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Development of Pharmacogenomics in Clinical Oncology

Research Project

Project/Area Number 21390182
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionNagasaki University

Principal Investigator

KAMIHIRA Shimeru  長崎大学, 大学院・医歯薬学総合研究科, 教授 (80108290)

Co-Investigator(Kenkyū-buntansha) HASEGAWA Hiroo  長崎大学, 病院, 講師 (00398166)
YAMADA Yasuaki  長崎大学, 大学院・医歯薬学総合研究科, 准教授 (60145232)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2009: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords腫瘍検査学 / 個別化医療 / IL-28B / 分子標的療法 / Genomic Test / SNP / Bio-marker / IL28B / Genediagnostics / IFN-r / oncogenomics / 遺伝子検査 / Ras
Research Abstract

Now, 30% of people are death by cancer and 70% of humans are said to be once troubled with cancer in the future near aging society. therefore, the thing for which promotion of Personalized Oncology called ideal medical model is aimed at-people-it wishes widely. Especially simultaneously with evaluation of the immunity character characteristic(Immunophenotype) of the position of a clinical examination to" cancer cell, or the gene characteristic(Cytogenetic), it is the constitutional characteristic(germ-line-genes information) and the tumor genome characteristic of an individual. It is made to meet and genomic test system which can contribute to development of Personalized Oncology simultaneously is built. The part was carried out for the purpose of things.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (52 results)

All 2012 2011 2010 2009

All Journal Article (44 results) (of which Peer Reviewed: 21 results) Presentation (6 results) Book (2 results)

  • [Journal Article] Paradoxical expression of IL-28B mRNA in peripheral blood in human T-cell leukemia virus Type-1 mono-infection and Co-infection with hepatitis C Virus2012

    • Author(s)
      Kamihira S, Usui T, Ichikawa T, Uno N, Morinaga Y, Mori S, Ngai K, Sasaki D, Hasegawa H, Yanagihara K, Honnda T, Ymada Y, Iwanaga M, Kanematu T, Nkao K
    • Journal Title

      Epub ahead of print

      Volume: Virol J 9(1) Pages: 40-40

    • Related Report
      2011 Final Research Report
  • [Journal Article] Successful treatment of a chronic-phase T-315I-mutated chronic myelogenous leukemia patient with a combination of imatinib and interferon-alfa2012

    • Author(s)
      Itonaga H, Tsushima H, Hata T, Matsuo E, Imanishi D, Imaizumi Y, Kawaguchi Y, Fukushima T, Doi Y, Mori S, Kamihira S, Tomonaga M, Miyazaki Y
    • Journal Title

      Int J Hematol

      Volume: 95(2) Pages: 209-13

    • NAID

      10030267492

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Paradoxical expression of IL-28B mRNA in peripheral blood in human T-cell leukemia virus Type-1 mono-infection and Co-infection with hepatitis C Virus2012

    • Author(s)
      Kamihira S, Usui T, Ichikawa T, Uno N, Morinaga Y, Mori S, Ngai K, Sasaki D, asegawa H, Yanagihara K, Honnda T, Ymada Y, Iwanaga M, Kanematu T, Nkao K
    • Journal Title

      Virol J.2012 Feb 15;9(1):40

      Volume: 9(1)(Epub ahead of print) Pages: 40-40

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nationwide survey of adult T-cell leukemia/ lymphoma(ATL) in Japan2011

    • Author(s)
      Yamada Y, Atogami S, Hasegawa H, Kamihira S, Soda M, Satake M, Yamaguchi K
    • Journal Title

      Rinsho Ketsueki

      Volume: 52(11) Pages: 1765-71

    • NAID

      10030462510

    • Related Report
      2011 Final Research Report
  • [Journal Article] Suppressor of cytokine signal 3 and IL28 genetic variation predict the viral response to peginterferon and ribavirin2011

    • Author(s)
      Miyaaki H, Ichikawa T, Yatsuhashi H, Taura N, Miuma S, Usui T, Mori S, Kamihira S, Tanaka Y, Mizokami M, Nakao K
    • Journal Title

      Hepatol Res

      Volume: 41(12) Pages: 1216-1222

    • NAID

      10031144200

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/ lymphoma cells2011

    • Author(s)
      Hasegawa H, Komoda M, Yamada Y, Yonezawa S, Tsutsumida H, Nagai K, Atogami S, Tsuruda K, Osaka A, Sasaki D, Yanagihara K, Imaizumi Y, Tsukasaki K, Miyazaki Y, Kamihira S
    • Journal Title

      Leuk Lymphoma

      Volume: 52(6) Pages: 1108-17

    • NAID

      120006984995

    • Related Report
      2011 Final Research Report
  • [Journal Article] LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/ lymphoma cells via activation of a novel RAIDD-caspase-2 pathway2011

    • Author(s)
      Hasegawa H, Yamada Y, Tsukasaki K, Mori N, Tsuruda K, Sasaki D, Usui T, Osaka A, Atogami S, Ishikawa C, Machijima Y, Sawada S, Hayashi T, Miyazaki Y, Kamihira S
    • Journal Title

      Leukemia

      Volume: 25(4) Pages: 575-87

    • NAID

      120006984803

    • Related Report
      2011 Final Research Report
  • [Journal Article] leukemia/ lymphoma as a target for epigenetic therapy2011

    • Author(s)
      Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez VE, Hayashi T, Yanagihara K, Moriwaki Y, Miyazaki Y, Kamihira S, Yamada Y
    • Journal Title

      Haematologica

      Volume: 96(5) Pages: 712-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis2011

    • Author(s)
      Hirai M, Kadowaki N, Kitawaki T, Fujita H, Takaori-Kondo A, Fukui R, Miyake K, Maeda T, Kamihira S, Miyachi Y, Uchiyama T
    • Journal Title

      Blood

      Volume: 117(2) Pages: 500-9

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Defective human T-lymphotropic virus type 1 provirus in asymptomatic carriers2011

    • Author(s)
      Takenouchi H, Umeki K, Sasaki D, Yamamoto I, Nomura H, Takajo I, Ueno S, Umekita K, Kamihira S, Morishita K, Okayama A
    • Journal Title

      Int J Cancer

      Volume: 128(6) Pages: 1335-43

    • Related Report
      2011 Final Research Report
  • [Journal Article] Nationwide survey of adult T-cell leukemia/lymphoma (ATL) in Japan2011

    • Author(s)
      Yamada Y, Atogami S, Hasegawa H, Kamihira S, Soda M, Satake M, Yamaguchi K
    • Journal Title

      Rinsho Ketsueki

      Volume: 52(11) Pages: 1765-71

    • NAID

      10030462510

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells2011

    • Author(s)
      Hasegawa H, Komoda M, Yamada Y, Yonezawa S, Tsutsumida H, Nagai K, Atogami S, Tsuruda K, Osaka A, Sasaki D, Yanagihara K, Imaizumi Y, Tsukasaki K, Miyazaki Y, Kamihira S
    • Journal Title

      Leuk Lymphoma

      Volume: 52(6) Pages: 1108-17

    • NAID

      120006984995

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway2011

    • Author(s)
      Hasegawa H, Yamada Y, Tsukasaki K, Mori N, Tsuruda K, Sasaki D, Usui T, Osaka A, Atogami S, Ishikawa C, Machijima Y, Sawada S, Hayashi T, Miyazaki Y, Kamihira S
    • Journal Title

      Leukemia

      Volume: 25(4) Pages: 575-87

    • NAID

      120006984803

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defective human T-lymphotropic virus type 1 provirus in asymptomatic carriers2011

    • Author(s)
      Takenouchi H, Umeki K, Sasaki D, Yamamoto I, Nomura H, Takajo I, Ueno S, Umekita K, Kamihira S, Morishita K, and Okayama A
    • Journal Title

      Int J Cancer

      Volume: 128 Issue: 6 Pages: 1335-43

    • DOI

      10.1002/ijc.25450

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy2011

    • Author(s)
      Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez VE, Hayashi T, Yanagihara K, Moriwaki Y, Miyazaki Y, Kamihira S, Yamada Y
    • Journal Title

      Haematologica

      Volume: 96(5) Pages: 712-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intra-and inter-laboratory variability in human T-cell leukemia virus type-1 proviral load quantification using real-time polymerase chain reaction assays : a multi-center study2010

    • Author(s)
      Kamihira S, Yamano Y, Iwanaga M, Sasaki D, Satake M, Okayama A, Umeki K, Kubota R, Izumo S, Yamaguchi K, Watanabe T
    • Journal Title

      Cancer Sci

      Volume: 101(11) Pages: 2361-7

    • NAID

      10027833409

    • Related Report
      2011 Final Research Report
  • [Journal Article] Human T-cell leukemia virus type I(HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers : a nationwide prospective study in Japan2010

    • Author(s)
      Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh KR, Ogata M, Kikuchi H, Sagara Y, Uozumi K, Mochizuki M, Tsukasaki K, Saburi Y, Yamamura M, Tanaka J, Moriuchi Y, Hino S, Kamihira S, Yamaguchi Kq
    • Journal Title

      Joint Study on Predisposing Factors of ATL Development investigators, Blood

      Volume: 116(8) Pages: 1211-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Long-term study of indolent adult T-cell leukemia-lymphoma2010

    • Author(s)
      Takasaki Y, Iwanaga M, Imaizumi Y, Tawara M, Joh T, Kohno T, Yamada Y, Kamihira S, Ikeda S, Miyazaki Y, Tomonaga M, Tsukasaki K
    • Journal Title

      Blood

      Volume: 115(22) Pages: 4337-43

    • Related Report
      2011 Final Research Report
  • [Journal Article] CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells2010

    • Author(s)
      Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge EJ, Murakami Y
    • Journal Title

      J Biol Chem

      Volume: 285(20) Pages: 15511-22

    • Related Report
      2011 Final Research Report
  • [Journal Article] Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia/ lymphoma in Nagasaki, Japan2010

    • Author(s)
      Koga Y, Iwanaga M, Soda M, Inokuchi N, Sasaki D, Hasegawa H, Yanagihara K, Yamaguchi K, Kamihira S, Yamada Y
    • Journal Title

      J Med Virol

      Volume: 82(4) Pages: 668-74

    • Related Report
      2011 Final Research Report
  • [Journal Article] Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma2010

    • Author(s)
      Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R
    • Journal Title

      J Clin Oncol

      Volume: 28(9) Pages: 1591-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] First Japanese patient treated with parathyroid hormone peptide immunization for refractory hypercalcemia caused by metastatic parathyroid carcinoma2010

    • Author(s)
      Horie I, Ando T, Inokuchi N, Mihara Y, Miura S, Imaizumi M, Usa T, Kinoshita N, Sekine I, Kamihara S, Eguchi K
    • Journal Title

      Endocr J

      Volume: 57(4) Pages: 287-92

    • Related Report
      2011 Final Research Report
  • [Journal Article] Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia/lymphoma in Nagasaki, Japan.2010

    • Author(s)
      Koga Y, Iwanaga M, Soda M, Inokuchi N, Sasaki D, Hasegawa H, Yanagihara K, Yamaguchi K, Kamihira S, Yamada Y
    • Journal Title

      J Med Virol 2010

      Volume: 82(4) Pages: 668-674

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells.2010

    • Author(s)
      Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge EJ, Murakami Y
    • Journal Title

      J Biol Chem

      Volume: 285(20) Pages: 15511-22

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First Japanese patient treated with parathyroid hormone peptide immunization for refractory hypercalcemia caused by metastatic parathyroid carcinoma.2010

    • Author(s)
      Horie I, Ando T, Inokuchi N, Mihara Y, Miura S, Imaizumi M, Usa T, Kinoshita N, Sekine I, Kamihara S, Eguchi K
    • Journal Title

      Endocr J

      Volume: 57(4) Pages: 287-92

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term study of indolent adult T-cell leukemia-lymphoma.2010

    • Author(s)
      Takasaki Y, Iwanaga M, Imaizumi Y, Tawara M, Joh T, Kohno T, Yamada Y, Kamihira S, Ikeda S, Miyazaki Y, Tomonaga M, Tsukasaki K
    • Journal Title

      Blood

      Volume: 115(22) Pages: 4337-43

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intra- and inter-laboratory variability in human T-cell leukemia virus type-1 proviral load quantification using real-time polymerase chain reaction assays : a multi-center study.2010

    • Author(s)
      Kamihira S, Yamano Y, Iwanaga M, Sasaki D, Satake M, Okayama A, Umeki K, Kubota R, Izumo S, Yamaguchi K, Watanabe T
    • Journal Title

      Cancer Science

      Volume: 101(11) Pages: 2361-7

    • NAID

      10027833409

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HTLV-1 proviral load and disease progression in asymptomatic HTLV-1 carriers : A nationwide prospective Study in Japan2010

    • Author(s)
      Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh KR, Ogata M, Kikuchi H, Sagara Y, Uozumi K, Mochizuki M, Tsukasaki K, Saburi Y, Yamamura M, Tanaka J, Moriuchi Y, Hino S, Kamihira S, Yamaguchi K
    • Journal Title

      Blood

      Volume: 116(8) Pages: 1211-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis.2010

    • Author(s)
      Hirai M, Kadowaki N, Kitawaki T, Fujita H, Takaori-Kondo A, Fukui R, Miyake, K, Maeda T, Kamihira S, Miyachi Y, Uchiyama T
    • Journal Title

      Blood

      Volume: 117(2) Pages: 500-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma.2010

    • Author(s)
      Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R
    • Journal Title

      J Clin Oncol

      Volume: 28 Pages: 1591-1598

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple immune abnormalities in a patient with idiopathic CD4+ T-lymphocytopenia2009

    • Author(s)
      Yamada Y, Okada M, Kamitamari A, Moriuchi H, Yanai M, Hano O, Tsukasaki K, Tsuruda K, Hasegawa H, Yanagihara K, Kamihira S
    • Journal Title

      Intern Med

      Volume: 48(22) Pages: 1967-71

    • NAID

      130000122220

    • Related Report
      2011 Final Research Report
  • [Journal Article] Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells2009

    • Author(s)
      Hasegawa H, Yamada Y, Iha H, Tsukasaki K, Nagai K, Atogami S, Sugahara K, Tsuruda K, Ishizaki A, Kamihira S
    • Journal Title

      Leukemia

      Volume: 23(11) Pages: 2090-101

    • NAID

      120006983888

    • Related Report
      2011 Final Research Report
  • [Journal Article] Elevation of serum KL-6 glycoprotein or surfactant protein-D in adult T-cell leukemia with distinct pulmonary complications2009

    • Author(s)
      Osaka A, Yanagihara K, Yamada Y, Hasegawa H, Inokuchi N, Hayashi T, Komoda M, Nakamura S, Aoyama M, Sawada T, Kamihira S
    • Journal Title

      Tohoku J Exp Med

      Volume: 218(2) Pages: 99-105

    • NAID

      10025106239

    • Related Report
      2011 Final Research Report
  • [Journal Article] High-resolution melting analysis for a reliable and two-step scanning of mutations in the tyrosine kinase domain of the chimerical bcr-abl gene2009

    • Author(s)
      Doi Y, Sasaki D, Terada C, Mori S, Tsuruda K, Matsuo E, Miyazaki Y, Nagai K, Hasegawa H, Yanagihara K, Yamada Y, Kamihira S
    • Journal Title

      Int J Hematol

      Volume: 90(1) Pages: 37-43

    • NAID

      10025162376

    • Related Report
      2011 Final Research Report
  • [Journal Article] Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations2009

    • Author(s)
      Kamihira S, Terada C, Sasaki D, Yanagihara K, Tsukasaki K, Hasegawa H, Yamada Y
    • Journal Title

      Eur J Haematol

      Volume: 82(4) Pages: 301-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] A novel role of serum cytochrome c as a tumor marker in patients with operable cancer2009

    • Author(s)
      Osaka A, Hasegawa H, Yamada Y, Yanagihara K, Hayashi T, Mine M, Aoyama M, Sawada T, Kamihira S
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 135(3) Pages: 371-7

    • NAID

      120006983957

    • Related Report
      2011 Final Research Report
  • [Journal Article] Serum cytochrome c to indicate the extent of ongoing tumor cell death2009

    • Author(s)
      Osaka A, Hasegawa H, Tsuruda K, Inokuchi N, Yanagihara K, Yamada Y, Aoyama M, Sawada T, Kamihira S
    • Journal Title

      Int J Lab Hematol

      Volume: 31(3) Pages: 307-14

    • Related Report
      2011 Final Research Report
  • [Journal Article] Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells.2009

    • Author(s)
      Hasegawa H, Yamada Y, Iha H, Tsukasaki K, Nagai K, Atogami S, Sugahara K, Tsuruda K, Ishizaki A, Kamihira S.
    • Journal Title

      Leukemia 23(11)

      Pages: 2090-2101

    • NAID

      120006983888

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations2009

    • Author(s)
      Kamihira S, Terada C, Sasaki D, Yanagihara K, Tsukasaki K, Hasegawa H, Yamada Y.
    • Journal Title

      Eur J Haematol 82(4)

      Pages: 301-307

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple immune abnormalities in a patient with idiopathic CD4+ T-lymphocytopenia.2009

    • Author(s)
      Yamada Y, Okada M, Kamitamari A, Moriuchi H, Yanai M, Hano O, Tsukasaki K, Tsuruda K, Hasegawa H, Yanagihara K, Kamihira S.
    • Journal Title

      Intern Med 48(22):

      Pages: 1967-71

    • NAID

      130000122220

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel role of serum cytochrome c as a tumor marker in patients with operable cancer.2009

    • Author(s)
      Osaka A, Hasegawa H, Yamada Y, Yanagihara K, Hayashi T, Mine M, Aoyama M, Sawada T, Kamihira S
    • Journal Title

      J Cancer Res Clin Oncol 135(3)

      Pages: 371-7

    • NAID

      120006983957

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevation of serum KL-6 glycoprotein or surfactant protein-D in adult T-cell leukemia with distinct pulmonary complications.2009

    • Author(s)
      Osaka A, Yanagihara K, Yamada Y, Hasegawa H, Inokuchi N, Hayashi T, Komoda M, Nakamura S, Aoyama M, Sawada T, Kamihira S
    • Journal Title

      Tohoku J Exp Med 218(2)

      Pages: 99-105

    • NAID

      10025106239

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution melting analysis for a reliable and two-step scanning of mutations in the tyrosine kinase domain of the chimerical bcr-abl gene.2009

    • Author(s)
      Doi Y, Sasaki D, Terada C, Mori S, Tsuruda K, Matsuo E, Miyazaki Y, Nagai K, Hasegawa H, Yanagihara K, Yamada Y, Kamihira S
    • Journal Title

      Int J Hematol 90(1)

      Pages: 37-43

    • NAID

      10025162376

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum cytochrome c to indicate the extent of ongoing tumor cell death.2009

    • Author(s)
      Osaka A, Hasegawa H, Tsuruda K, Inokuchi N, Yanagihara K, Yamada Y, Aoyama M, Sawada T, Kamihira S
    • Journal Title

      Int J Lab Hematol 31(3)

      Pages: 307-14

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Overexpression of enhancer of zeste homolog 2 with trimelthylation of lysine 27 on histone H3 in ATL as a target for epigenetic therapy2010

    • Author(s)
      Sasaki D
    • Organizer
      IJH
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Overexpression of enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in ATL as a target for epigenetic therapy2010

    • Author(s)
      Sasaki D
    • Organizer
      IJH
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Overexpression of Enhancer of Zeste Homologue 2 is Associated with Tumor Proliferation and Aggressive Behavior in Adult T-Cell Leukemia/ Lymphoma2009

    • Author(s)
      Sasaki D, Kamihira S
    • Organizer
      ASH American Annual Meeting
    • Place of Presentation
      USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 自然の実験系ATLに学ぶ臨床化2009

    • Author(s)
      上平憲
    • Organizer
      第49回日本臨床化学会学術集会
    • Place of Presentation
      長崎市
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] MDSの形態学的異形性に基づく診断確度区分2009

    • Author(s)
      鶴田一人、上平憲
    • Organizer
      日本臨床検査医学会
    • Place of Presentation
      三重
    • Related Report
      2011 Final Research Report
  • [Presentation] The Overexpression of Enhancer of Zeste Homologue 2 Is Associated withTumor Proliferati on and Aggressive Behavior in Adult T-Cell Leukemia/Lymphoma.2009

    • Author(s)
      Daisuke Sasaki, Shimeru Kamihira
    • Organizer
      ASH American Annual Meeting
    • Place of Presentation
      USA, New Orins
    • Related Report
      2009 Annual Research Report
  • [Book] 臨床検査ガイド2009-20102009

    • Author(s)
      上平憲
    • Publisher
      文光堂(東京)
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Book] 臨床検査カレッジ2009

    • Author(s)
      上平憲
    • Publisher
      文光堂(東京)
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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