Elucidation of developmental neurotoxicity mechanisms of polycyclic aromatic hydrocarbons via aryl hydrocarbon receptor

• Project/Area Number: 21390186
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: The University of Tokyo
• Principal Investigator: TOHYAMA Chiharu 東京大学, 大学院・医学系研究科, 教授 (10150872)
• Co-Investigator(Renkei-kenkyūsha): KAKEYAMA Masaki 東京大学, 大学院・医学系研究科, 助教 (30353535)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 発達神経毒性 / 芳香族炭化水素 / 行動毒性 / マウス / リスク評価 / ト芳香族炭化水素

Research Abstract

Polyaromatic hydrocarbons(PAHs) are accumulated in the environment, and humans are exposed to them via food and environmental media. The objective of the present study is to elucidate possible effects and toxicity mechanisms of gestational exposure to PAHs in mice using behavioral tests. As a result, aryl hydrocarbon receptor itself was suggested to play a responsible role in the behavioral abnormality. The possible biological significance of this receptor in the brain function warrants future studies.

Research Products

• [Journal Article] Automated test of behavioral flexibility in mice using a behavioral sequencing task in Intelli Cage (2011)
  • Author(s): Endo T, Maekawa F, Voikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M.
  • Journal Title: Behav Brain Res Volume: 221 Issue: 1 Pages: 172-181
  • DOI: 10.1016/j.bbr.2011.02.037
  • Peer Reviewed
• [Journal Article] Polychlorinated dioxins, furans and biphenyls in the blood of children and adults living in a dioxin-contaminated area in Tokyo (2011)
  • Author(s): Tohyama C, Uchiyama I, Hoshi S, Hijiya M, Miyata H, Nagai M, Nakai S, Yauchi M, Ohkubo S.
  • Journal Title: Environ Health Prev Med Volume: 16 Issue: 1 Pages: 6-15
  • DOI: 10.1007/s12199-010-0156-z
  • NAID: 10029519698
  • Peer Reviewed
• [Journal Article] Development of novel behavioral toxicity tests in rodents aimed for application to health risks in humans (2011)
  • Author(s): 掛山正心
  • Journal Title: Japanese Journal of Animal Psychology Volume: 61 Issue: 1 Pages: 33-42
  • DOI: 10.2502/janip.61.1.11
  • NAID: 130000780092
  • ISSN: 0916-8419, 1880-9022
  • Peer Reviewed
• [Journal Article] Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage. (2011)
  • Author(s): Endo T, Maekawa F, Voikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M.
  • Journal Title: Behav Brain Res. Volume: 221 Pages: 172-181
  • Peer Reviewed
• [Journal Article] Polychlorinated dioxins, furans and biphenyls in the blood of children and adults living in a dioxin-contaminated area in Tokyo. (2011)
  • Author(s): Tohyama C, Uchiyama I, Hoshi S, Hijiya M, Miyata H, Nagai M, Nakai S, Yauchi M, Ohkubo S.
  • Journal Title: Environ Health Prev Med. Volume: 16 Pages: 6-15
  • NAID: 10029519698
  • Peer Reviewed
• [Journal Article] In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice (2010)
  • Author(s): Haijima A, Endo T, Zhang Y, Miyazaki W, Kakeyama M, Tohyama C.
  • Journal Title: Neurotoxicology Volume: 31 Issue: 4 Pages: 385-390
  • DOI: 10.1016/j.neuro.2010.04.004
  • Peer Reviewed
• [Journal Article] In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice (2010)
  • Author(s): Haijima A, Endo T, Zhang Y, Miyazaki W, Kakeyama M, Tohyama C
  • Journal Title: Neurotoxicology (掲載確定,印刷中)
  • Peer Reviewed
• [Presentation] マウス行動試験法を用いた発達期ストレスの社会性影響評価 (2012)
  • Author(s): ベナー聖子、掛山正心、遠山千春
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2012-03-25
• [Presentation] Assessment of advanced cognitive behaviors in rodents : Maternal exposure to dioxin causes psychobehavioral abnormality and learning defecits (2011)
  • Author(s): Tohyama C, Kakeyama M.
  • Organizer: The 7th Congress of the Federations of Asian and Oceanian Physiological Societies
  • Place of Presentation: 台北、台湾
  • Year and Date: 2011-09-13
• [Presentation] Assessment of advanced cognitive behaviors in rodents : maternal exposure to dioxin causes psychobehavioral abnormality and learning deficits (2011)
  • Author(s): Tohyama C, Kakeyama M
  • Organizer: the 7th Congress of the Federations of Asian and Oceanian Physiological Societies (FAOPS)
  • Place of Presentation: NTUH Convention Center台北(台湾)(招待講演)
  • Year and Date: 2011-09-13
• [Presentation] 胎仔期・授乳期の低用量ダイオキシン曝露が情動機能に及ぼす影響:低用量特異的影響と用量依存的影響 (2010)
  • Author(s): 配島旭・張艶・遠藤俊裕・掛山正心・遠山千春
  • Organizer: 環境ホルモン学会第13回研究発表会
  • Place of Presentation: 東京大学(東京都)
  • Year and Date: 2010-12-16
• [Presentation] 実験動物高次脳機能評価法の今後の展開 (2010)
  • Author(s): 掛山正心・遠山千春
  • Organizer: 環境ホルモン学会第13回研究発表会
  • Place of Presentation: 東京大学(東京都)
  • Year and Date: 2010-12-16
• [Presentation] 実験動物高次脳機能評価法の今後展開 (2010)
  • Author(s): 掛山正心・遠山千春
  • Organizer: 環境ホルモン学会第13回研究発表会
  • Place of Presentation: 東京大学山上会館(東京都)
  • Year and Date: 2010-12-16
• [Presentation] 胎仔期・授乳期の低用量ダイオキシン曝露が情動機能に及ぼす影響:低用量特異的影響と用量依存的影響 (2010)
  • Author(s): 〓島旭・張艶・遠藤俊裕・掛山正心・遠山千春
  • Organizer: 環境ホルモン学会第13回研究発表会
  • Place of Presentation: 東京大学山上会館(東京都)
  • Year and Date: 2010-12-16
• [Presentation] Corridor shuttling spatial learning task[ 1]: Automated analysis of behavioral flexibility and reversal learning-set in mice using IntelliCage system (2010)
  • Author(s): Endo T, Maekawa F, Voikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wofler DP, Yada T, Tohyama C, Lipp HP, Kakeyama M.
  • Organizer: 40th Annual meeting of Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-10-17
• [Presentation] Corridor shuttling spatial learning task[ 2]: Chemically-induced emotional dysfunctions in group-housed mice as an animal model of perseveration and social anxiety (2010)
  • Author(s): Kakeyama M, Endo T, Tohyama C.
  • Organizer: 40th Annual meeting of Society for Neuroscience
  • Place of Presentation: San Diego. USA
  • Year and Date: 2010-10-17
• [Presentation] Corridor shuttling spatial learning task[1] : Automated analysis of behavioral flexibility and reversal learning-set in mice using IntelliCage system.2010/10, San Diego. (2010)
  • Author(s): Endo T, Maekawa F, Voikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wofler DP, Yada T, Tohyama C, Lipp HP, Kakeyama M.
  • Organizer: 40th Annual meeting of Society for Neuros cience
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2010-10-17
• [Presentation] Corridor shuttling spatial learning task[2] : Chemically-induced) emotional dysfunctions in group-housed mice as an animal model of perseveration and social anxiety. (2010)
  • Author(s): Kakeyama M, Endo T, Tohyama C.
  • Organizer: 40th Annual meeting of Society for Neuros cience
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2010-10-17
• [Presentation] 日本衛生学会賞受賞講演「環境と健康・・・衛生学徒の毒性学」 (2010)
  • Author(s): 遠山千春
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2010-05-10
• [Presentation] 日本衛生学会賞講演「環境と健康・・・衛生学徒の毒性学」 (2010)
  • Author(s): 遠山千春
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2010-05-10
• [Presentation] Perinatal TCDD exposure induce learning and affective behavioral deficits in adult male mice : Its low-dose specificity and the possible causal brain regions (2010)
  • Author(s): Endo T, Tohyama C, Kakeyama M.
  • Organizer: 49th Annual meeting of Society of Toxicology(SOT)
  • Place of Presentation: Salt Lake City、USA
  • Year and Date: 2010-03-10
• [Presentation] Perinatal TCDD exposure induce learning and affective behavioral deficits in adult male mice : Its low-dose specificity and the possible causal brain regions (2010)
  • Author(s): Endo T, Tohyama C, Kakeyama M
  • Organizer: 49^<th> Annual meeting of Society of Toxicology(SOT)
  • Place of Presentation: Salt Lake City U.S.A
  • Year and Date: 2010-03-10
• [Presentation] 『環境ホルモン』問題の現状と今後の課題 (2010)
  • Author(s): 遠山千春
  • Organizer: 松本大学特別講演会
  • Place of Presentation: 松本大学(長野県)
  • Year and Date: 2010-02-05
• [Presentation] 『環境ホルモン』問題の現状と今後の課題 (2010)
  • Author(s): 遠山千春
  • Organizer: 松本大学特別講演会
  • Place of Presentation: 松本大学長野県
  • Year and Date: 2010-02-05
• [Presentation] 内分泌かく乱化学物質のリスク研究と公衆衛生 (2009)
  • Author(s): 遠山千春
  • Organizer: 第68回日本公衆衛生学会総会
  • Place of Presentation: 奈良県文化会館(奈良県)
  • Year and Date: 2009-10-22
• [Presentation] 内分泌かく乱化学物質のリスク研究と公衆衛生 (2009)
  • Author(s): 遠山千春
  • Organizer: 第68回日本公衆衛生学会総会
  • Place of Presentation: 奈良県文化会館奈良県
  • Year and Date: 2009-10-22
• [Presentation] In utero and lactational exposure to dioxins induces deficits in fear conditioning in mice (2009)
  • Author(s): Haijima A, Endo T, Zhang Y, Kakeyama M, Tohyama C.
  • Organizer: 5th International Congress of Asian Society of Toxicology
  • Place of Presentation: 台北、台湾
  • Year and Date: 2009-09-10
• [Presentation] In utero and lactational exposure to dioxins induces deficits in fear conditioning in mice. (2009)
  • Author(s): Haijima A, Endo T, Zhang Y, Kakeyama M, Tohyama C.
  • Organizer: 5th International Congress of Asian Society of Toxicology
  • Place of Presentation: Taipei Taiwan
  • Year and Date: 2009-09-10
• [Presentation] Perinatal exposure to a low-dose of dioxin induces deficits in fear conditioning in mice (2009)
  • Author(s): Haijima A, Endo T, Zhang Y, Kakeyama M, Tohyama C.
  • Organizer: 29th International Symposium on Halogenated Persistent Organic Pollutants
  • Place of Presentation: 北京、中国
  • Year and Date: 2009-08-23
• [Presentation] Perinatal exposure to a low-dose of dioxin induces deficits in fear conditioning in mice. (2009)
  • Author(s): Haijima A, Endo T, Zhang Y, Kakeyama M, Tohyama C.
  • Organizer: 29th International Symposium on Halogenated Persistent Organic Pollutants(Dioxin2009)
  • Place of Presentation: Beijing China
  • Year and Date: 2009-08-23
• [Presentation] 集団型全自動マウス行動特性評価法の構築:周産期低用量TCDD曝露マウスを用いた行動毒性試験への応用 (2009)
  • Author(s): 遠藤俊裕、掛山正心、遠山千春
  • Organizer: 第36回日本トキシコロジー学会学術年会
  • Place of Presentation: 盛岡市民文化ホール(岩手県)
  • Year and Date: 2009-07-07
• [Presentation] 集団型全自動マウス行動特性評価法の構築:周産期低用量TCDD曝露マウスを用いた行動毒性試験への応用 (2009)
  • Author(s): 遠藤俊裕、掛山正心、遠山千春
  • Organizer: 第36回日本トキシコロジー学会学術年会
  • Place of Presentation: 盛岡市民文化ホール岩手県
  • Year and Date: 2009-07-07
• [Remarks]
  • URL: http://env-health.m.u-tokyo.ac.jp/
• [Remarks]
  • URL: http://env-health.m.u-tokyo.ac.jp/