Risk assessment of carcinogenicity and fibrogenicity in respiratory systems induced by fibrous and particulate materials

• Project/Area Number: 21390187
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Mie University
• Principal Investigator: HIRAKU Yusuke 三重大学, 大学院・医学系研究科, 講師 (30324510)
• Co-Investigator(Kenkyū-buntansha): MURATA Mariko 三重大学, 大学院・医学系研究科, 教授 (10171141)
• Co-Investigator(Renkei-kenkyūsha): HISANAGA Aomi 愛知教育大学, 保健環境センター, 教授 (90111856) ; SHIBATA Eiji 愛知医科大学, 医学部, 教授 (90206128)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 繊維・粒子状物質 / 石綿 / リスク評価 / 発がん / 慢性炎症 / 活性酸素・窒素種 / DNA損傷 / 8-ニトログアニン / ナノ素材 / アスベスト

Research Abstract

Inhalation exposure to fibrous and particlate materials induces chronic inflammation in respiratory systems, leading to carcinogenesis and fibrosis. We have demonstrated that inflammation-mediated oxidative/nitrative DNA damage is closely associated with asbestos exposure in animal and human lung tissues. Carbon nanomaterials induced nitrative DNA damage in human lung epithelial cells through cellular internalization. In addition, we demonstrated that molecules involved in tissue fibrosis participate in inflammation-related carcinogenesis using experimental animals and human plasma.

Research Products

• [Journal Article] Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cell (2012)
  • Author(s): Guo F, Ma N, Horibe Y, Kawanishi S, Murata M, Hiraku Y.
  • Journal Title: Toxicol. Appl. Pharmacol Volume: 260 Pages: 183-192
  • Peer Reviewed
• [Journal Article] Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells (2012)
  • Author(s): Guo, F.
  • Journal Title: Toxicol.Appl.Pharmacol. Volume: (印刷中) Issue: 2 Pages: 183-192
  • DOI: 10.1016/j.taap.2012.02.010
  • Peer Reviewed
• [Journal Article] Inflammation-induced protein carbonylation contributes to poor prognosis of cholangiocarcinoma (2012)
  • Author(s): Thanan, R.
  • Journal Title: Free Radic.Biol.Med. Volume: (印刷中) Issue: 8 Pages: 1465-1472
  • DOI: 10.1016/j.freeradbiomed.2012.01.018
  • Peer Reviewed
• [Journal Article] Plasma hydroxyproline, MMP-7 and collagen I as novel predictive risk markers of hepatobiliary disease-associated cholangiocarcinoma (2012)
  • Author(s): Prakobwong, S.
  • Journal Title: Int.J.Cancer Volume: (印刷中) Issue: 4
  • DOI: 10.1002/ijc.26443
  • Peer Reviewed
• [Journal Article] The liver fluke Opisthorchis viverrini expresses nitric oxide synthase but not gelatinases (2012)
  • Author(s): Prakobwong, S.
  • Journal Title: Parasitol.Int. Volume: 61 Issue: 1 Pages: 112-117
  • DOI: 10.1016/j.parint.2011.06.017
  • Peer Reviewed
• [Journal Article] Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis (2011)
  • Author(s): Prakobwong S, Khoontawad J, Yongvanit P, Pairojkul C, Hiraku Y, Sithithaworn P, Pinlaor P, Aggarwal BB, Pinlaor S
  • Journal Title: Int. J. Cancer Volume: 129 Pages: 88-100
  • Peer Reviewed
• [Journal Article] Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways (2011)
  • Author(s): Prakobwong, S.
  • Journal Title: Carcinogenesis Volume: 32 Issue: 9 Pages: 1372-1380
  • DOI: 10.1093/carcin/bgr032
  • Peer Reviewed
• [Journal Article] Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis (2011)
  • Author(s): Prakobwong, S.
  • Journal Title: Int.J.Cancer Volume: 129 Issue: 1 Pages: 88-100
  • DOI: 10.1002/ijc.25656
  • Peer Reviewed
• [Journal Article] Nitrative and oxidative DNA damage caused by K-ras mutation in mice (2011)
  • Author(s): Ohnishi, S.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 413 Issue: 2 Pages: 236-240
  • DOI: 10.1016/j.bbrc.2011.08.076
  • Peer Reviewed
• [Journal Article] Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosoma haematobium infection (2011)
  • Author(s): Ma N, et al
  • Journal Title: Biochem Biophys Res Commun Volume: 414 Issue: 2 Pages: 44-349
  • DOI: 10.1016/j.bbrc.2011.09.073
  • Peer Reviewed
• [Journal Article] Curcumin induces a nuclear factor-erythroid 2-related factor 2-driven response against oxidative and nitrative stress after praziquantel treatment in liver fluke-infected hamsters (2011)
  • Author(s): Charoensuk, L.
  • Journal Title: Int.J.Parasitol. Volume: 41 Issue: 6 Pages: 615-626
  • DOI: 10.1016/j.ijpara.2010.12.011
  • Peer Reviewed
• [Journal Article] Involvement of MMP-9 in peribiliary fibrosisand cholangiocarcinogenesis via Rac1-dependent DNA damage in a hamster model (2010)
  • Author(s): Prakobwong S, Yongvanit P, Hiraku Y, Pairojkul C, Sithithaworn P, Pinlaor P, Pinlaor S
  • Journal Title: Int. J. Cancer Volume: 127 Pages: 2576-2587
  • Peer Reviewed
• [Journal Article] The role of iNOS-mediated DNA damage in infection-and asbestos-induced carcinogenesis (2010)
  • Author(s): Hiraku Y, Kawanishi S, Ichinose T, Murata M.
  • Journal Title: Ann. NY Acad. Sci Volume: 1203 Pages: 15-22
  • Peer Reviewed
• [Journal Article] Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance. (2010)
  • Author(s): Hiraku Y
  • Journal Title: Environ Health Prev. Med Volume: 15 Pages: 63-72
  • NAID: 10026959928
  • Peer Reviewed
• [Journal Article] The role of iNOS-mediated DNA damage in infection- and asbestos-induced carcinogenesis (2010)
  • Author(s): Hiraku, Y.
  • Journal Title: Ann.NY Acad.Sci. Volume: 1203 Pages: 15-22
  • Peer Reviewed
• [Journal Article] Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance (2010)
  • Author(s): Hiraku, Y.
  • Journal Title: Environ.Health Prev.Med. Volume: 15 Pages: 63-72
  • NAID: 10026959928
  • Peer Reviewed
• [Journal Article] Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide (2010)
  • Author(s): Mizutani, H.
  • Journal Title: Cancer Sci. Volume: 101 Pages: 2214-2219
  • Peer Reviewed
• [Journal Article] Involvement of MMP-9 in peribiliary fibrosis and cholangiocarcinogenesis via Racl-dependent DNA damage in a hamster model (2010)
  • Author(s): Prakobwong, S.
  • Journal Title: Int.J.Cancer Volume: 127 Pages: 2576-2587
  • Peer Reviewed
• [Journal Article] Protective effect of melatonin against Opisthorchis viverrini-induced oxidative and nitrosative DNA damage and liver injury in hamsters (2010)
  • Author(s): Laothong, U.
  • Journal Title: J.Pineal.Res. Volume: 49 Pages: 271-282
  • Peer Reviewed
• [Journal Article] Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment (2010)
  • Author(s): Pinlaor, S.
  • Journal Title: Eur.J.Pharmacol. Volume: 638 Pages: 134-141
  • Peer Reviewed
• [Journal Article] Proteomic identification of peroxiredoxin 6 for host defense against Opisthorchis viverrini infection (2010)
  • Author(s): Khoontawad, J.
  • Journal Title: Parasite Immunol. Volume: 32 Pages: 314-323
  • Peer Reviewed
• [Journal Article] Oxidatively generated DNA damage induced by 3-amino-5-mercapto-1,2,4-triazole, a metabolite of carcinogenic amitrole (2010)
  • Author(s): Furukawa, A.
  • Journal Title: Mutat.Res. Volume: 694 Pages: 7-12
  • Peer Reviewed
• [Journal Article] DNA damage and estrogenic activity induced by the environmental pollutant 2-nitrotoluene and its metabolite (2010)
  • Author(s): Watanabe, C.
  • Journal Title: Environ.Health Prev.Med. Volume: 15 Pages: 319-326
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): 平工雄介, 川西正祐
  • Journal Title: 第7章 生体有害金属、7.3 鉛、食品安全ハンドブック (食品安全ハンドブック編集委員会 編)(丸善株式会社) Pages: 122-125
• [Journal Article] Immunohistochemical analysis of 8-nitroguanine, a nitrative DNA lesion, in relation to inflammation-associated carcinogenesis (2009)
  • Author(s): Hiraku Y, Kawanishi S
  • Journal Title: Methods Mol. Biol Volume: 512 Pages: 3-13
  • Peer Reviewed
• [Journal Article] Effect of praziquantel treatment on the expression of matrix metalloproteinases in relation to tissue resorption during fibrosis in hamsters with acute and chronic Opisthorchis viverrini infection (2009)
  • Author(s): Pinlaor, S., et al.
  • Journal Title: Acta Trop. 111 Pages: 181-191
  • Peer Reviewed
• [Journal Article] Curcumin reduces oxidative and nitrative DNA damage through balancing of oxidant-antioxidant status in hamsters infected with Opisthorchis viverrini (2009)
  • Author(s): Pinlaor, S., et al.
  • Journal Title: Mol.Nutr.Food Res. 53 Pages: 1316-1328
  • Peer Reviewed
• [Journal Article] Time profiles of the expression of metalloproteinases, tissue inhibitors of metalloproteases, cytokines and collagen in hamsters infected with Opisthorchis viverrini with special reference to peribiliary fibrosis and liver injury (2009)
  • Author(s): Prakobwong, S., et al.
  • Journal Title: Int.J.Parasitol. 39 Pages: 825-835
  • Peer Reviewed
• [Journal Article] Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion (2009)
  • Author(s): Oikawa, S., et al.
  • Journal Title: Free Radic.Biol.Med. 46 Pages: 1472-1477
  • Peer Reviewed
• [Journal Article] The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease (2009)
  • Author(s): Kobayashi, H., et al.
  • Journal Title: J.Neurochem. 108 Pages: 397-407
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 平工雄介, 川西正祐
  • Journal Title: Immunohistochemical analysis of 8-nitroguanine, a nitrative DNA lesion, in relation to inflammation-associated carcinogenesis, In : Methods in Molecular Biology. vol. 512, Inflammation and Cancer, Methods and Protocols : Volume 2 : Molecular Analysis and Pathways (Kozlov, S. V., Editor)(Humans Press, New York, NY, USA) Pages: 3-13
• [Journal Article] Plasma hydroxyproline, MMP-7 and collagen I as novel predictive risk markers of hepatobiliary disease-associated cholangiocarcinoma
  • Author(s): Prakobwong S, Charoensuk L, Hiraku Y, Pinlaor P, Pairojkul C, Mairiang E, Sithithaworn P, Yongvanit P, Khuntikeo N, Pinlaor S
  • Journal Title: Int. J. Cancer Volume: (掲載決定)
  • Peer Reviewed
• [Journal Article] Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer
  • Author(s): Thanan, R.
  • Journal Title: Mediat.Inflamm. Volume: (印刷中)(未定)
  • Peer Reviewed
• [Journal Article] Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance
  • Author(s): Hiraku, Y.
  • Journal Title: Environ.Health Prev.Med. (印刷中)
  • NAID: 10026959928
  • Peer Reviewed
• [Journal Article] Involvement of MMP-9 in peribiliary, fibrosis and cholangiocarcinogenesis via Racl dependent DNA damage in a hamster model
  • Author(s): Prakobwong, S., et al.
  • Journal Title: Int.J.Cancer (印刷中)
  • Peer Reviewed
• [Journal Article] Proteomic identification of peroxiredoxin 6 for host defense against Opisthorchis viverrini infection
  • Author(s): Khoontawad, J., et al.
  • Journal Title: Parasite Immunol. (印刷中)
  • Peer Reviewed
• [Presentation] 感染・炎症関連発がんにおける酸化・ニトロ化DNA損傷:その役割と意義 (2012)
  • Author(s): 平工雄介
  • Organizer: 日本薬学会東海支部特別講演会
  • Place of Presentation: 名古屋市
  • Year and Date: 2012-01-24
• [Presentation] 感染・炎症関連発がんにおける酸化・ニトロ化DNA損傷:その役割と意義 (2012)
  • Author(s): 平工雄介
  • Organizer: 日本薬学会東海支部特別講演会
  • Place of Presentation: 金城学院大学(名古屋市)(招待講演)
  • Year and Date: 2012-01-24
• [Presentation] ヒト肺組織における石綿繊維量とDNA損傷との関連 (2012)
  • Author(s): 平工雄介、酒井潔、柴田英治、上島通浩、久永直見、馬寧、川西正祐、村田真理子
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都市
• [Presentation] 多層カーボンナノチューブによる細胞内ニトロ化DNA損傷:繊維長との関連 (2012)
  • Author(s): Feiye Guo、馬寧、川西正祐、村田真理子、平工雄介
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都市
• [Presentation] ヒト肺組織における石綿繊維量とDNA損傷との関連 (2012)
  • Author(s): 平工雄介
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都大学(京都市)
• [Presentation] 多層カーボンナノチューブによる細胞内ニトロ化DNA損傷:繊維長との関連 (2012)
  • Author(s): Feiye Guo
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都大学(京都市)
• [Presentation] 多層カーボンナノチューブによる細胞内DNA損傷の解析s (2011)
  • Author(s): 平工雄介
  • Organizer: 日本産業衛生学会東海地方会
  • Place of Presentation: 藤田保健衛生大学(豊明市)
  • Year and Date: 2011-11-05
• [Presentation] 多層カーボンナノチューブで処理したヒト肺上皮細胞におけるニトロ化DNA損傷 (2011)
  • Author(s): Feiye Guo、馬寧、川西正祐、村田真理子、平工雄介
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] ヒト肺組織における酸化・ニトロ化DNA損傷と石綿曝露との関連 (2011)
  • Author(s): 平工雄介、酒井潔、柴田英治、上島通浩、久永直見、村田真理子
  • Organizer: 第84回日本産業衛生学会(優秀演題)
  • Place of Presentation: 東京
• [Presentation] ヒト肺上皮細胞におけるカーボンブラックナノ粒子によるニトロ化DNA損傷 (2011)
  • Author(s): 平工雄介、西川嘉広、馬寧、川西正祐、村田真理子
  • Organizer: 第11回日本NO学会学術集会
  • Place of Presentation: 町田市
• [Presentation] The role of nitrative DNA damage in inflammation-related carcinogenesis (2011)
  • Author(s): Hiraku Y
  • Organizer: International Symposium on Biodynamics in Host Defense
  • Place of Presentation: Tsu, Mie, Japan
• [Presentation] ヒト肺上皮細胞におけるカーボンブラックナノ粒子によるニトロ化DNA損傷 (2011)
  • Author(s): 平工雄介
  • Organizer: 第11回日本NO学会学術集会
  • Place of Presentation: 昭和薬科大学(町田市)
• [Presentation] ヒト肺組織における酸化・ニトロ化DNA損傷と石綿曝露との関連 (2011)
  • Author(s): 平工雄介
  • Organizer: 第84回日本産業衛生学会
  • Place of Presentation: シーサイドホテル芝弥生(東京)(優秀演題)
• [Presentation] 多層カーボンナノチューブで処理したヒト肺上皮細胞におけるニトロ化DNA損傷 (2011)
  • Author(s): Feiye Guo
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
• [Presentation] The role of nitrative DNA damage in inflammation-related carcinogenesis(炎症関連発がんにおけるニトロ化DNA損傷の役割) (2011)
  • Author(s): Yusuke Hiraku
  • Organizer: International Symposium on Biodynamics in Host Defense
  • Place of Presentation: 三重大学(津市)(招待講演)
• [Presentation] ヒト肺におけるDNA損傷とアスベスト曝露との関連 (2010)
  • Author(s): 平工雄介
  • Organizer: 日本産業衛生学会東海地方会
  • Place of Presentation: 浜松医科大学(浜松市)
  • Year and Date: 2010-11-13
• [Presentation] Tumor microenvironment & Oncogenesis (2010)
  • Author(s): Hiraku Y, Sakai K, Shibata E, Kamijima M, Hisanaga H, Ma N, Kawanishi S, Murata M.
  • Organizer: The 10th International Conference of the International Mesothelioma Interest Group
  • Place of Presentation: Kyoto, Japan
• [Presentation] iNOS-mediated DNA damage induced by nanoparticles : 8-nitroguanine formation in cultured cells treated with carbon black (2010)
  • Author(s): Hiraku Y, Ishiyama R, Matsunaga Y, Horibe Y, Ma N, Kawanishi S, Murata M.
  • Organizer: The 6th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto, Japan
• [Presentation] Nitrative DNA damage induced by multi-wall carbon nanotube in human lung epithelial cells(ヒト肺上皮細胞における多層カーボンナノチューブによるニトロ化DNA損傷) (2010)
  • Author(s): Feiye Guo
  • Organizer: 日本環境変異原学会第39回大会
  • Place of Presentation: つくば国際会議場(つくば市)
• [Presentation] Nitrative DNA damage induced by carbon black in human lung epithelial cells(ヒト肺上皮細胞におけるカーボンブラックによるニトロ化DNA損傷) (2010)
  • Author(s): Yoshihiro Nishikawa
  • Organizer: 日本環境変異原学会第39回大会
  • Place of Presentation: つくば国際会議場(つくば市)
• [Presentation] DNA damage induced by nanomaterials : 8-nitroguanine formation in cultured cells treated with carbon black(ナノ素材によるDNA損傷:カーボンブラック処理細胞における8-ニトログアニンの生成) (2010)
  • Author(s): 平工雄介
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪国際会議場(大阪市)
• [Presentation] Workshop "Tumor microenvironment & Oncogenesis", Formation of 8-nitroguanine, a DNA lesion associated with inflammation-related carcinogenesis, in human lung in relation to asbestos exposure(炎症関連発がんで生じるDNA損傷塩基8-ニトログアニンのヒト肺における生成:アスベスト曝露との関連) (2010)
  • Author(s): Yusuke Hiraku
  • Organizer: The 10th International Conference of the International Mesothelioma Interest Group
  • Place of Presentation: 国立京都国際会館(京都市)
• [Presentation] iNOS-mediated DNA damage induced by nanoparticles : 8-nitroguanine formation in cultured cells treated with carbon black(ナノ粒子によるiNOSを介したDNA損傷:カーボンブラックで処理した培養細胞における8-ニトログアニンの生成) (2010)
  • Author(s): Yusuke Hiraku
  • Organizer: The 6th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: 国立京都国際会館(京都市)
• [Presentation] ナノ素材のリスク評価に関する基礎的研究(第2報):カーボンブラックによる細胞内ニトロ化DNA損傷の解析 (2010)
  • Author(s): 平工雄介
  • Organizer: 第83回日本産業衛生学会
  • Place of Presentation: 福井県国際交流会館(福井市)
• [Presentation] ナノ素材による細胞内DNA損傷:カーボンブラックによる8-ニトログアニン生成 (2010)
  • Author(s): 平工雄介
  • Organizer: 第80回日本衛生学会総会
  • Place of Presentation: 仙台国際センター(仙台市)
• [Presentation] メチレンブルーによる金属依存性DNA損傷 : 新規発がん機構としての可能性 (2010)
  • Author(s): 平工雄介, 他
  • Organizer: 第9回分子予防環境医学研究会
  • Place of Presentation: 東京大学医学部 (東京)
• [Presentation] カーボンブラックによる細胞内DNA損傷の解析 (2009)
  • Author(s): 平工雄介, 村田真理子
  • Organizer: 日本産業衛生学会東海地方会
  • Place of Presentation: 名古屋市立大学医学部 (名古屋市)
  • Year and Date: 2009-11-14
• [Presentation] The role of iNOS-mediated DNA damage in inflammation-related carcinogenesis (2009)
  • Author(s): Hiraku Y, Kawanishi S, Ichinose T, Murata M
  • Organizer: 4th International Conference on Oxidative/Nitrosative Stress and Disease
  • Place of Presentation: New York, USA
• [Presentation] シンポジウム「NOと発がん・がん治療への応用」アスベスト曝露マウスの肺組織におけるニトロ化DNA損傷 (2009)
  • Author(s): 平工雄介、市瀬孝道、馬寧、吉田成一、定金香里、村田真理子、川西正祐
  • Organizer: 第9回日本NO学会学術集会
  • Place of Presentation: 静岡市
• [Presentation] Cellular nitrative DNA damage induced by carbon black (カーボンブラックによる細胞内ニトロ化DNA損傷) (2009)
  • Author(s): 平工雄介, 他
  • Organizer: 日本環境変異原学会第38回大会
  • Place of Presentation: 清水テルサ (静岡市)
• [Presentation] The role of iNOS-mediated DNA damage in inflammation-related carcinogenesis (2009)
  • Author(s): 平工雄介, et al.
  • Organizer: 4th International Conference on Oxidative/Nitrosative Stress and Disease
  • Place of Presentation: The New York Academy of Science Conference Center (New York, NY, USA)
• [Presentation] Metal-mediated oxidative DNA damage as a new possible mechanism of methylene blue-induced carcinogenesis (メチレンブルーによる発がんの新規機構としての金属依存性酸化的DNA損傷) (2009)
  • Author(s): 平工雄介, 他
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: パシフィコ横浜 (横浜市)
• [Presentation] ナノ素材のリスク評価に関する基礎的研究 : カーボンブラックおよびカーボンナノチューブによる細胞内DNA損傷の解析 (2009)
  • Author(s): 平工雄介, 村田真理子
  • Organizer: 第82回日本産業衛生学会
  • Place of Presentation: 福岡国際会議場 (福岡市)
• [Presentation] シンポジウム「NOと発がん・がん治療への応用」アスベスト曝露マウスの肺組織におけるニトロ化DNA損傷 (2009)
  • Author(s): 平工雄介, 他
  • Organizer: 第9回日本NO学会学術集会
  • Place of Presentation: グランシップ (静岡市)
• [Book] Role of chronic inflammation and resulting DNA damage in cervical carcinogenesis induced by human papillomavirus (2012)
  • Author(s): Hiraku Y
  • Publisher: Human Papillomavirus and Related Diseases-From Bench to Bedside-Research aspects, Broeck DV(ed.)
• [Book] Role of chronic inflammation and resulting DNA damage in cervical carcinogenesis induced by human papillomavirus, In : Human Papillomavirus and Related Diseases-From Bench to Bedside-Research aspects (2012)
  • Author(s): Hiraku, Y.
  • Publisher: InTech
• [Book] Prognostic significance of nitrative DNA damage in infection-and inflammation-related carcinogenesis, Prevention and Therapy, Bonavida B(ed.) (2010)
  • Author(s): Hiraku Y, Kawanishi S
  • Publisher: Nitric Oxide and Cancer : Prognosis
• [Book] II-6悪性腫瘍、d.感染・炎症関連発がん、改訂版分子予防環境医学 (2010)
  • Author(s): 平工雄介、川西正祐
  • Publisher: 本の泉社
• [Book] 物理化学的因子、4発がん因子、腫瘍薬学 (2010)
  • Author(s): 平工雄介、川西正祐
  • Publisher: 南山堂
• [Book] II-6悪性腫瘍、d.感染・炎症関連発がん、分子予防環境医学 (2010)
  • Author(s): 平工雄介
  • Publisher: 本の泉社
• [Book] Prognostic significance of nitrative DNA damage in infection- and inflammation-related carcinogenesis, In : Nitric Oxide and Cancer : Prognosis, Prevention and Therapy (2010)
  • Author(s): Hiraku, Y.
  • Publisher: Springer, New York, NY, USA
• [Book] 3)物理化学的因子、4発がん因子、腫瘍薬学 (2010)
  • Author(s): 平工雄介
  • Publisher: 南山堂
• [Book] 第7章生体有害金属、7.3鉛、食品安全ハンドブック (2010)
  • Author(s): 平工雄介
  • Publisher: 丸善
• [Book] 8-Nitroguanine : A potential biomarker to evaluate the risk of inflammation-related carcinogenesis, In : Biomarker
  • Author(s): Ma, N.
  • Publisher: InTech(印刷中)
• [Book] Prognostic significance of nitrative DNA damage in infection- and inflammation-related carcinogenesis, In : Nitric Oxide and Cancer : Prognosis, Prevention and Therapy
  • Author(s): 平工雄介, 川西正祐
  • Publisher: Springer, New York, NY, USA(印刷中)
• [Remarks] ホームページ
  • URL: http://www.medic.mie-u.ac.jp/eiseigaku/
• [Remarks]
  • URL: http://www.medic.mie-u.ac.jp/eiseigaku/
• [Remarks]
  • URL: http://www.medic.mie-u.ac.jp/eiseigaku/
• [Remarks]
  • URL: http://www.medic.mie-u.ac.jp/eiseigaku/