Study for the determination of cell fates by NotchL as environment factor
| Project/Area Number |
21390121
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ANDO Kiyoshi 東海大学, 医学部, 教授 (70176014)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 発生病理 / Notchリガンド / 分化環境 / 膵臟 / Sox9 / 膵細胞 / 未分化性 / 胸腺 / T細胞 |
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| Research Abstract |
Advances in the knowledge of the stem cells ; ES, iPS or tissue-specific stem cells, have allowed the significant improvement of regenerative medicine. However, these stem cells cannot differentiate into functional mature cells without an appropriate environment. Thus, the manipulation of the environment factors is necessary for the regeneration at various tissues. In this study, we have focused on Notch ligands as an environment factor, and examine their physiological significances for the development of lymphocytes or pancreas.
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Report
(4 results)
Research Products
(16 results)
