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Abnormal NKG2D ligand expression and disease

Research Project

Project/Area Number 21390112
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionHokkaido University

Principal Investigator

KASAHARA Masanori  北海道大学, 大学院・医学研究科, 教授 (30241318)

Co-Investigator(Kenkyū-buntansha) FUGO Kazunori  北海道大学, 大学院・医学研究科, 助教 (20431306)
OTSUKA Noriyuki  北海道大学, 大学院・医学研究科, 助教 (00447046)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
KeywordsNKG2D / ナチュラルキラー細胞 / 活性化リガンド / MHC / 皮膚免疫 / γ/δT細胞 / がん / 免疫監視
Research Abstract

NKG2D ligands are major histocompatibility complex class I-like molecules whose expression is induced by cellular stresses such as transformation and viral infections. They function as danger signals alerting the immune system to the presence of unhealthy, stressed cells. In the present study, we analyzed the structure and function of NKG2D ligands, and their role in pathologic processes, with emphasis on the analysis of H60c, a mouse NKG2D ligand identified in our laboratory.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (106 results)

All 2012 2011 2010 2009 Other

All Journal Article (40 results) (of which Peer Reviewed: 36 results) Presentation (56 results) Book (9 results) Remarks (1 results)

  • [Journal Article] 脊椎動物における抗原受容体の選択-相同リンパ球に発現される由来の異なる受容体2012

    • Author(s)
      須藤洋一, 笠原正典
    • Journal Title

      化学と生物

      Volume: (印刷中)

    • NAID

      10031123200

    • Related Report
      2011 Final Research Report
  • [Journal Article] Proteasome subunit β5t expression in cervical ectopic thymoma2012

    • Author(s)
      Tomaru, U., Yamada, Y., Ishizu, A., Kuroda, T., Matsuno, Y. and Kasahara, M
    • Journal Title

      J. Clin. Pathol.

      Volume: 65(9) Issue: 9 Pages: 858-859

    • DOI

      10.1136/jclinpath-2012-200820

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair2012

    • Author(s)
      Yoshida, S., Mohamed, R. H., Kajikawa, M., Koizumi, J., Tanaka, M., Fugo, K., Otsuka, N., Maenaka, K., Yagita, H., Chiba, H. and Kasahara, M.
    • Journal Title

      J. Immunol

      Volume: 188 Pages: 3972-3979

    • NAID

      10031131120

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities2012

    • Author(s)
      Tomaru, U., Takahashi, S., Ishizu, A., Miyatake, Y., Gohda, A., Suzuki, S., Ono, A., Ohara, J., Baba, T., Murata, S., Tanaka, K. and Kasahara, M
    • Journal Title

      Am. J. Pathol

      Volume: 180 Pages: 963-972

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] VLR-based adaptive immunity2012

    • Author(s)
      Boehm, T., McCurley, N., Sutoh, Y., Schorpp, M., Kasahara, M. and Cooper, M. D.
    • Journal Title

      Annu. Rev. Immunol.

      Volume: 30 Pages: 203-220

    • Related Report
      2011 Final Research Report
  • [Journal Article] Comparative genomic analysis of the proteasome β5t subunit gene : implications for the origin and evolution of thymoproteasomes2012

    • Author(s)
      Sutoh, Y., Kondo, M., Ohta, Y., Ota, T., Tomaru, U., Flajnik, M. F. and Kasahara, M.
    • Journal Title

      Immunogenetics

      Volume: 64 Pages: 49-58

    • NAID

      120005090593

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative genomic analysis of the proteasome β5t subunit gene : implications for the origin and evolution of thymoproteasomes2012

    • Author(s)
      Sutoh, Y., Kondo, M., Ohta, Y., Ota, T., Tomaru, U., Flajnik, M., Kasahara, M.
    • Journal Title

      Immunogenetics

      Volume: 64 Issue: 1 Pages: 49-58

    • DOI

      10.1007/s00251-011-0558-0

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VLR-based adaptive immunity2012

    • Author(s)
      Boehm, T.
    • Journal Title

      Annu.Rev.Immunol.

      Volume: 30 Issue: 1 Pages: 203-220

    • DOI

      10.1146/annurev-immunol-020711-075038

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities2012

    • Author(s)
      Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, Kasahara M
    • Journal Title

      Am.J.Pathol.

      Volume: 180 Issue: 3 Pages: 963-972

    • DOI

      10.1016/j.ajpath.2011.11.012

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair2012

    • Author(s)
      Yoshida, S.
    • Journal Title

      J.Immunol.

      Volume: 188 Issue: 8 Pages: 3972-3979

    • DOI

      10.4049/jimmunol.1102886

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteasome subunit β5t expression in cervical ectopic thymoma2012

    • Author(s)
      Tomaru, U.
    • Journal Title

      J.Clin.Pathol.

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immune system : evolutionary pressure of infectious agents2011

    • Author(s)
      Kasahara, M.
    • Journal Title

      In : D. N. Cooper and H. Kehrer-Sawatzki (eds.) : Encyclopedia of Life Sciences, John Wiley & Sons, Chichester, UK

    • DOI

      10.1002/9780470015902.a0001131.pub2

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of proteasome subunit 5t in thymic epithelial tumors2011

    • Author(s)
      Yamada, Y., Tomaru, U., Ishizu, A., Kiuchi, T., Marukawa, K., Matsuno, Y. and Kasahara, M.
    • Journal Title

      Am. J. Surg. Pathol

      Volume: 35 Pages: 1296-1304

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum-dependent, antibody and Fcγ receptor-mediated translocation of CD8 molecules from T cells to monocytes2011

    • Author(s)
      Iwasaki, S., Masuda, S., Baba, T., Tomaru, U., Katsumata, K., Kasahara, M. and Ishizu, A.
    • Journal Title

      Cytometry

      Volume: 79A Pages: 46-56

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum-dependent, antibody and Fc_Y receptor-mediated translocation of CD8 molecules from T cells to monocytes2011

    • Author(s)
      Iwasaki, S.
    • Journal Title

      Cytometry

      Volume: 79A Issue: 1 Pages: 46-56

    • DOI

      10.1002/cyto.a.20984

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of proteasome subunit β5t in thymic epithelial tumors2011

    • Author(s)
      Yamada, Y.
    • Journal Title

      Am.J.Surg.Pathol.

      Volume: 35 Issue: 9 Pages: 1296-1304

    • DOI

      10.1097/pas.0b013e3182237f5d

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum-dependent, antibody and Fe_Y receptor-mediated translocation of CD8 molecules from T cells to monocytes.2011

    • Author(s)
      Iwasaki, S., et al.
    • Journal Title

      Cytometry

      Volume: 79A Pages: 46-56

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 病原体認識戦略の進化2010

    • Author(s)
      笠松純, 瀬谷司, 笠原正典
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 54 Pages: 113-121

    • NAID

      40017263524

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Phylogenetic and expression analysis of lamprey Toll-like receptors2010

    • Author(s)
      Kasamatsu, J., Oshiumi, H., Matsumoto, M., Kasahara, M. and Seya, T.
    • Journal Title

      Dev. Comp. Immunol.

      Volume: 34 Pages: 855-865

    • NAID

      120002261717

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution2010

    • Author(s)
      Kondo, M., Maruoka, T., Otsuka, N., Kasamatsu, J., Fugo, K., Hanzawa, N. and Kasahara, M.
    • Journal Title

      Immunogenetics

      Volume: 62 Pages: 441-450

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a third variable lymphocyte receptor in the lamprey2010

    • Author(s)
      Kasamatsu, J., Sutoh, Y., Fugo, K., Otsuka, N., Iwabuchi, K. and Kasahara, M.
    • Journal Title

      Proc. Natl. Acad.Sci. USA

      Volume: 107 Pages: 14304-14308

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel type of E3-ligase for the Ufm1-conjugation system2010

    • Author(s)
      Tatsumi, K., Sou, Y.-S., Tada, N., Nakamura, E., Iemura, S., Natsume, T., Kang, S. H., Chung, C. H., Kasahara, M., Kominami, E., Yamamoto, M., Tanaka, K. and Komatsu, M.
    • Journal Title

      J. Biol. Chem.

      Volume: 285 Pages: 5417-5427

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Originand evolution of the adaptive immune system : genetic events and selective pressures2010

    • Author(s)
      Flajnik, M. F. and Kasahara, M.
    • Journal Title

      Nat. Rev. Genet.

      Volume: 11 Pages: 47-59

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Origin and evolution of the adaptive immune system : genetic events and selective pressures.2010

    • Author(s)
      Flajnik, M.F., Kasahara, M.
    • Journal Title

      Nat.Rev.Genet.

      Volume: 11 Pages: 47-59

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel type of E3-ligase for the Ufm 1-conjugation system.2010

    • Author(s)
      Tatsumi, K., et al.
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 5417-5427

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a third variable lymphocyte receptor in the lamprey.2010

    • Author(s)
      Kasamatsu, J., et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 107 Pages: 14304-14308

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution.2010

    • Author(s)
      Kondo, M., et al.
    • Journal Title

      Immunogenetics

      Volume: 62 Pages: 441-450

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome duplication and T cell immunity.2010

    • Author(s)
      Kasahara, M.
    • Journal Title

      Prog.Md.Biol.Transl.Sci.

      Volume: 92 Pages: 7-36

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phylogenetic and expression analysis of lamprey Toll-like receptors.2010

    • Author(s)
      Kasamatsu, J., et al.
    • Journal Title

      Dev.Comp.Immunol.

      Volume: 34 Pages: 855-865

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immune system : evolutionary pressure of infectious agents.2010

    • Author(s)
      Kasahara, M.
    • Journal Title

      Encyclopedia of Life Sciences

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Origin and evolution of the adaptive immune system : genetic events and selective pressures2010

    • Author(s)
      Flajnik, M.F.
    • Journal Title

      Nat.Rev.Genet. 11

      Pages: 47-59

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel type of E3-ligase for the Ufm1-conjugation system2010

    • Author(s)
      Tatsumi, K.
    • Journal Title

      J.Biol.Chem. 285

      Pages: 5417-5427

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a third variable lymphocyte receptor in the lamprey2010

    • Author(s)
      Kasamatsu, J.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 107(In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution2010

    • Author(s)
      Kondo, M.
    • Journal Title

      Immunogenetics 62(In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome duplication and T cell immunity2010

    • Author(s)
      Kasahara, M.
    • Journal Title

      Prog.Mol.Biol.Transl.Sci. 92(In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 非古典的MHCクラスI分子の構造と機能2009

    • Author(s)
      梶川瑞穂, 笠原正典
    • Journal Title

      生化学

      Volume: 81 Pages: 189-199

    • NAID

      10024916155

    • Related Report
      2011 Final Research Report
  • [Journal Article] Human endogenous retrovirus-R env glycoprotein as autoantigen in autoimmune disease2009

    • Author(s)
      Sasaki, N., Ogawa, Y., Tomaru, U., Katsumata, K., Tanaka, S., Otsuka, N., Kasahara, M., Yoshiki, T. and Ishizu, A.
    • Journal Title

      AIDS Res. Hum. Retroviruses

      Volume: 25 Pages: 889-896

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exclusive expression of proteasome subunit β5t in the human thymic cortex2009

    • Author(s)
      Tomaru, U, Ishizu, A., Murata, S., Miyatake, Y., Suzuki, S., Takahashi, S., Kazamaki, T., Ohara, J., Baba, T., Iwasaki, S., Fugo, K., Otsuka, N., Tanaka, K. and Kasahara, M.
    • Journal Title

      Blood

      Volume: 113 Pages: 5186-5191

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exclusive expression of proteasome subunit β5t in the human thymic cortex2009

    • Author(s)
      Tomaru, U.
    • Journal Title

      Blood 113

      Pages: 5186-5191

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human endogenous retrovirus-R env glycoprotein as autoantigen in autoimmune disease2009

    • Author(s)
      Sasaki, N.
    • Journal Title

      AIDS Res.Hum.Retroviruses 25

      Pages: 889-896

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Expression of thymoproteasome subunit β5t in type AB thymoma2012

    • Author(s)
      Yamada, Y.
    • Organizer
      101st Annual meeting of the USCAP
    • Place of Presentation
      Vancouver Convention Centre (Canada)
    • Year and Date
      2012-03-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Blockade of interactions between NKG2D and an NKG2D ligand H60c delays wound healing2011

    • Author(s)
      Rania Mohamed,吉田繁,小泉潤,富居一範,大塚紀幸,笠原正典
    • Organizer
      第44回北海道病理談話会
    • Place of Presentation
      旭川市国際会議場,旭川
    • Year and Date
      2011-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] プロテアソーム機能に着目した老化、脂質代謝異常の病態解明2011

    • Author(s)
      外丸詩野
    • Organizer
      第44回北海道病理談話会
    • Place of Presentation
      旭川市国際会議場(北海道)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Blockade of interactions between NKG2D and an NKG2D ligand H60c delays wound healing2011

    • Author(s)
      吉田繁
    • Organizer
      第44回北海道病理談話会
    • Place of Presentation
      旭川市国際会議場(北海道)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] TNFα変換酵素(TACE)の過剰発現が糖および脂質代謝へ及ぼす影響2011

    • Author(s)
      松井由希
    • Organizer
      第44回北海道病理談話会
    • Place of Presentation
      旭川市国際会議場(北海道)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胸腺プロテアソームの分子系統解析。特に、ゼブラフィッシュβ5tについて2011

    • Author(s)
      須藤洋一, 他
    • Organizer
      第30回日本胸腺研究会
    • Place of Presentation
      長崎(長崎大学医学部)
    • Year and Date
      2011-02-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胸腺上皮特異的マーカーを用いて確定診断に至った胸腺外胸腺腫の一例2011

    • Author(s)
      山田洋介, 他
    • Organizer
      第30回日本胸腺研究会
    • Place of Presentation
      長崎(長崎大学医学部)
    • Year and Date
      2011-02-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト癌組織におけるNKG2Dリガンドの発現2011

    • Author(s)
      藤田裕美,畑中豊,大塚紀幸,須藤洋一,久保田加奈子,三橋智子,笠原正典,松野吉宏
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知芸術文化センター,名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] NKG2Dリガンドの創傷治癒における役割の解析2011

    • Author(s)
      笠原正典,Rania Mohamed,小泉潤,富居一範,大塚紀幸,吉田繁
    • Organizer
      第20回日本組織適合性学会大会
    • Place of Presentation
      ツインメッセ静岡,静岡
    • Related Report
      2011 Final Research Report
  • [Presentation] 非古典的MHCクラスI分子の多様な機能2011

    • Author(s)
      笠原正典
    • Organizer
      第20回日本組織適合性学会大会
    • Place of Presentation
      ツインメッセ静岡,静岡
    • Related Report
      2011 Final Research Report
  • [Presentation] 胸腺プロテアソームの系統発生2011

    • Author(s)
      笠原正典,須藤洋一,外丸詩野
    • Organizer
      第23回日本比較免疫学会
    • Place of Presentation
      海洋研究開発機構横浜研究所,横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Structure and function of variable lymphocyte receptors : an update. Symposium Evolution and Diversity of Innate and Adaptive Immune Systems2011

    • Author(s)
      Kasahara, M., Sutoh, Y. and Kasamatsu, J.
    • Organizer
      International Congress of Comparative Physiology and Biochemistry
    • Place of Presentation
      Nagoya Congress Center,Nagoya, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of adaptive immune receptors in hagfish.2011

    • Author(s)
      Guo, P., Gartland, L. A., Li, J., Alder, M. N., Herrin, B. R., Sides, J. D., Kasahara, M. and Cooper, M. D.
    • Organizer
      American Association of Immunologists Meeting
    • Place of Presentation
      San Francisco, California, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒトNKG2Dリガンドの組織発現に関する免疫組織化学検討2011

    • Author(s)
      藤田裕美,須藤洋一,畑中豊,富居一範,大塚紀幸,松野吉宏,笠原正典
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      パシフィコ横浜,横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 体表組織におけるナチュラルキラー細胞活性化リガンドH60cの役割2011

    • Author(s)
      吉田繁,小泉潤,富居一範,近藤瑞穂,大塚紀幸,笠原正典
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      パシフィコ横浜,横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 母児間免疫寛容に関わるNKG2Dリガンド発現の解析2011

    • Author(s)
      大塚紀幸,近藤瑞穂,吉田繁,笠原正典
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      パシフィコ横浜,横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] プロテアソーム機能の低下と喫煙負荷がもたらす老化関連呼吸器系疾患の病態解明2011

    • Author(s)
      山田洋介
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 母児間免疫寛容に関わるNKG2Dリガンド発現の解析2011

    • Author(s)
      大塚紀幸
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 体表組織におけるナチュラルキラー細胞活性化リガンドH60cの役割2011

    • Author(s)
      吉田繁
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒトNKG2Dリガンドの組織発現に関する免疫組織化学検討2011

    • Author(s)
      藤田裕美
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] BCG接種語に判明した慢性肉芽腫症の一剖検例2011

    • Author(s)
      定本圭弘
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胸腺プロテアソームの異所性発現によるT細胞分化の異常2011

    • Author(s)
      小原次郎
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fcγ受容体を介したtrogocytosisの意義と制御機構の解析2011

    • Author(s)
      益田紗季子
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] TNFα変換酵素の過剰発現による炎症・線維化病態への影響2011

    • Author(s)
      松井由希
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 非古典的MHCクラスI分子の多様な機能2011

    • Author(s)
      笠原正典
    • Organizer
      第20回日本組織適合性学会大会
    • Place of Presentation
      ツインメッセ静岡(静岡県)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] NKG2Dリガンドの創傷治癒における役割の解析2011

    • Author(s)
      笠原正典
    • Organizer
      第20回日本組織適合性学会大会
    • Place of Presentation
      ツインメッセ静岡(静岡県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] New insights into cell-cell interactions between adult T-cell leukemia cells and endothelial cells2011

    • Author(s)
      Miyatake, Y
    • Organizer
      The XXV Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
    • Place of Presentation
      東京大学弥生講堂(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト癌組織におけるNKG2Dリガンドの発現2011

    • Author(s)
      藤田裕美
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知芸術文化センター(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロテアソーム活性の低下が腫瘍微小環境に与える影響:腫瘍増殖の抑制効果について2011

    • Author(s)
      小野綾子
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知芸術文化センター(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 皮膚における免疫監視に重要なNKG2DリガンドH60cの解析2010

    • Author(s)
      小泉潤,吉田繁,梶川瑞穂,近藤瑞穂,富居一範,大塚紀幸,前仲勝実,笠原正典
    • Organizer
      第99回北海道癌談話会例会
    • Place of Presentation
      北海道大学医学部臨床第3講堂,札幌
    • Year and Date
      2010-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 皮膚における免疫監視に重要なNKG2DリガンドH60cの解析2010

    • Author(s)
      小泉潤, 他
    • Organizer
      第99回北海道癌談話会例会
    • Place of Presentation
      札幌(北海道大学医学部)
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] プロテアソームの機能異常による病理作用2010

    • Author(s)
      高橋里実, 他
    • Organizer
      第99回北海道癌談話会例会
    • Place of Presentation
      札幌(北海道大学医学部)
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト末梢血に検出されるCD8陽性単球・顆粒球の解析2010

    • Author(s)
      益田紗季子, 他
    • Organizer
      第99回北海道癌談話会例会
    • Place of Presentation
      札幌(北海道大学医学部)
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] プロピルチオウラシル(PTU)投与によるANCA関連血管炎のモデル開発と病態解析2010

    • Author(s)
      中沢大悟, 他
    • Organizer
      第99回北海道癌談話会例会
    • Place of Presentation
      札幌(北海道大学医学部)
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] H60c is a specialized NKG2D ligand with a major role in immune surveillance at the body surface2010

    • Author(s)
      Yoshida, S., Fugo, K., Kajikawa, M., Kondo, M., Otsuka, N., Maenaka, K. and Kasahara, M.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe Convention Center, Kobe, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Skewed T cell development in mice with ectopic expression of thymoproteasome2010

    • Author(s)
      Tomaru, U., Suzuki, S., Ishizu, A., Takahashi, S., Ohara, J., Miyatake, Y., Murata, S., Tanaka, K. and Kasahara, M.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe Convention Center, Kobe, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution2010

    • Author(s)
      Kondo, M., Maruoka, T., Otsuka, N., Kasamatsu, J., Fugo, K., Hanzawa, N., and Kasahara, M.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe Convention Center,Kobe, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] 近交系マウスにおけるNKG2Dリガンド遺伝子のコピー数多型2010

    • Author(s)
      富居一範,皿田雄二,笠松純,近藤瑞穂,吉田繁,須藤洋一,大塚紀幸,笠原正典
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル,東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 粘膜免疫におけるナチュラルキラー細胞活性化リガンドH60cの役割2010

    • Author(s)
      吉田繁,富居一範,近藤瑞穂,大塚紀幸,笠原正典
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル,東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of variable lymphocyte receptors in hagfish2010

    • Author(s)
      Guo, P., Gartland, L. A., Alder, M. N, Herrin, B. R., Kasahara, M. and Cooper, M. D.
    • Organizer
      Keystone symposia Lymphocyte Activation and Gene Expression
    • Place of Presentation
      Breckenridge, Colorado, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] TNFα変換酵素(TACE)トランスジェニックマウスの解析2010

    • Author(s)
      深谷進司, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京(京王プラザホテル)
    • Related Report
      2010 Annual Research Report
  • [Presentation] プロテアソームサブユニットβ5tの胸腺腫における発現2010

    • Author(s)
      山田洋介, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京(京王プラザホテル)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト末梢血に検出されるCD8陽性単球・顆粒球の解析2010

    • Author(s)
      益田紗季子, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京(京王プラザホテル)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胸腺プロテアソームの異所性発現によるT細胞分化の異常2010

    • Author(s)
      鈴木小百合, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京(京王プラザホテル)
    • Related Report
      2010 Annual Research Report
  • [Presentation] プロテアソームの機能異常による病理作用2010

    • Author(s)
      高橋里美, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京(京王プラザホテル)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 粘膜免疫におけるナチュラルキラー細胞活性化リガンドH60cの役割2010

    • Author(s)
      吉田繁, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京(京王プラザホテル)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 近交系マウスにおけるNKG2Dリガンド遺伝子のコピー数多型2010

    • Author(s)
      富居一範, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京(京王プラザホテル)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution.2010

    • Author(s)
      Kondo, M., et al.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸(神戸ポートピアホテル)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Skewed T cell development in mice with ectopic expression of thymoproteasome.2010

    • Author(s)
      Tomaru, U., et al.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸(神戸ポートピアホテル)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Serum-dependent, antibody and Fcy receptor-mediated translocation of CD8 molecules from T cells to monocytes.2010

    • Author(s)
      Iwasaki, S., et al.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸(神戸ポートピアホテル)
    • Related Report
      2010 Annual Research Report
  • [Presentation] H60c is a specialized NKG2D ligand with a major role in immune surveillance at the body surface.2010

    • Author(s)
      Yoshida, S., et al.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸(神戸ポートピアホテル)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of a novel variable lymphocyte receptor : evidence for a third population of lymphocyte-like cells in the lamprey.2010

    • Author(s)
      Sutoh, Y., et al.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸(神戸ポートピアホテル)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 近交系マウスにおけるNKG2Dリガンド遺伝子のコピー数多型2009

    • Author(s)
      Fugo, K.
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] A mouse NKG2D ligand with a major role in skin immunity2009

    • Author(s)
      Yoshida, S.
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 哺乳類におけるNKG2D ligand領域の比較ゲノム解析2009

    • Author(s)
      近藤瑞穂,丸岡尊子,笠松純,大塚紀幸,吉田繁,富居一範,半澤直人,笠原正典
    • Organizer
      第11回日本進化学会大会
    • Place of Presentation
      北海道大学高等教育機能開発総合センター,札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] 哺乳類におけるNKG2D ligand領域の比較ゲノム解析2009

    • Author(s)
      近藤瑞穂,丸岡尊子,笠松純,大塚紀幸,吉田繁,富居一範,半澤直人,笠原正典
    • Organizer
      第21回日本比較免疫学会学術集会
    • Place of Presentation
      日本大学生物資源科学部本館3階中講堂,藤沢
    • Related Report
      2011 Final Research Report
  • [Book] 分子進化と分子系統樹,生化学事典2012

    • Author(s)
      笠原正典
    • Publisher
      朝倉書店,東京(印刷中)
    • Related Report
      2011 Final Research Report
  • [Book] 免疫システムの由来と成り立ち,現代生物科学入門,第5巻免疫・感染生物学2011

    • Author(s)
      笠原正典
    • Publisher
      岩波書店,東京
    • Related Report
      2011 Final Research Report
  • [Book] 現代生物科学入門,第5巻免疫・感染生物学2011

    • Author(s)
      笠原正典
    • Publisher
      岩波書店
    • Related Report
      2011 Annual Research Report
  • [Book] 現代生物科学入門,第5巻 免疫・感染生物学2011

    • Author(s)
      笠原正典
    • Publisher
      岩波書店
    • Related Report
      2010 Annual Research Report
  • [Book] 主要組織適合遺伝子複合体,ほか18項目,生物学辞典2010

    • Author(s)
      笠原正典
    • Publisher
      東京化学同人,東京
    • Related Report
      2011 Final Research Report
  • [Book] Genome duplication and T cell immunity, Development of T Cell Immunity, Progress in Molecular Biology and Translational Science (formerly, Progress in Nucleic Acid Research and MolecularBiology)2010

    • Author(s)
      Kasahara, M
    • Publisher
      Liston, A. (ed.), Elsevier, B.V.
    • Related Report
      2011 Final Research Report
  • [Book] 主物学辞典2010

    • Author(s)
      笠原正典
    • Publisher
      東京化学同人
    • Related Report
      2010 Annual Research Report
  • [Book] 主要組織適合遺伝子複合体,ほか15項目,医学大辞典第2版2009

    • Author(s)
      笠原正典
    • Publisher
      医学書院,東京
    • Related Report
      2011 Final Research Report
  • [Book] 免疫異常,NEWエッセンシャル病理学改訂6版2009

    • Author(s)
      外丸詩野,笠原正典
    • Publisher
      医歯薬出版
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.path1-hokudai.jp/path1/Welcome.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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