| Project/Area Number |
21390171
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
YANAI Kazuhiko 東北大学, 大学院・医学系研究科, 教授 (50192787)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Takehiko 東北大学, 大学院・医学系研究科, 名誉教授 (70028356)
YOSHIKAWA Takeo 東北大学, 大学院・医学系研究科, 助教 (70506633)
KURAMASU Atsuo 山口大学, 大学院・医学系研究科, 准教授 (90302091)
SAKURAI Eiko いわき明星大学, 薬学部, 教授 (90153949)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMURA Nobuyuki 東北大学, 大学院・医学系研究科, 准教授 (40361076)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | ヒスタミン / 神経変性疾患 / H3受容体 / 分子イメージング / PET / PMAT / H1受容体占拠率 / 膵ランゲルハンス島β細胞 / アルツハイマー病 / 分子イメニジング / 小動物用PET/CT / ヒト臨床研究 / 中枢神経系 / ノックアウトマウス / 抗ヒスタミン薬 |
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| Research Abstract |
Using leading-edge te chnologies, this study examined new roles of neuronal histamine which have not been fully dissolved. This study was performed on the experiments of molecular and cellular levels and whole animals, and we attempted the results were directly connected to tra nslational human PET studies. Main findings of this study are as follows : 1)The role of C-terminal on H3 receptors-mediated signal transduction were clarified ; 2)The transport of histamine in the CNS was mediated through a newly-identified non-specific t ransporter, PMAT (plasma membrane monoamine transporter)in astrocytes. 3)The existence and roles of H3 receptors in pancreatic islet cells were discovered for the first time. 4)The roles of histamine receptors on whole animals' behavioral levels were ex amined using histamine receptors knockout mice. 5)Brain pharmacokinetics of antihistamines was revealed using molecular PET imaging on the term of H1 receptor occupancy.
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