| Project/Area Number |
21390148
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Jun-ichiro 東京大学, 医科学研究所, 教授 (70176428)
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| Research Collaborator |
SHIMO Usuke 東京大学, 新領域創成科学科, 大学院生
HSHIMA Aisuke 東京大学, 新領域創成科学科, 大学院生
HINZAWA Miho 東京大学, 新領域創成科学科, 大学院生
KIYAMA Noubuko 東京大学, 医科学研究所, 客員研究員
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 免疫寛容 / 自己免疫 / 胸腺 / T細胞 / 遺伝子発現 / TNFレセプターファミリー / NF-kappaB / 転写制御 / TNFレセブターファミリー / インターフェロン |
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| Research Abstract |
T cells play critical roles in immune responses. During the development of T cells in the thymus, T cells recognizing self-antigens are eliminated, thereby preventing the onset of autoimmune diseases. Medullary thymic epithelial cells (mTECs) ectopically express self-antigen that are normally expressed in tissue specific manner. Our study identified transcription factors regulating gene expressions in mTEC, thereby modulating the differentiation of mTECs.
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