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Identification and characterization of host factors required for virus replication

Research Project

Project/Area Number 21390136
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

YAMAOKA Shoji  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (90263160)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywordsウイルス複製 / ウイルス / 細胞因子 / HIV / 複製
Research Abstract

Two host cell factors were identified that regulate the replication of HIV-1, the causative agent of AIDS. One is involved in the reverse transcription stage, while the other is potentially involved in the nuclear translocation stage. The fact that these host factors did not affect cell growth implicates these factors as a potential therapeutic target for treatment of HIV-1-infected individuals.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2012 2011 2010 2009 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (15 results) Remarks (1 results)

  • [Journal Article] BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction.2009

    • Author(s)
      Miyakawa K, 他
    • Journal Title

      PLoS Pathog. 12

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒトCPSF6のC末欠損体はHIV-1感染後の逆転写効率に影響をおよぼす因子である2012

    • Author(s)
      堀 恭徳, 武内 寛明, 佐久間 龍太, 山岡 昇司
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] HIV-1潜伏感染系を用いたプロウイルスを再活性化する植物抽出物の解析2011

    • Author(s)
      魚田, ほか
    • Organizer
      第25回日本エイズ学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] アカゲザルTRIM5aによるHIV-1産生阻害活性の細胞特異性におけるSOCS1の役割2011

    • Author(s)
      助川, ほか
    • Organizer
      第25回日本エイズ学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] TRIM 5αによるHIV-1の感染・産生阻害に重要な宿主因子の探索2011

    • Author(s)
      鹿間, ほか
    • Organizer
      第25回日本エイズ学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] The Role of Suppressor of Cytokine Signaling 1 (SOCS1) in Rhesus Macaque TRIM5a-mediated restriction of HIV-1 production and its cell line dependency.2011

    • Author(s)
      助川, ほか
    • Organizer
      IUMS2011(国際ウイルス学会)
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Involvemnt of Actin Binding Protein Coronin 1C IN HIV-1 Replication and Rhesus Macaque 5α-Mediated Ated Restriction.2011

    • Author(s)
      鹿間, ほか
    • Organizer
      IUMS2011(国際ウイルス学会)
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒトCPSF6-375はHIV-1の逆転写産物精製を阻害する2010

    • Author(s)
      堀 恭徳, 大迫 美穂, 山岡 昇司
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Related Report
      2011 Final Research Report
  • [Presentation] Involvement of suppressor of cytokine signaling 1 (SOCS1) protein in the rhesus macaque TRIM5α mediated late restriction2010

    • Author(s)
      Ryuta Sakuma
    • Organizer
      CSHL Meeting on Retroviruses
    • Place of Presentation
      U.S.A., Cold Spring Harbur labortory (New York)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular epidemiology of HIV in the eastern part of Democratic Republic of Congo2010

    • Author(s)
      Ido, E.
    • Organizer
      XVIII International AIDS Conference
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of suppressor of cytokine signaling 1 (SOCS1) protein in the Rhesus Macaque TRIM5α-mediated restriction of HIV-1 production2010

    • Author(s)
      Sayaka Sukegawa
    • Organizer
      第11回熊本エイズセミナー・GCOE合同国際シンポジウム
    • Place of Presentation
      熊本大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] HIV-1複製を阻害するcDNAの単離と解析2009

    • Author(s)
      山岡昇司
    • Organizer
      第57回ウイルス学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] HIV-1複製を阻害するcDNAの単離と解析2009

    • Author(s)
      山岡昇司, 他
    • Organizer
      第57回ウイルス学会
    • Place of Presentation
      東京都市センターホテル
    • Related Report
      2009 Annual Research Report
  • [Presentation] ガーナにおける抗レトロウイルス治療(ART)中HIV感染者のウイルス定量と薬剤耐性解析2009

    • Author(s)
      石川晃一, 他
    • Organizer
      第23回日本エイズ学会総会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] アカゲザルTRIM5alphaによるHIV-1複製阻害に重要なアミノ酸残基の同定2009

    • Author(s)
      佐久間龍太, 他
    • Organizer
      第57回ウイルス学会
    • Place of Presentation
      東京都市センターホテル
    • Related Report
      2009 Annual Research Report
  • [Presentation] HIV-1感染と麻疹ウイルス感染が相互に及ぼす影響およびその機構の解析2009

    • Author(s)
      光木裕也, 他
    • Organizer
      第57回ウイルス学会
    • Place of Presentation
      東京都市センターホテル
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://molv.org/index.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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