Regulation of CARMA1 signaling and its role in immune homeostasis
| Project/Area Number |
21390153
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Saga University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HIRAKAWA Hideki かずさDNA研究所, 主任研究員 (80372746)
FURUE Masutaka 九州大学, 医学研究院, 教授 (70134583)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
|
|---|
| Keywords | 抗原認識 / リンパ球 / 獲得免疫 / 免疫寛容・自己免疫 / シグナル伝達 / 癌 / アレルギー・ぜんそく / 免疫学 / ITAM / T細胞 / B細胞 / NF-κB / アレルギー / 免疫寛容 / 抗原受容体 |
|---|
| Research Abstract |
We demonstrated that SH3-GUK interactions in CARMA1 is essential for NF-κB activation through antigen receptors by regulating multimerization CARMA1 that controls formation of NF-κB signalosome at immunological synapse. However, lack of this interaction in aged mice developed autoimmune-like skin lesions with hyper-IgE due to an aberrant Th2 response. Thus, SH3-GUK interactions of CARMA1 play an important role in peripheral T cell homeostasis through antigen receptors.
|
Report
(4 results)
Research Products
(16 results)
