Studies for the adverse effects of environmental nanoparticles on sensitive pulmonary diseases
Project/Area Number |
21390197
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hygiene
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Research Institution | Kitasato University (2010-2011) National Institute for Environmental Studies (2009) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SONE Yuka 北里大学, 薬学部, 助教 (60550035)
柳澤 利枝 独立行政法人国立環境研究所, 環現健康研究領域, 主任研究員 (70391167)
|
Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
|
Keywords | 環境保健 |
Research Abstract |
In reality, we inhale suspended DEP and/or nanoparticles in ambient air Nevertheless, assessment of the impact of inhalation/intratracheal exposure to diesel engine-derived nanoparticles, a more realistic exposure, on the lung inflammation model has never been conducted. Furthermore, as far as we know, no study has examined the dose-dependent effects of inhaled nanoparticles on predisposed subjects. The present study investigated the impact of pulmonary exposure to diesel-engine-derived nanoparticles on emphysematous lung injury and allergic airway inflammation and dissolved its underlying mechanisms. In the first experiments, CBNP of 14 nm significantly induced acute lung inflammation in non-elicited subjects, and aggravated PPE-elicited airway neutrophilic inflammation at an early stage, which was concomitant with the enhanced lung expression of proinflammatory cytokines. In the next experiments, high concentration of NR-DE significantly deteriorated OVA-induced eosinophilic airway inflammation. On the other hand, DE gas did not influence PPE-induced pulmonary inflammation with emphysema. In in vitro experiments, NR-DEP significantly enhanced mucin-1 expression on BEAS-2B cells and surface expression of CD86 on mouse-derived splenocytes and dendritic cells.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Carbon black nanoparticles enhance bleomycin-induced lung inflammatory and fibrotic changes in mice2011
Author(s)
Kamata H, Tasaka S, Inoue K, Miyamoto K, Nakano Y, Shinoda H, Kimizuka Y, Fujiwara H, Ishii M, Hasegawa N, Takamiya R, Fujishima S, Takano H, Ishizaka A
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Journal Title
Exp Biol Med
Volume: 236
Pages: 315-324
URL
Related Report
Peer Reviewed
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