Memory Th1/Th2 cell differentiation and its epigenetic regulation

• Project/Area Number: 21390147
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Chiba University
• Principal Investigator: NAKAYAMA Toshinori 千葉大学, 大学院・医学研究院, 教授 (50237468)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: 免疫記憶 / アレルギー・喘息 / 細胞・組織 / シグナル伝達 / 免疫学 / タンパク質

Research Abstract

Immunological Memory is a central theme in acquired immunity. The findings from the research on Immunological Memory will contribute to the development of more effective and safer vaccines against infectious diseases, as well as can be beneficial to the development of therapeutic vaccines for controlling so called pathogenic immune memory cells that trigger allergy or autoimmune diseases, and furthermore, to the development of vaccines for cancer. In this study, we found that Polycomb group molecule EZH2 and Trithorax group molecules Men-1 control the generation and functional maintenance of Th2 memory cells.

Research Products

• [Journal Article] Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance (2012)
  • Author(s): Satoh, M., Andoh, Y., Clingan, S. C., Ogura, H., Fujii, S., Nakayama, T., Taniguchi, M., Hirata, N., Ishimori, N., Tsutsui, H., Onoe, K. Iwabuchi, K
  • Journal Title: PLoS ONE Volume: 7(2) Issue: 2 Pages: 1-12
  • DOI: 10.1371/journal.pone.0030568
  • NAID: 120004043739
  • Peer Reviewed
• [Journal Article] Murine Schnurri-2 controls Natural Killer cell function and lymphoma development (2012)
  • Author(s): Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., Tanaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S., Nakayama, T.
  • Journal Title: Leuk.Lymphoma Volume: 53 Issue: 3 Pages: 479-486
  • DOI: 10.3109/10428194.2011.625099
  • Peer Reviewed
• [Journal Article] The apelin/APJ system induces maturation of the tumor vasculature and improves the efficiency of immune therapy (2011)
  • Author(s): Kidoya, H., Kunii, N., Naito, H., Muramatsu, T., Okamoto, Y., Nakayama, T. Takakura, N
  • Journal Title: Oncogene in press
  • Peer Reviewed
• [Journal Article] Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice (2011)
  • Author(s): Tsuyusaki, J., Kuroda, F., Kasuya, Y., Ishizaki, I., Yamauchi, K., Sugimoto, H., Kono, T., Iwamura, C., Nakayama, T. Tatsumi, K
  • Journal Title: J. Recept. Sig. Transduct. Res Volume: 31 Pages: 434-439
  • Peer Reviewed
• [Journal Article] Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3 (2011)
  • Author(s): Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, J. D., Tokoyoda, K. Hosokawa, H., Yamashita, M. Nakayama, T
  • Journal Title: Immunity Volume: 35 Issue: 5 Pages: 733-745
  • DOI: 10.1016/j.immuni.2011.08.017
  • Peer Reviewed
• [Journal Article] IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation (2011)
  • Author(s): Takahashi, K., Hirose, K., Kawashima, S., Niwa, Y., Wakashin, H., Iwata, A., Tokoyoda, K., Renauland Nakad, J.-C., Iwamoto, I., Nakayama, T. Nakajima, H
  • Journal Title: J. Allergy Ciln. Immunol Volume: 128 Issue: 5 Pages: 1067-1076
  • DOI: 10.1016/j.jaci.2011.06.018
  • Peer Reviewed
• [Journal Article] Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin (2011)
  • Author(s): Yamauchi, K., Kasuya, Y., Kuroda, F., Tanaka, K., Tsuyusaki, J., Ishizaki, S., Matsunaga, H., Iwamura, C., Nakayama, T. Tatsumi, K
  • Journal Title: Respir. Res Volume: 12 Issue: 1 Pages: 131-131
  • DOI: 10.1186/1465-9921-12-131
  • Peer Reviewed
• [Journal Article] NKT-cell-based immunotherapies in clinical trials (2011)
  • Author(s): Exley, M. A., N Nakayama, T
  • Journal Title: Clin. Immunol Volume: 140 Issue: 2 Pages: 117-118
  • DOI: 10.1016/j.clim.2011.04.015
  • Peer Reviewed
• [Journal Article] Anti-tumor immune responses induced by iNKT cell-based immunotherapy for lung cancer and head and neck cancer (2011)
  • Author(s): Motohashi, S., Okamoto, Y., Yoshino, I. Nakayama, T
  • Journal Title: Ciln. Immunol Volume: 140 Issue: 2 Pages: 1647-176
  • DOI: 10.1016/j.clim.2011.01.009
  • Peer Reviewed
• [Journal Article] Memory type 2 helper T cells induce long-lasting anti-tumor immunityby activating natural killer cells (2011)
  • Author(s): Kitajima, M., Ito, T., Tumes, J. D., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Ziegler, F. S. Nakayama, T
  • Journal Title: Cancer Res Volume: 71 Issue: 14 Pages: 4790-4798
  • DOI: 10.1158/0008-5472.can-10-1572
  • Peer Reviewed
• [Journal Article] TSLP enhances the function of helper type2 cells. Eur (2011)
  • Author(s): Kitajima, M., Lee, H.-C., Nakayama, T. Ziegler, S. F
  • Journal Title: J. Immunol Volume: 41 Issue: 7 Pages: 1862-1870
  • DOI: 10.1002/eji.201041195
  • Peer Reviewed
• [Journal Article] Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses (2011)
  • Author(s): Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Kitajima, M., Shinoda, K., Namiki, T., Terasawa, K. Nakayama, T
  • Journal Title: Clin. Immunol Volume: 139 Issue: 3 Pages: 267-276
  • DOI: 10.1016/j.clim.2011.02.009
  • Peer Reviewed
• [Journal Article] Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3 (2011)
  • Author(s): Horiuchi, S., Onodera, A., Hosokawa, H., Watanabe, Y., Tanaka, T., Sugano, S., SuzukiY. Nakayama, T
  • Journal Title: J. Immunol Volume: 186 Issue: 11 Pages: 6378-6389
  • DOI: 10.4049/jimmunol.1100179
  • Peer Reviewed
• [Journal Article] ncrease of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in 2-year sublingual immunotherapy (SLIT) for Japanese cedar pollinosis (2011)
  • Author(s): Fujimura, T., Yonekura, S., Horiguchi, S., Taniguchi, Y., Saito, A., Yasueda, H., Inamine, A., Nakayama, T., Takemori, T., Taniguchi, M., Sakaguchi, M. Okamoto, Y
  • Journal Title: Clin. Immunol Volume: 139 Issue: 1 Pages: 65-74
  • DOI: 10.1016/j.clim.2010.12.022
  • Peer Reviewed
• [Journal Article] Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy (2011)
  • Author(s): Yamasaki, K., Horiguchi, S., Kurosaki, M., Kunii, N., Nagato, K., Hanaoka, H., Shimizu, N., Ueno, N., Yamamoto, S., Taniguchi, M., Motohashi, S., Nakayama, T. Okamoto, Y
  • Journal Title: Clin. Immunol Volume: 138 Issue: 3 Pages: 255-265
  • DOI: 10.1016/j.clim.2010.11.014
  • Peer Reviewed
• [Journal Article] Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function (2011)
  • Author(s): Yamashita, J., Iwamura, C., Sasaki, T., Mitsumori, K., Ohshima, K., Hada, K., Hara, N., Takahashi, M., Kaneshiro, Y., Tanaka, H., Kaneko, K. Nakayama, T
  • Journal Title: J. Immunol Volume: 186 Issue: 6 Pages: 3410-3420
  • DOI: 10.4049/jimmunol.1002924
  • Peer Reviewed
• [Journal Article] Migration and immunological reaction after the administration of αGalCer-pulsed antigen -presenting cells into the submucosa of patients with head and neck cancer (2011)
  • Author(s): Kurosaki, M., Horiguchi, S., Yamasaki, K., Uchida, Y., Motohashi, S., Nakayama, T., Sugimoto, A. Okamoto, Y
  • Journal Title: Cancer Immunol Volume: 60 Issue: 2 Pages: 207-215
  • DOI: 10.1007/s00262-010-0932-z
  • Peer Reviewed
• [Journal Article] Activation of pulmonary invariant NKT cells leads to exacerbation of acute lung injury caused by LPS through local production of IFN-_γ and TNF-α by Gr-1^+ monocytes (2011)
  • Author(s): Aoyagi, T., Yamamoto, N., Hatta, M., Tanno, D., Miyazato, A., Ishii, K., Suzuki, K., Nakayama, T., Taniguchi, M., Kunishima, H., Hirakata, Y., Kaku, M. Kawakami, K
  • Journal Title: Int. Immunol Volume: 23 Issue: 2 Pages: 97-108
  • DOI: 10.1093/intimm/dxq460
  • Peer Reviewed
• [Journal Article] Migration and immunological reaction after the administration of α GalCer-pulsed antigen-presenting cells into the submucosa of patients with head and neck cancer (2011)
  • Author(s): Kurosaki, M., Horiguchi, S., Yamasaki, K., Uchida, Y., Motohashi, S., Nakayama, T., Sugimoto, A., Okamoto, Y.
  • Journal Title: Cancer Immunol.Immunother Volume: 60 Pages: 207-215
  • Peer Reviewed
• [Journal Article] Activation of pulmonary invariant NKT cells leads to exacerbation of acute lung injury caused by LPS through local production of IFN-g and TNF-a by Gr-1^+ monocytes (2011)
  • Author(s): Aoyagi, T., Yamamoto, N., Hatta, M., Tanno, D., Miyazato, A., Ishii, K., Suzuki, K., Nakayama, T., Taniguchi, M., Kunishima, H., Hirakata, Y., Kaku, M., Kawakami, K.
  • Journal Title: Int.Immunol. Volume: 23 Pages: 97-108
  • Peer Reviewed
• [Journal Article] HIV-1 Nef impairs multiple T-cell functions in antigen-specific immune response in mice (2011)
  • Author(s): Fujii, H., Ato, M., Takahashi, Y., Otake, K., Hashimoto, S., Kaji, T., Tsunetsugu-Yokota, Y., Fujita, M., Adachi, A., Nakayama, T., Taniguchi, M. Koyasu, S., Takemori, T.
  • Journal Title: Int.Immunol. Volume: 23 Issue: 7 Pages: 433-441
  • DOI: 10.1093/intimm/dxr031
  • Peer Reviewed
• [Journal Article] Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice (2011)
  • Author(s): Tsuyusaki, J., Kuroda, F., Kasuya, Y., Ishizaki, I., Yamauchi, K., Sugimoto, H., Kono, T., Iwamura, C., Nakayama, T., Tatsumi, K.
  • Journal Title: J.Recept.Sig.Transduct.Res. Volume: 31 Issue: 6 Pages: 434-439
  • DOI: 10.3109/10799893.2011.631929
  • Peer Reviewed
• [Journal Article] ApolipoproteinA-II suppressed concanavalin A-induced hepatitis viainhibition of CD4 T cell function. (2011)
  • Author(s): Yamashita, J.
  • Journal Title: J.Immunol Volume: 186 Pages: 3410-3420
  • Peer Reviewed
• [Journal Article] Role of NKT cells in allergic asthma. Curr (2010)
  • Author(s): Iwamura, C. Nakayama, T
  • Journal Title: Opin. Immunol Volume: 22 Issue: 6 Pages: 807-81
  • DOI: 10.1016/j.coi.2010.10.008
  • Peer Reviewed
• [Journal Article] STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells (2010)
  • Author(s): Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Kanai, A., Suzuki, Y. Nakayama, T
  • Journal Title: J. Exp. Med Volume: 207 Issue: 11 Pages: 2493-2506
  • DOI: 10.1084/jem.20100760
  • Peer Reviewed
• [Journal Article] The TCR-mediated signaling pathways that control the direction of helper T cell differentiation (2010)
  • Author(s): Nakayama, T. Yamashita, M
  • Journal Title: Semin. Immunol Volume: 22 Issue: 5 Pages: 303-309
  • DOI: 10.1016/j.smim.2010.04.010
  • Peer Reviewed
• [Journal Article] Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species (2010)
  • Author(s): Suzuki, S., Tanaka, T., Poyurovsky, V. M., Nagano, H., Mayama, T., Ohkubo, S., Lokshin, M., Hosokawa, H., Nakayama, T., Suzuki, Y., Sugano, S., Sato, E., Nagao, T., Yokote, K., Tatsuno, I. Prives, C
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 107 Issue: 16 Pages: 7461-7466
  • DOI: 10.1073/pnas.1002459107
  • Peer Reviewed
• [Journal Article] Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung (2010)
  • Author(s): Suzuki, A., Iwamura, C., Shinoda, K., Tumes, J. D., Kimura, Y. M., Hosokawa, H., Endo, Y., Horiuchi, S., Tokoyoda, K., Koseki, H., Yamashita, M. Nakayama, T
  • Journal Title: J. Immunol Volume: 184 Issue: 8 Pages: 4510-4520
  • DOI: 10.4049/jimmunol.0903426
  • Peer Reviewed
• [Journal Article] The induced regulatory T-cell level, defined as the proportion of IL10+Foxp3+ cells among CD25+CD4+ leukocytes, is an available therapeutic biomarker for sublingual immunotherapy : A preliminary report (2010)
  • Author(s): Fujimura, T., Yonekura, S., Taniguchi, Y., Horiguchi, S., Saito, A., Yasueda, H., Nakayama, T., Takemori, T., Taniguchi, M., Sakaguchi, M. Okamoto, Y
  • Journal Title: Int. Arch. Allergy Immunol Volume: 153 Issue: 4 Pages: 378-387
  • DOI: 10.1159/000316349
  • Peer Reviewed
• [Journal Article] lColor-coded real-time cellular imaging of T lymphocyte accumulation and focus formation in mouse asthma model (2010)
  • Author(s): Hasegawa, A., Hayashi, K., Kishimoto, H., Yang, M., Tofukuji, S., Suzuki, K., Nakajima, H., Hoffman, R. M., Shirai, M. Nakayama, T
  • Journal Title: J Allergy Clin. Immunol Volume: 125 Issue: 2 Pages: 461-468
  • DOI: 10.1016/j.jaci.2009.09.016
  • Peer Reviewed
• [Journal Article] Organization of immunological memory by bone marrow stroma (2010)
  • Author(s): Tokoyoda, K., Hauser A. E., Nakayama, T. Radbruch, A
  • Journal Title: Nat. Rev. Immunol Volume: 10 Issue: 3 Pages: 193-200
  • DOI: 10.1038/nri2727
  • Peer Reviewed
• [Journal Article] Naringenin Chalcone Suppresses Allergic Asthma by Inhibiting the Type-2 Function of CD4 T Cells (2010)
  • Author(s): Iwamura, C., Shinoda, K., Yoshimura, M., Watanabe, Y., Obata, A. Nakayama, T
  • Journal Title: Allergology International Volume: 59 Issue: 1 Pages: 67-73
  • DOI: 10.2332/allergolint.09-OA-0118
  • NAID: 130004477071
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effect or Th2 cells in the lung. (2010)
  • Author(s): Suzuki, A.
  • Journal Title: J.Immunol. Volume: 184 Pages: 4510-4520
  • Peer Reviewed
• [Journal Article] Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. (2010)
  • Author(s): Suzuki, S.
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 107 Pages: 7461-7466
  • Peer Reviewed
• [Journal Article] The TCR-mediated signaling pathways that control the direction of helper Tcell differentiation. (2010)
  • Author(s): Nakayama, T.
  • Journal Title: Semin.Immunol. Volume: 22 Pages: 303-309
  • Peer Reviewed
• [Journal Article] STAT6-mediated displacement of polycomb by trithorax complexestablishes long-term maintenance of GATA3 expression in T helper type 2 cells. (2010)
  • Author(s): Onodera, A.
  • Journal Title: J.Exp.Med. Volume: 207 Pages: 2493-2506
  • Peer Reviewed
• [Journal Article] Role of NKT cells in allergic asthma. (2010)
  • Author(s): Iwamura, C.
  • Journal Title: Curr.Opin.Immunol Volume: 22 Pages: 807-810
  • Peer Reviewed
• [Journal Article] Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. (2010)
  • Author(s): Iwamura, C.
  • Journal Title: Allergology International 59 Pages: 67-73
  • Peer Reviewed
• [Journal Article] Color-coded real-time cellular imaging of T lymphocyte accumulation and focus formation in mouse asthma model. (2010)
  • Author(s): Hasegawa, A.
  • Journal Title: J Allergy Clin.Immunol 125
  • Peer Reviewed
• [Journal Article] Organization of immunological memory by bone marrow stroma. (2010)
  • Author(s): Tokoyoda, K.
  • Journal Title: Nat.Rev.Immunol. 10 Pages: 193-200
  • Peer Reviewed
• [Journal Article] CD69 controls the pathogenesis of allergic airway inflammation (2009)
  • Author(s): Miki, H. T., Hasegawa, A., Iwamura, C., Shinoda, K., Tofukuji, S., Watanabe, Y., Hosokawa, H., Motohashi, S., Hashimoto, K., Shirai, M., Yamashita, M. Nakayama, T
  • Journal Title: J. Immunol Volume: 183 Issue: 12 Pages: 8203-8215
  • DOI: 10.4049/jimmunol.0900646
  • Peer Reviewed
• [Journal Article] he Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3 (2009)
  • Author(s): Kohu, K., Ohmori, H., Wong, W. F., Onda, D., Wakoh, T., Kon, S., Yamashita, M., Nakayama, T., Kubo, M. Satake, M
  • Journal Title: J. Immunol Volume: 183 Issue: 12 Pages: 7817-7824
  • DOI: 10.4049/jimmunol.0802527
  • Peer Reviewed
• [Journal Article] Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice (2009)
  • Author(s): Kitajima, M., Iwamura, C., Miki, H. T., Shinoda, K., Endo, Y., Watanabe, Y., Shinnakasu, R., Hosokawa, H., Hashimoto, K., Motohashi, S., Koseki, H., Ohara, O., Yamashita, M. Nakayama, T.
  • Journal Title: J. Immunol Volume: 183 Issue: 8 Pages: 5388-5396
  • DOI: 10.4049/jimmunol.0804155
  • Peer Reviewed
• [Journal Article] Combination therapy of in vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma (2009)
  • Author(s): Kunii, N., Horiguchi, S., Motohashi, S., Yamamoto, H., Ueno, N., Yamamoto, S., Sakurai, D., Taniguchi, M., Nakayama, T. Okamoto, Y
  • Journal Title: Cancer Sci Volume: 100 Pages: 1092-1098
  • NAID: 10025146740
  • Peer Reviewed
• [Journal Article] Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory (2009)
  • Author(s): Nakayama, T. Yamashita, M
  • Journal Title: Semin. Immunol Volume: 21 Issue: 2 Pages: 78-83
  • DOI: 10.1016/j.smim.2009.02.001
  • Peer Reviewed
• [Journal Article] Natural killer T cell-mediated immunotherapy for malignant diseases. (2009)
  • Author(s): Motohashi, S.
  • Journal Title: Frontiers in Bioscience S1 Pages: 108-116
  • Peer Reviewed
• [Journal Article] Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory. (2009)
  • Author(s): Nakayama, T.
  • Journal Title: Semin.Immunol. 21 Pages: 78-83
  • Peer Reviewed
• [Journal Article] Combination therapy of in vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma. (2009)
  • Author(s): Kunii, N.
  • Journal Title: Cancer Sci. 100 Pages: 11092-1098
  • Peer Reviewed
• [Journal Article] Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice. (2009)
  • Author(s): Kitajima, M.
  • Journal Title: J.Immunol. 183 Pages: 5388-5396
  • Peer Reviewed
• [Journal Article] Bmil regulates memory Th cell survival via repression of the Noxa gene. (2009)
  • Author(s): Yamashita, M.
  • Journal Title: Proceedings of the 2^<nd> European Congress of Immunology Pages: 157-159
  • Peer Reviewed
• [Journal Article] The Runx3 transcription factor augments T_h1 and down-modulates T_h2 phenotypes by interacting with and attenuating GATA3. (2009)
  • Author(s): Kohu, K.
  • Journal Title: J.Immunol. 183 Pages: 7817-7824
  • Peer Reviewed
• [Journal Article] CD69 controls the pathogenesis of allergic airway inflammation. (2009)
  • Author(s): Miki, H.T.
  • Journal Title: J.Immunol. 183 Pages: 8203-8215
  • Peer Reviewed
• [Journal Article] The apelin/APJ system induces maturation of the tumor vasculature and improves the efficiency of immune therapy
  • Author(s): Kidoya, H., Kunii, N., Naito, H., Muramatsu, T., Okamoto, Y., Nakayama, T., Takakura, N.
  • Journal Title: Oncogen Volume: (in press)
  • Peer Reviewed
• [Journal Article] Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance
  • Author(s): Satoh, M., Andoh, Y., Clingan, S.C., Ogura, H., Fujii, S., Nakayama, T., Taniguchi, M., Hirata, N., Ishimori, N., Tsutsui, H., Onoe, K., Iwabuchi, K.
  • Journal Title: PLoS ONE Volume: (in press)
  • NAID: 120004043739
  • Peer Reviewed
• [Journal Article] Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung.
  • Author(s): Suzuki, A.
  • Journal Title: J.Immunol. (in press.)
  • Peer Reviewed
• [Journal Article] Phosphate activated glutaminase(GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species.
  • Author(s): Ishii, Y.
  • Journal Title: Proc.Natl.Acad.Sci.USA (in press.)
  • Peer Reviewed
• [Journal Article] The induced regulatory T-cell level, defined as the proportion of IL10^+Foxp3^+ cells among CD25^+CD4^+ leukocytes, is an available therapeutic biomarker for sublingual immunotherapy : A preliminary report.
  • Author(s): Fujimura, T.
  • Journal Title: Int.Arch.Allergy Immunol. (in press.)
  • Peer Reviewed
• [Presentation] Real-time cellular imaging of T lymphocyte accumulation in a mouse asthmamodel.喘息肺での浸潤リンパ球のリアルタイムイメージング 第85回日本細菌学会総会 (2012)
  • Author(s): Hasegawa, A., Shirai, M., Nakayama, T.
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2012-03-28
• [Presentation] The functional analysis of Exocyst complex subunit Sec8 on antigen presenting cells (2011)
  • Author(s): Matsunaga, S., Takahashi, K., Taguchi, J., Sakuramoto, M., Nakayama, T., Hashimoto, K.
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-15
• [Presentation] TGFβ converts an IL-4 function into a Th1 cell inducer (2011)
  • Author(s): Yamashita, M., Kuwahara, M., Suzuki, J., Nakayama, T., Tofukuji, S.
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-14
• [Presentation] VILI (Ventilator-Induced Lung Injury) modelにおけるNKT細胞の関与と役割/Protective role of NKT cells against ventilator-induced lung injury (2011)
  • Author(s): 志賀由佳、菅又龍一、長尾朋和、岩村千秋、川上和義、河内正治、中山俊憲、鈴木和男
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-29
• [Presentation] 肺炎球菌の血流感染及び肺炎における、IL-13による宿主防御の役割/Protective role of IL-13 in sepsis and respiratory infection against S.pneumoniae (2011)
  • Author(s): Yamamoto, N., DelaCruz, C., Takahashi, M., Fujita, T., Hosokawa, H., Nakayama, T., Akahori, Y., Yamamoto, H., Kawakami, K., Askenase, W.P., Kanemitsu, K.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-29
• [Presentation] 好酸球性慢性鼻副鼻腔炎に伴う鼻茸の病理学的形成機序の解明/Pathological mechanism of eosinophilic chronic rhinosinusitis with nasal polyps (2011)
  • Author(s): Iinuma, T., Inamine, A., Sakurai, T., Sakurai, D., Yamamoto, H., Nakayama, T., Okamoto, Y.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-29
• [Presentation] マウスSchnurri-2はNK細胞の機能とリンパ腫の発症を制御する/Murine Schnurri-2 controls Natural Killer cell function and lymphoma development (2011)
  • Author(s): Yamashita, J., Iwamura, C., Hosokawa, H., Sasaki, T., Tumes, D., Motohashi, S., Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] 進行期および再発非小細胞肺癌に対するa-GalCerパルス抗原提示細胞の局所投与療法-第I相試験-/A phase I study of loco-regional immunotherapy by trans-bronchial injection of a-Galactosylceramide-pulsed antigen presenting cells in patients with advanced and recurrent non-small cell lung cancer (2011)
  • Author(s): Ishibashi, F., Motohashi, S., Taniguchi, M., Yoshino, I., Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] 頭頸部癌患者に対するα GalCerパルス樹状細胞の投与部位と移動部位に関する検討/Migration and immunological reaction after administration of alpha-GalCer pulsed antigen presenting cells into submucosa of patients with head and neck cancer (2011)
  • Author(s): 佐々原剛、山崎一樹、本橋新一郎、岡本美孝、中山俊憲
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] メモリーTh2細胞はNK細胞を活性化し抗腫瘍効果を持続させる/Memory type2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells (2011)
  • Author(s): Ito, T., Kitajima, M., Tumes, J. D., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] 活性化NKT細胞によるメモリーTh2細胞の増加と機能変化/Selective expansion and functional modulation of memory Th2 cells by activated NKT cells in vivo (2011)
  • Author(s): 岩村千秋、篠田健太、高橋克己、中山俊憲
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] 腸炎の発症におけるCD69分子の役割/Crucial role for CD69 in the pathogenesis of DSS-induced colitis (2011)
  • Author(s): Hasegawa, A., Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] 骨髄におけるTヘルパー記憶の成立/Establishment of T helper memory in bone marrow (2011)
  • Author(s): Tokoyoda, K., Shinoda, K., Hanazawa, A., Hayashizaki, K., Radbruch, A., Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] α-GalCerパルスDCの口腔粘膜投与におけるアレルギー性鼻炎炎症の抑制機序の解明/Oral Submucosal administration of a-GalCer pulsed DCs inhibits local inflammation of allergic rhinitis (2011)
  • Author(s): Sakurai, T., Inamine, A., Sakurai, D., Iinuma, T., Ishii, Y., Nakayama, T., Okamoto, Y.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] STAT6 によって誘導されるポリコ.ムとトライソラックスの置換反応/ STAT6 -mediated displacement of Polycomb by Trithorax complex establishes long-term maintenance of GATA3 expression in Th2 cells (2011)
  • Author(s): Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Horiuchi, S., Watanabe, Y. Nakayama, T
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] TGFβはIL-4をTh1細胞分化誘導因子へと変換する/TGFβ converts IL-4 into a Th1 cell inducer (2011)
  • Author(s): Tofukuji, S., Kuwahara, M., Suzuki, J., Ohara, O., Nakayama, T., Yamashita, M.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] GATA3 ChIP-sequence解析を用いたTh2特異的遺伝子の転写調節機構の解明/Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3 (2011)
  • Author(s): 堀内周、小野寺淳、細川裕之、渡邊友紀子、中山俊憲
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] STAT6によって誘導されるポリコームとトライソラックスの置換反応/STAT6-mediated displacement of Polycomb by Trithorax complex establishes long-term maintenance of GATA3 expression in Th2 cells (2011)
  • Author(s): Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Horiuchi, S., Watanabe, Y., Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] Sox4はTGFβにより誘導され、Th2型免疫反応を抑制する/Sox4 acts as a downstream target of TGFβ and suppresses Th2 type immune responses (2011)
  • Author(s): Kuwahara, M., Iwamura, C, Shinoda, K., Tofukuji, S., Suzuki, J., Nakayama, T., Yamashita, M.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] Discovery of SH-2251 as a novel site-specific inhibitor for chromatin remodeling at the Il-5 gene locus (2011)
  • Author(s): Suzuki, J., Tofukuji, S., Kuwahara, M., Imamura, M., Nakayama, T., Ohara, O., Kato, F., Yamashita, M.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] Type II NKT 細胞は食事誘導性肥満を調節する/Type II NKT cells operatediet-induced obesity by mediating adipose tissue inflammation and steatohepatitis (2011)
  • Author(s): Satoh, M., Eshima, K., Nakayama, T., Taniguchi, M., Ishimori, N., Iwabuchi, K.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] 多発性筋炎マウスモデルにおける肥満細胞の役割の解析/Crucial roles of mast cells in a murine model of polymyositis (2011)
  • Author(s): 横田雅也、鈴木浩太郎、中込大樹、岩田有史、常世田好司、中山俊憲、上阪等、中島裕史
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] ROGはTh2による肥満細胞の脱顆粒を制御する事で接触性皮膚炎を抑制する/Repressor of GATA negatively regulates the induction of contact hypersensitivity via Th2-induced mast cell degranulation (2011)
  • Author(s): Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Shinoda, K., Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] α-GalCer-Ag DC の口腔粘膜下投与におけるアレルギー性鼻炎炎症の抑制機序の解明 (2011)
  • Author(s): 櫻井利興、稲嶺絢子、櫻井大樹、飯沼智久、米倉修二、石井保之、中山俊憲、岡本美孝
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-12
• [Presentation] アレルギー性鼻炎に対する免疫療法、最新の知見と展望 第61回日本アレルギー学会秋季学術大会 (2011)
  • Author(s): 櫻井大樹、米倉修二、山本陛三朗、稲嶺絢子、中山俊憲、岡本美孝
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-12
• [Presentation] IL-22は気道上皮細胞によるIL-25産生を抑制し、アレルギー性気道炎症を制御する (2011)
  • Author(s): 高橋健太郎、廣瀬晃一、川島沙紀、丹羽祐輔、若新英史、岩田有史、小林芳久、常世田好司、中山俊憲、谷口正実、秋山一男
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] 好酸球性副鼻腔炎鼻茸に浸潤するリンパ球の機能解析 (2011)
  • Author(s): 飯沼智久、稲嶺絢子、山本陛三朗、櫻井大樹、米倉修二、櫻井利興、中山俊憲、岡本美孝
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3 (2011)
  • Author(s): Onodera, A., Horiuchi, S., Hosokawa, H., Watanabe, Y., Suzuki, Y. Nakayama, T
  • Organizer: NCI Symposium on Chromosome Structure and Function
  • Place of Presentation: Bethesda, MD
  • Year and Date: 2011-11-01
• [Presentation] Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3 (2011)
  • Author(s): Onodera, A., Horiuchi, S., Hosokawa, H., Watanabe, Y., Suzuki, Y., Nakayama, T.
  • Organizer: NCI Symposium on Chromosome Structure and Function
  • Place of Presentation: Bethesda, MD, USA
  • Year and Date: 2011-11-01
• [Presentation] NKT cell-based Immunotherapy for non-small cell lung cancer (2011)
  • Author(s): Motohashi, S., Ishibashi, F., Taniguchi, M., Yoshino, I., Nakayama, T.
  • Organizer: 6th International Symposium on CD1 and NKT Cells
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-09-27
• [Presentation] NKT cell-mediated regulation of antigen-specific memory Th2 cell function (2011)
  • Author(s): Nakayama, T. Iwamura, C
  • Organizer: 6th International Symposium on CD1 and NKT Cells
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-09-25
• [Presentation] NKT細胞免疫系をターゲットにしたがんの免疫細胞治療 (2011)
  • Author(s): 中山俊憲、本橋新一郎
  • Organizer: 第15回日本がん免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-06-30
• [Presentation] Trans-bronchial intratumoral injection of α GalCer-pulsed APCs in patients with advanced or recurrent lung cancer (2011)
  • Author(s): Ishibashi, F., Motohashi, S., Taniguchi, M., Yoshino, I., Nakayama, T.
  • Organizer: 第15回日本がん免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-06-30
• [Presentation] Epigenetic regulation of GATA3 expression and its target genes in Th2 cells (2011)
  • Author(s): Nakayama, T
  • Organizer: 45th Joint Working Conference on Immunology and Viral Diseases
  • Place of Presentation: CA, USA
  • Year and Date: 2011-06-20
• [Presentation] Epigenetic regulation of GATA3 expression and its target genes in Th2 cells (2011)
  • Author(s): Nakayama, T.
  • Organizer: 45^<th> Joint Working Conference on Immunology and Viral Diseases
  • Place of Presentation: CA, USA
  • Year and Date: 2011-06-20
• [Presentation] Regulation of memory Th2 cell function and allergic airway inflammation via polycomb and trithorax molecules (2011)
  • Author(s): Nakayama, T. Onodera, A
  • Organizer: 30th Congress of the European Academy of Allergy and Clinical Immunology
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2011-06-15
• [Presentation] Regulation of memory Th2 cell function and allergic airway inflammation via polycomb and trithorax molecules (2011)
  • Author(s): Nakayama, T., Onodera, A.
  • Organizer: 30^<th> Congress of the European Academy of Allergy and Clinical Immunology
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2011-06-15
• [Presentation] TGFβはIL-4をTh1細胞分化誘導因子へと変換する (2011)
  • Author(s): 東福寺聡一、桑原誠、鈴木淳平、中山俊憲、山下政克
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] HMG box型転写因子Sox4はTGF-β刺激で誘導され、Th2細胞分化を抑制する (2011)
  • Author(s): 桑原誠、岩村千秋、篠田健太、東福寺聡一、鈴木淳平、中山俊憲、山下政克
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] Eomesodermin controls IL-5 production in memory Th2 cells through the inhibition of GATA3 activity (2011)
  • Author(s): 遠藤裕介、小野寺淳、細川裕之、中山俊憲
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] Selective expansion and functional modulation of memory Th2 cells by activated NKT cells in vivo (2011)
  • Author(s): 岩村千秋、篠田健太、花澤麻美、中山俊憲
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] Epigenetic control of memory Th2 cell function via Polycomb and Trithorax molecules (2011)
  • Author(s): Nakayama, T., Onodera, A
  • Organizer: EUThyme-Rolduc Meeting
  • Place of Presentation: Leeuwenhorst, NL
  • Year and Date: 2011-05-24
• [Presentation] GATA3 ChIP-sequence解析を用いたTh2特異的遺伝子の転写調節機構の解明 (2011)
  • Author(s): 堀内周, 小野寺淳, 細川裕之, 渡邊友紀子, 鈴木穣, 中山俊憲
  • Organizer: 第5回日本エピジェネティックス研究会
  • Place of Presentation: 熊本
  • Year and Date: 2011-05-19
• [Presentation] Generation and maintenance of memory Th1/Th2 cell identity (2010)
  • Author(s): Endo, Y., Onodera, A. Nakayama, T
  • Organizer: 2010 ASBMB
  • Place of Presentation: Tahoe City, USA
  • Year and Date: 2010-10-02
• [Presentation] ONODERA Atsushi, NAKAYAMA Toshinori.Generation and maintenance of memory Th1/Th2 cell identity. (2010)
  • Author(s): ENDO Yusuke
  • Organizer: ASBMB
  • Place of Presentation: Tahoe City, CA, USA
  • Year and Date: 2010-10-02
• [Presentation] STAT6-mediated displacement of Polycomb by Trithorax complex establishes long-term maintenance of GATA3 expression in Th2 cells (2010)
  • Author(s): Onodera, A., Endo, Y. Nakayama, T
  • Organizer: 2010 ASBMB
  • Place of Presentation: Tahoe City, USA
  • Year and Date: 2010-10-01
• [Presentation] STAT6-mediated disp acement of polycomb by trithorax complexestablishes long-term maintenance of GATA3 expression in T helpertype 2 cells. (2010)
  • Author(s): ONODERA Atshshi
  • Organizer: ASBMB
  • Place of Presentation: Tahoe City, CA, USA
  • Year and Date: 2010-10-01
• [Presentation] CD4 T cell memory controlled by Polycomb and Trithorax molecules (2010)
  • Author(s): Nakayama, T
  • Organizer: The 10th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, JAPAN
  • Year and Date: 2010-09-10
• [Presentation] CD4 T cell memory controlled by Polycomb and Trithorax molecules. (2010)
  • Author(s): Nakayama, T.
  • Organizer: The 10th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji(招待講演)
  • Year and Date: 2010-09-10
• [Presentation] 免疫記憶、ポリコ.ムとトライソラックスによる制御 (2010)
  • Author(s): 中山俊憲
  • Organizer: 第4回日本エピジェネティクス研究会
  • Place of Presentation: 米子
  • Year and Date: 2010-05-29
• [Presentation] 免疫記憶、ポリコームとトライソラックスによる制御 (2010)
  • Author(s): 中山俊憲
  • Organizer: 第4回日本エピジェネティクス研究会
  • Place of Presentation: 米子
  • Year and Date: 2010-05-29
• [Presentation] マクロファージ細胞株にみられる分泌輸送分子Sec8の貧食システムへの関与 (2009)
  • Author(s): 櫻本昌輝
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-12
• [Presentation] Regulation of GATA3-induced immune responses by the transcription factor Sox4. (2009)
  • Author(s): 山下政克
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-12
• [Presentation] Professional memory CD4 T lymphocytes preferentially reside and rest in the bone marrow. (2009)
  • Author(s): Tokoyoda, K.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Sox4 regulates GATA3-induced Th2 cell differentiation and Th2-dependent inflammatory responses. (2009)
  • Author(s): Kuwahara, M.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Transcription factor MLL regulates IL-4 mediated anti-tumor response by tumor specific memory Th2 cells. (2009)
  • Author(s): Hosokawa, H.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] The involvement of Sec8 molecule, a subunit of exocyst complex which supports vesicle trafficking, for activation process of B cell. (2009)
  • Author(s): 田口純
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Phase II study of ex vivo expanded natural killer T cells and α-GalactosylCeramide-pulsed antigen presenting cells administration before salvage operation in patients with recurrent head and neck carccinoma. (2009)
  • Author(s): Yamasaki, K.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] A set of genes whose expression is associated with the IFN-γ response/survival undergoing NKT cell-based immunotherapy. (2009)
  • Author(s): Motohashi, S.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] ApolipoproteinA-II protects from ConcanavalinA-induced hepatitis through the inhibition of CD4 T cell activation. (2009)
  • Author(s): 山下潤二
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] ヒト免疫疾患におけるメモリ-T細胞の役割:新展開 (2009)
  • Author(s): 中山俊憲
  • Organizer: 第37回日本臨床免疫学会(シンポジウム)
  • Place of Presentation: 東京
  • Year and Date: 2009-11-13
• [Presentation] Lactobacillus paracasei KW3110刺激により活性化された樹状細胞はアレルギー性鼻炎炎症を抑制する (2009)
  • Author(s): 稲嶺絢子
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田
  • Year and Date: 2009-10-31
• [Presentation] アレルギ-疾患の合併をどのように考えるか?基礎研究からの考察 (2009)
  • Author(s): 中山俊憲
  • Organizer: 第59回日本アレルギ-学会秋季学術大会(シンポジウム)
  • Place of Presentation: 秋田
  • Year and Date: 2009-10-31
• [Presentation] アレルギー性鼻炎モデルマウスに対するαGalCer-pulsed DC細胞療法 (2009)
  • Author(s): 植草康浩
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田
  • Year and Date: 2009-10-29
• [Presentation] Transcription factor MLL regulates IL-4 mediated anti-tumor response by tumor specific memory Th2 cells. (2009)
  • Author(s): Ito, T.
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] Phase II study of activated NKT cells and αGalcer-pulsed DCs before surgery in patients with head and neck cancer. (2009)
  • Author(s): Yamasaki, K.
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] A set of genes whose expression is associated with the IFN-γ response/survival undergoing NKT cell-based immunotherapy. (2009)
  • Author(s): Motohahsi, S.
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] iNKT cell based immunotherapy for cancer.招待講演 (2009)
  • Author(s): Nakayama, T.
  • Organizer: Japanese-German Cancer Workshop,(招待講演)
  • Place of Presentation: Hamburg, Germany
  • Year and Date: 2009-09-18
• [Presentation] Professional memory CD4 T lymphocytes reside and rest in the bone marrow. (2009)
  • Author(s): Tokoyoda, K.
  • Organizer: The2nd European Journal of Immunology 2009
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2009-09-16
• [Presentation] DC stimulated by lactobacillus paracasei KW3110, inhibits local inflammation of allergic rhinitis. (2009)
  • Author(s): Inamine, A.
  • Organizer: The2nd European Journal of Immunology 2009
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2009-09-16
• [Presentation] Bmil regulates memory Th2 cell survival via repression of the noxa gene. (2009)
  • Author(s): Nakayama, T.
  • Organizer: The2nd European Journal of Immunology 2009
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2009-09-15
• [Presentation] 抗原提示細胞にみられる泌小胞輸送分子Sec8と抗原ペプチドの動態 (2009)
  • Author(s): 櫻本昌輝
  • Organizer: 第18回日本バイオイメージング学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2009-09-04
• [Presentation] B細胞のプラズマ細胞化とその公化マーカー分子のイメージング解析 (2009)
  • Author(s): 松長修
  • Organizer: 第18回日本バイオイメージング学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2009-09-04
• [Presentation] 喘息肺へのTリンパ球細胞浸潤のイメージ (2009)
  • Author(s): 長谷川明洋
  • Organizer: 第18回日本バイオイメージング学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2009-09-04
• [Presentation] 次世代型"がん"治療 免疫治療の最前線 (2009)
  • Author(s): 中山俊憲
  • Organizer: 日本試薬協会講演会(招待講演)
  • Place of Presentation: 東京
  • Year and Date: 2009-09-01
• [Presentation] Development of new immunotherapy for cancer : iNKT cell-based immunotherapy. (2009)
  • Author(s): Nakayama, T.
  • Organizer: Thailand Research Expo 2009(招待講演)
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2009-08-29
• [Presentation] CD4陽性T細胞の機能分化:機能獲得と維持のメカニズム (2009)
  • Author(s): 中山俊憲
  • Organizer: 第21回日本比較免疫学会学術集会(特別講演)
  • Place of Presentation: 藤沢
  • Year and Date: 2009-08-04
• [Presentation] 免疫・アレルギ-疾患克服のためのトランスレーショナルリサーチ (2009)
  • Author(s): 中山俊憲
  • Organizer: 平成21年度第1回ちばバイオラクノロジーセミナー(招待講演)
  • Place of Presentation: 千葉
  • Year and Date: 2009-07-13
• [Presentation] NKT cell immunotherapy for lung cancer. (2009)
  • Author(s): 本橋新一郎
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 北九州
  • Year and Date: 2009-06-25
• [Presentation] Professional memory CD4^+ T lymphocytes reside and rest in the bone marrow. (2009)
  • Author(s): Tokoyoda, K.
  • Organizer: The 5^<th> International Workshop of Kyoto T Cell Conference 2009
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-06-04
• [Presentation] Regulation of memory Th cell survival and function by the polycomb and trithorax group gene products. The 5^<th> International Workshop of Kyoto T Cell Conference 2009, June 1-4, Kyoto, Japan (2009)
  • Author(s): Nakayama, T.
  • Organizer: The 5^<th> International Workshop of Kyoto T Cell Conference 2009
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-06-04
• [Presentation] ROG, repressor of GATA, regulates Th2-driven allergic airway inflammation and airway hyperresponsiveness. (2009)
  • Author(s): Nakayama, T.
  • Organizer: 96th Annual Meeting the American Association of Immunologists Immunology 2009(招待講演)
  • Place of Presentation: Seattle
  • Year and Date: 2009-05-09
• [Presentation] 免疫システム、その統御による免疫治療の開発研究 (2009)
  • Author(s): 中山俊憲
  • Organizer: 第9回Cardiovascular Frontier Conference(特別講演)
  • Place of Presentation: 東京
  • Year and Date: 2009-04-04
• [Remarks]
  • URL: http://www.m.chiba-u.ac.jp/class/meneki/homeb.htm
• [Remarks]
  • URL: http://www.isrt-gcoe-chiba.jp/
• [Patent(Industrial Property Rights)] 関節リウマチに対する抗IL-6受容体抗体療法の有効性の予測方法 (2011)
  • Inventor(s): 中島裕史(国立大学法人千葉大学大学院), 池田啓(国立大学法人千葉大学大学院), 加々美新一郎( 国立大学法人千葉大学大学院), 鈴木快枝(国立大学法人千葉大学大学院), 中山俊憲(国立大学法人千葉大学大学院), 岩本逸夫, 古田俊介, 小原收(財団法人かずさディー・エヌ・エー研究所), 野中謙, 山下政克(財団法人かずさディー・エヌ・エー研究所), 的場亮
  • Industrial Property Rights Holder: 国立大学法人千葉大学、財団法人かずさディー・エヌ・エー研究所
  • Filing Date: 2011-07-14
• [Patent(Industrial Property Rights)] 関節リウマチに対する抗IL-6受容体抗体療法の有効性の予測方法 (2011)
  • Inventor(s): 中島裕史、池田啓、加々美新一郎、鈴木快枝、中山俊憲、岩本逸夫、古田俊介、小原收、野中謙、山下政克、的場亮
  • Industrial Property Rights Holder: 国立大学法人千葉大学、財団法人かずさティー・エヌ・エー研究所
  • Filing Date: 2011-07-15
• [Patent(Industrial Property Rights)] INHIBITION OF CD69 FOR TREATMENT OF INFRAMMATORY CONDITIONS (2010)
  • Inventor(s): 中山俊憲(国立大学法人千葉大学), 長谷川明洋(国立大学法人山口大学), 白井睦訓国立大学法人山口大学)
  • Industrial Property Rights Holder: 国立大学法人千葉大学・国立大学法人山口大学
  • Filing Date: 2010-11-12
  • Overseas
• [Patent(Industrial Property Rights)] INHIBITION OF CD69 FOR TREATMENT OF INFRAMMATORY CONDITIONS (2010)
  • Inventor(s): 中山俊憲、長谷川明洋、白井睦訓
  • Industrial Property Rights Holder: 国立大学 法人千葉大学・国立大学法人 山口大学
  • Filing Date: 2010-11-12
  • Overseas