| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
|
|---|
| Research Abstract |
To put the molecular mechanism for pathogenesis of inflammatory pulmonary diseases to practical use, the following studies were performed. (1) Focusing on p38 which plays a central role in various inflammatory responses, one of mitogen-activated protein kinase (MAPK), we tried to produce transgenic mice exhibiting p38 activation in tetracycline-dependent and site (type II alveolar epithelial cell: AECII)-specific manners. (2) We confirmed that severity of bleomycin-induced interstitial pneumonia/pulmonary fibrosis is clearly dependent on the degree of p38 activation in AECII and that IL-6 produced from AECII plays a crucial role in the pathogenesis as a trigger. (3) We induced chronic obstructive pulmonary disease (COPD) in mice and comprehensively estimated plausible candidate molecules in COPD.
|
