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Establishment of molecular pathological diagnosis of lung and esophageal cancers : Detection of precancerous region and early stage cancer and evaluation of their malignant level.

Research Project

Project/Area Number 21390178
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionShiga University of Medical Science (2010-2011)
The University of Tokyo (2009)

Principal Investigator

DAIGO Yataro  滋賀医科大学, 医学部, 特任教授 (30345029)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords病態診断 / 個別化医療
Research Abstract

肺癌・食道癌の発症初期での検出および疾患増悪を早期に感知する統合的病態診断系を開発し、それを迅速に癌予防・診断・治療へ展開することを目的として、平成23年度は、バイオマーカー候補分子の同定を進めるとともに、複数のバイオマーカーを統合した新規診断システムの構築を行った。
(1)ELISA法等を用いた肺癌・食道癌の迅速血清診断系の構築
血清バイオマーカー候補に対する抗体を用いたELISA法による肺癌の早期血清診断システムの構築を行い、あらたに新規血清診断マーカーとしてEBI3を同定した。さらに複数のマーカーを組み合わせて、最小のマーカー数で最大の感度・特異度を示す診断系を検討した。糖鎖プロテオミクス解析と血清ペプチドーム解析による肺癌患者血清中のタンパクを探索して複数の候補バイオマーカーを同定した。
(2)免疫組織学的マーカーによる肺癌・食道癌の迅速悪性度診断法の構築
組織染色マーカーについて腫瘍組織マイクロアレイ(肺、食道癌他)および正常組織マイクロアレイを使用し免疫組織染色を行い、蛋白発現レベルと臨床病理・予後情報との相関を検討し、あらたに予後予測マーカーとして、CSTF2、CHODL、OIP5、CDC20、KIAA0101、MAD2、MCM7、EZH2を同定した。さらに最小のマーカー数で定量的に癌の悪性度を予測する診断法を検討した。
(3)肺癌・食道癌の迅速病態診断系の構築と検証
上記の血清および免疫組織学的マーカーを各診断段階で有機的に使い分ける肺癌・食道癌の迅速病態診断系を検討した。

Report

(4 results)
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (63 results)

All 2012 2011 2010 2009 Other

All Journal Article (39 results) (of which Peer Reviewed: 38 results) Presentation (16 results) Book (7 results) Remarks (1 results)

  • [Journal Article] Characterization of an Opa interacting protein 5 involved in lung and esophageal carcinogenesis2012

    • Author(s)
      Koinuma J, Akiyama H, Fujita M, Hosokawa M, Tsuchiya E, Kondo S, Nakamura Y, Daigo Y
    • Journal Title

      Cancer Sci

      Volume: 103 Issue: 3 Pages: 577-586

    • DOI

      10.1111/j.1349-7006.2011.02167.x

    • Related Report
      2011 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of CDC20 predicts poor prognosis in primary non-small cell lung cancer patients2012

    • Author(s)
      Kato T, Daigo Y, Aragaki M, Ishikawa K, Sato M, Kaji M
    • Journal Title

      J Surg Oncol

      Volume: (in press) Issue: 4 Pages: 423-430

    • DOI

      10.1002/jso.23109

    • Related Report
      2011 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway2011

    • Author(s)
      Toyokawa G, Cho HS, Masuda K, Yamane Y, Yoshimatsu M, Hayami S, Takawa M, Iwai Y, Daigo Y, Tsuchiya E, Tsunoda T, Field HI, Kelly JD, Neal DE, Maehara Y, Ponder BA, Nakamura Y, Hamamoto R
    • Journal Title

      Neoplasia

      Volume: 13 Pages: 887-898

    • Related Report
      2011 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G(1)/S transition in cancer cells via transcriptional regulation of the HOXA1 gene2011

    • Author(s)
      Cho HS, Toyokawa G, Daigo Y, Hayami S, Masuda K, Ikawa N, Yamane Y, Maejima K, Tsunoda T, Field HI, Kelly JD, Neal DE, Ponder BA, Maehara Y, Nakamura Y, Hamamoto R
    • Journal Title

      Int J Cancer

      Volume: (in press) Issue: 3

    • DOI

      10.1002/ijc.26501

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chondrolectin is a novel diagnostic biomarker and a therapeutic target for lung cancer2011

    • Author(s)
      Masuda K, Takano A, Oshita H, Akiyama H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y
    • Journal Title

      Clin Cancer Res

      Volume: 17 Pages: 7712-7722

    • Related Report
      2011 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Epstein-Barr Virus-Induced Gene 3 as a Novel Serum and Tissue Biomarker and a Therapeutic Target for Lung Cancer2011

    • Author(s)
      Nishino R, Takano A, Oshita H, Ishikawa N, Akiyama H, Ito H, Nakayama H, Miyagi Y, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y
    • Journal Title

      Clin Cancer Res

      Volume: 7 Pages: 6272-6286

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a Cleavage Stimulation Factor, 3' pre-RNA, Subunit 2, 64kDa (CSTF2) as a Therapeutic Target for Lung Cancer2011

    • Author(s)
      Aragaki M, Takahashi K, Akiyama H, Tsuchiya E, Kondo S, Nakamura Y, Daigo Y
    • Journal Title

      Clin Cancer Res

      Volume: 7 Pages: 5889-5900

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of KIAA0101 predicts poor prognosis in primary lung cancer patients2011

    • Author(s)
      Kato T, Daigo Y, Aragaki M, Ishikawa K, Sato M, Kaji M
    • Journal Title

      Lung Cancer

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer2011

    • Author(s)
      Toyokawa G, Masuda K, Daigo Y, Cho HS, Yoshimatsu M, Takawa M, Hayami S, Maejima K, Chino M, Field HI, Neal DE, Tsuchiya E, Ponder BA, Maehara Y, Nakamura Y, Hamamoto R
    • Journal Title

      Mol Cancer

      Volume: 10 Pages: 65-65

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker2011

    • Author(s)
      Takawa M, Masuda K, Kunizaki M, Daigo Y, Takagi K, Iwai Y, Cho HS, Toyokawa G, Yamane Y, Maejima K, Field HI, Kobayashi T, Akasu T, Sugiyama M, Tsuchiya E, Atomi Y, Ponder BA, Nakamura Y, Hamamoto R.
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 7 Pages: 1298-1305

    • DOI

      10.1111/j.1349-7006.2011.01958.x

    • Related Report
      2011 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A comprehensive peptidome profiling technology for the identification of early detection biomarkers for lung adenocarcinoma2011

    • Author(s)
      Ueda K, Saichi N, Takami S, Kang D, Toyama A, Daigo Y, Ishikawa N, Kohno N, Tamura K, Shuin T, Nakayama M, Sato TA, Nakamura Y, Nakagawa H
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deglycosylation and label-free quantitative LC-MALDI MS applied to efficient serum biomarker discovery of lung cancer2011

    • Author(s)
      Toyama A, Nakagawa H, Natsuda K, Ishikawa N, Kohno N, Daigo Y, Sato TA, Nakamura Y, Ueda K
    • Journal Title

      Proteome Sci

      Volume: 9 Pages: 18-18

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of MAD2 predicts clinical outcome in primary lung cancer patients2011

    • Author(s)
      Kato T, Daigo Y, Aragaki M, Ishikawa K, Sato M, Kondo S, Kaji M
    • Journal Title

      Lung Cancer

      Volume: 74 Pages: 24-131

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel tumor-associated antigen, cell division cycle 45-like can induce cytotoxic T-lymphocytes reactive to tumor cells2011

    • Author(s)
      Tomita Y, Imai K, Senju S, Irie A, Inoue M, Hayashida Y, Shiraishi K, Mori T, Daigo Y, Tsunoda T, Ito T, Nomori H, Nakamura Y, Kohrogi H, Nishimura Y
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 4 Pages: 697-705

    • DOI

      10.1111/j.1349-7006.2011.01865.x

    • Related Report
      2011 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Epstein-Barr Virus-Induced Gene 3 as a Novel Serum and Tissue Biomarker and a Therapeutic Target for Lung Cancer2011

    • Author(s)
      Nishino R, Takano A, Oshita H, Ishikawa N, Akiyama H, Ito H, Nakayama H, Miyagi Y, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.
    • Journal Title

      Clin Cancer Res

      Volume: 17 Pages: 6272-6282

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a Cleavage Stimulation Factor, 3' pre-RNA, Subunit 2, 64kDa(CSTF2) as a Therapeutic Target for Lung Cancer2011

    • Author(s)
      Aragaki M, Takahashi K, Akiyama H, Tsuchiya E, Kondo S, Nakamura Y, Daigo Y.
    • Journal Title

      Clin Cancer Res

      Volume: 7 Pages: 5889-5900

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of KIAA0101 predicts poor prognosis in primary lung cancer patients2011

    • Author(s)
      Kato T, Daigo Y, Aragaki M, Ishikawa K, Sato M, Kaji M.
    • Journal Title

      Lung Cancer

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer2011

    • Author(s)
      Toyokawa G, Masuda K, Daigo Y, Cho HS, Yoshimatsu M, Takawa M, Hayami S, Maejima K, Chino M, Field HI, Neal DE, Tsuchiya E, Ponder BA, Maehara Y, Nakamura Y, Hamamoto R.
    • Journal Title

      Mol Cancer

      Volume: 10 Pages: 65-65

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A comprehensive peptidome profiling technology for the identification of early detection biomarkers for lung adenocarcinoma2011

    • Author(s)
      Ueda K, Saichi N, Takami S, Kang D, Toyama A, Daigo Y, Ishikawa N, Kohno N, Tamura K, Shuin T, Nakayama M, Sato TA, Nakamura Y, Nakagawa H.
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deglycosylation and label-free quantitative LC-MALDI MS applied to efficient serum biomarker discovery of lung cancer2011

    • Author(s)
      Toyama A, Nakagawa H, Matsuda K, Ishikawa N, Kohno N, Daigo Y, Sato TA, Nakamura Y, Ueda K.
    • Journal Title

      Proteome Sci

      Volume: 9 Pages: 18-18

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of MAD2 predicts clinical outcome in primary lung cancer patients2011

    • Author(s)
      Kato T, Daigo Y, Aragaki M, Ishikawa K, Sato M, Kondo S, Kaji M.
    • Journal Title

      Lung Cancer

      Volume: 74 Pages: 124-131

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of MAD2 predicts clinical outcome in primary lung cancer patients.2011

    • Author(s)
      Kato T, Daigo Y, Aragaki M, Ishikawa K, Sato M, Kondo S, Kaji M.
    • Journal Title

      Lung Cancer

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G(1)/S transition in cancer cells via transcriptional regulation of the HOXA1 gene2010

    • Author(s)
      Cho HS, Toyokawa G, Daigo Y, Hayami S, Masuda K, Ikawa N, Yamane Y, Maejima K, Tsunoda T, Field HI, Kelly JD, Neal DE, Ponder BA, Maehara Y, Nakamura Y, Hamamoto R.
    • Journal Title

      Int J Cancer

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations2010

    • Author(s)
      Miki D, Kubo M, Takahashi A, Yoon KA, Kim J, Lee GK, Zo JI, Lee JS, Hosono N, Morizono T, Tsunoda T, Kamatani N, Chayama K, Takahashi T, Inazawa J, Nakamura Y, Daigo Y.
    • Journal Title

      Nature Genetics

      Volume: 42 Pages: 893-896

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of serum glycoproteomic profiling technique ; simultaneous identification of glycosylation sites and site-specific quantification of glycan structure changes2010

    • Author(s)
      Ueda K, Takami S, Saichi N, Daigo Y, Ishikawa N, Kohno N, Katsumata M, Yamane A, Ota M, Sato TA, Nakamura Y, Nakagawa H.
    • Journal Title

      Mol Cell Proteomics

      Volume: 9 Pages: 1819-1828

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy2010

    • Author(s)
      Sato N, Yamabuki T, Takano A, Koinuma J, Aragaki M, Masuda K, Ishikawa N, Kohno N, Ito H, Miyamoto M, Nakayama H, Miyagi Y, Tsuchiya E, Kondo S, Nakamura Y, Daigo Y.
    • Journal Title

      Cancer Res

      Volume: 70 Pages: 5326-5336

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis2010

    • Author(s)
      Nguyen MH, Koinuma J, Ueda K, Ito T, Tsuchiya E, Nakamura Y, Daigo Y.
    • Journal Title

      Cancer Res

      Volume: 70 Pages: 5337-5347

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] UHRF1 is a novel diagnostic marker of lung cancer2010

    • Author(s)
      Unoki M, Daigo Y, Koinuma J, Tsuchiya E, Hamamoto R, Nakamura Y.
    • Journal Title

      Br J Cancer

      Volume: 103 Pages: 217-222

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of an oncogenic TBC1D7(TBC1 domain family, member 7) protein in pulmonary carcinogenesis2010

    • Author(s)
      Sato N, Koinuma J, Ito T, Tsuchiya E, Kondo S, Nakamura Y, Daigo Y.
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 49 Pages: 353-367

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] UHRF1 is a novel diagnostic marker of lung cancer.2010

    • Author(s)
      Unoki M, Daigo Y, Koinuma J, Tsuchiya E, Hamamoto R, Nakamura Y.
    • Journal Title

      Br J Cancer

      Volume: 103 Pages: 217-222

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis.2010

    • Author(s)
      Nguyen MH, Koinuma J, Ueda K, Ito T, Tsuchiya E, Nakamura Y, Daigo Y.
    • Journal Title

      Cancer Res

      Volume: 70 Pages: 5337-5347

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy.2010

    • Author(s)
      Sato N, Yamabuki T, Takano A, Koinuma J, Aragaki M, Masuda K, Ishikawa N, Kohno N, Ito H, Miyamoto M, Nakayama H, Miyagi Y, Tsuchiya E, Kondo S, Nakamura Y, Daigo Y.
    • Journal Title

      Cancer Res

      Volume: 70 Pages: 5326-36

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of serum glycoproteomic profiling technique ; simultaneous identification of glycosylation sites and site-specific quantification of glycan structure changes.2010

    • Author(s)
      Ueda K, Takami S, Saichi N, Daigo Y, Ishikawa N, Kohno N, Katsumata M, Yamane A, Ota M, Sato TA, Nakamura Y, Nakagawa H.
    • Journal Title

      Mol Cell Proteomics

      Volume: 9 Pages: 1819-1828

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer.2009

    • Author(s)
      Takano A, et al.
    • Journal Title

      Cancer Res 69

      Pages: 6694-6703

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted serum glycoproteomics for the discovery of lungcancer-associated glycosylation disorders using lectin-coupled ProteinChip arrays.2009

    • Author(s)
      Ueda K, et al.
    • Journal Title

      Proteomics 9

      Pages: 2182-2192

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Epithelial Cell Transforming Sequence 2(ECT2)Oncoant igen in Lung and Esophageal Cancer Progression.2009

    • Author(s)
      Hirata D, et al.
    • Journal Title

      Clin Cancer Res 15

      Pages: 256-266

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vaccination with Multiple Peptides derived from Novel Cancer-Testis Antigens Can Induce Specific T-Cell Responses and Clinical Responses in Advanced Esophageal cancer.2009

    • Author(s)
      Kono K, et al.
    • Journal Title

      Cancer Sci 100

      Pages: 1502-1509

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.2009

    • Author(s)
      Kamatani Y
    • Journal Title

      Nature genetics 41

      Pages: 591-595

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      醍醐弥太郎(共著)
    • Journal Title

      最新医学「臨床遺伝子学'09 がんの遺伝子学」(最新医学社)

      Pages: 100-110

    • Related Report
      2009 Annual Research Report
  • [Presentation] Genome-wide association study of lung cancer : Association of variation in TP63 with lung adenocarcinoma susceptibility2011

    • Author(s)
      Yataro Daigo, Daiki Miki, Michiaki Kubo, Tatsuhiko Tsunoda, Naoyuki Kamatani, Kazuaki Chayama, Takashi Takahashi, Johji Inazawa, Yusuke Nakamura
    • Organizer
      第56回人類遺伝学会大会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] VARIATION IN TP63 GENE CONFERS THE RISK OF LUNG ADENOCARCINOMA INTHE EAST ASIAN POPULATION2011

    • Author(s)
      Yataro Daigo, Yusuke Nakamura
    • Organizer
      THE U.S.-JAPAN COOPERATIVE CANCER RESEARCH PROGRAM WORKSHOP : Cancer Genomics and Epigenomics : Towards personalized cancer medicine
    • Place of Presentation
      Kyoto, Japan(招待講演)
    • Year and Date
      2011-10-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genome-wide association study of lung cancer : Association of variation in TP63 with lung adenocarcinoma susceptibility2011

    • Author(s)
      Yataro Daigo, Yusuke Nakamura
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] From Cancer Genomics to Medical Oncology : Novel Biomarker and Therapeutic Target Discovery for Lung and Esophageal Cancer2011

    • Author(s)
      Yataro Daigo, Yusuke Nakamura
    • Organizer
      Japanese-German Cancer Workshop
    • Place of Presentation
      Hiroshima, Japan(招待講演)
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of a novel oncoprotein CDCA5 as a biomarker and a molecular target for cell-permeable peptide/small molecule-based drugs2011

    • Author(s)
      Yataro Daigo, Atsushi Takano, Minh Hue Nguyen, Yusuke Nakamura
    • Organizer
      第9回日本臨床腫瘍学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Discovery of oncoproteins as cancer biomarkers and molecular targets for antibody-based immunotherapy2011

    • Author(s)
      Yataro Daigo, Atsushi Takano, Yusuke Nakamura
    • Organizer
      2011 ASCO Annual meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-06-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] From Cancer Genomic to the Cancer Clinic : Novel Biomarker and Therapeutic Targecs Discovery for Lung and Esophageal Cancer2011

    • Author(s)
      Yataro Daigo, Yusuke Nakamura
    • Organizer
      Cold Spring Harbor Asia Conference on Translational Approaches to Cancer
    • Place of Presentation
      Suzhou, China(招待講演)
    • Year and Date
      2011-05-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dickkopf-1 as a Biomarker and a Molecular Target for Antibody-based Cancer Immunotherapy2011

    • Author(s)
      Yataro Daigo, Nagato Sato, Atsushi Takano, Yusuke Nakamura
    • Organizer
      102nd AACR Annual meeting
    • Place of Presentation
      Florida, USA
    • Year and Date
      2011-04-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] VARIATION IN TP63 GENE CONFERS THE RISK OF LUNG ADENOCARCINOMA INTHE EAST ASIAN POPULATION2011

    • Author(s)
      Yataro Daigo, Yusuke Nakamura
    • Organizer
      THE U. S.-JAPAN COOPERATIVE CANCER RESEARCH PROGRAM WORKSHOP : Cancer Genomics and Epigenomics : Towards personalized cancer medicine
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Genome-wide association study of lung cancer : Association of variation in TP63 with lung adenocarcinoma susceptibility2011

    • Author(s)
      Yataro Daigo, Yusuke Nakamura
    • Organizer
      日本癌学会第70回総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] From Cancer Genomics to Medical Oncology : Novel Biomarker and Therapeutic Target Discovery for Lung and Esophageal Cancer2011

    • Author(s)
      Yataro Daigo, Yusuke Nakamura
    • Place of Presentation
      Hiroshima, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] From Cancer Genomics to the Cancer Clinic : Novel Biomarker and Therapeutic Target Discovery for Lung and Esophageal Cancer2011

    • Author(s)
      Yataro Daigo, Yusuke Nakamura
    • Organizer
      Cold Spring Harbor Asia Conference on Translational Approaches to Cancer
    • Place of Presentation
      Suzhou, China
    • Related Report
      2010 Final Research Report
  • [Presentation] Integrated genomics-based discovery of new oncoproteins as a biomarker and a molecular target for lung cancer.2010

    • Author(s)
      Yataro Daigo, et al.
    • Organizer
      2010米国臨床腫瘍学会(ASCO) Annual meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nectin-4 cell-surface oncoprotein in serum and tumor issue as a diagnostic and therapeutic target for lung cancer2010

    • Author(s)
      Yataro Daigo, Yusuke Nakamura
    • Organizer
      American Association for Cancer Research 101st Annual Meeting
    • Place of Presentation
      Washington D. C., USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Targeting molecular pathology of lung cancer : hope, promise, and progress.2009

    • Author(s)
      Yataro Daigo, et al.
    • Organizer
      19th International Symposium of the Hiroshima Cancer Seminar(HCS)
    • Place of Presentation
      広島
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Recent Progress in Carcinogenesis, Progression and Therapy of Lung Cancer : Targeting molecular pathology of lung cancer2009

    • Author(s)
      Yataro Daigo
    • Organizer
      19th International Symposium of the Hiroshima Cancer Seminar(HCS)
    • Place of Presentation
      Hiroshima, Japan
    • Related Report
      2010 Final Research Report
  • [Book] カレントセラピー2011

    • Author(s)
      醍醐弥太郎
    • Total Pages
      90
    • Publisher
      ライフメディコム社
    • Related Report
      2011 Annual Research Report
  • [Book] がん治療レクチャー2011

    • Author(s)
      高野淳、醍醐弥太郎
    • Total Pages
      450
    • Publisher
      総合医学社
    • Related Report
      2011 Annual Research Report
  • [Book] 分子腫瘍マーカー研究と遺伝子2011

    • Author(s)
      醍醐弥太郎
    • Publisher
      ライフメディコム社
    • Related Report
      2010 Final Research Report
  • [Book] 呼吸器内科「遺伝子・蛋白質の網羅的発現情報解析による肺癌の個別化医療の開発」2010

    • Author(s)
      醍醐弥太郎, 中村祐輔
    • Publisher
      科学評論社
    • Related Report
      2010 Final Research Report
  • [Book] 分子呼吸器病「特集呼吸器病学TOPICS 2009 :ゲノミクス解析による肺癌のバイオマーカー探索と臨床移行」2010

    • Author(s)
      醍醐弥太郎、中村祐輔
    • Publisher
      先端医学社
    • Related Report
      2010 Final Research Report
  • [Book] 最新医学「肺癌の分子マーカー」2009

    • Author(s)
      醍醐弥太郎, 中村祐輔
    • Publisher
      最新医学社
    • Related Report
      2010 Final Research Report
  • [Book] 肺癌「網羅的発現解析による肺癌の分子病態理解と新規治療標的分子の探索」2009

    • Author(s)
      醍醐弥太郎, 中村祐輔
    • Publisher
      日本肺癌学会
    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/nakamura/daigo/cv_daigo.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2017-05-19  

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