Study on roles of basophils under physiological and pathological conditions

• Project/Area Number: 21390116
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KARASUYAMA Hajime 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (60195013)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: 炎症 / 好塩基球 / アレルギー / 寄生虫感染 / モデルマウス / 蛋白分解酵素 / mMCP-11 / 浮腫 / asialo GM1 / NK細胞 / mMCP-8 / ジフテリア毒素受容体 / 寄生虫 / マダニ / 感染症 / マスト細胞 / 生体防御 / GFP / 遺伝子改変マウス

Research Abstract

The functional analysis of basophils in vivo has long been hampered by the lack of model animals that are deficient only in basophils. To overcome this limitation, we established Mcpt8^<DTR> mice in that basophils can be conditionally ablated by administration of diphtheria toxin. Taking advantage of this mouse model, we showed that basophils play an important role in the acquired protective immunity against tick infestation.

Research Products

• [Journal Article] Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-αon macrophages through the autocrine action of IL-6 (2012)
  • Author(s): Ogawa, H., Mukai, K., Kawano, Y., Minegishi, Y., and Karasuyama, H.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 420 Pages: 114-118
  • Peer Reviewed
• [Journal Article] Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness (2012)
  • Author(s): Sawaguchi, M., Tanaka, S., Nakatani, Y., Harada, Y., Mukai, K., Matsunaga, Y., Ishiwata, K., Oboki, K., Kambayashi, T., Watanabe, N., Karasuyama, H., Nakae, S., Inoue, H., and Kubo, M.
  • Journal Title: J. Immunol Volume: 188 Pages: 1809-1818
  • Peer Reviewed
• [Journal Article] Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness (2012)
  • Author(s): Sawaguchi, M.
  • Journal Title: J.Immunol. Volume: 188 Issue: 4 Pages: 1809-1818
  • DOI: 10.4049/jimmunol.1101746
  • Peer Reviewed
• [Journal Article] Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expre ssion of transmembrane TNF-α on macrophages through the autocrine action of IL-6 (2012)
  • Author(s): Ogawa, H.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 420 Issue: 1 Pages: 114-118
  • DOI: 10.1016/j.bbrc.2012.02.124
  • Peer Reviewed
• [Journal Article] Melanocortin Receptors 1 and 5 might mediate inhibitory effects of α-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice (2012)
  • Author(s): Etori, M.
  • Journal Title: J.Invest.Dermatol. Volume: 132 Issue: 7 Pages: 1925-1927
  • DOI: 10.1038/jid.2012.68
  • Peer Reviewed
• [Journal Article] Nonredundant roles of basophils in immunity (2011)
  • Author(s): Karasuyama, H., Mukai, K., Obata, K., Tsujimura, Y., and Wada, T.
  • Journal Title: Annu. Rev. Immunol Volume: 29 Pages: 45-69
  • Peer Reviewed
• [Journal Article] Mouse and human neutrophils induce anaphylaxis (2011)
  • Author(s): Jonsson, F., Mancardi, D. A., Kita, Y., Karasuyama, H., Iannascoli, B., Van Rooijen, N., Shimizu, T., Daeron, M, and Bruhns, P.
  • Journal Title: J. Clin. Invest Volume: 121 Pages: 1484-1496
  • Peer Reviewed
• [Journal Article] NK cell-depleting anti-asialo GM1 Ab exhibits a lethal off-target effect on basophils in vivo (2011)
  • Author(s): Nishikado, H., Mukai, K., Kawano, Y., Minegishi, Y., and Karasuyama, H.
  • Journal Title: J. Immunol Volume: 186 Pages: 5766-5771
  • Peer Reviewed
• [Journal Article] Newly appreciated roles for basophils in allergy and protective immunity (2011)
  • Author(s): Karasuyama, H., Obata, K., Wada, T., Tsujimura, Y., and Mukai, K.
  • Journal Title: Allergy Volume: 66 Pages: 1133-1141
  • Peer Reviewed
• [Journal Article] Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cereberal malaria (2011)
  • Author(s): Porcherie, A., Mathieu, C., Peronet, R., Schneider, E., Claver, J., Commere, P-H., Kiefer-Biasizzo, H., Karasuyama, H., Milon, G., Dy, M., Kinet, J-P., Louis, J., Blank, U., and Mecheri, S.
  • Journal Title: J. Exp. Med Volume: 208 Pages: 2225-2236
  • Peer Reviewed
• [Journal Article] Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner (2011)
  • Author(s): Yamagishi, H., Mochizuki, Y., Hamakubo, T., Obata, K., Ugajin, T., Sato, S., Kawano, Y., Minegishi, Y., and Karasuyama, H.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 415 Pages: 709-713
  • Peer Reviewed
• [Journal Article] 最近クローズアップされた好塩基球の重要性 (2011)
  • Author(s): 烏山一
  • Journal Title: 感染・炎症・免疫 Volume: 40(4) Pages: 12-21
• [Journal Article] アレルギーと生体防御における好塩基球の新たな役割 (2011)
  • Author(s): 烏山一
  • Journal Title: アレルギー・免疫 Volume: 18(4) Pages: 42-49
• [Journal Article] 慢性アレルギーと好塩基球 (2011)
  • Author(s): 小畑一茂、石川亮、烏山一
  • Journal Title: 慢性炎症-多様な疾患の基盤病態,実験医学増刊号 Volume: 29(10) Pages: 151-155
• [Journal Article] 好塩基球の研究の進歩 (2011)
  • Author(s): 江川真由美、烏山一
  • Journal Title: 血液フロンティア Volume: 21(6) Pages: 92-95
• [Journal Article] Nonredundant roles of basophils in immunity (2011)
  • Author(s): Karasuyama, H.
  • Journal Title: Annu.Rev.Immunol. Volume: 29 Issue: 1 Pages: 45-69
  • DOI: 10.1146/annurev-immunol-031210-101257
  • Peer Reviewed
• [Journal Article] Mouse and human neutrophils induce anaphylaxis (2011)
  • Author(s): Jonsson, F.
  • Journal Title: J.Clin.Invest. Volume: 121 Pages: 1484-1496
  • Peer Reviewed
• [Journal Article] Antigen-specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells (2011)
  • Author(s): Ishikawa, Y.
  • Journal Title: Respir.Res. Volume: 12 Issue: 1 Pages: 42-42
  • DOI: 10.1186/1465-9921-12-42
  • Peer Reviewed
• [Journal Article] NK cell-depleting anti-asialo GM1 Ab exhibits a lethal off-target effect on basophils in vivo (2011)
  • Author(s): Nishikado, H.
  • Journal Title: J.Immunol. Volume: 186 Issue: 10 Pages: 5766-5771
  • DOI: 10.4049/jimmunol.1100370
  • Peer Reviewed
• [Journal Article] Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cereberal malaria (2011)
  • Author(s): Porcherie, A.
  • Journal Title: J.Exp.Med. Volume: 208 Issue: 11 Pages: 2225-2236
  • DOI: 10.1084/jem.20110845
  • Peer Reviewed
• [Journal Article] Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner (2011)
  • Author(s): Yamagishi H
  • Journal Title: Biochem Biophys Res Commun Volume: Dec2 ; 415(4) Issue: 4 Pages: 709-13
  • DOI: 10.1016/j.bbrc.2011.10.150
  • Peer Reviewed
• [Journal Article] 慢性アレルギーと好塩基球 (2011)
  • Author(s): 小畑一茂
  • Journal Title: 慢性炎症-多様な疾患の基盤病態実験医学増刊号 Volume: 29(10) Pages: 151-155
• [Journal Article] Nonredundant roles of basophils in immunity. (2011)
  • Author(s): Karasuyama, H.
  • Journal Title: Annu. Rev. Immunol. Volume: 29 Pages: 45-69
  • Peer Reviewed
• [Journal Article] Emerging roles of basophils in protective immunity against parasites (2011)
  • Author(s): Karasuyama, H.
  • Journal Title: Trends Immunol Volume: 32 Pages: 125-130
  • Peer Reviewed
• [Journal Article] Antigen-specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells. (2011)
  • Author(s): Ishikawa, Y.
  • Journal Title: Respir. Res. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Neutrophils as inducers of anaphylaxis. (2011)
  • Author(s): Jonsson, F.
  • Journal Title: J. Clin. Invest. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner (2010)
  • Author(s): Nakata, K., Kobayashi, K., Ishikawa, Y., Yamamoto, M., Funada, Y., Kotani, Y., Blumberg, R. S., Karasuyama, H., Yoshida, M., and Yoshihiro Nishimura.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 395 Pages: 238-243
  • NAID: 120003338607
  • Peer Reviewed
• [Journal Article] Role for basophils in systemic anaphylaxis (2010)
  • Author(s): Karasuyama, H., Tsujimura Y., Obata, K., and Mukai, K.
  • Journal Title: Chem. Immunol. Allergy Volume: 95 Pages: 85-97
  • Peer Reviewed
• [Journal Article] Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks (2010)
  • Author(s): Wada, T., Ishiwata, K., Koseki, H., Ishikura, T., Ugajin, T., Ohnuma, N., Obata, K., Ishikawa, R., Yoshikawa, S., Mukai, K., Kawano, Y., Minegishi, Y., Yokozeki, H., Watanabe, N., and Karasuyama, H.
  • Journal Title: J. Clin. Invest Volume: 120 Pages: 2867-2875
  • Peer Reviewed
• [Journal Article] An atopic dermatitis-like skin disease with hyper-IgEemia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2(Act1/CIKS) gene (2010)
  • Author(s): Matsushima, Y., Kikkawa, Y., Takada, T, Matsuoka, K., Seki, Y., Yoshida, H., Minegishi, Y., Karasuyama, H., and Yonekawa, H.
  • Journal Title: J. Immunol Volume: 185 Pages: 2340-2349
  • Peer Reviewed
• [Journal Article] Nonredundant roles for basophils in immediate-and delayed-onset allergic reactions (2010)
  • Author(s): Karasuyama, H., Mukai, K., Obata, K., Tsujimura, Y., Kawano, Y., and Minegishi, Y.
  • Journal Title: The Open Allergy Journal Volume: 3 Pages: 73-80
  • Peer Reviewed
• [Journal Article] Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematode (2010)
  • Author(s): Torrero, M. N., Hubner, M. P., Larson, D., Karasuyama, H., and Mitre, E.
  • Journal Title: Litomosoides sigmodontis. J. Immunol Volume: 185 Pages: 7426-7434
  • Peer Reviewed
• [Journal Article] IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen (2010)
  • Author(s): Ishikawa, R., Tsujimura, Y., Obata, K., Kawano, Y., Minegishi, Y., and Karasuyama, H.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 402 Pages: 742-746
  • Peer Reviewed
• [Journal Article] 急性ならびに慢性アレルギー発症における好塩基球の新たな役割 (2010)
  • Author(s): 烏山一
  • Journal Title: 炎症と免疫 Volume: 18(1) Pages: 23-27
• [Journal Article] 好塩基球が主役を演じるIgE依存性慢性アレルギー炎症 (2010)
  • Author(s): 烏山一
  • Journal Title: IgE practice in asthma Pages: 1-5
• [Journal Article] 吸血ダニに対する抵抗性、好塩基球が鍵を握っていた (2010)
  • Author(s): 烏山一
  • Journal Title: メディカルバイオ Volume: 7(6) Pages: 52-55
• [Journal Article] The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dep endent manner (2010)
  • Author(s): Nakata, K.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 395 Pages: 238-243
  • Peer Reviewed
• [Journal Article] Selective ablation of basophils in mice reveals their nonredun dant role in acquired immunity against ticks. (2010)
  • Author(s): Wada, T.
  • Journal Title: J. CIin. Invest. Volume: 120 Pages: 2867-2875
  • Peer Reviewed
• [Journal Article] An atopic dermatitis like skin disease with hyper-lgEemia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2(Actl/CIKS)gene. (2010)
  • Author(s): Matsushima, Y.
  • Journal Title: J. Immunol. Volume: 185 Pages: 2340-2349
  • Peer Reviewed
• [Journal Article] Schistosoma eggs have a direct role in the induction of basop hill capable of a high level of IL-4 production Comparative study of single-and bisexual infection of Schistosoma mansoni in vivo. (2010)
  • Author(s): Anyan, W.K.
  • Journal Title: Trop. Med. Health Volume: 38 Pages: 13-22
  • Peer Reviewed
• [Journal Article] Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematode Litosoides sigmodontis. (2010)
  • Author(s): Torrero, M. N.
  • Journal Title: J. Immunol. Volume: 185 Pages: 7426-7434
  • Peer Reviewed
• [Journal Article] IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen. (2010)
  • Author(s): Ishikawa, R.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 402 Pages: 742-746
  • Peer Reviewed
• [Journal Article] Role for basophils in systemic anaphylaxis. (2010)
  • Author(s): Karasuyama, H.
  • Journal Title: Chew. Immunol. Allergy Volume: 95 Pages: 85-97
  • Peer Reviewed
• [Journal Article] Nonredundant roles for basophils in immediate-and delayed (2010)
  • Author(s): Karasuyama, H.
  • Journal Title: onset allergic reactions.The Open Allergy Journal. Volume: 3 Pages: 73-80
  • Peer Reviewed
• [Journal Article] 吸血ダニに対する抵抗性、好塩基球が鍵を握っていた (2010)
  • Author(s): 烏山一
  • Journal Title: メデイカルバイオ Volume: 7 Pages: 52-55
• [Journal Article] The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner (2010)
  • Author(s): Nakata, K.
  • Journal Title: Biochem.Biophys.Res.Commun. (印刷中)
  • Peer Reviewed
• [Journal Article] 急性ならびに慢性アレルギー発症における好塩基球の新たな役割 (2010)
  • Author(s): 烏山一
  • Journal Title: 炎症と免疫 18 Pages: 23-27
• [Journal Article] Newly-discovered roles for basophils : a neglected minority gains new respect (2009)
  • Author(s): Karasuyama, H., Mukai, K., Tsujimura, Y. and Obata, K.
  • Journal Title: Nat. Rev. Immunol Volume: 9 Pages: 9-13
  • Peer Reviewed
• [Journal Article] Fc receptorγ-chain, a constitutive component of the interleukin 3 receptor is required for interleukin 3-induced interleukin 4 (2009)
  • Author(s): Hida, S., Yamasaki, S., Sakamoto, Y., Takamoto, M., Obata, K., Takai, T., Karasuyama, H., Sugane, K., Saito, T. and Taki, S.
  • Journal Title: Nat. Immunol Volume: 10 Pages: 214-222
  • Peer Reviewed
• [Journal Article] New insights into the roles for basophils in acute and chronic allergy (2009)
  • Author(s): Mukai, K., Obata, K., Tsujimura, Y. and Karasuyama, H.
  • Journal Title: Allergol. Int Volume: 58 Pages: 11-19
  • NAID: 10025108898
  • Peer Reviewed
• [Journal Article] Peanuts can contribute to anaphylactic shock by activating complement (2009)
  • Author(s): Khodoun, M., Strait, R., Orekov, T., Hogan, S., Karasuyama, H., Herbert, D. R., Kohl, J. and Finkelman, F. D.
  • Journal Title: J. Allergy Clin. Immunol Volume: 58 Pages: 11-19
  • Peer Reviewed
• [Journal Article] Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells (2009)
  • Author(s): Ugajin, T., Kojima, T., Mukai, K., Obata K., Kawano, Y., Minegishi, Y., Eishi Y., Yokozeki, H., and Karasuyama, H.
  • Journal Title: J. Leukoc. Biol Volume: 86 Pages: 1417-1425
  • Peer Reviewed
• [Journal Article] 好塩基球とアレルギー (2009)
  • Author(s): 向井香織、小畑一茂、辻村祐佑、烏山一
  • Journal Title: 日本臨床 Volume: 67(11) Pages: 2095-2009
• [Journal Article] アレルギーにおける好塩基球の新たな役割 (2009)
  • Author(s): 烏山一
  • Journal Title: 実験医学増刊「アレルギー疾患の免疫機構」 Volume: 27(20) Pages: 68-74
• [Journal Article] アレルギーにおける好塩基球の新たな役割 (2009)
  • Author(s): 烏山一
  • Journal Title: Annual Review 2009呼吸器 Pages: 44-51
• [Journal Article] 免疫アレルギー研究の表舞台に躍り出た好塩基球 (2009)
  • Author(s): 烏山一
  • Journal Title: アレルギー・免疫 Volume: 16(3) Pages: 9-10
• [Journal Article] CD200R3を介した好塩基球とマスト細胞の活性化 (2009)
  • Author(s): 小島利之、小畑一茂、烏山一
  • Journal Title: アレルギー・免疫 Volume: 16(3) Pages: 44-51
• [Journal Article] 好塩基球によるIgG型アナフィラキシーの誘導 (2009)
  • Author(s): 辻村祐佑、小畑一茂、烏山一
  • Journal Title: アレルギー・免疫 Volume: 16(3) Pages: 62-71
• [Journal Article] 慢性アレルギー炎症ならびにアナフィラキシーにおける好塩基球のあらたな役割 (2009)
  • Author(s): 烏山一
  • Journal Title: 医学のあゆみ別冊「最新免疫研究Update」 Pages: 77-82
• [Journal Article] 好塩基球が主役を演じる慢性アレルギー炎症 (2009)
  • Author(s): 向井香織、烏山一
  • Journal Title: アレルギー・免疫 Volume: 16(3) Pages: 72-77
• [Journal Article] 好塩基球・マスト細胞の機能とCD200R3 (2009)
  • Author(s): 小島利之、小畑一茂、向井香織、烏山一
  • Journal Title: 臨床免疫アレルギー科 Volume: 52(1) Pages: 49-57
• [Journal Article] Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome (2009)
  • Author(s): 峯岸克行
  • Journal Title: J.Exp.Med. 206 Pages: 1291-1301
  • Peer Reviewed
• [Journal Article] The study of allergy by Japanese researchers : a historical perspective (2009)
  • Author(s): 向井香織
  • Journal Title: Int.Immunol. 21 Pages: 1311-1316
  • Peer Reviewed
• [Journal Article] Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells (2009)
  • Author(s): Ugajin, T.
  • Journal Title: J.Leukoc.Biol. 86 Pages: 1417-1425
  • Peer Reviewed
• [Journal Article] 好塩基球・マスト細胞の機能とCD200R3 (2009)
  • Author(s): 小島利之
  • Journal Title: 臨床免疫アレルギー科 52 Pages: 49-57
• [Journal Article] 自己免疫現象と疾患発症 (2009)
  • Author(s): 烏山一
  • Journal Title: ひらかれた小児リウマチ診療(日本小児リウマチ学会) Pages: 13-16
• [Journal Article] 高IgE症候群の原因遺伝子は何か (2009)
  • Author(s): 峯岸克行
  • Journal Title: 分子リウマチ治療 2 Pages: 19-21
• [Journal Article] 好塩基球とアレルギー (2009)
  • Author(s): 向井香織
  • Journal Title: 日本臨床 67 Pages: 2095-2099
• [Journal Article] アレルギーにおける好塩基球の新たな役割 (2009)
  • Author(s): 烏山一
  • Journal Title: 実験医学増刊「アレルギー疾患の免疫機構」 27 Pages: 68-74
• [Journal Article] Emerging roles of basophils in protective immunity against parasites
  • Author(s): Karasuyama, H., Wada, T., Yoshikawa, S., and Obata, K.
  • Journal Title: Trends Immunol Volume: 32 Pages: 125-130
  • Peer Reviewed
• [Presentation] 外部ならびに内部寄生虫感染防御における好塩基球の役割 (2012)
  • Author(s): 烏山一
  • Organizer: 第81回日本寄生虫学会大会
  • Place of Presentation: 兵庫(招待講演)
  • Year and Date: 2012-03-23
• [Presentation] 生体防御ならびに免疫疾患における好塩基球の新たな役割 (2012)
  • Author(s): 烏山一
  • Organizer: 第30回Cytoprotection研究会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2012-03-09
• [Presentation] Macrophages stimulated with Th2 cytokine mediate soluble and transmembrane TNF-&alpha through IL-33 in a STAT6-dependent manner (2011)
  • Author(s): Ogawa H
  • Organizer: The 34^<th> Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 2011-12-14
• [Presentation] Emerging roles of basophils in protective and pathological immune responses (2011)
  • Author(s): Karasuyama, H.
  • Organizer: EMBRN-COST International Mast Cell and Basophil Meeting
  • Place of Presentation: Southampton, UK
  • Year and Date: 2011-11-25
• [Presentation] Emerging roles of basophils in protective and pathological immune responses (2011)
  • Author(s): Karasuyama H.
  • Organizer: EMBRN-COST International Mast Cell and Basophil Meeting
  • Place of Presentation: Southampton, UK.(招待講演)
  • Year and Date: 2011-11-25
• [Presentation] アレルギーならびに生体防御における好塩基球の新たな役割 (2011)
  • Author(s): 烏山一
  • Organizer: 第15回栃木県血液疾患講演会
  • Place of Presentation: 宇都宮(招待講演)
  • Year and Date: 2011-11-17
• [Presentation] 好塩基球研究のルネサンス (2011)
  • Author(s): 烏山一
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] 遺伝子改変モデルマウスを用いた好塩基球の動態・機能解明 (2011)
  • Author(s): 吉川宗一郎
  • Organizer: 第61回日本アレルギー学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] Newly appreciated roles for basophils in allergy and protective immunity. Japan Korea China Joint Symposium' Inflammatory cells in allergic diseases' (2011)
  • Author(s): Karasuyama, H.
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Year and Date: 2011-11-10
• [Presentation] Newly appreciated roles for basophils in allergy and protective immunity (2011)
  • Author(s): Karasuyama H.
  • Organizer: Japan-Korea-China Joint Symposium 'Infla mmatory cells in allergic diseases'
  • Place of Presentation: 東京
  • Year and Date: 2011-11-10
• [Presentation] アレルギーならびに生体防御における好塩基球の新たな役割 (2011)
  • Author(s): 烏山一
  • Organizer: 第7回中国研究皮膚科セミナー
  • Place of Presentation: 広島(招待講演)
  • Year and Date: 2011-11-05
• [Presentation] アレルギーならびに生体防御における好塩基球の新たな役割 (2011)
  • Author(s): 烏山一
  • Organizer: 東海小児アレルギー懇話会
  • Place of Presentation: 静岡(招待講演)
  • Year and Date: 2011-10-09
• [Presentation] 新たなアレルギー発症機構の解明とその制御 (2011)
  • Author(s): 烏山一
  • Organizer: CRESTシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-09-30
• [Presentation] アレルギーならびに生体防御における好塩基球の新たな役割 (2011)
  • Author(s): 烏山一
  • Organizer: 第67回臨床アレルギー研究会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-07-23
• [Presentation] Emerging roles of basophils in protective and pathological immune responses (2011)
  • Author(s): Karasuyama, H.
  • Organizer: JSICR MMCB 2011
  • Place of Presentation: Osaka
  • Year and Date: 2011-05-26
• [Presentation] Emerging roles of basophils in protective and pathological immune responses (2011)
  • Author(s): Karasuyama H.
  • Organizer: JSICR-MMCB2011
  • Place of Presentation: Osaka(招待講演)
  • Year and Date: 2011-05-26
• [Presentation] Emerging roles of basophils in protective and pathological immunity (2011)
  • Author(s): Karasuyama H.
  • Organizer: SIgN Seminar
  • Place of Presentation: Singapore(招待講演)
  • Year and Date: 2011-04-18
• [Presentation] Novel roles for basophils in allergy and protective immunity (2011)
  • Author(s): Karasuyama, H.
  • Organizer: ESF-JSPS Frontier Science Conference for Young Researchers
  • Place of Presentation: Hulshot, The Netherlands(招待講演)
  • Year and Date: 2011-03-04
• [Presentation] 好塩基球はNippostrongylus brasiliensisに対するTh2型獲得免疫に重要である (2011)
  • Author(s): 小畑一茂
  • Organizer: 第80回日本寄生虫学会大会
  • Place of Presentation: 東京
• [Presentation] 日本住血虫感染IL-4/IL-13DKOマウスにおけるIL-17非依存的な肉芽腫形成 (2011)
  • Author(s): 関丈典
  • Organizer: 第80回日本寄生虫学会大会
  • Place of Presentation: 東京
• [Presentation] Basophils but not mast cells play an important role in IgE mediated acquired immunity to Nippostrongylus brasiliensis helminth nematode (2011)
  • Author(s): Obata K.
  • Organizer: The 41th JSI annual meeting
  • Place of Presentation: Chiba
• [Presentation] Mast cells regulate basophil mobility at tick feeding sites for efficient protective immunity (2011)
  • Author(s): Yoshikawa S.
  • Organizer: The 41th JSI annual meeting
  • Place of Presentation: Chiba
• [Presentation] Basophils interact with tissue-infiltrating inflammatory monoc ytes to induce their differentiation into M2-type macrophages during a chronic allergic reaction (2011)
  • Author(s): Egawa M.
  • Organizer: The 41th JSI annual meeting
  • Place of Presentation: Chiba
• [Presentation] Analysis of membrane tumor necrosis factor alpha on macrophages in the present of Th2 cytokine (2010)
  • Author(s): Ogawa, H.
  • Organizer: BMB2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-12-08
• [Presentation] アレルギーならびに生体防御における好塩基球の新たな役割 (2010)
  • Author(s): 烏山一
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-26
• [Presentation] IgGを介する全身性アナフィラキシーショックの誘導 (2010)
  • Author(s): 石川亮介
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-26
• [Presentation] Basophils as a non-redundant player in allergy and protective immunity (2010)
  • Author(s): Karasuyama, H.
  • Organizer: The 20^<th> Annual Johns Hopkins Asthma and Allergy Center Symposium
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2010-11-19
• [Presentation] Basophils as a non-redundant player in allergy and protective immunity (2010)
  • Author(s): Karasuyama, H.
  • Organizer: The 20^<th> Annual Johns Hopkins Asthma and Allergy Center Symposium
  • Place of Presentation: Baltimore, USA(招待講演)
  • Year and Date: 2010-11-19
• [Presentation] Novel roles for basophils in allergy and protective immunity (2010)
  • Author(s): Karasuyama, H.
  • Organizer: Cold Spring Harbor-Asia Conference' Frontiers of Immunology in Health & Diseases'
  • Place of Presentation: Suzhou, China
  • Year and Date: 2010-11-09
• [Presentation] Novel roles for basophils in allergy and protective immunity (2010)
  • Author(s): Karasuyama, H.
  • Organizer: Cold Spring Harbor-Asia Conference Frontiers of Immunology in Health, &, Diseases
  • Place of Presentation: Suzhou, China
  • Year and Date: 2010-11-09
• [Presentation] IgEを介するアレルギー・免疫反応における好塩基球の新たな役割 (2010)
  • Author(s): 烏山一
  • Organizer: IgEフォーラムin千葉
  • Place of Presentation: 千葉(招待講演)
  • Year and Date: 2010-10-05
• [Presentation] 好塩基球研究の新展開～日陰者が一気に檜舞台に～ (2010)
  • Author(s): 烏山一
  • Organizer: 第47回日本小児アレルギー学会
  • Place of Presentation: 横浜(招待講演)
  • Year and Date: 2010-10-04
• [Presentation] Newly discovered roles for basophils : aneglected minority gains new respect (2010)
  • Author(s): Karasuyama, H.
  • Organizer: The 8th German-Japanese Symposium-Regulation of Immune Response and Disease
  • Place of Presentation: Cuxhaven, Germany
  • Year and Date: 2010-09-26
• [Presentation] Newly discovered roles for basophils : a neglected minority gains new respect (2010)
  • Author(s): Karasuyama, H.
  • Organizer: The 40th Annual Meeting of the German Society for Immunology
  • Place of Presentation: Leipzig, Germany
  • Year and Date: 2010-09-23
• [Presentation] Newly discovered roles for basophils : aneglected minority gains new respect (2010)
  • Author(s): Karasuyama, H.
  • Organizer: The 40th Annual Meeting of the German Society for Immunology
  • Place of Presentation: Leipzig, Germany(招待講演)
  • Year and Date: 2010-09-23
• [Presentation] Nonredundant role for basophils in antibody-mediated, acquired immunity against ticks (2010)
  • Author(s): Karasuyama, H.
  • Organizer: The 10^<th> Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji
  • Year and Date: 2010-09-10
• [Presentation] Novel roles for basophils in allergy and immunity (2010)
  • Author(s): Karasuyama, H.
  • Organizer: International Congress of Immunology 2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-26
• [Presentation] Dynamics of basophils in immune and allergic responses : invivo imaging analysis using basophil-specific GFP mice (2010)
  • Author(s): Yoshikawa, S.
  • Organizer: International Congress of Immunology 2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-26
• [Presentation] A novel CD200R ligand that is selectively expressed in the small intestine (2010)
  • Author(s): Kojima, T.
  • Organizer: International Congress of Immunology 2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-26
• [Presentation] Importance of the polyclonality of antibody for efficient induction of IgG-mediated systemic anaphylaxis (2010)
  • Author(s): Ishikawa, R.
  • Organizer: International Congress of Immunology 2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-24
• [Presentation] The generation of induced Treg (iTreg) but not naturally occurring Treg (nTreg) is impaired in the hyper IgE syndrome (2010)
  • Author(s): Saito, M.
  • Organizer: International Congress of Immunology 2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-24
• [Presentation] A crucial role for basophils in antibody-mediated, acquired protective immunity to ticks (2010)
  • Author(s): Wada, T.
  • Organizer: International Congress of Immunology 2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-24
• [Presentation] The investigation of cutaneous basophil hypersensitivity in mice (2010)
  • Author(s): Egawa, M.
  • Organizer: International Congress of Immunology 2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-24
• [Presentation] A novel mechanism for the autonomous termination of pre-B cell receptor expression through BLNK-mediated induction of Laptm5 (2010)
  • Author(s): Kawano, Y.
  • Organizer: International Congress of Immunology 2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-24
• [Presentation] 好塩基球とアレルギー (2010)
  • Author(s): 烏山一
  • Organizer: 第31回日本炎症, 再生医学会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-08-06
• [Presentation] 好塩基球とアレルギー (2010)
  • Author(s): 烏山一
  • Organizer: 重症気管支喘息学術フォーラム
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2010-07-24
• [Presentation] 好塩基球の新たな役割 悪玉細胞それとも善玉細胞 (2010)
  • Author(s): 烏山一
  • Organizer: 第75回日本インターフェロン/サイトカイン学会
  • Place of Presentation: 小倉
  • Year and Date: 2010-06-26
• [Presentation] フタトゲチマダニHaemaphysalis longicornis 吸血に対する抵抗性獲得における好塩基球の重要な役割 (2010)
  • Author(s): 和田剛
  • Organizer: 第79回日本寄生虫学会学術大会
  • Place of Presentation: 旭川
  • Year and Date: 2010-05-21
• [Presentation] Novel roles for immune and allergic responses (2010)
  • Author(s): Karasuyama, H.
  • Organizer: The 97^<th> Annual Meeting of the American Association of Immunologists
  • Place of Presentation: Baltimore, USA.
  • Year and Date: 2010-05-08
• [Presentation] Novel roles for basophils in immune and allergic responses (2010)
  • Author(s): Karasuyama, H.
  • Organizer: The 97^(th) Annual Meeting of the American Association of Immunologists
  • Place of Presentation: Baltimore, USA(招待講演)
  • Year and Date: 2010-05-08
• [Presentation] Basophils contribute to the acquired protective immunity to helminth infection (2010)
  • Author(s): Obata, K.
  • Organizer: International Congress of Immunology 2010
  • Place of Presentation: Kobe
• [Presentation] Basophils play a critical role in the Th2-dependent protection against Nippostrongylus brasiliensis in the secondary infection (2010)
  • Author(s): Obata, K.
  • Organizer: 第79回日本寄生虫学会学術大会
  • Place of Presentation: 旭川
• [Presentation] Newly discovered roles for basophils in allergy and parasitic infections (2010)
  • Author(s): 烏山一
  • Organizer: US-Japan Joint Symposium : Adaptive and innate immune responses to neglected tropical diseases conference
  • Place of Presentation: San Diego, USA.
• [Presentation] Previously unrecognized roles for basophils in immune and allergic responses(招待講演) (2010)
  • Author(s): 烏山一
  • Organizer: 3^<rd> International Singapore symposium of immunology
  • Place of Presentation: Singapore
• [Presentation] Novel roles for basophilsin allergy. International Symposium ; Eosinophils, other inflammatory cells and molecules in allergy (2009)
  • Author(s): Karasuyama, H.
  • Organizer: 第59回日本アレルギー学術秋季学術大会
  • Place of Presentation: 秋田
  • Year and Date: 2009-10-30
• [Presentation] Newly discovered roles for basophils-a neglected minority gains new respect (2009)
  • Author(s): Karasuyama, H.
  • Organizer: 6th Biennial International Symposium of the International Eosinophil Society
  • Place of Presentation: Bruges, Belgium
  • Year and Date: 2009-07-08
• [Presentation] アレルギーにおける好塩基球の二面性:悪玉細胞それとも善玉細胞?(招待講演) (2009)
  • Author(s): 烏山一
  • Organizer: 第28回漢方免疫アレルギー研究会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-27
• [Presentation] アレルギーならびに生体防御における好塩基球の新たな役割(招待講演) (2009)
  • Author(s): 烏山一
  • Organizer: 第5回金沢小児・皮膚免疫アレルギー研究会
  • Place of Presentation: 金沢
  • Year and Date: 2009-06-24
• [Presentation] 高IgE症候群の責任遺伝子の同定と病態解明(招待講演) (2009)
  • Author(s): 烏山一、峯岸克行
  • Organizer: 第3回千葉小児皮膚免疫アレルギー研究会
  • Place of Presentation: 千葉
  • Year and Date: 2009-05-14
• [Presentation] The role for basophils in IgG but not IgE-mediated systemic anaphylaxis(招待講演) (2009)
  • Author(s): 烏山一
  • Organizer: First Croatian Congdress of Allergology and Clinical Immunology
  • Place of Presentation: Zagreb, Croatia
• [Presentation] Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome(招待講演) (2009)
  • Author(s): 烏山一
  • Organizer: First Croatian Congdress of Allergology and Clinical Immunology
  • Place of Presentation: Zagreb, Croatia
• [Presentation] Newly discovered roles for basophils : a neglected minority gains new respect(招待講演) (2009)
  • Author(s): 烏山一
  • Organizer: 6^<th> Biennial Symposium International Eosinophil Society(Eosinophil 2009)
  • Place of Presentation: Bruges, Belgium
• [Presentation] Basophils play an important role in the resolution of inflammation by inducing alternative activation of macrophages through Th2 cytokine release (2009)
  • Author(s): 烏山一
  • Organizer: 2nd European Congress of Immunology(ECI 2009)
  • Place of Presentation: Berlin, Germany
• [Presentation] Basophils play a possible immunoregulatory role during Schistosoma mansoni infection in mice. (2009)
  • Author(s): William Anyan K.
  • Organizer: 58^<th> Annual Meeting of American Society of Tropical Medicine and Hygiene
  • Place of Presentation: Washington DC.USA.
• [Presentation] 好塩基球と生体防御(招待講演) (2009)
  • Author(s): 烏山一
  • Organizer: 第20回日本生体防御学会学術総会
  • Place of Presentation: 東京
• [Presentation] アレルギーにおける好塩基球の二面性:悪玉細胞それとも善玉細胞?(招待講演) (2009)
  • Author(s): 烏山一
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田
• [Presentation] アレルギー疾患における好塩基球の役割 (2009)
  • Author(s): 烏山一
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田
• [Presentation] Novel roles for basophils in allergy (2009)
  • Author(s): 烏山一
  • Organizer: 第59回日本アレルギー学会秋季学術大会International Symposium
  • Place of Presentation: 秋田
• [Presentation] 好塩基球による皮膚慢性アレルギーの誘導と炎症終焉(招待講演) (2009)
  • Author(s): 烏山一
  • Organizer: 第39回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 京都
• [Presentation] Dyanamics of basophil behavior in immune and allergic responses : in vivo imaging analysis using basophil-specific GFP mice. (2009)
  • Author(s): Yoshikawa, S.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Dominant negative mutation in STAT3 results in defective osteoblast and osteoclast function in hyper-IgE syndrome (2009)
  • Author(s): 峯岸克行
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Establishment of diphtheria toxin based in vivo deletion system of basophils and mast cells (2009)
  • Author(s): Sawaguchi, M.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Basophils play an important role in the acquisition of resistance to infections with nematodes (2009)
  • Author(s): Obata, K.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] The role for basophils in the development of resistance to external parasites (2009)
  • Author(s): Wada, T.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] The generation of induced Treg(iTreg)but not naturally occurring Treg(nTreg)is impaired in the hyper IgE syndrome (2009)
  • Author(s): Saito, M.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Importance of the subclass and oligoclonality of IgG for efficient induction of systemic anaphylaxis (2009)
  • Author(s): Ishikawa, R.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] A novel mechanism for the autonomous termination of pre-B cell receptor expression through BLINK-mediated induction of LAPTM5 (2009)
  • Author(s): Kawano, Y.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Book] Environmental and genetic factors in allergy and clinical immunology (2010)
  • Author(s): Karasuyama, H., Tsujimura Y., Obata, K., Mukai, K., and Minegishi Y.
  • Publisher: Basophils and mast cells play distinct roles in acute and chronic allergic reactions
• [Book] 「粘膜における自然免疫:肥満細胞・好酸球・好塩基球」臨床粘膜免疫学 (2010)
  • Author(s): 斎藤博久、大保木啓介、中江進、烏山一
  • Publisher: シナジー社
• [Book] Environmental and genetic factors in allergy and clinical immunology (2010)
  • Author(s): Karasuyama, H.
  • Publisher: Basophils and mast cells play distinct roles in acute and chronic allergic reactions
• [Book] 臨床粘膜免疫学 (2010)
  • Author(s): 斎藤博久、大保木啓介、中江進、烏山一
  • Publisher: 粘膜における自然免疫 肥満細胞・好酸球・好塩基球
• [Remarks]
  • URL: http://www.tmd.ac.jp/med/mbch/top_Japanese.htm
• [Remarks]
  • URL: http://www.tmd.ac.jp/med/mbch/top_Japanese.htm
• [Remarks]
  • URL: http://www.tmd.ac.jp/med/mbch/top_Japanese.htm
• [Remarks]
  • URL: http://www.tmd.ac.jp/med/mbch/top_Japanese.htm