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Molecular basis for the functional regulation of intractable inflammatory disorders by Osteopontin

Research Project

Project/Area Number 21390113
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionHokkaido University

Principal Investigator

UEDE Toshimitsu  北海道大学, 遺伝子病制御研究所, 教授 (00160185)

Co-Investigator(Kenkyū-buntansha) MORIMOTO Junko  徳島大学, 疾患酵素学研究センター, 助教 (20451396)
MATSUI Yutaka  北海道大学, 遺伝子病制御研究所, 特任准教授 (30431381)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords炎症 / 細胞外マトリックス / Matricellular protein / α9β1インテグリン / 抗体医薬 / 難治性炎症性疾患 / アルファ9インテグリン / リンパ管上皮 / S1P / テナーシンC / ケモカイン受容体 / リンパ球動員阻害 / インテグリン / オステオポンチン / matricellular protein / α9インテグリン
Research Abstract

There is a distinct group of molecules within classical extracellular matrix proteins (ECM). These molecules should be called as matricellular proteins and we demonstrated that these proteins are involved in the pathogenesis of various intractable inflammatory disorders including rheumatoid arthritis and multiple sclerosis. Osteopontin (OPN) and tenascin-C (TN-C) are two examples and share common receptor, alpha9beta1 integrin and transducer intracellular signaling via this integrin receptor. Importantly, we found that OPN, TN-C and alpha9beta1 integrin are therapeutic targets in various inflammatory diseases and blocking monoclonal antibodies against OPN, TN-C and alpha9beta1 integrin can be future therapeutic antibody drugs.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (113 results)

All 2012 2011 2010 2009 Other

All Journal Article (37 results) (of which Peer Reviewed: 37 results) Presentation (72 results) (of which Invited: 4 results) Book (4 results)

  • [Journal Article] Extracellul- ar matrix protein Tenascin-C is req- uired in the bone marrow microenvio- nment primed for hematopoietic rege- neration2012

    • Author(s)
      Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasa- wa T, Suda T, Kubota Y
    • Journal Title

      Blood

      Volume: 119 Issue: 23 Pages: 5429-5437

    • DOI

      10.1182/blood-2011-11-393645

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteopontin regulates interleukin-17 production in hepatitis2012

    • Author(s)
      Diao H, Liu X, Wu Z, Kang L, Cui G, Morimoto J, Denhardt D, Rittling S, Iwakura Y, Uede T, Li L
    • Journal Title

      Cytokine

      Volume: 60 Issue: 1 Pages: 129-137

    • DOI

      10.1016/j.cyto.2012.06.287

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteopontin is critical to determine symptom sever- ity of influenza through the regula- tion of NK cell population2012

    • Author(s)
      Sato K, Iwai A, Nakayama Y, Morimot- o J, Takada A, Maruyama M, Kida H, Uede T, Miyazaki T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 417 Issue: 1 Pages: 274-279

    • DOI

      10.1016/j.bbrc.2011.11.100

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ATM-mediated DNA damage signals mediate immune escape through integrin αvβ3-dependent mechanisms.2012

    • Author(s)
      Jinushi M
    • Journal Title

      Cancer Res

      Volume: 72 Issue: 1 Pages: 56-65

    • DOI

      10.1158/0008-5472.can-11-2028

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17A deficiency accelerates unstable atherosclerotic plaque for mation in apolipoprotein E-deficient mice2012

    • Author(s)
      K.Danzaki
    • Journal Title

      Arterioscler Thromb Vase Biol

      Volume: 32 Issue: 2 Pages: 273-280

    • DOI

      10.1161/atvbaha.111.229997

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CLIPR-59 regulates TNF-α-induced apoptosis by controlling ubiquitination of RIP1.2012

    • Author(s)
      Fujikura D
    • Journal Title

      Cell Death Dis

      Volume: 52 Issue: 2 Pages: 9310-9315

    • DOI

      10.1038/cddis.2012.3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local delivery of AAV2-CTLA4lgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec2 mouse model of Sjögren’s syndrome.2012

    • Author(s)
      Yin H
    • Journal Title

      Arthritis Res Ther

      Volume: 14 Issue: 1

    • DOI

      10.1186/ar3753

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quinolone-induced upregulation of osteopontin gene promoter activity in human lung epithelial cell line A5492012

    • Author(s)
      Shiratori B
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 56 Issue: 6 Pages: 2868-2872

    • DOI

      10.1128/aac.06062-11

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteopontin plays a critical role in interstitial fibrosis but not glomerular sclerosis in diabetic nephropathy.2012

    • Author(s)
      Nagao T
    • Journal Title

      Nephron Extra

      Volume: 2 Issue: 1 Pages: 87-103

    • DOI

      10.1159/000337330

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.2012

    • Author(s)
      Chen C
    • Journal Title

      J Clin Invest

      Volume: 122 Issue: 8 Pages: 2916-2927

    • DOI

      10.1172/jci60387

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. S.2012

    • Author(s)
      Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J. V. Gorman, J. D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi.
    • Journal Title

      Nat. Immunol.

      Volume: 13 Issue: 9 Pages: 832-842

    • DOI

      10.1038/ni.2376

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteopontin modulates the generation of memory CD8+T cells during influenza virus infection2011

    • Author(s)
      Morimoto J, Sato K, Nakayama Y, Kim- ura C, Kajino K, Matsui Y, Miyazaki T, Uede T
    • Journal Title

      J Immunol

      Volume: 187 Issue: 11 Pages: 5671-83

    • DOI

      10.4049/jimmunol.1101825

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alpha9beta1 integrin-mediated signaling servesas an intrinsic regulator of pathog- enic Th17 cell generation2011

    • Author(s)
      Kanayama M, Morimoto J, Matsui Y, I- kesue M, Danzaki K, Kurotaki D, Ito K, Yoshida T, Uede T
    • Journal Title

      J Immunol

      Volume: 187 Issue: 11 Pages: 5851-64

    • DOI

      10.4049/jimmunol.1101524

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crucial role of the cryptic epitope SLAYGLR within osteopontinin renal crystal formation of mice2011

    • Author(s)
      Hamamoto S, Yasui T, Okada A, Hirose M, Matsui Y, Kon S, Sakai F, Kojima Y, Hayashi Y, Tozawa K, Uede T, Ko- hri K
    • Journal Title

      J Bone Miner Res

      Volume: 26 Issue: 12 Pages: 2967-77

    • DOI

      10.1002/jbmr.495

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alpha9beta1 Integrin-Mediated Signaling Serves as an Intrinsic Regulator of Pathogenic Th17 Cell Generation2011

    • Author(s)
      Kanayama M
    • Journal Title

      J Immunol

      Volume: 187(11) Pages: 5851-5864

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteopontin modulates the generation of memory CD8+T cells during influenza virus infection2011

    • Author(s)
      Morimoto J
    • Journal Title

      J Immunol

      Volume: 187(11) Pages: 5671-5683

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of osteopontin, a multifunctional protein, in allergy and asthma2011

    • Author(s)
      Konno S
    • Journal Title

      Clin Exp Allergy

      Volume: 41(10) Issue: 10 Pages: 1360-1366

    • DOI

      10.1111/j.1365-2222.2011.03775.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of experimental autoimmune uveoretinitis by blockade of osteopontin with small interfere-ing RNA2010

    • Author(s)
      Iwata D, Kitamura M, Kitaichi N, Sa- ito Y, Kon S, Namba K, Morimoto J, Ebihara A, Kitamei H, Yoshida K, Is- hida S, Ohno S, Uede T, Onoe K, Iwa- buchi K
    • Journal Title

      Exp Eye Res

      Volume: 90 Issue: 1 Pages: 41-48

    • DOI

      10.1016/j.exer.2009.09.008

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] An- tigen specific induction of osteopo- ntin contributes to the chronificat- ion of allergic contact dermatitis2010

    • Author(s)
      Seier AM, Renkl AC, Chulz GS, Uebele T, Ahrens T, Sindrilaru A, Iben S, Liaw L, Kon S, Uede T, Weiss JM
    • Journal Title

      Am J Pathol

      Volume: 176 Issue: 1 Pages: 246-258

    • DOI

      10.2353/ajpath.2010.090488

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] NMR characterization of intramolecular interaction of osteopontin, an intrinsically disordered protein with cryptic integrin-binding motifs.2010

    • Author(s)
      Y.Yamaguchi
    • Journal Title

      Biochemical and Biophysical Research Communications.

      Volume: 393 Pages: 487-491

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Osteopontin Reduces Liver Metastasis of Human Pancreatic Cancer Xenografts Injected into the Spleen in a Mouse Model.2010

    • Author(s)
      K.Ohno
    • Journal Title

      Surgery Today.

      Volume: 40 Pages: 347-356

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of interaction of alpha9 integrin with its ligands hinders the formation of granulation in cutaneous wound healing.2010

    • Author(s)
      Nakayama Y
    • Journal Title

      Lab Invest.

      Volume: 90(6) Pages: 881-894

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction.2010

    • Author(s)
      Tosa N
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 395(3) Pages: 356-360

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of experimental autoimmune uveoretinitis by blockade of osteopontin with small interfering RNA.2010

    • Author(s)
      D.Iwata
    • Journal Title

      Exp Eye Res. 90

      Pages: 41-48

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antigen-specific induction of osteopontin contributes to the chronification of allergic contact dermatitis.2010

    • Author(s)
      AM.Seier
    • Journal Title

      Am J Pathol. 176

      Pages: 246-258

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired angiogenic response in the cornea of mice lacking osteopontin.2010

    • Author(s)
      N.Fujita
    • Journal Title

      Invest Ophthalmol Vis Sci. 51

      Pages: 790-794

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The differential amino acid require- ment within osteopontin in alpha4and alpha9 integrin-mediated cell binding and migration2009

    • Author(s)
      Ito K, Kon S, Nakayama Y, Kurotaki D, Saito Y, Kanayama M, Kimura C, Diao H, Morimoto J, Matsui Y, Uede T
    • Journal Title

      Matrix Biol

      Volume: 28 Issue: 1 Pages: 11-19

    • DOI

      10.1016/j.matbio.2008.10.002

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alpha9 integrin and its lignads con- stitute critical joint microenviron- ments for development of autoimmune arthritis2009

    • Author(s)
      Kanayama M, Kurotaki D, Morimoto J, Asano T, Matsui Y, Nakayama Y, Saito Y, Ito K, Kimura C, Iwasaki N, Suzu ki K, Harada T, Li HM, Uehara J, Mi- yazaki T, Minami A, Kon S, Uede T
    • Journal Title

      J Immunol

      Volume: 182 Issue: 12 Pages: 8015-8025

    • DOI

      10.4049/jimmunol.0900725

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The differential amino acid requirement within osteopontin in alpha4 and alpha9 integrin-mediated cell binding and migration.2009

    • Author(s)
      K.Ito
    • Journal Title

      Matrix Biol. 28

      Pages: 11-19

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway.2009

    • Author(s)
      T.Haga
    • Journal Title

      J Mol Cell Cardiol. 46

      Pages: 719-727

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aplpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis.2009

    • Author(s)
      M.Kanayama
    • Journal Title

      J Immunol. 182

      Pages: 8015-8025

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New dual monoclonal ELISA for measuring plasma osteopontin as a biomarker associated with survival in prostate cancer : clinical validation and comparison of multiple ELISAs.2009

    • Author(s)
      PH.Anborgh
    • Journal Title

      Clin Chem. 55

      Pages: 895-903

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus.2009

    • Author(s)
      Y.Maeno
    • Journal Title

      Viral Immunol. 22

      Pages: 139-144

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteopontin is involved in migration of eosinophils in asthma.2009

    • Author(s)
      A.Takahashi
    • Journal Title

      Clin Exp Allergy. 39

      Pages: 1152-1159

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice.2009

    • Author(s)
      Y.Matsui
    • Journal Title

      Arthritis Rheum. 60

      Pages: 2362-2371

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of cathepsin K in synovium leads to progression of osteoarthritis in rabbits.2009

    • Author(s)
      D.Takahashi
    • Journal Title

      Arthritis Rheum. 60

      Pages: 2372-2380

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory role of DC-derived osteopontin in systemic allergen sensitization.2009

    • Author(s)
      M.Kurokawa
    • Journal Title

      Eur J Immunol. 39

      Pages: 3323-3330

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The role of matricellular p- roteins and their integrin receptors in generation of tumor tissue micr-oenvironments2012

    • Author(s)
      Uede T
    • Organizer
      第71回日本癌学会学術総会モーニングレクチャー
    • Place of Presentation
      札幌市教育文化会館(札幌)
    • Related Report
      2012 Final Research Report
  • [Presentation] Tissue matricellular protei- ns regulate effector Tcells from dr- aining lymph nodes via alpah9 integ- rin-signaling2012

    • Author(s)
      Uede T
    • Organizer
      FASEB summer research conference Osteopontin Biology
    • Place of Presentation
      Vermont Academy(USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] The role of splen-ic CD103+CD8α+cDCs in the inductionof CTL responses during respiratory virus infection2012

    • Author(s)
      Morimoto J, Kajino K, Danzaki K, Na- kayama Y, Uede T
    • Organizer
      99th Annual Meeting the American Association of Immunol- ogists
    • Place of Presentation
      Hynes Convention Center(USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] Regulation of autoimmunity by interaction of matricellular proteins and their integrin receptors.2012

    • Author(s)
      Toshimitsu Uede
    • Organizer
      Medical Science Forum Tokyo 2012 on Immunity for the Control of Autoimmune Diseases
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 細胞外マトリックスが創り出す関節リウマチ病巣及び局所リンパ節微小環境。2012

    • Author(s)
      上出利光
    • Organizer
      第101回日本病理学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オステオポンチン-インテグリン相互作用を標的とした新規成人T細胞白血病治療法の開発。2012

    • Author(s)
      前田直良
    • Organizer
      第23回日本生体防御学会学術総会
    • Place of Presentation
      品川区総合区民会館(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Tissue matoricellular proteins regulate effector Tcells from draining lymph nodes via alpha9integrin-signaling.2012

    • Author(s)
      Toshimitsu Uede
    • Organizer
      FASEB summer research conference Osteopontin Biology
    • Place of Presentation
      Vermont Academy(USA)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The role of splenic CD103+CD8α+cDCs in the induction of CTL responses during respiratory virus infection.2012

    • Author(s)
      Junko Morimoto
    • Organizer
      99th Annual Meeting The American Association of Immunologists
    • Place of Presentation
      Hynes Convention Center(USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The role of Syndecan-4 in the development of rheumatoid arthritis.2012

    • Author(s)
      Tsutomu Endo
    • Organizer
      99th Annual Meeting The American Association of Immunologists
    • Place of Presentation
      Hynes Convention Center(USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Osteopontin as a novel molecular target for antibody-mediated immunotherapy in adult T cell-leukemia.2012

    • Author(s)
      Naoyoshi Maeda
    • Organizer
      FASEB summer research conterence Osteopontin Biology
    • Place of Presentation
      Vermont Academy(USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The role of matricellular proteins and their integrin receptors in generation of tumortissue microenvironments.2012

    • Author(s)
      Toshimitsu Uede
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Osteopontin-integrin interaction as a molecular target for antibody-mediated immunotherapy in adult T-cell leukemia.2012

    • Author(s)
      Maeda Naoyoshi
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 乳癌細胞の増殖とリンパ節転移におけるα9β1インテグリンの機能解析。2012

    • Author(s)
      太田大地
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Monocyte specific marker positive CD103+CD11chi DCs appear in the spleen and produce complements during influenza virus infection.2012

    • Author(s)
      Morimoto Junko
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Role of Syndecan-4 in the development of rheumatoid arthritis.2012

    • Author(s)
      遠藤努
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Factor X発現抑制・欠損による細胞コレステロール吸収、及び動脈硬化症への関与。2012

    • Author(s)
      池末昌弘
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Osteopontin modulates the generation of memory CD8+T cells during influenza virus infection2011

    • Author(s)
      森本純子
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Th17細胞の分化におけるα9インテグリンの機能解析2011

    • Author(s)
      金山剛士
    • Organizer
      第91回北海道医学大会病理分科会・第44回北海道病理談話会
    • Place of Presentation
      旭川市国際会議場(旭川市)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Matricellular proteins as intrinsic regulators of tumor invasion and metastasis in tumor tissue microenvironments2011

    • Author(s)
      上出利光
    • Organizer
      平成23年度遺伝子病制御研究所共同研究集会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Interaction of α9 integrin on medullary sinus with its ligand regulates lymphocyte egress via regulating S1P transporter, Spns2 expression and2011

    • Author(s)
      Koyu Ito
    • Organizer
      98th Annual meeting the American Associaton of Immunoligists
    • Place of Presentation
      The Moscone Center (USA)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Alpha9beta1 Integrin-Mediated Signaling Serves as an Intrinsic Regulator of Pathogenic Th17 Cell Generation2011

    • Author(s)
      Masashi Kanayama
    • Organizer
      98th Annual meeting the American Associaton of Immunoligists
    • Place of Presentation
      The Moscone Center (USA)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] α9β1 integrin, as a critical regulator of lymphatic metastasis and growth of human breast cancer cells2011

    • Author(s)
      Daichi Ohta
    • Organizer
      American Association for Cancer Research 102nd Annual Meeting 2011
    • Place of Presentation
      Orange County Convention Center (USA)
    • Year and Date
      2011-04-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Interaction of alpha9 integrin on medullary sin-us with its ligand regulates lympho- cyte egress via regulating S1P tran- sporter, Spns2 expression and subse- quent S1P secretion under inflammat- ory condition2011

    • Author(s)
      Ito K, Matsui Y, Kurotaki D, Morimo- to J, Kihara A, Uede T
    • Organizer
      98th Annual Meeting the American Association of Immunol- ogists
    • Place of Presentation
      Moscone Center (USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] Alpha9 beta1 integ- rin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation2011

    • Author(s)
      Kanayama M, Morimoto J, Matsui Y, Y- oshida T, Uede T
    • Organizer
      98th Annual Meet-ing the American Association of Imm- unologists
    • Place of Presentation
      Moscone C- enter(USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] Alpha9 beta1 integrin, as a critical regulator of lymphat-ic metastasis and growth of human b- reast cancer cells2011

    • Author(s)
      Ohta D, Uede T
    • Organizer
      American Associ- ation for Cancer Research 102nd Annu- al Meeting 2011
    • Place of Presentation
      Orange County Convention Center(USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] Matricellular proteins and their integrin receptors-new drug targets for inflammatory disorders and cancers2010

    • Author(s)
      上出利光
    • Organizer
      Novo Nordisk Symposium
    • Place of Presentation
      Novo Nordisk(北京市・中国) 招待講演
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Osteopontin, a key intrinsic regulator of various intractable inflammatory disorders.2010

    • Author(s)
      上出利光
    • Organizer
      浙江大学講演会
    • Place of Presentation
      浙江大学(杭州市・中国) 招待講演
    • Year and Date
      2010-06-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] The aberrant interaction of matricellular proteins and integrins in pathological foci leads to infl- ammatory tissue damage2010

    • Author(s)
      Uede T
    • Organizer
      Invited spe- aker, FASEB summer research confere- nces
    • Place of Presentation
      The Steamboat Gra- nd Resort(USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] The role of osteopontin in the generation of virus-specific memory CD8T cells2010

    • Author(s)
      Morimoto J
    • Organizer
      Invited speaker, FASEB summer research conferences
    • Place of Presentation
      The Steamboat Grand Reso- rt(USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] 組織微小環境の内的調節因子、オステオポンチンの病態病理学2010

    • Author(s)
      上出利光
    • Organizer
      第99回日本病理学会総会宿題報告
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of Syndecan-4 in neointimal hyperplasia and atherosclerosis.2010

    • Author(s)
      Masahiro Ikesue
    • Organizer
      AHA's Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference
    • Place of Presentation
      Hilton Union Square(サンフランシスコ・USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Interleukin-17 Deficiency Accelerates Atherosclerotic Plaque Formation in Apolipoprotein E-Deficient Mice.2010

    • Author(s)
      Keiko Danzaki
    • Organizer
      ABA's Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference
    • Place of Presentation
      Hilton Union Square(サンフランシスコ・USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 組織微小環境の内的調節因子、オステオポンチンの病態病理学2010

    • Author(s)
      上出利光
    • Organizer
      第99回日本病理学会総会宿題報告
    • Place of Presentation
      京王プラザホテル(東京都) 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] 心筋梗塞におけるSyndecan4の機能解析2010

    • Author(s)
      松井裕
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 実験的自己免疫性脳脊髄炎におけるα9インテグリンの機能解析2010

    • Author(s)
      伊藤甲雄
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] α9インテグリンは滑膜細胞の炎症促進的な機能を制御する2010

    • Author(s)
      金山剛士
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Abrogation of integrin α9β1-mediated signaling skews the generation of functional Th17 cells in regional lymph nodes of arthritic mice.2010

    • Author(s)
      Masashi Kanayama
    • Organizer
      97^<th> Annual Meeting the American Association of Immunologists
    • Place of Presentation
      Baltimore Convention Center(ボルチモア・USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] リンパ管内皮細胞上のα9インテグリンはリンパ管リンパ節からの細胞の移出を調整する2010

    • Author(s)
      Koyu Ito
    • Organizer
      ゴードンリサーチカンファランス
    • Place of Presentation
      IL Ciocco Hotel and Resort(ルッカ・イタリア)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 動脈硬化の進展におけるInterleukin-17Aの役割の検討2010

    • Author(s)
      檀崎敬子
    • Organizer
      第21回日本生体防御学会学術総会
    • Place of Presentation
      仙台市戦災復興記念館(仙台市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] The aberrant interaction of matricellular proteins and integrins in pathological foci leads to inflammatory tissue damage.2010

    • Author(s)
      上出利光
    • Organizer
      FASEB summer research conferences
    • Place of Presentation
      The Steamboat Grand Resort(スティームボート・USA) 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] Alpha9 integrin is involved in the development of experimental autoimmune encephalomyelitis by regulating cell migration from lymph node.2010

    • Author(s)
      Koyu Ito
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] α9β1 integrin regulates the generation and egress of pathoge-nic Th17 cells in autoimmune arthritis.2010

    • Author(s)
      Masashi Kanayama
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of Syndecan-4 in Neointimal Hyperplasia and Atherosclerosis.2010

    • Author(s)
      Masahiro Ikesue
    • Organizer
      American Heart Association soientific sessions
    • Place of Presentation
      McCormick Place Convention Center(シカゴ・USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of osteopontin in the generation of virus-specific memory CD8T cells.2010

    • Author(s)
      Junko Morimoto
    • Organizer
      Cell Symposia
    • Place of Presentation
      Washington Marriott Hotel(ワシントン・USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Alpha9 integrin and its ligands con- stitute critical joint microenviron- ments for development of autoimmunearthritis2009

    • Author(s)
      Kanayama M, Kurotaki D, Morimoto J, Asano T, Matsui Y, Nakayama Y, Saito Y, Ito K, Kimura C, Iwasaki N, Suz- uki K, Harada T, Li HM, Uehara J, M- iyazaki T, Minami A, Kon S, Uede T
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2012 Final Research Report
  • [Presentation] Regulation of T cell responses by a distinct subset of resident splenic macrophages.2009

    • Author(s)
      Daisuke Kurotaki
    • Organizer
      1st International Conference on Immune Tolerance.
    • Place of Presentation
      The Seaport Hotel Boston
    • Related Report
      2009 Annual Research Report
  • [Presentation] 組織固着マクロファージサブセットによるT細胞免疫応答制御機構の解明2009

    • Author(s)
      黒滝大翼
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2009 Annual Research Report
  • [Presentation] α9インテグリンは関節炎の発症に重要な微小環境を構成する2009

    • Author(s)
      金山剛士
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of osteopontin in the cardiovascular diseases.2009

    • Author(s)
      松井裕
    • Organizer
      第61回日本細胞生物学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regulation of T cell responses by a distinct subset of resident splenic macrophages.2009

    • Author(s)
      Daisuke Kurotaki
    • Organizer
      マクロファージ分子細胞生物学国際シンポジウム
    • Place of Presentation
      金沢KKRホテル
    • Related Report
      2009 Annual Research Report
  • [Presentation] 実験的自己免疫性脳脊髄炎におけるα9インテグリンの機能解析2009

    • Author(s)
      伊藤甲雄
    • Organizer
      第20回生体防御学会学術集会
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] Osteopontinによる変形性関節症の発症及び進行抑制効果2009

    • Author(s)
      松井雄一郎
    • Organizer
      第9回オステオポンチン研究会
    • Place of Presentation
      北海道大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心筋梗塞におけるSyndecan-4の機能解析2009

    • Author(s)
      松井裕
    • Organizer
      第9回オステオポンチン研究会
    • Place of Presentation
      北海道大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] インフルエンザAウイルス感染防御免疫応答におけるOpnの機能解析2009

    • Author(s)
      森本純子
    • Organizer
      第9回オステオポンチン研究会
    • Place of Presentation
      北海道大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regulation of T cell responses by a novel subset of resident splenic macrophages.2009

    • Author(s)
      Daisuke Kurotaki
    • Organizer
      第9回オステオポンチン研究会
    • Place of Presentation
      北海道大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] アレルゲン全身感作に及ぼすオステオポンチン(OPN)の影響2009

    • Author(s)
      今野哲
    • Organizer
      第9回オステオポンチン研究会
    • Place of Presentation
      北海道大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] オステオポンチンの欠如は皮膚創傷治癒を遅延する2009

    • Author(s)
      木田真紀
    • Organizer
      第9回オステオポンチン研究会
    • Place of Presentation
      北海道大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synovial fibroblasts and macrophages differentially contributes to the development of autoimmune arthritis via α9 integrin.2009

    • Author(s)
      Masashi Kanayama
    • Organizer
      第9回オステオポンチン研究会
    • Place of Presentation
      北海道大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] Administration of Osteopontin small interfering RNA ameliorates experimental autoimmune uveoretinitis model in mice.2009

    • Author(s)
      Kazuya Iwabuchi
    • Organizer
      第9回オステオポンチン研究会
    • Place of Presentation
      北海道大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 絡膜血管新生におけるオステオポンチンの役割2009

    • Author(s)
      藤田織人
    • Organizer
      第9回オステオポンチン研究会
    • Place of Presentation
      北海道大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 関節リウマチにおけるα9インテグリン-リガンド間相互作用の解析2009

    • Author(s)
      浅野毅
    • Organizer
      第24回日本整形外科学会基礎学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regulation of T Cell responses by a distinct subset of resident splenic macrophages.2009

    • Author(s)
      Daisuke Kurotaki
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] The interaction of α9 integrin and its ligands contributes to the development of rheumatoid arthritis.2009

    • Author(s)
      Tsuyoshi Asano
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] Osteopontin deficiency promotes secondary immune response to influenza A virus infection, possibly by regulating the maintenance of virus-specific memory CD8^+ T cells.2009

    • Author(s)
      Junko Morimoto
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synovial fibroblasts and macrophages differentially contributes to the development of autoimmune arthritis via α9 integrin.2009

    • Author(s)
      Masashi Kanayama
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] Alpha9 integrin is involved in the development of experimental autoimmune encephalomyelitis by regulating inflammatory cell migration from draining lymph node to central nervous systems.2009

    • Author(s)
      Koyu Ito
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] Syndecan-4 protects from cardiac rupture and dysfunction after myocardial infarction.2009

    • Author(s)
      Yutaka Matsui
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Interleukin-17 deficiency accelerates atherosclerotic plaque formation in Apolipoprotein E-deficient mice.2009

    • Author(s)
      Keiko Danzaki
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新生内膜形成と動脈硬化におけるシンデカン-4の機能。2009

    • Author(s)
      池末昌弘
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] The functional significance of interactions between ADAM15 and integrins in the invasion of breast cancer cells.2009

    • Author(s)
      太田大地
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional role of CLIPR-59 in TNF medicated pro-apoptotic signal.2009

    • Author(s)
      藤倉大輔
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞外マトリックス分子による成人T細胞白血病の病態発現制御とその臨床応用。

    • Author(s)
      前田直良
    • Organizer
      金沢大学がん進展制御研究所・北海道大学遺伝子病制御研究所ジョイントシンポジウム「がんの悪性進展過程とその微小環境」
    • Place of Presentation
      北海道大学(札幌)
    • Related Report
      2012 Annual Research Report
  • [Book] 医科免疫学2010(改訂第6版),163-184免疫反応の制御機構(菊地浩吉、上出利光、小野江和則編.470頁)2010

    • Author(s)
      上出利光
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 医科免疫学2010(改訂第6版)2010

    • Author(s)
      上出利光
    • Total Pages
      494
    • Publisher
      南江堂
    • Related Report
      2010 Annual Research Report
  • [Book] 炎症・再生医学辞典,106-108 オステオポンチン(松島綱治、西脇徹編、)2009

    • Author(s)
      森本純子, 上出利光
    • Publisher
      朝倉書店
    • Related Report
      2012 Final Research Report
  • [Book] 炎症・再生医学事典2009

    • Author(s)
      森本純子
    • Total Pages
      3
    • Publisher
      朝倉書店
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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