Identification and characterization of host factors required for virus replication
| Project/Area Number |
21390136
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YAMAOKA Shoji 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (90263160)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | ウイルス複製 / ウイルス / 細胞因子 / HIV / 複製 |
|---|
| Research Abstract |
Two host cell factors were identified that regulate the replication of HIV-1, the causative agent of AIDS. One is involved in the reverse transcription stage, while the other is potentially involved in the nuclear translocation stage. The fact that these host factors did not affect cell growth implicates these factors as a potential therapeutic target for treatment of HIV-1-infected individuals.
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Report
(4 results)
Research Products
(17 results)
