Development of Redox Controlling Nanomedicine Based on Albumin Fusion

• Project/Area Number: 21390177
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Sojo University
• Principal Investigator: OTAGIRI Masaki 崇城大学, 薬学部, 教授 (80120145)
• Co-Investigator(Kenkyū-buntansha): MARUYAMA Toru 熊本大学, 薬学部, 教授 (90423657) ; WATANABE Hiroshi 熊本大学, 薬学部, 准教授 (70398220)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
• Keywords: ドラッグデリバリー / ヒト血清アルブミン / Thioredoxin 1 / Pichia酵母 / 肺障害 / 抗酸化能 / 酸化ストレス / Thioredexin 1

Research Abstract

Using albumin fusion technology, a novel redox controlling nanomedicine was designed and evaluated for applications in clinical settings. The results from various studies suggested that HSA-thioredoxin fusion protein has great potential as a therapeutic agent for treating oxidative stress and inflammation related diseases. In addition, a significant tumor metastasis activity from the EPR effect of SNO-HSA dimer has been confirmed. Based on the results of the current studies, preparations for a clinical trial led by a clinician are now in progress.

Research Products

• [Journal Article] Characterization of the hepatic cellular uptake of α(1)-acid glycoprotein (AGP), part 1: A peptide moiety of human AGP is recognized by the hemoglobin β-chain on mouse liver parenchymal cells (2012)
  • Author(s): Nishi K, Komori H, Kikuchi M, Uehara N, Fukunaga N, Matsumoto K, Watanabe H, Nakajou K, Misumi S, Suenaga A, Maruyama T, Otagiri M
  • Journal Title: J Pharm Sci Volume: 101 Pages: 1599-606
  • Peer Reviewed
• [Journal Article] Characterization of hepatic cellular uptake of α1-acid glycoprotein (AGP), part 2: Involvement of hemoglobin β-chain on plasma membranes in the uptake of human AGP by liver parenchymal cells (2012)
  • Author(s): Komori H, Nishi K, Uehara N, Watanabe H, Shuto T, Suenaga A, Maruyama T, Otagiri M
  • Journal Title: J Pharm Sci Volume: 101 Pages: 1607-15
  • Peer Reviewed
• [Journal Article] Quantitative evaluation of the role of cysteine and methionine residues in the antioxidant activity of human serum albumin using recombinant mutants (2012)
  • Author(s): Iwao Y, Ishima Y, Yamada J, Noguchi T, Kragh-Hansen U, Mera K, Honda D, Suenaga A, Maruyama T, Otagiri M
  • Journal Title: IUBMB Life Volume: 64 Pages: 450-454
  • Peer Reviewed
• [Journal Article] Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity (2011)
  • Author(s): Taguchi K, Miyasato M, Watanabe H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M
  • Journal Title: J Pharm Sci Volume: 100 Pages: 775-83
  • Peer Reviewed
• [Journal Article] Repeated injection of high doses of hemoglobin-encapsulated liposomes (hemoglobin vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model (2011)
  • Author(s): Taguchi K, Iwao Y, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M
  • Journal Title: Drug Metab Dispos Volume: 26 Pages: 2498-502
  • Peer Reviewed
• [Journal Article] Fluid resuscitation with hemoglobin vesicles prevents Escherichia coli growth via complement activation in a hemorrhagic shock rat model (2011)
  • Author(s): Taguchi K, Ogaki S, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M
  • Journal Title: J Pharmacol Exp Ther Volume: 337 Pages: 201-8
  • Peer Reviewed
• [Journal Article] Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney (2011)
  • Author(s): Miyamoto Y, Watanabe H, Noguchi T, Kotani S, Nakajima M, Kadowaki D, Otagiri M, Maruyama T
  • Journal Title: Nephrol Dial Transplant Volume: 26 Pages: 2498-502
  • Peer Reviewed
• [Journal Article] Spectroscopic studies of interactions of chondroitin sulfates with cisplatin (2011)
  • Author(s): Zhang JS, Anraku M, KadowakiD, Imai T, Suenaga A, Odai A, Otagiri M
  • Journal Title: Carbohydr Res Volume: 346 Pages: 631-37
  • Peer Reviewed
• [Journal Article] Structural insights into differences in drug-binding selectivity between two forms of human alphal-acid glycoprotein genetic variants, the A and F1^*S forms (2011)
  • Author(s): Nishi K, Ono T, Nakamura T, Fukunaga N, Izumi M, Watanabe H, Suenaga A, Maruyama T, Yamagata Y, Curry S, Otagiri M
  • Journal Title: J Biol Chem Volume: 286 Pages: 14427-34
  • Peer Reviewed
• [Journal Article] An autoantibody against N (ε)-(carboxyethyl) lysine (CEL) :possible involvement in the removal of CEL-modified proteins by macrophages (2011)
  • Author(s): Mera K, Nagai R, Takeo K, Izumi M, Maruyama T, Otagiri M
  • Journal Title: Biochem Biophys Res Commun Volume: 407 Pages: 420-5
  • Peer Reviewed
• [Journal Article] Vitamin D receptor activator reduces oxidative stress in hemodialysis patients with secondary hyperparathyroidism (2011)
  • Author(s): Tanaka M, Tokunaga K, Komaba H, Itoh K, Matsushita K, Watanabe H, Kadowaki D, Maruyama T, Otagiri M, Fukagawa M
  • Journal Title: Ther Apher Dial Volume: 15 Pages: 161-8
  • Peer Reviewed
• [Journal Article] Quantitative analysis of cysteine-34 on the anitioxidative properties of human serum albumin in hemodialysis patients (2011)
  • Author(s): Anraku M, Takeuchi K, Watanabe H, Kadowaki D, Kitamura K, Tomita K, Kuniyasu A, Suenaga A, Maruyama T, Otagiri M
  • Journal Title: J Pharm Sci Volume: 100 Pages: 3968-76
  • Peer Reviewed
• [Journal Article] Histidine146 of human serum albumin plays a prominent role at the interface of subdomains IA and IIA in allosteric ligand binding (2011)
  • Author(s): Kaneko K, Chuang VT, Minomo A, Yamasaki K, Bhagavan NV, Maruyama T, Otagiri M
  • Journal Title: IUBMB Life Volume: 63 Pages: 277-85
  • Peer Reviewed
• [Journal Article] Loss of functional albumin triggers acceleration of transthyretin amyloid fibril formation in familial amyloidotic polyneuropathy (2011)
  • Author(s): Kugimiya T, Jono H, Saito S, Maruyama T, Kadowaki D, Misumi Y, Hoshii Y, Tasaki M, Su Y, Ueda M, Obayashi K, Shono M, Otagiri M, Ando Y
  • Journal Title: Lab Invest Volume: 91 Pages: 1219-28
  • Peer Reviewed
• [Journal Article] Parathyroidectomy markedly reduces oxidative stress in a patient with primary hyperparathyroidism (2011)
  • Author(s): Tanaka M, Tokunaga K, Maruyama T, Otagiri M, Tominaga Y, Itoh K, Matsushita K, Komaba H, Fukagawa M
  • Journal Title: Ther Apher Dial Volume: 15 Pages: 38-41
  • Peer Reviewed
• [Journal Article] Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury (2011)
  • Author(s): Furukawa M, Tanaka R, Chuang VT, Ishima Y, Taguchi K, Watanabe H, Maruyama T, Otagiri M
  • Journal Title: J Control Release Volume: 154 Pages: 189-95
  • Peer Reviewed
• [Journal Article] Toxicodynamic evaluation of a cisplatin-chondroitin sulfate complex using a perfused kidney and human proximal tubular cells (2011)
  • Author(s): Zhang JS, Kadowaki D, Nonoguchi H, Hirata S, Seo H, Imai T, Suenaga A, Giam Chuang VT, Otagiri M
  • Journal Title: Ren Fail Volume: 33 Pages: 609-14
  • Peer Reviewed
• [Journal Article] Cellular uptake mechanisms and responses to NO transferred from mono- and poly-S-nitrosated human serum albumin (2011)
  • Author(s): Ishima Y, Yoshlda F, Kragh-Hansen U, Watanabe K, Katayama N, Nakajou K, Akaike T, Kai T, Maruyama T, Otagiri M
  • Journal Title: Free Radic Res Volume: 45 Pages: 1196-206
  • Peer Reviewed
• [Journal Article] Biological characteristics of two lysines on human serum albumin in the high-affinity binding of 4Z, 15Z-bilirubin-LXα revealed by phage display (2011)
  • Author(s): Minomo A, Ishima y, Kragh-Hansen U, Chuang VT, Uchida M, Taguchi K, Watanabe H, Maruyama T, Morioka H, Otagiri M
  • Journal Title: FEBS J Volume: 278 Pages: 4100-11
  • Peer Reviewed
• [Journal Article] S-Nitrosated Human Serum Albumin Dimer is not only a Novel Anti-Tumor Drug but also a Potentiator for Anti-Tumor Drugs with Augmented EPR Effects. f (2011)
  • Author(s): Ishima Y, Chen D, Fang J, Maeda H, Minomo A, Kragh-Hansen U, Kai T, Maruyama T, Otagiri M
  • Journal Title: Bioconjug Chem Volume: 23 Pages: 264-71
  • Peer Reviewed
• [Journal Article] New insight into the redox properties of uremic solute indoxyl sulfate as a pro- and anti-oxidant (2011)
  • Author(s): Miyamoto Y, Watanabe H, Otagiri M, Maruyama T
  • Journal Title: Ther Apher Dial Volume: 15 Pages: 129-31
  • Peer Reviewed
• [Journal Article] Pharmacokinetic properties of hemoglobin vesicles as a substitute for red blood cells (2011)
  • Author(s): Taguchi K, Maruyama T, Otagiri M
  • Journal Title: Drug Metab Rev Volume: 43 Pages: 362-73
  • Peer Reviewed
• [Journal Article] Update on the pharmacokinetics and redox properties of protein-bound uremic toxins (2011)
  • Author(s): Watanabe H, Miyamoto Y, Otagiri M, Maruyama T
  • Journal Title: J Pharm Sci Volume: 100 Pages: 3682-95
  • Peer Reviewed
• [Journal Article] Pharmacokinetic properties of hemoglobin vesicles as a substitute for red blood cells. (2011)
  • Author(s): Taguchi K, Maruyama T, Otagiri M.
  • Journal Title: Drug Metab Rev. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Vitamin d receptor activator reduces oxidative stress in hemodialysis patients with secondary hyperparathyroidism. (2011)
  • Author(s): Tanaka M, Tokunaga K, Komaba H, Itoh K, Matsushita K, Watanabe H, Kadowaki D, Maruyama T, Otagiri M, Fukagawa M.
  • Journal Title: Ther Apher Dial. Volume: 15 Pages: 161-8
  • Peer Reviewed
• [Journal Article] New insight into the redox properties of uremic solute indoxyl sulfate as a pro- and anti-oxidant. (2011)
  • Author(s): Miyamoto Y, Watanabe H, Otagiri M, Maruyama T.
  • Journal Title: Ther Apher Dial. Volume: 15 Pages: 129-31
  • Peer Reviewed
• [Journal Article] An autoantibody against N(ε)-(carboxyethyl)lysine (CEL) : Possible involvement in the removal of CEL-modified proteins by macrophages. (2011)
  • Author(s): Mera K, Nagai R, Takeo K, Izumi M, Maruyama T, Otagiri M.
  • Journal Title: Biochem Biophys Res Commun. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Spectroscopic studies of interactions of chondroitin sulfates with cisplatin. (2011)
  • Author(s): Zhang JS, Anraku M, Kadowaki D, Imai T, Suenaga A, Odani A, Otagiri M.
  • Journal Title: Carbohydr Res. Volume: 346 Pages: 631-7
  • Peer Reviewed
• [Journal Article] Structural insights into differences in drug binding selectivity between two forms of human {alpha}1-acid glycoprotein genetic variants, the A and FI^*S forms. (2011)
  • Author(s): Nishi K, Ono T, Nakamura T, Fukunaga N, Izumi M, Watanabe H, Suenaga A, Maruyama T, Yamagata Y, Curry S, Otagiri M.
  • Journal Title: J Biol Chem. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney. (2011)
  • Author(s): Miyamoto Y, Watanabe H, Noguchi T, Kotani S, Nakajima M, Kadowaki D, Otagiri M, Maruyama T.
  • Journal Title: Nephrol Dial Transplant. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Fluid Resuscitation with Hemoglobin Vesicles Prevents Escherichiacoli Growth via Complement Activation in a Hemorrhagic Shock Rat Model. (2011)
  • Author(s): Taguchi K, Ogaki S, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
  • Journal Title: J Pharmacol Exp Ther. Volume: 337 Pages: 201-8
  • Peer Reviewed
• [Journal Article] Repeated injection of high doses of hemoglobin-encapsulated liposomes (hemoglobin vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model. (2011)
  • Author(s): Taguchi K, Iwao Y, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
  • Journal Title: Drug Metab Dispos. Volume: 39 Pages: 484-9
  • Peer Reviewed
• [Journal Article] Superior plasma retention of a cross-linked human serum albumin dimer in nephrotic rats as a new type of plasma expander. (2010)
  • Author(s): Taguchi K, Urata Y, Anraku M, Watanabe H, Kawai K, Komatsu T, Tsuchida E, Maruyama T, Otagiri M.
  • Journal Title: Drug Metab Dispos. Volume: 38 Pages: 2124-9
  • Peer Reviewed
• [Journal Article] The antioxidative and antilipidemic effects of different molecular weight chitosans in metabolic syndrome model rats. (2010)
  • Author(s): Anraku M, Michihara A, Yasufuku T, Akasaki K, Tsuchiya D, Nishio H, Maruyama T, Otagiri M, Maezaki Y, Kondo Y, Tomida H.
  • Journal Title: Biol Pharm Bull. Volume: 33 Pages: 1994-8
  • NAID: 130000402332
  • Peer Reviewed
• [Journal Article] Enhancement of the aqueous solubility and masking the bitter taste of famotidine using drug/SBE-beta-CyD/povidone K30 complexation approach. (2010)
  • Author(s): Mady FM, Abou-Taleb AE, Khaled KA, Yamasaki K, Iohara D, Ishiguro T, Hirayama F, Uekama K, Otagiri M.
  • Journal Title: J Pharm Sci. Volume: 99 Pages: 4285-94
  • Peer Reviewed
• [Journal Article] Inhibitory effects of uraemic toxins 3-indoxyl sulfate and p-cresol on losartan metabolism in vitro. (2010)
  • Author(s): Tsujimoto M, Higuchi K, Shima D, Yokota H, Furukubo T, Izumi S, Yamakawa T, Otagiri M, Hirata S, Takara K, Nishiguchi K.
  • Journal Title: J Pharm Pharmacol. Volume: 62 Pages: 133-8
  • Peer Reviewed
• [Journal Article] Enhancement of dissolution and bioavailability of flurbiprofen by low molecular weight chitosans. (2010)
  • Author(s): Anraku M, Arahira M, Mady FM, Khaled KA, Yamasaki K, Seo H, Imai T, Otagiri M.
  • Journal Title: Pharmazie. Volume: 65 Pages: 461-6
  • Peer Reviewed
• [Journal Article] Evaluation of carboxymethyl-beta-cyclodextrin with acid function : improvement of chemical stability, oral bioavailability and bitter taste of famotidine. (2010)
  • Author(s): Mady FM, Abou-Taleb AE, Khaled KA, Yamasaki K, Iohara D, Taguchi K, Anraku M, Hirayama F, Uekama K, Otagiri M.
  • Journal Title: Int J Pharm. Volume: 397 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity. (2010)
  • Author(s): Taguchi K, Miyasato M, Watanabe H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
  • Journal Title: J Pharm Sci. Volume: 100 Pages: 775-83
  • Peer Reviewed
• [Journal Article] Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin vesicles, can be safely used under conditions of hepatic impairment. (2010)
  • Author(s): Taguchi K, Miyasato M, Ujihira H, Watanabe H, Kadowaki D, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
  • Journal Title: Toxicol Appl Pharmacol. Volume: 248 Pages: 234-41
  • Peer Reviewed
• [Journal Article] Albumin fusion of thioredoxin--the production and evaluation of its biological activity for potential therapeutic applications. (2010)
  • Author(s): Ikuta S, Chuang VT, Ishima Y, Nakajou K, Furukawa M, Watanabe H, Maruyama T, Otagiri M.
  • Journal Title: J Control Release. Volume: 147 Pages: 17-23
  • Peer Reviewed
• [Journal Article] Construction of an expression system for human alpha(1)-acid glycoprotein in E.coli : The roles of oligosaccharide moieties in structural and functional properties. (2010)
  • Author(s): Nishi K, Fukunaga N, Ono T, Akuta T, Yumita N, Watanabe H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
  • Journal Title: Drug Metab Pharmacokinet. Volume: 25 Pages: 200-7
  • Peer Reviewed
• [Journal Article] One-step preparation of S-nitrosated human serum albumin with high biological activities. (2010)
  • Author(s): Ishima Y, Hiroyama S, Kragh-Hansen U, Maruyama T, Sawa T, Akaike T, Kai T, Otagiri M.
  • Journal Title: Nitric Oxide. Volume: 23 Pages: 121-7
  • NAID: 120002971552
  • Peer Reviewed
• [Journal Article] The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions. (2010)
  • Author(s): Miyamoto Y, Iwao Y, Tasaki Y, Sato K, Ishima Y, Watanabe H, Kadowaki D, Maruyama T, Otagiri M.
  • Journal Title: FEBS Lett. Volume: 584 Pages: 2816-20
  • Peer Reviewed
• [Journal Article] Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics. (2010)
  • Author(s): Hirata K, Maruyama T, Watanabe H, Maeda H, Nakajou K, Iwao Y, Ishima Y, Katsumi H, Hashida M, Otagiri M.
  • Journal Title: J Control Release. Volume: 145 Pages: 9-16
  • Peer Reviewed
• [Journal Article] Receptor-mediated uptake of human alpha1-acid glycoprotein into liver parenchymal cells in mice. (2010)
  • Author(s): Matsumoto K, Nishi K, Kikuchi M, Watanabe H, Nakajou K, Komori H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
  • Journal Title: Drug Metab Pharmacokinet. Volume: 25 Pages: 101-7
  • Peer Reviewed
• [Journal Article] Construction of an expression system for human alfa_1-acid glycoprotein in E.coli : the role of oligosaccharide moieties on structural and functional properties (2010)
  • Author(s): Nishi K
  • Journal Title: Drug Metab Pharmacokinet (印刷中)
  • Peer Reviewed
• [Journal Article] Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics (2010)
  • Author(s): Hirata K
  • Journal Title: J Control Release (印刷中)
  • Peer Reviewed
• [Journal Article] Receptor-mediated uptake of human alpha1-acid glycoprotein into liver parenchymal cells in mice (2010)
  • Author(s): Matsumoto K
  • Journal Title: Drug Metab Pharmacokinet 25 Pages: 101-107
  • Peer Reviewed
• [Journal Article] Nitrosylated human serum albumin (SNO-HSA) induces apoptosis in tumor cells (2010)
  • Author(s): Katayama N
  • Journal Title: Nitric Oxide 22 Pages: 259-265
  • Peer Reviewed
• [Journal Article] Effect of reactive-aldehydes on the modification and dysfunction of human serum albumin (2010)
  • Author(s): Mera K
  • Journal Title: J Pharm Sci 99 Pages: 1614-1625
  • Peer Reviewed
• [Journal Article] Evaluation for antioxidant and renoprotective activity of olmesartan using nephrectomy rats (2009)
  • Author(s): Kadowaki D
  • Journal Title: Biol Pharm Bull 32 Pages: 2041-2045
  • Peer Reviewed
• [Journal Article] Updates on contemporary protein binding techniques (2009)
  • Author(s): Chuang VT
  • Journal Title: Drug Metab Pharmacokinet 24 Pages: 358-364
  • Peer Reviewed
• [Journal Article] Albumin as a nitric oxide-traffic protein : characterization, biochemistry and possible future therapeutic applications (2009)
  • Author(s): Ishima Y
  • Journal Title: Drug Metab Pharmacokinet 24 Pages: 308-317
  • Peer Reviewed
• [Journal Article] Hemoglobin vesicles, polyethylene glycol (PEG)ylated liposomes developed as a red blood cell substitute, do not induce the accelerated blood clearance phenomen on in mice (2009)
  • Author(s): Taguchi K
  • Journal Title: Drug Metab Dispos 37 Pages: 2197-2203
  • Peer Reviewed
• [Journal Article] Antioxidant properties of some different molecular weight chitosans (2009)
  • Author(s): Tomida H
  • Journal Title: Carbohydr Res 344 Pages: 1690-1696
  • Peer Reviewed
• [Journal Article] Pharmacokinetic study of enclosed hemoglobin and outer lipid component after the administration of hemoglobin vesicles as an artificial oxygen carrier (2009)
  • Author(s): Taguchi K
  • Journal Title: Drug Metab Dispos 37 Pages: 1456-1463
  • Peer Reviewed
• [Journal Article] Pharmacokinetics of single and repeated injection of hemoglobin-vesicles in hemorrhagic shock rat model (2009)
  • Author(s): Taguchi K
  • Journal Title: J Control Release 136 Pages: 232-239
  • Peer Reviewed
• [Journal Article] A site-directed mutagenesis study of drug-binding selectivity in genetic variants of human alpha(1)-acid glycoprotein (2009)
  • Author(s): Nishi K
  • Journal Title: J Pharm Sci 98 Pages: 4316-4326
  • Peer Reviewed
• [Journal Article] Altered chain-length and glycosylation modify the pharmacokinetics of human serum albumin (2009)
  • Author(s): Iwao Y
  • Journal Title: Biochim Biophys Acta 1794 Pages: 634-641
  • Peer Reviewed
• [Presentation] Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics (2011)
  • Author(s): Maruyama T, Otagiri M, et al
  • Organizer: 2011 AAPS Annual Meeting and Exposition
  • Place of Presentation: Chicago
• [Presentation] Quantitative Analysis of Cysteine-34 on the Anitioxidative Properties of Human Serum Albumin and its Physiological Significance in Hemodialysis Patients (2011)
  • Author(s): Anraku M, Otagiri M, et al
  • Organizer: Helsinki Drug Research 2011 Congress
  • Place of Presentation: Helsinki, Finland
• [Presentation] Albumin Fusion of Thioredoxin : Evaluation of Its Biological Activity for Potential Therapeutic Applications (2011)
  • Author(s): Otagiri M
  • Organizer: 8th Retro metabolism Based Drug Design and Targeting Conference
  • Place of Presentation: Graz, Austria
• [Presentation] Effect of genetically mannosylated-human serum albumin with nitric oxide on hepatic ischemia reperfusion injury (2011)
  • Author(s): Ishima Y, Otagiri M, et al
  • Organizer: 4th Asia Pacific Regional ISSX Meeting
  • Place of Presentation: Tainan. Taiwan
• [Presentation] Poly-SNO-アルブミンによる抗癌剤耐性克服効果 (2011)
  • Author(s): 渡邊博志、丸山徹、小田切優樹, 他
  • Organizer: 日本薬学会年会第131年会
  • Place of Presentation: 静岡
• [Presentation] The uremic solute indoxyi sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions (2011)
  • Author(s): Yohei Miyamoto, Masaki Otagiri, et al
  • Organizer: 4th Asia Pacific Regional ISSX Meeting
  • Place of Presentation: Tainan. Taiwan
• [Presentation] Characterization of structure and function of human serum albumin in patients with liver disease (2011)
  • Author(s): Nagumo K, Otagiri M, et al
  • Organizer: 4th Asia Pacific Regional ISSX Meeting
  • Place of Presentation: Tainan. Taiwan
• [Presentation] Carbon monoxide binding red blood cells prevent cytochrome p450 degradation in resuscitation after hemorrhagic shock in a rat model (2011)
  • Author(s): Shigeru Ogaki, Masaki Otagiri, et al
  • Organizer: 4th Asia Pacific Regional ISSX Meeting
  • Place of Presentation: Tainan. Taiwan
• [Presentation] Improved therapeutic effect of thioredoxin by fusing to human serum albumin against ovalbumin-induced lung injury (2011)
  • Author(s): Ryota Tanaka, Masaki Otagiri, et al
  • Organizer: 4th Asia Pacific Regional ISSX Meeting
  • Place of Presentation: Tainan. Taiwan
• [Presentation] Acute-phase protein alphal-acid glycoprotein acquires anti-bacterial activity through S-nitrosylation by a nitric oxide-dependent mechanism (2011)
  • Author(s): Kaori Watanabe, Masaki Otagiri, et al
  • Organizer: 4th Asia Pacific Regional ISSX Meeting
  • Place of Presentation: Tainan. Taiwan
• [Presentation] Involvement of hemoglobin beta-chain on plasma membrane in uptake of human alpha1-acid glycoprotein into liver (2011)
  • Author(s): Hisakazu Komori, Masaki Otagiri, et al
  • Organizer: 2011 AAPS Annual Meeting and Exposition
  • Place of Presentation: Chicago
• [Presentation] A peptide moiety of human α1-acid glycoprotein is recognized by the hemoglobin β-chain on mouse liver parenchymal cells (2011)
  • Author(s): Suenaga T, Otagiri M, et al
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Malaysia, Kuala Lumpur
• [Presentation] Interaction between p-cresyl sulfate and indoxyl sulfate during body disposition can influence their serum free concentrations in chronic kidney disease (2011)
  • Author(s): Hiroshi Watanabe, Masaki Otagiri, et al
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Malaysia, Kuala Lumpur
• [Presentation] Carbon monoxide bound red blood cells prevent alteration of hepatic cytochrome P450 activity after hemorrhagic shock and resuscitation (2011)
  • Author(s): Shigeru Ogaki, Masaki Otagiri, et al
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Malaysia, Kuala Lumpur
• [Presentation] Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury (2011)
  • Author(s): Yu Ishima, Masaki Otagiri, et al
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Malaysia, Kuala Lumpur
• [Presentation] Quantitative assessment of cysteinylated human serum albumin using ESI-TOF/MS and its clinical significance in chronic liver disease (2011)
  • Author(s): Nagumo K, Otagiri M, et al
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Malaysia, Kuala Lumpur
• [Presentation] 尿毒症物質CMPFの酸化ストレス誘発メカニズム (2011)
  • Author(s): 宮本洋平、岩尾康範、米良克美、渡邊博志、門脇大介、異島優、佐藤圭創、小田切優樹、丸山徹
  • Organizer: 日本薬学会年会第131年会
  • Place of Presentation: 静岡
• [Presentation] 尿毒症物質p-cresyl sulfateの酸化ストレスに及ぼす影響 (2011)
  • Author(s): 本田大輔、宮本洋平、渡邊博志、門脇大介、丸山徹、小田切優樹
  • Organizer: 日本薬学会年会第131年会
  • Place of Presentation: 静岡
• [Presentation] 高尿酸血症治療薬ベンズプロマロンの抗酸化作用評価 (2011)
  • Author(s): 坂口翔一、宮本洋平、佐藤圭創、丸山徹、小田切優樹、平田純生、門脇大介
  • Organizer: 日本薬学会年会第131年会
  • Place of Presentation: 静岡
• [Presentation] MS解析を用いた慢性肝炎時におけるヒト血清アルブミンのレドックス解析と構造及び機能との関連性 (2011)
  • Author(s): 南雲恒平、杉森剛志、窪田和幸、山田尚之、異島優、渡邊博志、田中基彦、佐々木裕、小田切優樹、丸山徹
  • Organizer: 日本薬学会年会第131年会
  • Place of Presentation: 静岡
• [Presentation] プレオマイシン誘発肺線維症に対するアルブミン-チオレドキシン融合体の有用性評価 (2011)
  • Author(s): 田中遼大、古川真斗、異島優、田中健一郎、水島徹、渡邊博志、小田切優樹、丸山徹
  • Organizer: 日本薬学会年会第131年会
  • Place of Presentation: 静岡
• [Presentation] 一酸化炭素結合型赤血球による肝CYP保護効果 (2011)
  • Author(s): 大柿滋、田口和明、渡邊博志、門脇大介、小田切優樹、丸山徹
  • Organizer: 日本薬学会年会第131年会
  • Place of Presentation: 静岡
• [Presentation] 112位と114位のアミノ酸残基はα1・酸性糖タンパク質バリアント間の薬物結合選択機構に寄与する (2011)
  • Author(s): 丸山徹、和泉実代子、中村照也、西弘二、小野知実、渡邊博志、山縣ゆり子、小田切優樹
  • Organizer: 日本薬学会年会第131年会
  • Place of Presentation: 静岡
• [Presentation] 出血性ショックモデルラットにおけるヘモグロビン小胞体頻回投与時での体内動態について (2011)
  • Author(s): 田口和明、渡邊博志、酒井宏水、丸山徹、小田切優樹
  • Organizer: 日本薬学会年会第131年会
  • Place of Presentation: 静岡
• [Presentation] 抗酸化作用に対するオルメサルタンとアゼルニジピンの併用効果 (2011)
  • Author(s): 末永綾香、麻生美紗子、宮本洋平、門脇大介、渡邊博志、小田切優樹、丸山徹
  • Organizer: 日本薬学会年会第131年会
  • Place of Presentation: 静岡
• [Presentation] α1-acid glycoprotein enhances the expression of hemoglobin scavenge receptor CD163 through the activation of TLR4 signaling (2010)
  • Author(s): 小森久和, 渡邊博志, 首藤剛, 丸山徹, 小田切優樹
  • Organizer: 第4回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-11-27
• [Presentation] ファージディスプレイ法を用いたHSA分子上のBR結合部位の探索 (2010)
  • Author(s): 蓑毛藍、小田切優樹, 他
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2010-03-27
• [Presentation] 肺障害モデルマウスに対するアルブミンチオレドキシン融合タンパク質の有用性評価 (2010)
  • Author(s): 丸山徹、小田切優樹, 他
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2010-03-27
• [Presentation] 糖鎖付加アルブミンを用いたクッパー細胞へのNOターゲティング (2010)
  • Author(s): 平田憲史朗、小田切優樹, 他
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2010-03-27
• [Presentation] 尿毒症物質フランジカルボン酸CMPFのレドックス特性 (2010)
  • Author(s): 宮本洋平
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2010-03-27
• [Presentation] α1-酸性糖タンパク質のヘモグロビンβ鎖を介した肝実質細胞取り込み機構の解明 (2010)
  • Author(s): 小森久和
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2010-03-27
• [Presentation] 慢性肝障害時におけるヘモグロビン小胞体(HbV)の体内動態特性 (2010)
  • Author(s): 田口和明
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2010-03-27
• [Presentation] S-ニトロソアルブミンによる細胞内NO輸送におけるNO修飾率の影響 (2010)
  • Author(s): 渡邊博志
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2010-03-27
• [Presentation] ヒト血清アルブミンの非酵素的糖化修飾における各中間体アルデヒドの役割 (2010)
  • Author(s): 末永綾香
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2010-03-27
• [Presentation] 血中における内因性S-cGMP化血清アルブミンの検出と機能評価 (2010)
  • Author(s): 異島優
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2010-03-27
• [Presentation] ヘモグロビン小胞体の出血性ショックモデルラットにおける大腸菌増殖抑制効果 (2010)
  • Author(s): 田口和明、渡邊博志、丸山徹、小田切優樹, 他
  • Organizer: 第17回日本血液代替物学会
  • Place of Presentation: 熊本
• [Presentation] ヒトa_1-酸性糖タンパク質/薬物複合体のX線結晶構造解析 (2010)
  • Author(s): 和泉実代子、小野知実、中村照也、西弘二、渡邊博志、丸山徹、山縣ゆり子、小田切優樹
  • Organizer: 日本薬剤学会第25年会
  • Place of Presentation: 徳島
• [Presentation] 尿毒症物質CMPFの酸化ストレス誘発機序解明 (2010)
  • Author(s): 宮本洋平、岩尾康範、渡邊博志、門脇大介、佐藤圭創、小田切優樹、丸山徹
  • Organizer: 日本薬剤学会第25年会
  • Place of Presentation: 徳島
• [Presentation] 一酸化炭素結合型赤血球による肝チトクロームP450の保護効果 (2010)
  • Author(s): 大柿滋、田口和明、渡邉博志、小田切優樹、丸山徹
  • Organizer: 日本薬剤学会第25年会
  • Place of Presentation: 徳島
• [Presentation] ヘモグロビン小胞体の体内動態と慢性肝障害の関係に関する検討 (2010)
  • Author(s): 田口和明, 宮里麻友美, 渡邊博志, 土田英俊, 小林紘一, 丸山徹, 小田切優樹
  • Organizer: 第26回日本DDS学会
  • Place of Presentation: 大阪
• [Presentation] チオレドキシンとアルブミン融合体の作製と生物活性の評価 (2010)
  • Author(s): 小田切優樹, 生田祥太郎, Tuan Giam Chung Victor, 異島優, 中城圭介, 古川真斗, 渡邊博志, 丸山徹
  • Organizer: 第26回日本DDS学会
  • Place of Presentation: 大阪
• [Presentation] α1-酸性糖タンパク質によるCD163の発現誘導 (2010)
  • Author(s): 小森久和, 渡邊博志, 首藤剛, 丸山徹, 小田切優樹
  • Organizer: 第35回 西日本薬剤学研究会
  • Place of Presentation: 大分
• [Presentation] IMPROVED THERAPEUTIC EFFECT OF THIOREDOXIN BY FUSION TO HUMAN SERUM ALBUMIN AGAINST BLEOMYCIN-INDUCED PULMONARY FIBROSIS (2010)
  • Author(s): 田中遼大、古川真斗、異島優、田中健一郎、水島徹、渡邊博志、小田切優樹、丸山徹
  • Organizer: 日本薬物動態学会 第25回年会
  • Place of Presentation: 東京
• [Presentation] PROTECTIVE EFFECT OF S-NITROSYLATED HUMAN SERUM ALBUMINS TO ORGAN INJURY (2010)
  • Author(s): Shinji Yoneshige, Yu Ishima, Ayaka Suenaga, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama
  • Organizer: 日本薬物動態学会 第25回年会
  • Place of Presentation: 東京
• [Presentation] X-RAY CRYSTALLOGRAPHIC STUDY OF HUMAN ALPHA1-ACID GLYCOPROTEIN AND DRUG COMPLEX (2010)
  • Author(s): Miyoko Izumi, Tomomi Ono, Teruya Nakamura, Koji Nishi, Hiroshi Watanabe, Toru Maruyama, Yuriko Yamagata, Masaki Otagiri
  • Organizer: 日本薬物動態学会 第25回年会
  • Place of Presentation: 東京
• [Presentation] Effect OF combination treatment of Azelnidipine on Antioxidative activity of Ol mesaltan In human vascular endothelial cells (2010)
  • Author(s): Misako Aso, Yohei Miyamoto, Daisuke Kadowaki, Hiroshi Watanabe, Ayaka Suenaga, Masaki Otagiri, Toru Maruyama
  • Organizer: 日本薬物動態学会 第25回年会
  • Place of Presentation: 東京
• [Presentation] POLY-S-NITROSYLATED HUMAN SERUM ALBUMIN REVERTS THE RESISTANCE TO DOXORUBICIN IN HUMAN MYELOGENOUS LEUKEMIC CELLS (2010)
  • Author(s): 原茉梨絵、異島優、末永綾香、小田切優樹、丸山徹
  • Organizer: 日本薬物動態学会 第25回年会
  • Place of Presentation: 東京
• [Presentation] CHARACTERIZATION OF STRUCTURE AND FUNCTION OF HUMAN SERUM ALBUMIN IN PATIENTS WITH LIVER DISEASE (2010)
  • Author(s): Kohei Nagumo, Tsuyoshi Sugimori, Motohiko Tanaka, Yutaka Sasaki, Yu Ishima, Hiroshi Watanabe, Kazuyuki Kubota, Naoyuki Yamada, Masaki Otagiri, Toru Maruyama.
  • Organizer: 日本薬物動態学会 第25回年会
  • Place of Presentation: 東京
• [Presentation] α_1-酸性糖タンパク質はS-ニトロソ化により抗菌活性を獲得する (2010)
  • Author(s): 渡辺佳織, 異島優, 末永綾香, 渡邊博志, 甲斐俊哉, 丸山徹, 小田切優樹
  • Organizer: 第17回日本血液代替物学会
  • Place of Presentation: 熊本
• [Presentation] 出血性ショックモデルラットにおける一酸化炭素結合型赤血球のチトクロームP450の保護効果 (2010)
  • Author(s): 大柿滋、田口和明、渡邉博志、小田切優樹、丸山徹
  • Organizer: 第17回日本血液代替物学会
  • Place of Presentation: 熊本
• [Presentation] ヘモグロビン小胞体の体内動態特性に基づく安全性評価 (2010)
  • Author(s): 田口和明, 丸山徹, 小田切優樹
  • Organizer: 第17回日本血液代替物学会
  • Place of Presentation: 熊本
• [Presentation] S-ニトロソ化α_1-酸性糖タンパク質の抗菌活性評価 (2010)
  • Author(s): 渡辺佳織, 異島優, 末永綾香, 渡邊博志, 甲斐俊哉, 丸山徹, 小田切優樹
  • Organizer: 第32回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 富山
• [Presentation] 出血性ショックモデルラットにおける一酸化炭素結合型赤血球の肝チトクロームP450保護効果 (2010)
  • Author(s): 大柿滋、田口和明、渡邊博志、小田切優樹、丸山徹
  • Organizer: 第32回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 富山
• [Presentation] リポソーム型人工酸素運搬体 ヘモグロビン小胞体の脂質膜構成成分の安全性に関する検討 (2010)
  • Author(s): 田口和明, 渡邊博志, 酒井宏水, 丸山徹, 小田切優樹
  • Organizer: 第32回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 富山
• [Presentation] 尿毒症物質CMPFの生体内レドックス特性 (2010)
  • Author(s): 宮本洋平、岩尾康範、渡邊博志、門脇大介、佐藤圭創、小田切優樹、丸山徹
  • Organizer: 第27回臨床フリーラジカル会議
  • Place of Presentation: 京都
• [Presentation] 一酸化炭素を付加した赤血球は大量出血時における肝チトクロームP450を保護する (2010)
  • Author(s): 大柿滋、田口和明、渡邉博志、小田切優樹、丸山徹
  • Organizer: 第27回日本薬学会九州支部大会
  • Place of Presentation: 長崎
• [Presentation] BLM誘発肺線維症に対するアルブミン-チオレドキシン融合タンパク質の有用性評価 (2010)
  • Author(s): 田中遼大、古川真斗、異島優、田中健一郎、水島徹、渡邊博志、小田切優樹、丸山徹
  • Organizer: 第27回日本薬学会九州支部大会
  • Place of Presentation: 長崎
• [Presentation] α_1-酸性糖タンパク質はS-ニトロソ化により抗菌活性を獲得する (2010)
  • Author(s): 渡辺佳織, 異島優, 末永綾香, 渡邊博志, 甲斐俊哉, 丸山徹, 小田切優樹
  • Organizer: 第27回日本薬学会九州支部大会
  • Place of Presentation: 長崎
• [Presentation] Poly-SNO-アルブミンによる抗癌剤多剤耐性克朋効果 (2010)
  • Author(s): 原茉梨絵、異島優、末永綾香、丸山徹、小田切優樹
  • Organizer: 第27回日本薬学会九州支部大会
  • Place of Presentation: 長崎
• [Presentation] 肝疾患時におけるアルブミンの構造及び機能評価 (2010)
  • Author(s): 南雲恒平, 杉森剛志, 田中基彦, 佐々木裕, 異島優, 渡邊博志, 窪田和幸, 山田尚之, 小田切優樹, 丸山徹
  • Organizer: 第27回日本薬学会九州支部大会
  • Place of Presentation: 長崎
• [Presentation] オルメサルタンの抗酸化作用に及ぼすアゼルニジピンの影響 (2010)
  • Author(s): 麻生美紗子、宮本洋平、門脇大介、渡邊博志、末永綾香、小田切優樹、丸山徹
  • Organizer: 第27回日本薬学会九州支部大会
  • Place of Presentation: 長崎
• [Presentation] α_1-酸性糖タンパク質の薬物結合部位に関する構造生物学的研究 (2010)
  • Author(s): 和泉実代子、中村照也、小野知実、渡邊博志、丸山徹、山縣ゆり子、小田切優樹
  • Organizer: 第27回日本薬学会九州支部大会
  • Place of Presentation: 長崎
• [Presentation] 臓器障害に対する各種SNO-HSAの保護効果 (2010)
  • Author(s): 米重梓二、異島優、末永綾香、渡邊博志、小田切優樹、丸山徹
  • Organizer: 第27回日本薬学会九州支部大会
  • Place of Presentation: 長崎
• [Presentation] Identification of bilirubin binding site in human serum albumin via construction and bilirubin binding screening of a phage library (2009)
  • Author(s): Minomo A
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-09
• [Presentation] Involvement of hemoglobin β-chain mediated endocytic pathway in hepatic uptake of α1-acid glycoprotein (2009)
  • Author(s): Komori H
  • Organizer: 第31回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 大阪大学
  • Year and Date: 2009-11-29
• [Presentation] Transferring from Poly-S-Nitrosylated Human Serum Albumin is Involved in Cell-Surface Protein Disulfide Isomerase (2009)
  • Author(s): Yoshida F
  • Organizer: 第31回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 大阪大学
  • Year and Date: 2009-11-29
• [Presentation] 3-carboxy-4-metyl-5- propyl-2-furan propionate, an uremic toxin, increase oxidative stress through over-generation of super-oxide anion radical (2009)
  • Author(s): Miyamoto Y
  • Organizer: 第31回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 大阪大学
  • Year and Date: 2009-11-29
• [Presentation] REACTIVE ALDEHYDES INDUCE STRUCTUAL CHANGE AND DISFUNCTION OF HUMAN SERUM ALBUMIN (2009)
  • Author(s): Takeo K
  • Organizer: 第24回日本薬物動態学会年会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2009-11-26
• [Presentation] EFFECT OF ALBUMIN BINDING AND ANTIOXIDATIVE ACTIVITY ON TRANSTHYRETIN AMYLOID FORMATION (2009)
  • Author(s): Kugimiya T
  • Organizer: 第24回日本薬物動態学会年会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2009-11-26
• [Presentation] IMPROVED THERAPEUTIC EFFECT OF THIOREDOXIN BY FUSION TO HUMAN SERUM ALBUMIN AGAINST OVALBUMIN-INDUCED LUNG INJURY (2009)
  • Author(s): Furukawa M
  • Organizer: 第24回日本薬物動態学会年会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2009-11-26
• [Presentation] IMPACT OF CINACALCET ON SERUM OXIDATIVE STRESS IN SECONDARY HYPERPARATHYROIDISM (2009)
  • Author(s): Tokunaga K
  • Organizer: 第24回日本薬物動態学会年会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2009-11-26
• [Presentation] PHARMACOKINETIC STUDY OF ENCLOSED HEMOGLOBIN AND OUTER LIPID COMPONENT AFTER THE ADMINISTRATION OF HEMOGLOBIN VESICLES AS AN ARTIFICIAL OXYGEN CARRIER (2009)
  • Author(s): Taguchi K
  • Organizer: 第24回日本薬物動態学会年会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2009-11-26
• [Presentation] THE DETECTION OF ENDOGENOUS S-GUANYLATED HUMAN SERUM ALBUMIN (2009)
  • Author(s): Hoshino H
  • Organizer: 第24回日本薬物動態学会年会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2009-11-26
• [Presentation] α1-酸性糖タンパク質のヘモグロビンβ鎖を介した肝細胞取り込み機構 (2009)
  • Author(s): 小森久和
  • Organizer: 第3回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 九州大学
  • Year and Date: 2009-11-14
• [Presentation] 強力な臓器保護剤としての新規S-ニトロソヒト血清アルブミンの開発 (2009)
  • Author(s): 異島優
  • Organizer: 第16回血液代替物学会年次大会
  • Place of Presentation: 慶應義塾大学
  • Year and Date: 2009-10-15
• [Presentation] 出血性ショックモデルラットにおけるヘモグロビン小胞体頻回投与時の体内動態解析 (2009)
  • Author(s): 田口和明
  • Organizer: 第16回血液代替物学会年次大会
  • Place of Presentation: 慶應義塾大学
  • Year and Date: 2009-10-15
• [Presentation] 四塩化炭素誘発肝障害モデルラットにおけるヘモグロビン小胞体の体内動態の評価 (2009)
  • Author(s): 宮里麻友美
  • Organizer: 第16回血液代替物学会年次大会
  • Place of Presentation: 慶應義塾大学
  • Year and Date: 2009-10-15
• [Presentation] HUMAN ALBUMIN BASED DRUG DELIVERY : ALBUMIN FUSION OF THIOREDOXIN (2009)
  • Author(s): Chuang VTG
  • Organizer: Asian Federation for Pharmaceutical Sciences
  • Place of Presentation: 九州大学
  • Year and Date: 2009-10-15
• [Presentation] MODIFICATION WITH REACTIVE ALDEHYDES ALTERS THE STRUCTURE AND FUNCTION OF HUMAN SERUM ALBUMIN (2009)
  • Author(s): Mera K
  • Organizer: Asian Federation for Pharmaceutical Sciences
  • Place of Presentation: 九州大学
  • Year and Date: 2009-10-15
• [Presentation] PROPOSED DOSE OF HEMOGLOBIN VESICLES, PEGYLATED LIPOSOMES DEVELOPED AS A RED BLOOD SUBSTITUTE, DOES NOT INDUCE THE ACCELERATED BLOOD CLEARANCE PHENOMENON IN MICE (2009)
  • Author(s): Taguchi K
  • Organizer: Asian Federation for Pharmaceutical Sciences
  • Place of Presentation: 九州大学
  • Year and Date: 2009-10-15
• [Presentation] EVALUATION FOR ANTIOXIDANT AND RENOPROTECTIVE ACTIVITY OF OLMESARTAN USING NEPHRECTOMY RATS (2009)
  • Author(s): Kadowaki D
  • Organizer: Asian Federation for Pharmaceutical Sciences
  • Place of Presentation: 九州大学
  • Year and Date: 2009-10-15
• [Presentation] ANTIOXIDANT PROPERTY OF SEVERAL MOLECULAR WEIGHT CHITOSANSIN IN VITRO AND IN VIVO STUDIES (2009)
  • Author(s): Anraku M
  • Organizer: Asian Federation for Pharmaceutical Sciences
  • Place of Presentation: 九州大学
  • Year and Date: 2009-10-15
• [Presentation] FATTY ACIDS COULD BE A NOVEL TYPE OF MEDIATOR OF S-DENITROSATION FROM S-NITROSYLATED HUMAN SERUM ALBUMIN (2009)
  • Author(s): Ishima Y
  • Organizer: Asian Federation for Pharmaceutical Sciences
  • Place of Presentation: 九州大学
  • Year and Date: 2009-10-15
• [Presentation] GENETICALLY ENGINEERED MANNOSY-LATED-HUMAN SERUM ALBUMINAS A VERSATILE CARRIER FOR LIVER-SELECTIVE THERPEUTICS (2009)
  • Author(s): Hirata K
  • Organizer: Asian Federation for Pharmaceutical Sciences
  • Place of Presentation: 九州大学
  • Year and Date: 2009-10-15
• [Presentation] Pharmacokinetic profiles of hemoglobin-vesicles as an artificial oxygen carrier (2009)
  • Author(s): Taguchi K
  • Organizer: XII Symposium on Blood Substitute
  • Place of Presentation: Parma
  • Year and Date: 2009-08-25
• [Presentation] Mannosylated- Recombinant albumin as a NO traffic protein for the treatment of hepaticischemia/reperfusion injury (2009)
  • Author(s): Hirata K
  • Organizer: XII Symposium on Blood Substitute
  • Place of Presentation: Parma
  • Year and Date: 2009-08-25
• [Presentation] DDS担体としての組換え型アルブミン二量体の有用性評価 (2009)
  • Author(s): 異島優
  • Organizer: 第25回日本DDS学会
  • Place of Presentation: 東京ドームホテル
  • Year and Date: 2009-07-03
• [Presentation] ヘモグロビン小胞体の体内動態の検討 (2009)
  • Author(s): 田口和明
  • Organizer: 第25回日本DDS学会
  • Place of Presentation: 東京ドームホテル
  • Year and Date: 2009-07-03
• [Presentation] α1-酸性糖タンパク質のヘモグロビンβ鎖を介した肝細胞取り込み機構の解析 (2009)
  • Author(s): 小森久和
  • Organizer: 日本薬剤学会第24年会
  • Place of Presentation: グランシップ静岡
  • Year and Date: 2009-05-21
• [Presentation] イヌアルブミン分子上のケトプロフェン結合部位のトポロジー解析 (2009)
  • Author(s): 小田切優樹
  • Organizer: 第9回日本蛋白質科学会年会
  • Place of Presentation: 熊本市民会館
  • Year and Date: 2009-05-20
• [Presentation] S-ニトロソヒト血清アルブミンの臓器保護作用は、脂肪酸結合により増強される (2009)
  • Author(s): 異島優
  • Organizer: 第9回日本蛋白質科学会年会
  • Place of Presentation: 熊本市民会館
  • Year and Date: 2009-05-20
• [Presentation] S-ニトロソヒト血清アルブミンの臓器保護作用は、脂肪酸結合により増強される (2009)
  • Author(s): 異島優
  • Organizer: 第9回日本NO学会学術集会
  • Place of Presentation: 静岡グランシップ
  • Year and Date: 2009-05-08
• [Presentation] 組換え型糖鎖付加アルブミンの肝ターゲティング担体としての有用性評価 (2009)
  • Author(s): 平田憲史郎
  • Organizer: 第9回日本NO学会学術集会
  • Place of Presentation: 静岡グランシップ
  • Year and Date: 2009-05-08
• [Presentation] 肝障害モデルラットにおけるヘモグロビン小胞体の体内動態特性 (2008)
  • Author(s): 宮里麻友美
  • Organizer: 第26回日本薬学会九州支部大会
  • Place of Presentation: 九州大学
  • Year and Date: 2008-12-12
• [Book] HUMAN SERUM ALBUMIN (2011)
  • Author(s): Masaki Otagiri(Ed)
  • Total Pages: 300
  • Publisher: Sojo University Publishing Center
• [Book] HUMAN SERUM ALBUMIN (2011)
  • Author(s): Masaki Otagiri (Ed)
  • Total Pages: 300
  • Publisher: Sojo University Publishing Center
• [Patent(Industrial Property Rights)] S-ニトロソ化α1-酸性糖タンパク質を含有する抗菌剤 (2011)
  • Inventor(s): 渡辺佳織、異島優、末永綾香、渡邊博志、甲斐俊哉、丸山徹、小田切優樹
  • Industrial Property Rights Holder: ニプロ株式会社
  • Filing Date: 2011-07-02
• [Patent(Industrial Property Rights)] 抗癌剤増感剤 (2011)
  • Inventor(s): 小田切優樹、異島優、渡邊博志、丸山徹
  • Industrial Property Rights Holder: ニプロ株式会社
  • Filing Date: 2011-08-12
• [Patent(Industrial Property Rights)] 高リガンド親和性アルブミン変異体の製造方法 (2010)
  • Inventor(s): 蓑毛藍、異島優、丸山徹、森岡弘志、小田切優樹
  • Industrial Property Rights Holder: ニプロ株式会社
  • Patent Publication Number: 2010-172277
  • Acquisition Date: 2010-08-12
• [Patent(Industrial Property Rights)] S-ニトロソ基含有アルブミン及びその製造方法ならびに抗がん剤 (2009)
  • Inventor(s): 小田切優樹、中城圭介、片山直久、甲斐俊哉
  • Industrial Property Rights Holder: ニプロ株式会社
  • Patent Publication Number: 2009-057318
  • Acquisition Date: 2009-03-19
• [Patent(Industrial Property Rights)] 融合タンパク質、該融合タンパク質に関連する遺伝子、ベクター、形質転換体及び抗炎症性医薬組成物 (2009)
  • Inventor(s): 小田切優樹、生田祥太朗
  • Industrial Property Rights Holder: ニプロ株式会社
  • Patent Publication Number: 2009-055838
  • Acquisition Date: 2009-03-19
• [Patent(Industrial Property Rights)] 脂肪酸を含有するS-ニトロソタンパク質とその製法 (2008)
  • Inventor(s): 異島優、赤池孝章、小田切優樹
  • Industrial Property Rights Holder: ニプロ株式会社
  • Patent Publication Number: 2008-050294
  • Acquisition Date: 2008-03-06
• [Patent(Industrial Property Rights)] 糖鎖含有アルブミン、その製造方法およびその用途 (2008)
  • Inventor(s): 中城圭介、片山直久、甲斐俊哉、小田切優樹
  • Industrial Property Rights Holder: ニプロ株式会社
  • Patent Publication Number: 2008-043285
  • Acquisition Date: 2008-02-28
• [Patent(Industrial Property Rights)] ピキア酵母を用いた組換えヒトヘモグロビンの製造 (2008)
  • Inventor(s): 中城圭介、帆足洋平、甲斐俊哉、宇野公之、小田切優樹
  • Industrial Property Rights Holder: ニプロ株式会社
  • Patent Publication Number: 2008-017774
  • Acquisition Date: 2008-01-31