Telomere dysfunction and chromosomal instability in uninvolved tissue with carcinoma by original FISH
| Project/Area Number |
21390109
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
TAKUBO Kaiyo 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (00154956)
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| Co-Investigator(Renkei-kenkyūsha) |
AIDA Junko 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (80425678)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | テロメア / FISH / 染色体不安定性 / ヒト癌 / FISH法 / 組織切片 / 老化 / 癌化 / Q-FISH法 |
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| Research Abstract |
1.We demonstrated telomere dysfunction in the uninvolved epithelium with esophageal squamous cell carcinoma and telomere shortening occurred due to excessive alcohol consumption. 2.We first demonstrated excessive telomere shortening of the epidermis in Werner's syndrome patients. 3.We reported the annual reduction-rate of telomere in the human pituitary gland.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Short telomeres in an oral precancerous lesion : Q-FISH analysis of leukoplakia2012
Author(s)
Aida J, Kobayashi T, Saku T, Yamaguchi M, Shimomura N, Nakamura KI, Ishikawa N, Maruyama S, Cheng J, Poon SS, Sawabe M, aida T, Takubo K.
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Journal Title
Journal of Oral pathology & Medicine
Volume: 41(5)
Pages: 372-378
DOI
Related Report
Peer Reviewed
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[Journal Article] Hepatocellular Telomere Length in Biliary Atresia Measured by Q-FISH2012
Author(s)
Sanada Y, Aida J, Kawano Y, Nakamura KI, Shimomura N, Ishikawa N, Arai T, Poon SS, Yamada N, Okada N, Wakiya T, Hayashida M, Saito T, Egami S, Hishikawa S, Ihara Y, Urahashi T, Mizuta K, Yasuda Y, Kawarasaki H, Takubo K.
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Journal Title
World J Surg
Volume: 36
Pages: 908-16
DOI
Related Report
Peer Reviewed
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[Journal Article] Palisade vessels as a new histologic marker of esophageal origin in ER Specimens from columnar-lined esophagus2011
Author(s)
Aida J, Vieth M, Ell C, May A, Pech O, Hoshihara Y, Kumagai Y, Kawada K, Hishima T, Tateishi Y, Sawabe M, Arai T, Matsuura M, Takubo K
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Journal Title
Am J Surg Pathol
Volume: 36
Pages: 1140-1145
DOI
Related Report
Peer Reviewed
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[Journal Article] Accelerated in vivo epidermal telomere loss in Werner syndrome2011
Author(s)
Ishikawa N, Nakamura K, Izumiyama-Shimomura N, Aida J, Ishii A, Goto M, Ishikawa Y, Asaka R, Matsuura M, Hatamochi A, Kuroiwa M, Takubo K
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Journal Title
Aging
Volume: 3
Pages: 417-429
Related Report
Peer Reviewed
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[Journal Article] Alcoholics show reduced telomere length in the oesophagus2011
Author(s)
Aida J, Yokoyama A, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SSS, Fujiwara M, Sawabe M, Matsuura M, Arai T, Takubo K
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Journal Title
J Pathol
Volume: 223
Pages: 410-416
DOI
URL
Related Report
Peer Reviewed
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[Journal Article] Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence2010
Author(s)
Takubo K, Aida J, Izumiyama N, Ishikawa N, Fujiwara M. Poon SSS, Kondo H, Kammori M, Matsuura M, Sawabe M, Arai T, Baird DM, Nakamura K
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Journal Title
Mech Age Dev
Volume: 131
Pages: 614-624
DOI
Related Report
Peer Reviewed
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[Journal Article] Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ2010
Author(s)
Takubo K, Fujita M, Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Grabsch H, Arai T, Aida J
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Journal Title
J Pathol
Volume: 221
Pages: 201-209
DOI
URL
Related Report
Peer Reviewed
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