Elucidation of developmental neurotoxicity mechanisms of polycyclic aromatic hydrocarbons via aryl hydrocarbon receptor
Project/Area Number |
21390186
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hygiene
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Research Institution | The University of Tokyo |
Principal Investigator |
TOHYAMA Chiharu 東京大学, 大学院・医学系研究科, 教授 (10150872)
|
Co-Investigator(Renkei-kenkyūsha) |
KAKEYAMA Masaki 東京大学, 大学院・医学系研究科, 助教 (30353535)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
|
Keywords | 発達神経毒性 / 芳香族炭化水素 / 行動毒性 / マウス / リスク評価 / ト芳香族炭化水素 |
Research Abstract |
Polyaromatic hydrocarbons(PAHs) are accumulated in the environment, and humans are exposed to them via food and environmental media. The objective of the present study is to elucidate possible effects and toxicity mechanisms of gestational exposure to PAHs in mice using behavioral tests. As a result, aryl hydrocarbon receptor itself was suggested to play a responsible role in the behavioral abnormality. The possible biological significance of this receptor in the brain function warrants future studies.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Automated test of behavioral flexibility in mice using a behavioral sequencing task in Intelli Cage2011
Author(s)
Endo T, Maekawa F, Voikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M.
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Journal Title
Behav Brain Res
Volume: 221
Issue: 1
Pages: 172-181
DOI
Related Report
Peer Reviewed
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[Journal Article] Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage.2011
Author(s)
Endo T, Maekawa F, Voikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M.
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Journal Title
Behav Brain Res.
Volume: 221
Pages: 172-181
Related Report
Peer Reviewed
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[Presentation] Corridor shuttling spatial learning task[ 1]: Automated analysis of behavioral flexibility and reversal learning-set in mice using IntelliCage system2010
Author(s)
Endo T, Maekawa F, Voikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wofler DP, Yada T, Tohyama C, Lipp HP, Kakeyama M.
Organizer
40th Annual meeting of Society for Neuroscience
Place of Presentation
San Diego, USA
Year and Date
2010-10-17
Related Report
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[Presentation] Corridor shuttling spatial learning task[1] : Automated analysis of behavioral flexibility and reversal learning-set in mice using IntelliCage system.2010/10, San Diego.2010
Author(s)
Endo T, Maekawa F, Voikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wofler DP, Yada T, Tohyama C, Lipp HP, Kakeyama M.
Organizer
40th Annual meeting of Society for Neuros cience
Place of Presentation
San Diego (USA)
Year and Date
2010-10-17
Related Report
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