| Budget Amount *help |
¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Research Abstract |
We demonstrated that SH3-GUK interactions in CARMA1 is essential for NF-κB activation through antigen receptors by regulating multimerization CARMA1 that controls formation of NF-κB signalosome at immunological synapse. However, lack of this interaction in aged mice developed autoimmune-like skin lesions with hyper-IgE due to an aberrant Th2 response. Thus, SH3-GUK interactions of CARMA1 play an important role in peripheral T cell homeostasis through antigen receptors.
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