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Research on functional analysis of circulating tumor cells in association with cancer metastasis.

Research Project

Project/Area Number 21390181
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionKyoto University

Principal Investigator

TOI Masakazu  京都大学, 医学研究科, 教授 (10207516)

Co-Investigator(Kenkyū-buntansha) ISHIGURO Hirosh  京都大学, 医学研究科, 講師 (20422925)
OHNO Shinji  独立行政法人国立病院機構, 九州がんセンター臨床研究部乳腺科 (50203881)
UENO Takayuki  京都大学, 医学研究科, 助教 (40452362)
TSUJI Wakako  京都大学, 医学研究科, 助教 (00531815)
OKABE Hiroshi  京都大学, 医学研究科, 准教授 (10335250)
岩田 広治  愛知がんセンター, 乳腺科, 部長 (90295600)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords腫瘍検査学 / 血中循環癌細胞 / 転移 / アポトーシス / M30 / EpCAM / P-cadherin / 上皮間葉転換 / CTC / EMT / ZEB1 / 乳癌 / サイトケラチン / 混合抗体 / CD44 / cytokeratin / 胃癌
Research Abstract

We investigated the way to improve sensitivity and reproducibility of CTC assay. Recovery rate of basal type phenotype was improved with additional staining with anti-EpCAM antibody and anti-P-cadherin antibody. CTC count and viability in patients with breast cancer who received neoajuvant chemotherapy was also evaluated. Evaluation of CTC viability using M30 may help to evaluate response of neoadjuvant chemotherapy.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (9 results)

  • [Journal Article] Multi-center study evaluating circulating tumor cells as a surrogate for response to treatment and overall survival in metastatic breast cancer2010

    • Author(s)
      Nakamura S, Yagata H, Ohno S, Yamaguchi H, Iwata H, Tsunoda N, Ito Y, Tokudome N, Toi M, Kuroi K, Suzuki E
    • Journal Title

      Breast Cancer

      Volume: 17(3) Issue: 3 Pages: 199-204

    • DOI

      10.1007/s12282-009-0139-3

    • NAID

      10027255780

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Evaluation of CTC viability with M30 : Early predictive factor for response of neoadjuvant chemotherapy2011

    • Author(s)
      Noriyoshi Fujisawa, Sunao Tanaka, Takayuki Ueno, Masakazu Toi
    • Organizer
      8th International Symposium on Minimal Residual Cancer
    • Place of Presentation
      Osaka
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical significance of minimal residual cancer in the treatment of breast cancer2011

    • Author(s)
      Masakazu Toi
    • Organizer
      8th International Symposium on Minimal Residual Cancer
    • Place of Presentation
      Osaka
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical significance of minimal residual cancer in the treatment on breast cancer2011

    • Author(s)
      Masakazu Toi
    • Organizer
      h International Symposium on Minimal Residual Canc
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evalutaion of CTC viability with M30 : Early predictive factor for response of neoadjuvant chemotherapy2011

    • Author(s)
      Noriyoshi Fujisawa
    • Organizer
      h International Symposium on Minimal Residual Canc
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 乳癌症例のCTC(循環血液中腫瘍細胞)数の検討2010

    • Author(s)
      藤澤憲良, 上野貴之, 竹内恵, 辻和香子, 山城大泰, 石黒洋, 杉江知治, 戸井雅和
    • Organizer
      18回日本乳癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-25
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Circulating tumor cells in primary breast cancer2010

    • Author(s)
      Takayuki Ueno, Tomoharu Sugie, Hiroyasu Yamashiro, Megumi Takeuchi, Wakako Tsuji, Hiroshi Ishiguro, Sunao Tanaka, Masakazu Toi
    • Organizer
      Organizaion for Oncology and Translational Research
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] Circulating tumor cells in primary breast cancer2010

    • Author(s)
      Takayuki Ueno
    • Organizer
      Organisation for Oncology and Translational Research
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] Circulating tumor cells in primary breast cancer2009

    • Author(s)
      Takayuki Ueno, Sunao Tanaka, Masakazu Toi
    • Organizer
      American Society for Cell Biology
    • Place of Presentation
      SanDiego
    • Year and Date
      2009-12-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Circulating tumor cells in primary breast cancer2009

    • Author(s)
      Takayuki Ueno
    • Organizer
      American Society for Cell Biology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2009-12-06
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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