| Project/Area Number |
21390131
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Jun 九州大学, 医学研究院, 准教授 (60271441)
IIDA Ken-ichiro 九州大学, 医学研究院, 助教 (00346777)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | レジオネラ / 細胞内寄生 / 糖代謝 / 環境 / 生理学 / Legionella pneumophila / Legionella oakridgensis / 細胞内増殖 / Legionella dumoffii / 小胞体 / 低温 / グルコース代謝 / 細胞内寄生菌 / アメーバ |
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| Research Abstract |
Legionellae cause pneumonia in humans. Microbes that cause pneumonia usually live in the upper-respiratory organs and infect humans by droplets. In contrast, Legionella organisms are living in the environment such as surface water and soil. Hence, to totally understand Legionella infection, it is important to know how Legionella survives under environmental stress. One of their remarkable characteristics is their ability to grow in amoeba. They also have other abilities to survive in environmental stresses like low temperatures, low nutrition, etc. In this study, we tried to elucidate(1) the molecular mechanism by which they are able to grow in the amoeba at low temperature,(2) glucose metabolism which enables intracellular growth, and(3) micromillieu for intracellular bacterial growth in the host cells.
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