Development of novel therapy against the transcriptional regulatory mechanism of human immunodeficiency virus(HIV).
Project/Area Number |
21390142
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Virology
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Research Institution | Nagoya City University |
Principal Investigator |
OKAMOTO Takashi 名古屋市立大学, 大学院・医学研究科, 教授 (40146600)
|
Co-Investigator(Kenkyū-buntansha) |
ASAMITSU Kaori 名古屋市立大学, 大学院・医学研究科, 講師 (20381783)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
Keywords | HIV-1 / NF-κB / Tat / Cyclin T1 / 潜伏感染 / HDAC / クロマチン / HIV / 転写機構 |
Research Abstract |
In this study, we have been exploring the step of viral transcription that is the rate-determining step of viral replication in order to provide vital information for the development of novel anti-HIV strategy. We have clarified the interaction between Tat and CycT1 at the AA side chain level by creating a number of CycT1 mutants in which critical AA resides were substituted by Ala based recently published 3D structure of Tat-CycT1 molecular complex. These findings have provided scientific basis for the development of Tat inhibitors.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Follicular Dendritic Cells Activate HIV-1 Replication in Monocytes/Macrophages Through a Juxtacrine Mechanism Mediated by P-Selectin Glycoprotein Ligand-112009
Author(s)
Kenji Ohba, Akihide Ryo, Zahidunnabi Dewan, Mayuko Nishi, Toshio Naito, Xiaohua Qi, Yoshio Inagaki, Yoji Nagashima, Yuetsu Tanaka, Takashi Okamoto, Kazuo Terashima, Naoki Yamamoto
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Journal Title
J.Immunol. 183
Pages: 524-532
Related Report
Peer Reviewed
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[Journal Article] Inhibition of the SDF-1α-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells form ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice2009
Author(s)
Akira Kawaguchi, Yasuo Orba, Takashi Kimura, Hidekatsu Iha, Masao Ogata, Takahiro Tsuji, Akira Ainai, Tetsutaro Sata, Takashi Okamoto, William W.Hall, Hirofumi Sawa, Hideki Hasegawa
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Journal Title
Related Report
Peer Reviewed
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