| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Research Abstract |
We carried out this study according to four themes that we initially laid out. For analysis of preinvasive and in-situ lesions, we could establish definition of adenocarcinoma in-situ in the new adenocarcinoma classification as a member of the IASLC pathology panel. We are still analyzing multiple lesions using SNP array that is of our second theme. To the third theme of intra-tumor heterogeneity, we could show that different EGFR mutation status within individual tumors was caused by combination of heterogeneous distribution of gene amplification and mutation allele specific imbalance, and we called the phenomenon"pseudo-heterogeneity". We have also achieved sufficient results for the fourth theme, because we participated in international collaborative studies to establish ALK diagnostic algorithm and established it as a guidance requested from the Japanese Lung Cancer Association.
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