Gastric tumorigenesis through cooperation of COX-2/PGE2 pathway and inflammatory responses

• Project/Area Number: 21390118
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kanazawa University
• Principal Investigator: OSHIMA Masanobu 金沢大学, がん進展制御研究所, 教授 (40324610)
• Co-Investigator(Renkei-kenkyūsha): OSHIMA Hiroko 金沢大学, がん進展制御研究所, 助教 (80362515) ; ISHIKAWA Tomoo 金沢大学, がん進展制御研究所, 助教 (70322162)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 胃がん / 炎症 / COX-2 / PGE_2 / マウスモデル / PGE2 / TGF-beta

Research Abstract

To generate a novel mouse model in which TGF-βsignaling is blocked and COX-2/PGE_2 pathway is activated, we tried construction of transgenic mice expressing Cre in gastric epithelial cells using K19 gene promoter. However, we found that K19 promoter is active in whole body during embryogenesis and its expression efficiency is very low in adult stomach, indicating that other promoter than K19 is required for future construction of stomach specific Cre mice.

Research Products

• [Journal Article] Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells (2012)
  • Author(s): Kong D, Piao YS, Yamashita S, Oshima H, Oguma K, Fushida S, Fujimura T, Minamoto T, Seno H, Yamada Y, Satou K, Ushijima T, Ishikawa T, and Oshima M.
  • Journal Title: Oncogene Volume: (in press) Issue: 35 Pages: 3949-60
  • DOI: 10.1038/onc.2011.558
  • NAID: 120003779577
  • Peer Reviewed
• [Journal Article] The inflammatory network in the gastrointestinal tumor microenvironment : Lessons from mouse models (2012)
  • Author(s): Oshima H, and Oshima M.
  • Journal Title: J Gastroenterol Volume: 47 Issue: 2 Pages: 97-106
  • DOI: 10.1007/s00535-011-0523-6
  • NAID: 10030295848
  • Peer Reviewed
• [Journal Article] Prostaglandin E_2 signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors (2011)
  • Author(s): Oshima H, Hioki K, Popivanova BK, Oguma K, van Rooijen N, Ishikawa T, and Oshima M.
  • Journal Title: Gastroenterology Volume: 140 Issue: 2 Pages: 596-607
  • DOI: 10.1053/j.gastro.2010.11.007
  • NAID: 120002829318
  • Peer Reviewed
• [Journal Article] Activation of epidermal growth factor receptor signaling by the prostaglandin E_2 receptor EP4 pathway during gastric tumorigenesis (2011)
  • Author(s): Oshima H, Popivanova BK, Oguma K, Kong D, Ishikawa T, and Oshima M.
  • Journal Title: Cancer Sci Volume: 102 Issue: 4 Pages: 713-719
  • DOI: 10.1111/j.1349-7006.2011.01847.x
  • NAID: 10029291933
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors. (2011)
  • Author(s): Oshima H, et al.
  • Journal Title: Gastroenterology Volume: 140 Pages: 596-607
  • NAID: 120002829318
  • Peer Reviewed
• [Journal Article] Activation of epidermal growth factor receptor signaling by the prostaglandin E_2 receptor EP4 pathway during gastric tumorigenesis. (2011)
  • Author(s): Oshima H, et al.
  • Journal Title: Cancer Science Volume: 102 Pages: 713-719
  • NAID: 10029291933
  • Peer Reviewed
• [Journal Article] Mouse models of gastric tumors : Wnt activation and PGE_2 induction (2010)
  • Author(s): Oshima H and Oshima M.
  • Journal Title: Pathol Int Volume: 60 Issue: 9 Pages: 599-607
  • DOI: 10.1111/j.1440-1827.2010.02567.x
  • NAID: 10031123383
  • Peer Reviewed
• [Journal Article] Inflammation, tumor necrosis factor and Wnt promotion in gastric cancer development (2010)
  • Author(s): Oguma K, Oshima H, and Oshima M.
  • Journal Title: Future Oncol Volume: 6 Pages: 515-526
  • URL: http://www.futuremedicine.com/doi/abs/10.2217/fon.10.13
  • Peer Reviewed
• [Journal Article] Gastric tumor mouse models : Wnt activation and PGE_2 induction. (2010)
  • Author(s): Oshima H, et al.
  • Journal Title: Pathology International Volume: 60 Pages: 599-607
  • Peer Reviewed
• [Journal Article] Inflammation, tumor necrosis factor and Wnt promotion in gastric cancer development. (2010)
  • Author(s): Oguma K, et al.
  • Journal Title: Future Oncology Volume: 6 Pages: 515-526
  • Peer Reviewed
• [Journal Article] Induction and downregulation of Sox17 and its roles during the course of gastrointestinal tumorigenesis (2009)
  • Author(s): Du Y-C, Oshima H, Kitamura T, Itadani H, Fujimura T, Piao YS, Yoshimoto T, Minamoto T, Taketo, MM, and Oshima M.
  • Journal Title: Gastroenterology Volume: 137 Issue: 4 Pages: 1346-1357
  • DOI: 10.1053/j.gastro.2009.06.041
  • Peer Reviewed
• [Journal Article] Induction of prostaglandin E_2 pathway promotes gastric hamartoma development with suppression of bone morphogenetic protein signaling (2009)
  • Author(s): Oshima H, Itadani H, Kotani H, Taketo MM, and Oshima M.
  • Journal Title: Cancer Res Volume: 69 Issue: 7 Pages: 2729-2733
  • DOI: 10.1158/0008-5472.can-08-4394
  • NAID: 120001413737
  • Peer Reviewed
• [Journal Article] Prostaglandin E_2, Wnt and BMP in gastric tumor mouse models (2009)
  • Author(s): Oshima H, Oguma K, Du Y-C, and Oshima M.
  • Journal Title: Cancer Sci Volume: 100 Pages: 1779-1785
  • NAID: 10027195136
  • Peer Reviewed
• [Journal Article] Induction of proltaglandin E2 pathway promotes gastric hamartoma development with suppression of bone morphogenetic protein signaling (2009)
  • Author(s): Oshima H, et al.
  • Journal Title: Cancer Research 69 Pages: 2729-2733
  • Peer Reviewed
• [Journal Article] Induction and downregulation of Sox17 and its possible roles during the course of gastrointestinal (2009)
  • Author(s): Du YC, et al.
  • Journal Title: Gastroenterology 137 Pages: 1346-1357
  • Peer Reviewed
• [Journal Article] Prostaglandin E2, Wnt and BMP in gastric tumor mouse models (2009)
  • Author(s): Oshima H, et al.
  • Journal Title: Cancer Science 100 Pages: 1779-1785
  • NAID: 10027195136
  • Peer Reviewed
• [Journal Article] Mouse gastric tumor models with prostaglandin E2 pathway activation show similar gene expression profiles to intestinal-type human gastric cancer (2009)
  • Author(s): Itadani H, et al.
  • Journal Title: BMC Genomics 10 Pages: 615-615
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 小熊圭祐, 大島正伸
  • Journal Title: 分子細胞治療 特集「炎症反応と消化器発がん」(先端医学社) Pages: 188-193
• [Presentation] Inflammatory-associated promotion of gastric tumorigenesis (2011)
  • Author(s): Oshima M.
  • Organizer: 9^<th> Japan-China Cancer Research Workshop
  • Place of Presentation: Oriental Riversideホテル(中国)
  • Year and Date: 2011-12-23
• [Presentation] Inflammatory-associated promotion of gastric tumorigenesis (2011)
  • Author(s): Oshima M
  • Organizer: 9^<th> Japan-China Cancer Research Workshop
  • Place of Presentation: Oriental Riversideホテル(中国)(招待講演)
  • Year and Date: 2011-12-23
• [Presentation] Effects of inflammatin on the epithelial differentiation and tumorigenesis (2011)
  • Author(s): Ishikawa T, and Oshima M.
  • Organizer: 16^<th> Japan-Korea Cancer Research Workshop
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2011-12-10
• [Presentation] TNF-αand infectious stimulation in gastric tumorigenesis (2011)
  • Author(s): Oshima M.
  • Organizer: 1^<st> International Scientific Coordination Network(ISCN)<日仏がんワークショップ>
  • Place of Presentation: モンペリエ・メルキュールホテル(フランス)
  • Year and Date: 2011-11-22
• [Presentation] TNF-α and infectious stimulation in gastric tumorigenesis (2011)
  • Author(s): Oshima M
  • Organizer: 1^<st> International Scientific Coordination Network (ISCN)
  • Place of Presentation: モンペリエ・メルキュールホテル(フランス)(招待講演)
  • Year and Date: 2011-11-22
• [Presentation] TNF-αand inflammatory responses in mouse gastric tumorigenesis (2011)
  • Author(s): Oshima M.
  • Organizer: 23^<th> Annual Meeting of the Korean Society for Molecular and Cellular Biology
  • Place of Presentation: ソウルCOEX(韓国)
  • Year and Date: 2011-10-06
• [Presentation] TNF-α and inflammatory responses in mouse gastric tumorigenesis (2011)
  • Author(s): Oshima M
  • Organizer: 23^<th> Annual Meeting of the Korean Society for Molecular and Cellular Biology
  • Place of Presentation: COEXセンター(韓国)(招待講演)
  • Year and Date: 2011-10-06
• [Presentation] Inflammatory responses in gastric cancer development (2011)
  • Author(s): Oshima M.
  • Organizer: 70^<th> Annual Meeting for Japanese Cancer Association
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] Inflammatory responses in gastric cancer development (2011)
  • Author(s): Oshima M
  • Organizer: 70^<th> Annual Meeting for Japanese Cancer Association
  • Place of Presentation: 名古屋国際会議場(愛知)(招待講演)
  • Year and Date: 2011-10-05
• [Presentation] Inflammatory responses and TNF-αin mouse gastric tumorigenesis (2011)
  • Author(s): Oshima H, and Oshima M.
  • Organizer: 70^<th> Annual Meeting for Japanese Cancer Association
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-04
• [Presentation] Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis (2011)
  • Author(s): Ishikawa T, and Oshima M.
  • Organizer: 70^<th> Annual Meeting for Japanese Cancer Association
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-03
• [Presentation] Mouse models of gastric cancer by Wnt activation and PGE_2 induction (2011)
  • Author(s): Oshima M.
  • Organizer: 4^<th> Annual Scientific Meeting of Singapore Gastric Cancer Consortium
  • Place of Presentation: 国立シンガポール大学(シンガポール)
  • Year and Date: 2011-07-05
• [Presentation] Mouse models of gastric cancer by Wnt activation and PGE_2 induction (2011)
  • Author(s): Oshima M
  • Organizer: 4^<th> Annual Scientific Meeting of Singapore Gastric Cancer Consortium
  • Place of Presentation: 国立シンガポール大学(シンガポール)(招待講演)
  • Year and Date: 2011-07-04
• [Presentation] 炎症性微小環境と消化管発がん (2011)
  • Author(s): 大島正伸
  • Organizer: 第1回「がん微小環境」公開ワークショップ
  • Place of Presentation: 東京大学(東京)
  • Year and Date: 2011-06-17
• [Presentation] 炎症性微小環境と消化管発がん (2011)
  • Author(s): 大島正伸
  • Organizer: 第1回新学術領域「がん微小環境」公開ワークショップ
  • Place of Presentation: 東京大学(東京都)(招待講演)
  • Year and Date: 2011-06-17
• [Presentation] Inflammatory microenvironment by cooperation of PGE_2 and bacterial infection in mouse gastric tumors (2011)
  • Author(s): Oshima H, Kong D, Ju XiaoLi, and Oshima M
  • Organizer: 日本分子生物学会第11回春季シンポジウム/金沢国際がん生物学シンポジウム
  • Place of Presentation: 石川県立音楽堂(石川県)
  • Year and Date: 2011-05-25
• [Presentation] COX-2/PGE_2 signaling and infectious stimulation in mouse gastric tumorigenesis (2011)
  • Author(s): Oshima H, and Oshima M.
  • Organizer: 9^<th> International Gastric Cancer Congress(IGCC)
  • Place of Presentation: ソウルCOEX(韓国)
  • Year and Date: 2011-04-21
• [Presentation] COX-2/PGE_2 signaling and infectious stimulation in mouse gastric tumorigenesis (2011)
  • Author(s): Oshima H, Oshima M
  • Organizer: 9^<th> International Gastric Cancer Congress (IGCC)
  • Place of Presentation: COEXセンター(韓国)(招待講演)
  • Year and Date: 2011-04-21
• [Presentation] Prostaglandin E_2-associated inflammation and bacterial infection in gastric tumorigenesis (2011)
  • Author(s): Oshima M.
  • Organizer: 1^<st> International Symposium on Carcinogenic Spiral
  • Place of Presentation: 東京大学(東京都)
  • Year and Date: 2011-02-02
• [Presentation] Downregulation of tumor suppressor microRNA in inflammatory microenvironment. (2011)
  • Author(s): Oshima H, et al.
  • Organizer: 1^<st> International Symposium on Carcinogenic Spiral
  • Place of Presentation: 東京大学(東京都)
  • Year and Date: 2011-02-01
• [Presentation] Inflammatory microenvironment by cooperation of PGE_2 and bacterial infection in mouse gastric tumors (2010)
  • Author(s): Oshima H, and Oshima M
  • Organizer: 15^<th> Japan-Korea Cancer Research Workshop
  • Place of Presentation: 仁川シェラトンホテル(韓国)
  • Year and Date: 2010-12-22
• [Presentation] Inflammatory microenvironment by cooperation of PGE_2 and bacterial infection in mouse gastric tumors. (2010)
  • Author(s): Oshima H, et al.
  • Organizer: 15^<th> Japan-Korea Cancer Research Workshop
  • Place of Presentation: Incheon Sheraton Hotel (Incheon, Korea)
  • Year and Date: 2010-12-22
• [Presentation] Promotion of gastric tumorigenesis by inflammatory prostaglandin E_2 (2010)
  • Author(s): Oshima M.
  • Organizer: 第33回日本分子生物学会年会/第83回日本生化学会大会合同大会[ BMB2010]
  • Place of Presentation: 神戸ポートピア(兵庫県)
  • Year and Date: 2010-12-07
• [Presentation] Promotion of gastric tumorigenesis by inflammatory prostaglandin E_2 (2010)
  • Author(s): 大島正伸
  • Organizer: 第33回日本分子生物学会年会/第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県) 招待講演
  • Year and Date: 2010-12-07
• [Presentation] Gastric cancer mouse models to understand the "biology of cancer" (2010)
  • Author(s): Oshima M.
  • Organizer: Seoul National Univ. Cancer Research Institute Symposium-Linking Systems Biology to Cancer Research
  • Place of Presentation: ソウル大学(韓国)
  • Year and Date: 2010-11-06
• [Presentation] Inflammatory responses and infection in Gastric tumorigenesis of mouse model (2010)
  • Author(s): Oshima M.
  • Organizer: International symposium on TGF-βsignaling, Inflammation and Cancer Prevention
  • Place of Presentation: CHAメディカルセンター(韓国)
  • Year and Date: 2010-11-05
• [Presentation] Inflammatory responses and infection in Gastric tumorigenesis of mouse model. (2010)
  • Author(s): Oshima M.
  • Organizer: 2^<nd> International Symposium on TGF-β signaling, Inflammation and Cancer Prevention.
  • Place of Presentation: CHA Cancer Institute (Seoul, Korea) 招待講演
  • Year and Date: 2010-11-05
• [Presentation] Gastric tumorigenesis through bacterial infection and COX-2/PGE_2 signaling pathway (2010)
  • Author(s): 大島浩子、大島正伸
  • Organizer: 第69回日本癌学会学術集会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪府)
  • Year and Date: 2010-09-22
• [Presentation] Gastric tumorigenesis in mice through Wnt activation and PGE_2-induced inflammatory responses (2010)
  • Author(s): Oshima M.
  • Organizer: International Symposium on Tumor Biology in Kanazawa-Satellite Symposium of 14^<th> International Congress of Immunology
  • Place of Presentation: KKRホテル(石川県)
  • Year and Date: 2010-08-28
• [Presentation] Gastric tumorigenesis in mice through Wnt activation and PGE_2-induced inflammatory responses. (2010)
  • Author(s): Oshima M.
  • Organizer: Satellite Symposium of 14^<th> International Congress of Immunology
  • Place of Presentation: 金沢KKRホテル(石川県) 招待講演
  • Year and Date: 2010-08-28
• [Presentation] 胃発がんにおける炎症反応とプロスタグランジンE_2の役割 (2010)
  • Author(s): 大島正伸
  • Organizer: 第25回発癌病理研究会
  • Place of Presentation: 松島一の坊(宮城県)
  • Year and Date: 2010-08-26
• [Presentation] 胃発がんにおける炎症反応とプロスタグランジンE_2の役割 (2010)
  • Author(s): 大島正伸
  • Organizer: 第25回発がん病理研究会
  • Place of Presentation: 松島一の坊ホテル(宮城県) 招待講演
  • Year and Date: 2010-08-26
• [Presentation] 胃癌発生を促進する炎症反応の分子機序 (2010)
  • Author(s): 大島正伸
  • Organizer: 第7回日本病理学会カンファレンス
  • Place of Presentation: 岡山全日空ホテル(岡山県)
  • Year and Date: 2010-08-06
• [Presentation] 胃癌発生を促進する炎症反応の分子機序 (2010)
  • Author(s): 大島正伸
  • Organizer: 第7回日本病理学会カンファレンス
  • Place of Presentation: 岡山コンベンションセンター(岡山県) 招待講演
  • Year and Date: 2010-08-06
• [Presentation] Wnt活性化と炎症による胃がん発生の分子機序 (2010)
  • Author(s): 大島正伸
  • Organizer: 第29回分子病理学研究
  • Place of Presentation: 筑波大学(茨城県)
  • Year and Date: 2010-07-31
• [Presentation] 炎症と胃がん発生:Pathway specificマウスモデルからのアプローチ (2010)
  • Author(s): 大島正伸
  • Organizer: 第29回分子病理学研究会
  • Place of Presentation: 筑波大学(茨城県) 招待講演
  • Year and Date: 2010-07-31
• [Presentation] Inflammatory responses in gastrointestinal tumorigenesis (2010)
  • Author(s): Oshima M.
  • Organizer: 5^<th> International Symposium of Institute Network
  • Place of Presentation: KKRホテル(石川県)
  • Year and Date: 2010-06-24
• [Presentation] 胃癌モデルマウスにおけるinitiation-promotion解析 (2010)
  • Author(s): 大島正伸
  • Organizer: 第19回日本がん転移学会学術集会
  • Place of Presentation: 金沢市文化ホール(石川県)
  • Year and Date: 2010-06-16
• [Presentation] 胃癌モデルマウスにおけるinitiation-promotion解析 (2010)
  • Author(s): 大島正伸
  • Organizer: 第19回日本がん転移学会学術集会
  • Place of Presentation: 金沢市文化ホール(石川県) 招待講演
  • Year and Date: 2010-06-16
• [Presentation] Recruitment of tumor-associated macrophages by cooperation of PGE_2 pathway and infectious stimulation (2010)
  • Author(s): Oshima H, Oguma K, Hioki K, and Oshima M.
  • Organizer: 101^<th> Annual Meeting of American Association for Cancer Research(AACR)
  • Place of Presentation: Washington DCコンベンションセンター(米国)
  • Year and Date: 2010-04-21
• [Presentation] Recruitment of tumor-associated macrophages by cooperation of PGE_2 pathway and infectious stimulation. (2010)
  • Author(s): Oshima H, et al.
  • Organizer: 101^<th> Annual Meeting of AACR (米国癌学会)
  • Place of Presentation: Convention Center (Washington DC, USA)
  • Year and Date: 2010-04-18
• [Presentation] 炎症と胃がん発生: Pathway specificマウスモデルからのアプローチ (2010)
  • Author(s): 大島正伸
  • Organizer: 第26回日本毒性病理学会
  • Place of Presentation: 石川県立音楽堂(石川県)
  • Year and Date: 2010-02-03
• [Presentation] 炎症と胃がん発生 : Pathway specific マウスモデルからのアプローチ (2010)
  • Author(s): 大島正伸
  • Organizer: 第26回日本毒性病理学会
  • Place of Presentation: 石川県立音楽堂 (石川県)
  • Year and Date: 2010-02-03
• [Presentation] Tumor macrophages and inflammatory pathway on gastric tumorigenesis (2009)
  • Author(s): Oshima M, Oguma K, and Oshima H.
  • Organizer: 14^<th> Korea-Japan Cancer Research Workshop
  • Place of Presentation: 金沢ANAクラウンプラザホテル(石川県)
  • Year and Date: 2009-12-20
• [Presentation] Promotion of Wnt/β-catenin signaling by TNF-α in gastrointestinal tumor cells (2009)
  • Author(s): 小熊圭祐, 大島浩子, 大島正伸
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: パシフィコ横浜 (神奈川県)
  • Year and Date: 2009-12-10
• [Presentation] Gastric tumorigenesis through cooperation of oncogenic activation and COX-2/PGE_2 pathway (2009)
  • Author(s): Oshima M.
  • Organizer: International Symposium on TGF-β, Inflammation, and Cancer Prevention
  • Place of Presentation: 仁川シェラトンホテル(韓国)
  • Year and Date: 2009-11-20
• [Presentation] 胃がん発生におけるCOX-2/PGE_2経路の役割 (2009)
  • Author(s): 大島正伸
  • Organizer: 第51回日本消化器病学会大会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2009-10-16
• [Presentation] 胃がん発生におけるCOX-2/PGE2経路の役割 (2009)
  • Author(s): 大島正伸
  • Organizer: 第51回日本消化器病学会
  • Place of Presentation: 国立京都国際会館 (京都府)
  • Year and Date: 2009-10-16
• [Presentation] Inflammation and gastric tumor mouse model[ Symposium] (2009)
  • Author(s): Oshima H, Oguma K, and Oshima M.
  • Organizer: 68^<th> Annual Meeting for Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-10-02
• [Presentation] Inflammation and gastric tumor mouse model (2009)
  • Author(s): 大島浩子, et al.
  • Organizer: 68^<th> Annual Meeting for Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜 (神奈川県)
  • Year and Date: 2009-10-02
• [Presentation] Gastric tumorigenesis through suppression of BMP signaling (2009)
  • Author(s): 大島正伸, et al.
  • Organizer: 68^<th> Annual Meeting for Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜 (神奈川県)
  • Year and Date: 2009-10-02
• [Presentation] Gastric tumorigenesis through suppression of BMP signaling[ International Session] (2009)
  • Author(s): Oshima H, and Oshima M.
  • Organizer: 68^<th> Annual Meeting for Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-10-01
• [Presentation] Gastric tumorigenesis through bacterial infection and COX-2/PGE_2 signaling pathway (2009)
  • Author(s): Oshima H, and Oshima M.
  • Organizer: 69^<th> Annual Meeting for Japanese Cancer Association
  • Place of Presentation: リーガロイヤルホテル(大阪府)
  • Year and Date: 2009-09-23
• [Presentation] Prostaglandin E_2 signaling and inflammation in gastric tumorigenesis (2009)
  • Author(s): Oshima M.
  • Organizer: 29^<th> International Symposium on Cancer
  • Place of Presentation: 北海道大学学術交流会館(北海道)
  • Year and Date: 2009-07-13
• [Presentation] Prostaglandin E2 signaling and inflammation in gastric tumorigenesis (2009)
  • Author(s): 大島正伸
  • Organizer: 29^<th> International Symposium on Cancer
  • Place of Presentation: 北海道大学学術交流会館 (北海道)
  • Year and Date: 2009-07-13
• [Presentation] Expression of Wnt antagonist Sox17 during the course of gastrointestinal tumorigenesis (2009)
  • Author(s): Du YC, et al.
  • Organizer: 29^<th> International Symposium on Cancer
  • Place of Presentation: 北海道大学学術交流会館 (北海道)
  • Year and Date: 2009-07-13
• [Presentation] Gastric tumorigenesis caused by cooperation of inflammation and oncogenic activation (2009)
  • Author(s): 大島正伸
  • Organizer: 17^<th> International Symposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: 金沢KKRホテル (石川県)
  • Year and Date: 2009-07-04
• [Presentation] Gastric tumorigenesis caused by cooperation of inflammation and oncogenic activation (2009)
  • Author(s): Oshima M.
  • Organizer: 17^<th> International Symposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: KKRホテル(石川県)
  • Year and Date: 2009-07-03
• [Presentation] Activated macrophages promote Wnt/β-catenin signaling activity in gastric epithelial cells through TNF-α (2009)
  • Author(s): 小熊圭祐, et al.
  • Organizer: 100^<th> Annual Meeting of AACR
  • Place of Presentation: Denver Convention Center, (USA)
  • Year and Date: 2009-04-22
• [Book] 消化管(胃・腸管)(疾患モデルマウス表現型解析指南) (2011)
  • Author(s): 大島正伸
  • Publisher: 中山書店
• [Book] 炎症とがん-最新の知見・総論-(侵襲と免疫) (2011)
  • Author(s): 大島正伸
  • Publisher: メジカルビュー社
• [Book] 癌と炎症(血管医学) (2011)
  • Author(s): 大島正伸
  • Publisher: メディカルレビュー社
• [Book] 消化器がん発生における慢性炎症の役割(医学のあゆみ) (2011)
  • Author(s): 大島正伸
  • Publisher: 医歯薬出版
• [Book] COX-2/PGE_2経路と発がん(実験医学) (2011)
  • Author(s): 大島正伸
  • Publisher: 羊土社
• [Book] 炎症反応による発癌促進のメカニズム(実験医学) (2011)
  • Author(s): 大島正伸
  • Publisher: 羊土社
• [Book] 慢性炎症と発がん:炎症性微小環境による発癌機構(実験医学) (2011)
  • Author(s): 大島浩子、大島正伸
  • Publisher: 羊土社
• [Book] 実験医学増刊「癌研究と分子標的治療」 (2011)
  • Author(s): 大島正伸
  • Publisher: 羊土社
• [Book] 実験医学増刊「慢性炎症」 (2011)
  • Author(s): 大島正伸
  • Publisher: 羊土社
• [Book] 血管医学(Vol.12/No.1) (2011)
  • Author(s): 大島正伸
  • Publisher: メディカルレビュー社
• [Book] 侵襲と免疫(Vol.20/No.4) (2011)
  • Author(s): 大島正伸
  • Publisher: メジカルビュー社
• [Book] 疾患モデルマウス表現型解析指南 (2011)
  • Author(s): 大島正伸
  • Publisher: 中山書店
• [Book] 実験医学増刊「癌研究と分子標的治療」:可炎症反応による発がん促進のメカニズム」 (2011)
  • Author(s): 大島正伸
  • Publisher: 羊土社
• [Book] 医学のあゆみ「慢性炎症と生活習慣病・癌」:「消化器がん発生における慢性炎症の般割」 (2011)
  • Author(s): 大島正伸
  • Publisher: 医歯薬出版
• [Book] 血管医学特集「生活習慣病と癌の基盤病態としての慢性炎症」:可癌と炎症」 (2011)
  • Author(s): 大島正伸
  • Publisher: メディカルレビュー社
• [Book] 胃癌発生における炎症反応の役割(細胞工学) (2010)
  • Author(s): 大島浩子、大島正伸
  • Publisher: 秀潤社
• [Book] COX-2/プロスタグランジンと消化器がん (2009)
  • Author(s): 大島正伸
  • Publisher: The Lipid
• [Remarks]
  • URL: http://genetics.w3.kanazawa-u.ac.jp/
• [Remarks]
  • URL: http://genetics.w3.kanazawa-u.ac.jp/
• [Remarks]
  • URL: http://www.kanazawa-u.ac.jp/~ganken/oshima/index.html
• [Remarks]
  • URL: http://www.kanazawa-u.ac.jp/~ganken/oshima/index.html