| Project/Area Number |
21390195
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OIKAWA Shinji 三重大学, 大学院・医学系研究科, 准教授 (10277006)
OHNISHI Shiho 鈴鹿医療科学大学, 薬学部, 助手 (80511914)
MA Ning 鈴鹿医療科学大学, 保健衛生学部, 教授 (30263015)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Sumiko 鈴鹿医療科学大学, 薬学部, 准教授 (20378657)
TABATA Tsutomu 三重大学, 大学院・医学系研究科, 准教授 (40252358)
KOBAYASHI Yoshinao 三重大学, 大学院・医学系研究科, 講師 (70378298)
HORIKI Noriyuki 三重大学, 医学部・付属病院, 講師
IIJIMA Katsunori 東北大学病院, 消化器内科, 助教 (60375003)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 8-ニトログアニン / 8-oxodG / DNA損傷 / 炎症 / 感染 / 活性窒素種 / バイオマーカー / がん予防 / 発がん機構 / 幹細胞 / 一酸化窒素 / プロテオミクス |
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| Research Abstract |
8-Nitroguanine was formed in Oct3/4-positive stem cells in S. haematobium-associated cystitis and cancer tissues. 8-Nitroguanine and stem cell marker glypican-3 was observed in Barrett's esophagus tissues. In conclusion, inflammation by various facters may increase the number of mutant stem cells, in which nitrative DNA damage occurs, leading to tumor development.
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