucin phenotype : Reduction during tumor progression and favorable prognosis (2012)
  • Author(s): Sentani K, one N, Naito Y, Sakamoto N, Anami K, 00 HZ, Uraoka N, Aoyagi K, Sasaki H and Yasui W
  • Journal Title: Carcinogenesis Volume: (in press)
  • Peer Reviewed
• [Journal Article] Cytokeratin 7 is a predictive marker for survival and effect of adjuvant chemotherapy in patients with esophageal squamous cell carcinoma (2012)
  • Author(s): oue N, Noguchi T, Anami K, Kitano S, Sakamoto N, Sentani K, Uraoka N, Aoyagi K, Yoshida T, Sasaki H and Yasui W
  • Journal Title: Ann Surg Oncol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Deficiency of claudin-l8 causes paracellular H+ leakage, up regulation of interleukinlbeta, and atrophic gastritis in mice (2012)
  • Author(s): Hayashi D, Tamura A, Tanaka H, Yamazaki Y, Watanabe S, Suzuki K, Suzuki K, Sentani K, Yasui W, Rakugi H, Isaka Y and Tsukita S
  • Journal Title: Gastroenterology Volume: 142 Pages: 292-304
  • Peer Reviewed
• [Journal Article] Cytokeratin expression profiling in gastric carcinoma : clinicopathologic significance and comparison with tumor-associated molecules (2012)
  • Author(s): Takami H
  • Journal Title: Pathobiology Volume: 79 Pages: 154-161
  • Peer Reviewed
• [Journal Article] Expression of podoplanin/D2-40 in pericryptal stromal cells in superficial colorectal epithelial neoplasia (2012)
  • Author(s): Nakayama H
  • Journal Title: Med Mol Morphol Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Cytokeratin 7 is a predictive marker for survival and effect of adjuvant chemotherapy in patients with esophageal squamous cell carcinoma (2012)
  • Author(s): Oue N
  • Journal Title: Ann Surg Oncol Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Upregutation of HOXA 10 in gastric cancer with the intestinal mucin phenotype : Reduction during tumor progression and favorable prognosis (2012)
  • Author(s): Sentani K
  • Journal Title: Carcinogenesis Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD (2012)
  • Author(s): Gersemann M
  • Journal Title: J Crohns Colitis Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Identification of transmembrane protein in prostate cancer by the Escherichia coll ampicillin secretion trap : Expression of CDON is involved in tumor cell growth and invasion (2011)
  • Author(s): Hayashi T, one N, Sakamoto N, Anami K, 00 HZ, Sentani K, Ohara S, Teishima J, Matsubara A and Yasui W
  • Volume: 78
  • Pages: 277-284
  • Peer Reviewed
• [Journal Article] Antistromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic mouse model (2011)
  • Author(s): Sumida T, Kitadai Y, Shinagawa K, Tanaka M, Kodama M, Ohnishi M, Ohara E, Tanaka S, Yasui W and Chayama K
  • Volume: 128
  • Pages: 2050-2062
  • Peer Reviewed
• [Journal Article] A functional SNP in MUCl, at chromosome lq22, determines susceptibility to diffuse-type gastric cancer Short title : MUClis a gastric cancer susceptibility gene (2011)
  • Author(s): Saeki N, Saito A, Choi II, Matsuo K, Ohnami S, Totsuka H, Chiku S, Kuchiba A, Lee YS, Yoon KA, Kook MC, Park SR, Kim YW, Tanaka H, Ta j ima K, Hirose H, Tanioka F, Matsuno Y, Sugimura H, Kate S, Nakamura T, Nishina T, Yasui W, Aoyagi K, Sasaki H, Yanagiha
  • Journal Title: Gastroenterology Volume: 140 Pages: 892-902
  • Peer Reviewed
• [Journal Article] A functional SNP in MUC1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer Short title : MUClis a gastric cancer susceptibility gene (2011)
  • Author(s): Saeki N
  • Journal Title: Gastroenterology Volume: 140 Pages: 892-902
  • Peer Reviewed
• [Journal Article] Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic mouse model (2011)
  • Author(s): Sumida T
  • Journal Title: Int J Cancer Volume: 128 Pages: 2050-2062
  • Peer Reviewed
• [Journal Article] Identification of transmembrane protein in prostate cancer by the Escherichia coli ampicillin secretion trap : Expression of CDON is involved in tumor cell growth and invasion (2011)
  • Author(s): Hayashi T
  • Journal Title: Pathobiology Volume: 78 Pages: 277-284
  • Peer Reviewed
• [Journal Article] Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metatasis of gastric cancer (2011)
  • Author(s): Wakamatsu Y
  • Journal Title: Pathol Int Volume: 62 Pages: 112-119
  • Peer Reviewed
• [Journal Article] Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1beta, and atrophic gastritis in mice (2011)
  • Author(s): Hayashi D
  • Journal Title: Gastroenterology Volume: 142 Pages: 292-304
  • Peer Reviewed
• [Journal Article] Molecular pathology of gastric cancer : Research and practice (2011)
  • Author(s): Yasui W
  • Journal Title: Path Res Pract Volume: 207 Pages: 608-612
  • Peer Reviewed
• [Journal Article] Future Perspective of Gastric Cancer Treatment-From Bench to Bedside- (2011)
  • Author(s): Yasui W
  • Journal Title: Pathobiology Volume: 78 Pages: 293-294
  • Peer Reviewed
• [Journal Article] Serum concentration and expression of Reg IV in patients with esophageal cancer : age-related elevation of serum Reg IV concentration (2011)
  • Author(s): Oue N
  • Journal Title: Oncol Lett Volume: 2 Pages: 235-239
  • Peer Reviewed
• [Journal Article] A functional SNP in MUC1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer Short title : MUC1 is a gastric cancer susceptibility gene (2011)
  • Author(s): Saeki N
  • Journal Title: Gastroenterology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Upregulation of connexin 30 in intestinal phenotype gastric cancer and its reduction during tumor progression (2010)
  • Author(s): Sentani K, one N, Sakamoto N, Anami K, Naito Y, Aoyagi K, Sasaki H and Yasui W
  • Journal Title: Pathobiology Volume: 77 Pages: 241-248
  • NAID: 120002753722
  • Peer Reviewed
• [Journal Article] Chemoprevention by nonsteroidal antiinflammatory drug eliminates oncogenic intestinal stem cells via SMACdependent apoptosis (2010)
  • Author(s): Qui W, Wang X, Leibowitz, Lin H, Barker N, Okada H, one N, Yasui W, Clevers H, Schoen RE, Yu J and Zhang L
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 20027-20032
  • Peer Reviewed
• [Journal Article] CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium (2010)
  • Author(s): Takakura Y, Hinoi T, one N, Sasada T, Kawaguchi Y, Okajima M, Akyol A, Fearon ER, Yasui W and Ohdan H
  • Journal Title: Cancer Res Volume: 70 Pages: 6767-6778
  • Peer Reviewed
• [Journal Article] Potential role for vascular endothelial growth factor-D as an autocrine factor for human gastric carcinoma cells (2010)
  • Author(s): Tanaka M, Kitadai Y, Kodama M, Shinagawa K, Sumida T, Tanaka S, one N, Yasui W and Chayama K
  • Journal Title: Cancer Sci Volume: 101 Pages: 2121-2127
  • NAID: 10027832106
  • Peer Reviewed
• [Journal Article] Expression of plateletderived growth factor(PDGF)-B and PDGFreceptor b is associated with lymphatic metastasis in human gastric carcinoma (2010)
  • Author(s): Kodama M, Kitadai Y, Sumida T, Ohnishi M, Ohara E, Tanaka M, Shinagawa K, Tanaka S, Yasui W and Chayama K
  • Journal Title: Cancer Sci Volume: 101 Pages: 1984-1989
  • Peer Reviewed
• [Journal Article] Mesenchymal stem cells enhance growth and metastasis of colon cancer (2010)
  • Author(s): Shinagawa K, Kitadai Y, Tanaka M, Sumida T, Kodama M, Higashi Y, Tanaka S, Yasui W and Chayama K
  • Journal Title: Int J Cancer Volume: 127 Pages: 2323-2333
  • Peer Reviewed
• [Journal Article] Search for transmembrane protein in gastric cancer by the Escherichia coll ampicillin secretion trap : expression of DSC2 in gastric cancer with intestinal phenotype (2010)
  • Author(s): Anami K, one N, Noguchi T, Sakamoto N, Sentani K, Hayashi T, Hinoi T, Okajima M, Graft IM and Yasui W
  • Journal Title: J Pathol Volume: 221 Pages: 275-284
  • Peer Reviewed
• [Journal Article] Relation between microRNA expression and progression and prognosis of gastric cancer : a microRNA expression analysis (2010)
  • Author(s): Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S, Alder H, Lin CG, one N, Yasui W, Yoshida K, Sasaki H, Nomura S, Seto Y, Kaminishi M, Carin GA and Croce CM
  • Journal Title: Lancet Oncol Volume: 11 Pages: 136-146
  • Peer Reviewed
• [Journal Article] Serial analysis of gene expression of esophageal squamous cell carcinoma : ADAMTSl6 is upregulated in esophageal squamous cell carcinoma (2010)
  • Author(s): Sakamoto N, one N, Noguchi T, Sentani K, Anami K, Sanada Y, Yoshida K and Yasui W
  • Journal Title: Cancer Sci Volume: 101 Pages: 1038-1044
  • Peer Reviewed
• [Journal Article] Wntsa signaling is involved in aggressiveness of prostate cancer and expression of metalloproteinase (2010)
  • Author(s): Yamamoto H, one N, Sate A, Hasegawa Y, Yamamoto H, Matsubara A, Yasui W and Kikuchi A
  • Journal Title: Oncogene Volume: 29 Pages: 2036-2046
  • Peer Reviewed
• [Journal Article] Immunostaining of gastric cancer with neuroendocrine differentiation : Reg IV-positive neuroendocrine cells are associated with gastrin, serotonin, somatostatin and pancreatic polypeptide (2010)
  • Author(s): Sentani K
  • Journal Title: Pathol Int Volume: 60 Pages: 291-297
  • Peer Reviewed
• [Journal Article] Serial analysis of gene expression of esophageal squamous cell carcinoma : ADAMTS16 is up-regulated in esophageal squamous cell carcinoma (2010)
  • Author(s): Sakamoto N
  • Journal Title: Cancer Sci Volume: 101 Pages: 1038-1044
  • Peer Reviewed
• [Journal Article] Olfactomedin 4 (GW112, hGC-1) is an independent prognostic marker for survival in patients with colorectal cancer (2010)
  • Author(s): Seko N
  • Journal Title: Exp Ther Med Volume: 1 Pages: 73-78
  • Peer Reviewed
• [Journal Article] Search for transmembrane protein in gastric cancer by the Escherichia coli ampicillin secretion trap : expression of DSC2 in gastric cancer with intestinal phenotype (2010)
  • Author(s): Anami K
  • Journal Title: J Pathol Volume: 221 Pages: 275-284
  • Peer Reviewed
• [Journal Article] Up-regulation of connexin 30 in intestinal phenotype gastric cancer and its reduction during tumor progression (2010)
  • Author(s): Sentani K
  • Journal Title: Pathobiol Volume: 77 Pages: 241-248
  • Peer Reviewed
• [Journal Article] Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor ss is associated with lymphatic metastasis in human gastric carcinoma (2010)
  • Author(s): Kodama M
  • Journal Title: Cancer Sci Volume: 101 Pages: 1984-1989
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of colorectal cancer with gastric phenotype : Ectopic expression of claudin-18 is associated with poor prognosis (2010)
  • Author(s): Matsuda M
  • Journal Title: Pathol Int Volume: 60 Pages: 673-680
  • Peer Reviewed
• [Journal Article] Chemoprevention by nonsteroidal anti-inflammatory drug eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis (2010)
  • Author(s): Qui W
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 20027-20032
  • Peer Reviewed
• [Journal Article] Immunostaining of gastric cancer with neuroendocrine differentiation : Reg IV-positive neuroendocrine cells are associated with gastrin, serotonin, somatostatin and pancreatic polypeptide (2010)
  • Author(s): Sentani K
  • Journal Title: Pathol Int (印刷中)
  • Peer Reviewed
• [Journal Article] Serial analysis of gene expression of esophageal squamous cell carcinoma : ADAMTS16 is up-regulated in esophageal squamous cell carcinoma (2010)
  • Author(s): Sakamoto N
  • Journal Title: Cancer Sci (印刷中)
  • Peer Reviewed
• [Journal Article] Relation between microRNA expression and progression and prognosis of gastric cancer : a microRNA expression analysis (2010)
  • Author(s): Ueda T
  • Journal Title: Lancet Oncol (印刷中)
  • Peer Reviewed
• [Journal Article] Olfactomedin 4 (GW112, hGC-1) is an independent prognostic marker for survival in patients with colorectal cancer (2010)
  • Author(s): Seko N
  • Journal Title: Exp Ther Med 1 Pages: 73-78
  • Peer Reviewed
• [Journal Article] Transcriptome dissection of gastric cancerIdentification of novel diagnostic and therapeutic targets from pathology specimens(review article) (2009)
  • Author(s): Yasui W, one N, Sentani K, Sakamoto N and Motoshita J
  • Journal Title: Pathol Int cancer Volume: 59 Pages: 121-136
  • Peer Reviewed
• [Journal Article] Serum olfactomedin 4(GWll2, hGC-l) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients (2009)
  • Author(s): Oue N, Sentani K, NOGUCHI T, Ohara S, Sakamoto N, Hayashi T, Anami K, Motoshita J, Ito M, Tanaka S, Yoshida K and Yasui W
  • Journal Title: Int J Cancer Volume: 125 Pages: 2382-2392
  • Peer Reviewed
• [Journal Article] Laminin gamma2 mediates Wnt5a-induced invasion by gastric cancer cells (2009)
  • Author(s): Yamamoto H, Kitadai Y, Yamamoto H, one N, Ohdan H, Yasui W and Kikuchi A
  • Journal Title: Gastroenterol Volume: 137 Pages: 242-252
  • Peer Reviewed
• [Journal Article] h-prune is an independent prognostic marker for survival in esophageal squamous cell carcinoma (2009)
  • Author(s): Noguchi T, one N, Wada S, Sentani K, Sakamoto N, Kikuchi A and Yasui W
  • Journal Title: Ann Surg Oncol Volume: 16 Pages: 1390-1396
  • Peer Reviewed
• [Journal Article] Characteristic gene expression in stromal cells of gastric cancers among atomic-bomb survivors (2009)
  • Author(s): one N, Sentani K, Sakamoto N, Motoshita J, Nishisaka T, Fukuhara T, Matsuura H, Sasaki H, Nakachi K and Yasui W
  • Journal Title: Int J Cancer Volume: 124 Pages: 1112-1121
  • Peer Reviewed
• [Journal Article] Reg IV enhances peritoneal metastasis of gastric carcinomas (2009)
  • Author(s): Kuniyasu H
  • Journal Title: Cell Proliferation 42 Pages: 110-121
  • Peer Reviewed
• [Journal Article] Characteristic gene expression in stromal cells of gastric cancers among atomic-bomb survivors (2009)
  • Author(s): Oue N
  • Journal Title: Int J Cancer 124 Pages: 1112-1121
  • Peer Reviewed
• [Journal Article] h-Prune is an independent prognostic marker for survival in esophageal squamous cell carcinoma (2009)
  • Author(s): Noguchi T
  • Journal Title: Ann Surg Oncol 16 Pages: 1390-1396
  • Peer Reviewed
• [Journal Article] Laminin gamma2 mediates Wnt5a-induced invasion by gastric cancer cells (2009)
  • Author(s): Yamamoto H
  • Journal Title: Gastroenterol 137 Pages: 242-252
  • Peer Reviewed
• [Journal Article] Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients (2009)
  • Author(s): Oue N
  • Journal Title: Int J Cancer 125 Pages: 2382-2392
  • Peer Reviewed
• [Journal Article] Transcriptome dissection of gastric cancer : Identification of novel diagnostic and therapeutic targets from pathology specimens (2009)
  • Author(s): Yasui W
  • Journal Title: Pathol Int 59 Pages: 121-136
  • NAID: 10027379286
  • Peer Reviewed
• [Presentation] Molecular characteristics of gastric and intestinal phenotypes of gastric cancer (2011)
  • Author(s): Yasui W
  • Organizer: The 21^<st> International Symposium of the Hiroshima Cancer Seminar
  • Place of Presentation: Hiroshima (Japan)(招待講演)
  • Year and Date: 2011-11-06
• [Presentation] microRNA-143の胃癌における機能解析と腫瘍マーカーとしての有用性 (2011)
  • Author(s): 内藤寛
  • Organizer: 第31回日本分子腫瘍マーカー研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-02
• [Presentation] CAST法で同定したTSPAN8の胃癌における発現と機能解析 (2011)
  • Author(s): 阿南勝宏、大上直秀、坂本直也、仙谷和弘、浦岡直礼、内藤寛、HtooZarniOo、野口剛、安井弥
  • Organizer: 第22回日本消化器癌発生学会、ワークショップ2
  • Place of Presentation: 佐賀
• [Presentation] 胃癌におけるmiR-148aの発現低下とMMP7を介した浸潤への関与 (2011)
  • Author(s): 坂本直也、内藤寛、仙谷和弘、大上直秀、安井弥
  • Organizer: 第22回日本消化器癌発生学会、ワークショップ3
  • Place of Presentation: 佐賀
• [Presentation] CAST法を用いた胃癌細胞株における遺伝子発現解析 (2011)
  • Author(s): 阿南勝宏、大上直秀、坂本直也、林哲太郎、仙谷和弘、浦岡直礼、HtooZarniOo、内藤寛、坂根潤一、後藤景介、野口剛、安井弥
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] SAGE法を用いた食道扁平上皮癌の解析:食道扁平上皮癌におけるNRD1の発現亢進 (2011)
  • Author(s): 浦岡直礼、坂本直也、大上直秀、仙谷和弘、阿南勝宏、野口剛、真田雄市、吉田和弘、安井弥
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Gene expression profile of scirrhous type gastric cancer analyzed by CAST method (2011)
  • Author(s): Oo HZ, Uraoka N, Hayashi T, Anami K, Sakamoto N, Sentani K, Oue N and Yasui W
  • Organizer: 8th International Symposium on Minimal Residual Cancer
  • Place of Presentation: Osaka (Japan)
• [Presentation] Identification of novel diagnostic and therapeutic targets of gastric cancer by transcriptome dissection (2011)
  • Author(s): Yasui W
  • Organizer: The Third CREAST-SBM International Conference
  • Place of Presentation: Hiroshima (Japan)
• [Presentation] 胃癌の発生・進展の分子機序のマイルストーン (2011)
  • Author(s): 安井弥
  • Organizer: 第100回日本病理学会総会、シンポジウム1
  • Place of Presentation: 横浜
• [Presentation] 胃癌におけるmicroRNA発現解析 (2011)
  • Author(s): 坂本直也、内藤寛、仙谷和弘、大上直秀、安井弥
  • Organizer: 第100回日本病理学会総会、ワークショップ1
  • Place of Presentation: 横浜
• [Presentation] SAGE法を用いた食道扁平上皮癌の新規マーカーNRD1の同定 (2011)
  • Author(s): 浦岡直礼、坂本直也、大上直秀、仙谷和弘、阿南勝宏、野口剛、真田雄市、吉田和弘、安井弥
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
• [Presentation] Novel diagnostic and therapeutic targets of gastric cancer identified by" Omics" study (2011)
  • Author(s): YasuiW, SentaniK, SakamotoN, AnamiK, NaitoY and OueN
  • Organizer: 9^<th> International Gastric Cancer
  • Place of Presentation: Seoul(Korea)
• [Presentation] Gene expression profile in scirrhous type gastric mcancer by CAST method. 9th International Gastric Cancer Congress (2011)
  • Author(s): OoHZ, UraokaN, HayashiT, AnamiK, SakamotoN, SentaniK, OueN and YasuiW
  • Organizer: 9^<th> International Gastric Cancer Congress, Seoul(Korea)
  • Place of Presentation: Seoul(Korea)
• [Presentation] Unique microRNA signatures associated with progression and prognosis of gastric cancer. 9th International Gastric Cancer Congress (2011)
  • Author(s): UedaT, YasuiW, YoshidaK, SasakiS, NomuraS, SetoY, KaminishiM, CalinG, CroceC, VoliniaS, OkumuraH, ShimizuM, TaccioliC, RossiS, AlderH, LiuC and OueN
  • Organizer: 9^<th> International Gastric Cancer Congress, Seoul(Korea)
  • Place of Presentation: Seoul(Korea)
• [Presentation] miR-l48aa is down羊egulated in gastric cancer and involved in gastric cancer invasion by repression ofMMPi7 expression (2011)
  • Author(s): SakamotoN, NaitoY, UraokaN, AnamiK, SentaniK, OueN and YasuiW
  • Organizer: 9^<th> International Gastric Cancer Congress, Seoul(Korea)
  • Place of Presentation: Seoul(Korea)
• [Presentation] Molecular character of gastric and intestinal phenotypes of gastric cancer (2011)
  • Author(s): YasuiW, OueN, SentaniK, and SakamotoN
  • Organizer: The 6th International Conference on Gastroenterological Carcinogenesis, Lecture
  • Place of Presentation: Houston, Texas(USA)
• [Presentation] Transcriptional regulation of REG4, a novel diagnostic marker of gastrointestinal cancer by CDX2 (2011)
  • Author(s): Naito Y
  • Organizer: The 102nd Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Orland, Florida (USA)
• [Presentation] Blockade of PDFR signaling impairs the tumor promoting effect of bone marrow-derived mesenchymal stem cell in colon cancer (2011)
  • Author(s): Shinagawa K
  • Organizer: The 102nd Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Orland, Florida (USA)
• [Presentation] Novel diagnostic and therapeutic targets of gastric cancer identified by "Omics" study (2011)
  • Author(s): Yasui W
  • Organizer: 9^<th> International Gastric Cancer Congress
  • Place of Presentation: Seoul (Korea)(招待講演)
• [Presentation] Gene expression profile in scirrhous type gastric cancer by CAST method (2011)
  • Author(s): Oo HZ
  • Organizer: 9^<th> International Gastric Cancer Congress
  • Place of Presentation: Seoul (Korea)
• [Presentation] microRNA expression profiles in gastric cancer : miR-148a is down-regulated in gastric cancer and involved in gastric cancer invasion by repression of MMP7 expression (2011)
  • Author(s): Sakamoto N
  • Organizer: 9^<th> International Gastric Cancer Congress
  • Place of Presentation: Seoul (Korea)
• [Presentation] Unique microRNA signatures associated with progression and prognosis of gastric cancer (2011)
  • Author(s): Ueda T
  • Organizer: 9^<th> International Gastric Cancer Congress
  • Place of Presentation: Seoul (Korea)
• [Presentation] Identification of transmembrane protein in prostate cancer by the Escherichia coli ampicillin secretion trap : expression of CDON is involved in tumor cell growth and invasion (2011)
  • Author(s): Hayashi T
  • Organizer: The 2011 Annual Meeting of the American Urological Association
  • Place of Presentation: Washington D.C.(USA)
• [Presentation] Identification of novel diagnstic and therapeutic targets of gastric cancer by transcriptome dissection (2011)
  • Author(s): Yasui W
  • Organizer: The Third CREAST-SBM International Conference
  • Place of Presentation: Hiroshima (Japan)(招待講演)
• [Presentation] Gene expression profile of scirrhous type gastric cancer analyzed by CAST method (2011)
  • Author(s): Oo HZ
  • Organizer: 8^<th> International Symposium on Minimal Residual Cancer
  • Place of Presentation: Osaka (Japan)
• [Presentation] Overexpression of SEC11A is associated with tumor progression through TGF-alpha secretion in gastric cancer (2011)
  • Author(s): Oue N
  • Organizer: 8^<th> International Symposium on Minimal Residual Cancer
  • Place of Presentation: Osaka (Japan)
• [Presentation] 胃癌の発生・進展の分子機序のマイルストーン (2011)
  • Author(s): 安井弥
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜(招待講演)
• [Presentation] CAST法で同定されたTSPAN8の胃型胃癌における発現と機能解析 (2011)
  • Author(s): 阿南勝宏
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
• [Presentation] SAGE-based microarrayにより同定したSEC11A (SPC18)はTGF-a万分泌を促進し胃癌の進行に関連している (2011)
  • Author(s): 大上直秀
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
• [Presentation] 胃癌組織を用いたCAST法による解析:新規マーカーTM9SF3の同定 (2011)
  • Author(s): Htoo Zarni Oo
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
• [Presentation] 大腸癌増殖・転移促進作用における骨髄由来間葉系幹細胞の重要性とPDGF/レセプター系の関与 (2011)
  • Author(s): 品川慶
  • Organizer: 第20回日本がん転移学会学術集会・総会
  • Place of Presentation: 浜松(招待講演)
• [Presentation] miR-21の発現は大腸癌の予後、薬剤感受性に関与する (2011)
  • Author(s): 大上直秀
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 胃癌で発現低下しているmiR-148aはMMP7を標的とし、浸潤に関与する (2011)
  • Author(s): 坂本直也
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Molecular basis of intestinal and gastric phenotypes of gastric cancer (2010)
  • Author(s): YasuiW
  • Organizer: The 17th Seoul International Cancer Symposium" Gastric Cancer Update 2010"
  • Place of Presentation: Seoul(Korea)
  • Year and Date: 2010-06-01
• [Presentation] Molecular basis of intestinal and gastric phenotypes of gastric cancer (2010)
  • Author(s): Yasui W
  • Organizer: The 17^<th> Seoul International Cancer Symposium "Gastric Cancer Update 2010"
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2010-06-01
• [Presentation] トランスクリプトーム解析による新規診断標的の同定とがん病理診断への応用 (2010)
  • Author(s): 安井弥
  • Organizer: 第69回日本癌学会学術総会、シンポジウム5
  • Place of Presentation: 大阪
• [Presentation] 胃癌の進行と予後に関与するmicroRNAの探索 (2010)
  • Author(s): 上田哲也、StefanoVolinia、奥村浩、Chang-goneLiu、大上直秀、安井弥、吉田和弘、佐々木博己、野村幸世、瀬戸泰之、上西紀夫、GeorgeA. Calin、CarloM. Croce
  • Organizer: 第69回日本癌学会学術総会、インターナショナルセッション8
  • Place of Presentation: 大阪
• [Presentation] 胃癌における細胞表面蛋白質desmocollin2の解析 (2010)
  • Author(s): 大上直秀、阿南勝宏、内藤寛、坂本直也、仙谷和弘、安井弥
  • Organizer: 第19回日本がん転移学会学術集会・総会ミニシンポジウム(2)
  • Place of Presentation: 金沢
• [Presentation] Desmocollin 2(DSC2), identified by CAST method, is associated with intestinal phenotype of gastric cancer (2010)
  • Author(s): AnamiK, OueN, SakamotoN, HayashiT, OharaS, SentaniK, NoguchiT and Yasui W
  • Organizer: The 101st Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Maryland(USA)
• [Presentation] Serial Analysis of gene expression(SAGE) of esophageal squamous cell carcinoma : ADAMTS-l66 is up-regulated in esophageal squamous cell carcinoma (2010)
  • Author(s): SakamotoN, OueN, NoguchiT, SentaniK, AnamiK, SanadaY, YoshidaK and YasuiW
  • Organizer: The 101st Annual Meeting of the American Association for Cancer Research, Washington D. C.
  • Place of Presentation: Maryland(USA)
• [Presentation] Analyses of novel genes encoding secreted and transmembrane proteins identified by CAST method : Cdon is highly expressed in prostate cancer (2010)
  • Author(s): Hayashi T, Yasui W
  • Organizer: The 101st Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Washington D.C., USA
• [Presentation] Desmocollin 2 (DSC2), identified by CAST method, is associated with intestinal phenotype of gastric cancer (2010)
  • Author(s): Anami K, Yasui w
  • Organizer: The 101st Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Washington D.C., USA
• [Presentation] Serial Analysis of gene expression (SAGE) of esophageal squamous cell carcinoma : ADAMTS-16 is up-regulated in esophageal squamous cell carcinoma (2010)
  • Author(s): Sakamoto N, Yasui W
  • Organizer: The 101st Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Washington D.C., USA
• [Presentation] Immunohistochemical analysis of colorectal cancer with gastric phenotype : claudin-18 is associated with poor prognosis (2010)
  • Author(s): Sentani K, Yasui W
  • Organizer: The 198th Scientific Meeting of the Pathological Society of Great Britain & Ireland
  • Place of Presentation: St Andrews (Scotland), UK
• [Presentation] Novel diagnostic and therapeutic targets of gastrointestinal cancer, identified by "Omics" study (2010)
  • Author(s): Yasui W
  • Organizer: The 9^<th> International Conference of the Asian Clinical Oncology Society
  • Place of Presentation: Gifu, Japan(招待講演)
• [Presentation] 胃癌におけるDSC2発現と腸型粘液形質との関係 (2010)
  • Author(s): 阿南勝宏、安井弥
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] ホルマリン固定パラフィン包埋(FFPE)標本を用いた胃癌におけるmicroRNA発現解析 (2010)
  • Author(s): 坂本直也、安井弥
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 胃癌における細胞表面蛋白質desmocollin2の解析 (2010)
  • Author(s): 大上直秀、安井弥
  • Organizer: 第19回日本がん転移学会学術集会・総会
  • Place of Presentation: 金沢(招待講演)
• [Presentation] 前立腺癌におけるCDONの発現と増殖・浸潤との関連 (2010)
  • Author(s): 林哲太郎、安井弥
  • Organizer: 第19回日本がん転移学会学術集会・総会
  • Place of Presentation: 金沢
• [Presentation] トランスクリプトーム解析による新規診断標的の同定とがん病理診断への応用 (2010)
  • Author(s): 安井弥
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪(招待講演)
• [Presentation] 胃癌におけるmicroRNA発現解析:miR-148aの胃癌組織における発現低下 (2010)
  • Author(s): 坂本直也、安井弥
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
• [Presentation] 胃癌細胞株を用いたCAST法による胃癌特異的な分泌・膜蛋白質の同定 (2010)
  • Author(s): 阿南勝宏、安井弥
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
• [Presentation] 胃癌組織を用いたCAST法による胃癌の新たなバイオマーカーの探索 (2010)
  • Author(s): 安井弥
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
• [Presentation] 前立腺癌細胞株において発現している分泌/膜貫通蛋白質のCAST法を用いた解析 (2010)
  • Author(s): 坂根潤一、安井弥
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
• [Presentation] CAST法で同定された胃型胃癌関連分子TSPAN8の解析 (2010)
  • Author(s): 阿南勝宏、安井弥
  • Organizer: 第21回日本消化器癌発生学会総会
  • Place of Presentation: 軽井沢
• [Presentation] 胃がんの新規診断治療標的の同定と展開 (2009)
  • Author(s): 安井弥
  • Organizer: 第68回日本癌学会学術総会、シンポジウム
  • Place of Presentation: 横浜
• [Presentation] 胃がんの組織像とオーミクス (2009)
  • Author(s): 安井弥
  • Organizer: 第6回日本病理学会カンファレンス、レクチャー
  • Place of Presentation: 筑波
• [Presentation] Identification of potential therapeutic targets in gastric cancer by basic and translational research state of art lecture- (2009)
  • Author(s): YasuiW
  • Organizer: 8^<th> International Gastric Cancer Congress, Lectureat Plenary session 1
  • Place of Presentation: Krakow(Poland)
• [Presentation] Olfactomedin 4 in combination with Reg IV have utility in the early detection of gastric cancer (2009)
  • Author(s): Oue N, Yasui W
  • Organizer: The 100th Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Colorado (USA)
• [Presentation] Induction of intestinal phenotype in gastric cancer by EGFR signaling (2009)
  • Author(s): Sakamoto N, Yasui W
  • Organizer: The 100th Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Colorado (USA)
• [Presentation] Usefulness of Reg IV and claudin-18 immunostaining in the diagnosis of gastrointestinal signet ring cell carcinoma (2009)
  • Author(s): 仙谷和弘, 安井弥
  • Organizer: 8^<th> International Gastric Cancer Congress
  • Place of Presentation: Krakow (Poland)
• [Presentation] Identification of potential therapeutic targets in gastric cancer by basic and translational research-state of art lecture- (2009)
  • Author(s): 安井弥
  • Organizer: 8^<th> International Gastric Cancer Congress
  • Place of Presentation: Krakow (Poland)
• [Presentation] Identification of novel genes encoding secretory and transmembrane protein in gastric cancer using CAST method (2009)
  • Author(s): 阿南勝宏, 安井弥
  • Organizer: 8^<th> International Gastric Cancer Congress
  • Place of Presentation: Krakow (Poland)
• [Presentation] 胃癌における olfactomedin 4の発現と血清腫瘍マーカーとしての意義 (2009)
  • Author(s): 大上直秀, 安井弥
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会館(京都市)
• [Presentation] ADAMTS 16は食道癌において高発現しており, 浸潤を促進する (2009)
  • Author(s): 本下潤一, 安井弥
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会館(京都市)
• [Presentation] 遺伝子発現プロファイルで同定されたHOXA 10の胃癌における解析 (2009)
  • Author(s): 仙谷和弘, 安井弥
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会館(京都市)
• [Presentation] CAST法を用いた胃癌における分泌・膜蛋白の同定 (2009)
  • Author(s): 阿南勝宏, 安井弥
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会館(京都市)
• [Presentation] 胃がんの組織像とオーミクス (2009)
  • Author(s): 安井弥
  • Organizer: 第6回日本病理学会カンファレンス
  • Place of Presentation: つくば国際会議場(つくば市)
• [Presentation] 胃がんの新規診断治療標・的の同定と展開 (2009)
  • Author(s): 安井弥
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] SAGE法を用いた食道扁平上皮癌における新規マーカーの同定 (2009)
  • Author(s): 本下潤一, 安井弥
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] CAST法で同定された胃がんにおける分泌・膜蛋白質の解析 (2009)
  • Author(s): 阿南勝宏, 安井弥
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフイコ横浜(横浜市)
• [Presentation] 分泌/膜貫通蛋白質のCAST法を用いた解析:CDONは前立腺癌で高発現している膜貫通蛋白である (2009)
  • Author(s): 林哲太郎, 安井弥
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] 胃癌におけるサイトケラチン発現パターンと各種がん関連分子の発現との相関 (2009)
  • Author(s): 高見北斗, 安井弥
  • Organizer: 第68回角本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] 新しい診断・治療標的同定へのオーミクス解析によるアプローチ (2009)
  • Author(s): 安井弥
  • Organizer: 第20回日本消化器癌発生学会
  • Place of Presentation: オリエンタルホテル広島(広島市)
• [Presentation] 胃癌におけるDSC2発現と腸型粘液形質との関連 (2009)
  • Author(s): 阿南勝宏, 安井弥
  • Organizer: 第20回日本消化器癌発生学会
  • Place of Presentation: オリエンタルホテル広島(広島市)
• [Book] Principle of molecular diagnostics and personalized cancer therapy (2012)
  • Author(s): Yasui W
  • Publisher: Lippincott Williams & Wilkins(印刷中)
• [Book] スキルス胃癌-基礎と臨床-改訂版 (2010)
  • Author(s): 安井弥、本下潤一、大上直秀
  • Total Pages: 435
  • Publisher: 医薬ジャーナル社
• [Book] Histological and serological tumor markers and their clinical usefulness in cancers (2010)
  • Author(s): Yasui W
  • Total Pages: 512
  • Publisher: Nova Publishers, New York
• [Book] Histoogical and serological tumor markers of gastric cancer. In Histological and serological tumor markers and their clinical usefulness in cancers, ed. By Dan Hellberg (2009)
  • Author(s): YasuiW, SentaniK, SakamotoN, MotoshitaJandOueN
  • Publisher: Nova Science Publishers, NewYork
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/byori1/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/byoril/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/byoril/kenkyu_gyouseki.html