| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Research Abstract |
Using the viral adaptation in cells and genetic engineering in vitro, we have successfully generated macaque-tropic HIV-1(HIV-1mt) that evades the anti-viral effect of all known anti-HIV-1 factors present in macaque cells(CypA, TRIM5., APOBEC3 and Tetherin). By improving the infection system of HIV-1mt and macaque monkeys, it would be possible to analyze experimentally the battle between HIV-1 and hosts. This would lead to the accomplishment of in vivo evaluation system for HIV-1 otherwise impossible.
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