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Studies on cross-reactive antibodies to multiple subtypes of influenza virus henagglutinin induced by mucosal immunization

Research Project

Project/Area Number 21390134
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionHokkaido University

Principal Investigator

TAKADA Ayato  北海道大学, 人獣共通感染症リサーチセンター, 教授 (10292062)

Co-Investigator(Renkei-kenkyūsha) SUZUKI Yasuhiko  北海道大学, 人獣共通感染症リサーチセンター, 教授 (90206540)
ITO Kimihito  北海道大学, 人獣共通感染症リサーチセンター, 教授 (60396314)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords感染防御 / ワクチン / インフルエンザ / 抗体 / 粘膜免疫 / 交差感染防御
Research Abstract

Currently used parenteral influenza vaccines induce serum IgG antibody response against hemagglutinin (HA), but do not protect primary infection in the respiratory tissues. In addition, vaccine-induced antibodies are not cross-reactive to viruses with different HA subtypes from that of vaccine strains. In this study, we found that intranasal immunization of mice with inactivated influenza viruses induced antibodies cross-reactive to multiple HA subtypes. Furthermore, it was suggested that IgA antibodies associated with mucosal immunity played an important role in heterosubtypic inhibition of virus replication.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (42 results)

All 2012 2011 2010 2009 Other

All Journal Article (21 results) (of which Peer Reviewed: 11 results) Presentation (16 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Protective efficacy of neutralizing monoclonal antibodies in a nonhumar primate model of ebola hemorrhagic Fever2012

    • Author(s)
      Marzi A, Yoshida R, Miyamoto H, Ishijima M, Suzuki Y, Higuchi M, Matsuyama Y, Igarashi M, Nakayama E, Kuroda M, Saijo M, Feldmann F, Brining D, Feldmann H, Takada A
    • Journal Title

      PLoS One

      Volume: 7(4) Issue: 4 Pages: e36192-e36192

    • DOI

      10.1371/journal.pone.0036192

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adaptation of a duck influenza A virus in quail2011

    • Author(s)
      Yamada S, Shinya K, Takada A, Ito T, Suzuki T, Suzuki Y, Le QM, Ebina M, Kasai N, Kida H, Horimoto T, Rivailler P, Chen LM, Donis RO, Kawaoka Y
    • Journal Title

      J Virol

      Volume: 86(3) Issue: 3 Pages: 1411-1420

    • DOI

      10.1128/jvi.06100-11

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gnarled-trunk evolutionary model of influenza A virus hemagglutinin2011

    • Author(s)
      Ito K, Igarashi M, Miyazaki Y, Murakami T, Iida S, Kida H, Takada A
    • Journal Title

      PLoS ONE

      Volume: 6(10) Issue: 10 Pages: e25953-e25953

    • DOI

      10.1371/journal.pone.0025953

    • NAID

      120005476103

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross-protective peptide vaccine against influenza A viruses developed in HLA-A*2402 human immunity model2011

    • Author(s)
      Ichihashi T, Yoshida R, Sugimoto C, Takada A, Kajino K
    • Journal Title

      PLoS ONE

      Volume: 6(9) Issue: 9 Pages: e24626-e24626

    • DOI

      10.1371/journal.pone.0024626

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A vaccine prepared from a non-pathogenic H5N1 influenza virus strain from the influenza virus library conferred protective immunity to chickens against the challenge with antigenically drifted highly pathogenic avian influenza virus2011

    • Author(s)
      Samad RA, Nomura N, Tsuda Y, Manzoor R, Kajihara M, Tomabechi D, Sasaki T, Kokumai N, Ohgitani T, Okamatsu M, Takada A, Sakoda Y, Kida H
    • Journal Title

      Jpn J Vet Res

      Volume: 59 (1) Pages: 23-29

    • NAID

      120002777848

    • Related Report
      2011 Final Research Report
  • [Journal Article] An H5N1 highly pathogenic avian influenza virus that invaded Japan through waterfowl migration2011

    • Author(s)
      Kajihara M, Matsuno K, Simulundu E, Muramatsu M, Noyori 0, Manzoor R, Nakayama E, Igarashi M, Tomabechi D, Yoshida R, Okamatsu M, Sakoda Y, Ito K, Kida H, Takada A
    • Journal Title

      Jpn J Vet Res

      Volume: 59(2 & 3) Pages: 89-100

    • NAID

      120003354967

    • Related Report
      2011 Final Research Report
  • [Journal Article] Requirement of Siva-1 for replication of influenza A virus through apoptosis induction2011

    • Author(s)
      Shiozaki T, Iwai A, Kawaoka Y, Takada A, Kida H, Miyazaki T
    • Journal Title

      J Gen Virol

      Volume: 92(Pt2) Issue: 2 Pages: 315-325

    • DOI

      10.1099/vir.0.028316-0

    • Related Report
      2011 Final Research Report
  • [Journal Article] Characterization of influenza A viruses isolated from wild waterfowls in Zambia2011

    • Author(s)
      Simulundu E, et al
    • Journal Title

      J.Gen.Virol.

      Volume: 92 Issue: 6 Pages: 1416-1427

    • DOI

      10.1099/vir.0.030403-0

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic characterization and susceptibility on poultry and mammal of H7N6 subtype avian influenza virus isolated in Japan in 2009.2011

    • Author(s)
      Uchida Y, Kanehira K, Mase M, Takemae N, Watanabe C, Usui T, Fujimoto Y, Ito T, Igarashi M, Ito K, Takada A, Sakoda Y, Okamatsu M, Yamamoto Y, Nakamura K, Kida H, Hiromoto Y, Tsuda T, Saito T
    • Journal Title

      Vet Microbiol

      Volume: 147(1-2) Issue: 1-2 Pages: 1-10

    • DOI

      10.1016/j.vetmic.2010.05.037

    • Related Report
      2011 Final Research Report
  • [Journal Article] Characterization of human single-chain antibodies against highly pathogenic avian influenza H5N1 viruses : mimotope and neutralizing activity2010

    • Author(s)
      Yang, J., Yoshida, R., Kariya, Y., Zhang, X., Hashiguchi, S., Nakashima, T., Suda, Y., Takada, A., Ito, Y., Sugimura, K.
    • Journal Title

      Journal of biochemistry

      Volume: 148 Pages: 507-515

    • DOI

      10.1093/jb/mvq084

    • NAID

      10027879101

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influenza A virus polymerase inhibits type I interferon inductionby binding to interferon {beta} promoter stimulator 1.2010

    • Author(s)
      Iwai A, Shiozaki T, Kawai T, Akira S, Kawaoka Y, Takada A, Kida H, Miyazaki T
    • Journal Title

      J Biol Chem

      Volume: 285(42) Issue: 42 Pages: 32064-32074

    • DOI

      10.1074/jbc.m110.112458

    • Related Report
      2011 Final Research Report
  • [Journal Article] Characterization of H5N1 highly pathogenic avian influenza virus strains isolated from migratory waterfowl in Mongolia on the way back from the southern Asia to their northern territory2010

    • Author(s)
      Sakoda Y, Sugar S, Batchluun D, Erdene-Ochir TO, Okamatsu M, Isoda N, Soda K, Takakuwa H, Tsuda Y, Yamamoto N, Kishida N, Matsuno K, Nakayama E, Kajihara M, Yokoyama A, Takada A Sodnomdarjaa R, Kida H
    • Journal Title

      Virology

      Volume: 406(1) Pages: 88-94

    • Related Report
      2011 Final Research Report
  • [Journal Article] Antigenic, genetic, and pathogenic characterization of H5N1 highly pathogenic avian influenza viruses isolated from dead whooper swans (Cygnus cygnus) found in northern Japan in 20082010

    • Author(s)
      Okamatsu M, Tanaka T, Yamamoto N, Sakoda Y, Sasaki T, Tsuda Y, Isoda N, Kokumai N, Takada A, Umemura T, Kida H
    • Journal Title

      Virus Genes

      Volume: 41(3) Issue: 3 Pages: 351-357

    • DOI

      10.1007/s11262-010-0530-3

    • Related Report
      2011 Final Research Report
  • [Journal Article] Predicting the Antigenic Structure of the Pandemic (H1N1) 2009 Influenza Virus Hemagglutinin2010

    • Author(s)
      Igarashi M, Ito K, Yoshida R, Tomabechi D, Kida H, Takada A
    • Journal Title

      PLoS ONE

      Volume: 5(1) Issue: 1 Pages: e8553-e8553

    • DOI

      10.1371/journal.pone.0008553

    • NAID

      120001804925

    • Related Report
      2011 Final Research Report
  • [Journal Article] Antigenic, genetic, and pathogenic characterization of H5N1 highly pathogenic avian influenza viruses isolated from dead whooper swans (Cygnus cygnus) found in northern Japan in 20082010

    • Author(s)
      Okamatsu M, et al.
    • Journal Title

      Virus Genes

      Volume: 41 Pages: 351-357

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of H5N1 highly pathogenic avian influenza virus strains isolated from migratorywaterfowl in Mongolia on the way back from the southern Asia to their northern territory.2010

    • Author(s)
      Sakoda Y, et al.
    • Journal Title

      Virology

      Volume: 406 Pages: 88-94

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of human single-chain antibodies against highly pathogenic avian influenza H5N1 viruses : Mimotope and neutralizing activity2010

    • Author(s)
      Yang J, et al.
    • Journal Title

      J Biochem

      Volume: 148 Pages: 507-515

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predicting the Antigenic Structure of the Pandemic(H1N1)2009 Influenza Virus Hemagglutinin.2010

    • Author(s)
      Igarashi, M., Ito, K., Yoshida, R., Tomabechi, D., Kida, H., Takada, A.
    • Journal Title

      PLoS ONE 5

    • NAID

      120001804925

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of H3N6 avian influenza virus isolated from a wild white pelican in Zambia2009

    • Author(s)
      Simulundu E, Mweene A, Tomabechi D, Hang' ombe B, Ishii A, Suzuki Y, Nakamura I, Sawa H, Sugimoto C, Ito K, Kida H, Saiwana L, Takada A
    • Journal Title

      Arch Virol

      Volume: 154(9) Issue: 9 Pages: 1517-1522

    • DOI

      10.1007/s00705-009-0467-9

    • NAID

      120002383247

    • Related Report
      2011 Final Research Report
  • [Journal Article] Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutin of influenza A viruses2009

    • Author(s)
      Yoshida R, Igarashi M, Ozaki H, Kishida N, Tomabechi D, Kida H, Ito K, Takada A
    • Journal Title

      PLoS Pathog

      Volume: 5(3) Issue: 3 Pages: e1000350-e1000350

    • DOI

      10.1371/journal.ppat.1000350

    • Related Report
      2011 Final Research Report
  • [Journal Article] Characterization of H3N6 avian influenza virus isolated from a wild white pelican in Zambia.2009

    • Author(s)
      Simulundu, E., Mweene, A., Tomabechi, D., Hang'ombe, B., Ishii, A., Suzuki, Y., Nakamura, I., Sawa, H., Sugimoto, C., Ito, K., Kida, H., Saiwana, L., Takada, A.
    • Journal Title

      Arch.Virol. 154

      Pages: 1517-1522

    • NAID

      120002383247

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ウイルス感染と粘膜免疫2012

    • Author(s)
      高田礼人
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Related Report
      2011 Final Research Report
  • [Presentation] ウイルス感染と粘膜免疫2012

    • Author(s)
      高田礼人
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌市)(招待講演)
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] Characterization of monoclonal antibodies against the 2009 pandemic H1N1 Influenza virus hemagglutinin2011

    • Author(s)
      Yoshida R, Tomabechi D, Igarashi M, Miyamoto H, Yokoyama A, Kase T, Kida H, Takada A
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo
    • Year and Date
      2011-09-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of monoclonal antibodies against the 2009 pandemic H1N1 influenza virus hemagglutinin2011

    • Author(s)
      Yoshida R, et al
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] A highly pathogenic avian influenza virus (H5N1) that invaded Japan through waterfowl migration2011

    • Author(s)
      Ka jihara M, Matsuno K, Simulundu E, Muramatsu M, Noyori O, Manzoor R,Igarashi M, Okamatsu M, Sakoda Y, Kida H, Takada A
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo
    • Year and Date
      2011-09-14
    • Related Report
      2011 Final Research Report
  • [Presentation] A highly pathogenic avian influenza virus (H5N1) that invaded Japan through waterfowl migration2011

    • Author(s)
      Kajihara M, et al
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] パンデミックインフルエンザAウイルス(HIN1)ヘマグルチニンに対するモノクローナル抗体の性状解析2010

    • Author(s)
      吉田玲子,苫米地大輔,五十嵐学,宮本洋子,加瀬哲男,喜田宏,高田礼人
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-08
    • Related Report
      2011 Final Research Report
  • [Presentation] H3N2インフルエンザウイルスHAに付加された糖鎖は周辺エピトープを覆い隠していたか?~糖鎖付加部位周辺アミノ酸残基の多様性変化の解析~2010

    • Author(s)
      五十嵐学,高田礼人,喜田宏,伊藤公人
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-08
    • Related Report
      2011 Final Research Report
  • [Presentation] ウイルスの病原性と宿主域-人獣共通感染症としてのインフルエンザ-2010

    • Author(s)
      高田礼人
    • Organizer
      第75回日本民族衛生学会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-09-25
    • Related Report
      2011 Final Research Report
  • [Presentation] ウイルスの病原性と宿主域-人獣共通感染症としてのインフルエンザ-2010

    • Author(s)
      高田礼人
    • Organizer
      第75回日本民族衛生学会
    • Place of Presentation
      北海道大学(札幌市) 招待講演
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prediction of antigenic structure of hemagglutinin of pandemic (H1N1) 2009 influenza virus2010

    • Author(s)
      Igarashi M, Ito K, Kida H, Takada A
    • Organizer
      International Conference on Negative Strand Viruses
    • Place of Presentation
      Brugge
    • Year and Date
      2010-06-21
    • Related Report
      2011 Final Research Report
  • [Presentation] ホモロジーモデリング法による新型HINIインフルエンザウイルスのヘマグルチニンの抗原構造の解析2009

    • Author(s)
      五十嵐学,伊藤公人,吉田玲子,喜田宏,高田礼人
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-10-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 愛知県でウズラから分離されたH7N6亜型鳥インフルエンザウイルスの遺伝子解析2009

    • Author(s)
      内田裕子,真瀬昌司,竹前喜洋,廣本靖明,五十嵐学,伊藤公人,高田礼人,西藤岳彦,津田知幸,山口成夫
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-10-26
    • Related Report
      2011 Final Research Report
  • [Presentation] インフルエンザウイルスのヘマグルチニンのMDS解析と変異予測への応用2009

    • Author(s)
      伊藤公人,五十嵐学,村上悌治,喜田宏,高田礼人
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-10-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 人獣共通感染症としてのインフルエンザ2009

    • Author(s)
      高田礼人
    • Organizer
      第47回全国大学保健管理研究集会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 人獣共通感染症としてのインフルエンザ2009

    • Author(s)
      高田礼人
    • Organizer
      第47回全国大学保健管理研究集会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Book] インフルエンザウイルスの抗原変異予測とワクチン2009

    • Author(s)
      伊藤公人,高田礼人
    • Related Report
      2011 Final Research Report
  • [Book] インフルエンザウイルスの基礎月間化学642009

    • Author(s)
      高田礼人
    • Related Report
      2011 Final Research Report
  • [Book] 特集パンデミックインフルエンザ

    • Author(s)
      高田礼人
    • Publisher
      インフルエンザウイルスに対する免疫応答・感染防御機構
    • Related Report
      2011 Final Research Report
  • [Remarks] ホームページでの研究成果公開。

    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] インフルエンザウイルスに対する抗体およびその利用2009

    • Inventor(s)
      樋口恵,鈴木定彦,高田礼人,喜田宏,吉田玲子,五十嵐学,宮本洋子
    • Industrial Property Rights Holder
      科学技術振興機構,国立大学法人北海道大学
    • Industrial Property Number
      2009-275367
    • Filing Date
      2009-12-03
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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