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Genome epidemiologic study on lung cancer and inflammation-related genes

Research Project

Project/Area Number 21390190
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKyushu University

Principal Investigator

KIYOHARA Chikako  九州大学, 医学研究院, 講師 (00169963)

Co-Investigator(Kenkyū-buntansha) NAKANISHI Yoichi  九州大学, 大学院・医学研究院, 教授 (20172356)
TAKAYAMA Koichi  九州大学, 大学院・医学研究院, 准教授 (50274444)
HORIUCHI Takahiko  九州大学, 大学院・医学研究院, 准教授 (90219212)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords肺がん / ゲノム疫学 / 遺伝子多型 / 国際共同研究 / 交互作用 / 喫煙 / 炎症
Research Abstract

Chronic inflammation has been implicated in the development of lung cancer. The aims of this study were to evaluate the association between inflammation- related polymorphismsand lung cancer and the modifying effects of the polymorphisms on the association of cigarette smoking with lung cancer risk. We genotyped IL1B -511T>C, IL1B -31C>T, IL1B 3954C>T, IL6 rs1800796, IL10 rs1800871, IL13 rs1800925, T NFA rs1799724, TNFR2 rs1061622, MPO rs2333227, CRPrs2794520, COX2 rs5275, PPARG rs13073869 and PPARG rs4135249 polymorphisms in Japanese.Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI). The CRP rs2794520 polymorphism was significantly associated with lung cancer risk (OR for CT genotype vs. TT genotype = 1.59, 95% CI = 1.14 - 2.22; OR for CC genotype vs.TT genotype = 1.92, 95% CI = 1.10-3.38) while other polymorphisms were not. The interactions between either the IL1B -511 T>C, CRP rs2794520 or PPARG rs13073869 polymorphisms and smoking were significant. There were no significant interactions between smoking and either of the remaining polymorphisms. Additional studies are required to clarify the effects of the inflammation-related polymorphisms and the smoking-polymorphism interactions on lung cancer.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (23 results)

All 2012 2011 2010 2009 Other

All Journal Article (18 results) (of which Peer Reviewed: 9 results) Presentation (2 results) Book (3 results)

  • [Journal Article] Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium2012

    • Author(s)
      Cote ML, Kiyohara C, et al
    • Journal Title

      Eur J Cancer

      Volume: 48 Issue: 13 Pages: 1957-1968

    • DOI

      10.1016/j.ejca.2012.01.038

    • Related Report
      2012 Final Research Report
  • [Journal Article] Genetic polymorphisms involved in carcinogen metabolism and DNA repair and lung cancer risk in a Japanese population2012

    • Author(s)
      Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y
    • Journal Title

      J Thorac Oncol

      Volume: 7 Issue: 6 Pages: 954-962

    • DOI

      10.1097/jto.0b013e31824de30f

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk: a case-control study in a Japanese population2011

    • Author(s)
      Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y
    • Journal Title

      BMC Cancer

      Volume: 11 Issue: 1 Pages: 459-459

    • DOI

      10.1186/1471-2407-11-459

    • NAID

      120005133102

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alcohol consumption and lung cancer risk among Japanese: a meta-analysis2010

    • Author(s)
      Uehara Y, Kiyohara C
    • Journal Title

      Fukuoka Acta Med

      Volume: 101(5) Pages: 101-8

    • NAID

      120002383161

    • Related Report
      2012 Final Research Report
  • [Journal Article] Lung cancer risk and genetic polymorphisms in DNA repair pathways: a meta-analysis2010

    • Author(s)
      Kiyohara C, Takayama K, Nakanishi Y
    • Journal Title

      J Nucleic Acids

      Volume: 14 Issue: 1 Pages: 701760-701760

    • DOI

      10.4061/2010/701760

    • Related Report
      2012 Final Research Report
  • [Journal Article] Sex differences in lung cancer susceptibility: a review2010

    • Author(s)
      Kiyohara C, Ohno Y
    • Journal Title

      Gend Med

      Volume: 7(5) Issue: 5 Pages: 381-401

    • DOI

      10.1016/j.genm.2010.10.002

    • Related Report
      2012 Final Research Report
  • [Journal Article] Lung cancer susceptibility and hOGG1 polymorphism: A meta-analysis2010

    • Author(s)
      Kiyohara C, Takayama K, Nakanishi Y
    • Journal Title

      Cancers

      Volume: 2 Pages: 1813-1829

    • Related Report
      2012 Final Research Report
  • [Journal Article] Genetic Susceptibility to EnvironmentalCarcinogens group (Agundez JA, Kiyohara C, et al.). Assessment of cumulative evidence for the association between glutathione S-transferase polymorphisms and lung cancer: application of the Venice interim guidelines2010

    • Author(s)
      Langevin SM, Ioannidis JP, Vineis P, Taioli E
    • Journal Title

      Pharmacogenet Genomics

      Volume: 20 Issue: 10 Pages: 586-597

    • DOI

      10.1097/fpc.0b013e32833c3892

    • Related Report
      2012 Final Research Report
  • [Journal Article] Cigarette smoking, TP53 Arg72Pro, TP53BP1 Asp353Glu, and the risk of lung cancer in a Japanese population2010

    • Author(s)
      Kiyohara C, Horiuchi T, Miyake Y, Takayama K, Nakanishi Y
    • Journal Title

      Oncol Rep

      Volume: 23 Pages: 1361-1368

    • Related Report
      2012 Final Research Report
  • [Journal Article] International Lung Cancer Consortium: Coordinated association study of 10 potential lung cancer susceptibility variants2010

    • Author(s)
      Truong T, Kiyohara C, et al
    • Journal Title

      Carcinogenesis

      Volume: 31 Issue: 4 Pages: 625-633

    • DOI

      10.1093/carcin/bgq001

    • Related Report
      2012 Final Research Report
  • [Journal Article] IL1B rs1143634 polymorphism, cigarette smoking, alcohol use, and lung cancer risk in a Japanese population2010

    • Author(s)
      Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y
    • Journal Title

      J Thorac Oncol

      Volume: 5 Issue: 3 Pages: 299-304

    • DOI

      10.1097/jto.0b013e3181c8cae3

    • NAID

      120005227456

    • Related Report
      2012 Final Research Report
  • [Journal Article] Alcohol consumption and lung cancer risk among Japanese : a meta-analysis.2010

    • Author(s)
      Uehara Y, Kiyohara C
    • Journal Title

      Fukuoka Acta Medica

      Volume: 101 Pages: 101-108

    • NAID

      120002383161

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lung cancer susceptibility and hOGG1 polymorphism : A meta-analysis.2010

    • Author(s)
      Kiyohara C, Takayama K, Nakanishi Y
    • Journal Title

      Cancers

      Volume: 2 Pages: 1813-1829

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoking, TP53 Arg72Pro, TP53BP1 Asp353Glu, and the risk of lung cancer in a Japanese population.2010

    • Author(s)
      Kiyohara C, Horiuchi T, Miyake Y, Takayama K, Nakanishi Y
    • Journal Title

      Oncology Report

      Volume: 23 Pages: 1361-1368

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lung cancer risk and genetic polymorphisms in DNA repair pathways : A meta-analysis.2010

    • Author(s)
      Kiyohara C, Takayama K, Nakanishi Y
    • Journal Title

      Journal of Nucleic Acid

      Volume: 2010(電子版のみ) Pages: 17-17

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL1B rs1143634 polymorphism, cigarette smoking, alcohol use, and lung cancer risk in a Japanese population.2010

    • Author(s)
      Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y.
    • Journal Title

      Journal of Thoracic Oncology 5

      Pages: 299-304

    • NAID

      120005227456

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肺がんにおける炎症関連遺伝子の役割2009

    • Author(s)
      徳永一, 清原千香子.
    • Journal Title

      福岡医学雑誌 100

      Pages: 229-234

    • NAID

      120001452098

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms involved in carcinogen metabolism and DNA repair and lung cancer risk in a Japanese population

    • Author(s)
      Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y
    • Journal Title

      J Thorac Oncol

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Influence of genetic polymorphisms of TP53 Arg72Pro and TP53BP1 Asp353Glu and smoking on lung cancer risk2011

    • Author(s)
      Kiyohara C, Horiuchi T, Nakanishi Y
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] A pooled analysis on the associations between involuntary smoking and lung cancer risk by histological types.2010

    • Author(s)
      Lee YA, Kiyohara C, et al.
    • Organizer
      American Society for Preventive Oncology 34th Annual Meeting
    • Place of Presentation
      Bethesda, USA
    • Year and Date
      2010-03-22
    • Related Report
      2009 Annual Research Report
  • [Book] NY2012

    • Author(s)
      Kiyohara C, Washio M. Lung cancer andsmoking habit. Encyclopedia of Cancer, 3rd Edition, Schwab M (ed.)
    • Publisher
      Springer-Verlag
    • Related Report
      2012 Final Research Report
  • [Book] Encyclopedia of Cancer (執筆タイトル Lung cancer and smoking habit)2012

    • Author(s)
      Kiyohara C, et al.
    • Total Pages
      4070
    • Publisher
      Springer-Verlag. NY
    • Related Report
      2012 Annual Research Report
  • [Book] 公衆衛生学(分担執筆喫煙、飲酒93-101頁)2012

    • Author(s)
      清原千香子
    • Total Pages
      220
    • Publisher
      化学同人
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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