Analysis of lung adenocarcinoma according to molecular biological classification
Project/Area Number |
21390110
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Aichi Cancer Center Research Institute |
Principal Investigator |
YATABE Yasushi 愛知県がんセンター(研究所), 分子腫瘍学部, 研究員 (90280809)
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Co-Investigator(Kenkyū-buntansha) |
MITSUDOMI Tetsuya 愛知県がんセンター研究所, 分子腫瘍学部, 研究員 (70209807)
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Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Takashi 名古屋大学, 大学院・医学研究科, 教授 (50231395)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
|
Keywords | 呼吸器 / 縦隔(肺腺癌、分子病理学) / 肺癌 / 遺伝子変異 / 上皮増殖因子受容体 / 腺癌 / KRAS遺伝子 / 生物学的腫瘍分類 / 腫瘍内多様性 / ALK遺伝子 |
Research Abstract |
We carried out this study according to four themes that we initially laid out. For analysis of preinvasive and in-situ lesions, we could establish definition of adenocarcinoma in-situ in the new adenocarcinoma classification as a member of the IASLC pathology panel. We are still analyzing multiple lesions using SNP array that is of our second theme. To the third theme of intra-tumor heterogeneity, we could show that different EGFR mutation status within individual tumors was caused by combination of heterogeneous distribution of gene amplification and mutation allele specific imbalance, and we called the phenomenon"pseudo-heterogeneity". We have also achieved sufficient results for the fourth theme, because we participated in international collaborative studies to establish ALK diagnostic algorithm and established it as a guidance requested from the Japanese Lung Cancer Association.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article]2011
Author(s)
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y
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Journal Title
J Thorac Oncol
Volume: 6
Pages: 244-85
Related Report
Peer Reviewed
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[Journal Article] ALK Lung Cancer Study Group. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors2010
Author(s)
Choi YL, Soda M, Yamashita Y, Ueno T, Takashima J, Nakajima T, Yatabe Y, Takeuchi K, Hamada T, Haruta H, Ishikawa Y, Kimura H, Mitsudomi T, Tanio Y, Mano H
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Journal Title
N Engl J Med
Volume: 363
Pages: 1734-9
Related Report
Peer Reviewed
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[Journal Article] Regulation of DNA Polymerase Pold4 Influences Genomic Instability in Lung Cancer2010
Author(s)
Huang QM, Tomida S, Masuda Y, Arima C, Cao K, Kasahara TA, Osada H, Yatabe Y, Akashi T, Kamiya K, Takahashi T, Suzuki M.
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Journal Title
Cancer Res
Volume: 70
Pages: 8407-16
Related Report
Peer Reviewed
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[Journal Article] Pathologic Diagnosis of Advanced Lung Cancer Based on Small Biopsies and Cytology2010
Author(s)
Travis WD, Rekhtman N, Riley GJ, Geisinger KR, Asamura H, Brambilla E, Garg K, Hirsch FR, Noguchi M, Powell CA, Rusch VW, Scagliotti G, Yatabe Y.
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Journal Title
J Thorac Oncol
Volume: 5
Pages: 411-4
Related Report
Peer Reviewed
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[Journal Article] Combined Inhibition of Met and Egfr Suppresses Proliferation of Malignant Mesothelioma Cells2009
Author(s)
Kawaguchi K, Murakami H, Taniguchi T, Fujii M, Kawata S, Fukui T, Kondo Y, Osada H, Usami N, Yokoi K, Ueda Y, Yatabe Y, Ito M, Horio Y, Hida T, Sekido Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Egfr and Her2 Genomic Gain in Recurrent Non-Small Cell Lung Cancer after Surgery : Impact on Outcome to Treatment with Gefitinib and Association with Egfr and Kras Mutations in a Japanese Cohort2009
Author(s)
Varella-Garcia M, Mitsudomi T, Yatabe Y, Kosaka T, Nakajima E, Xavier AC, Skokan M, Zeng C, Franklin WA, Bunn PA, Jr., Hirsch FR
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Journal Title
J Thorac Oncol.
Volume: 4
Pages: 318-25
Related Report
Peer Reviewed
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