Research on the fetal origin of adult disease hypothesis using large scale longitudinal twin-family data

• Project/Area Number: 21390206
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Ishikawa Prefectural Nursing University
• Principal Investigator: OOKI Syuichi 石川県立看護大学, 看護学部, 教授 (00303404)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
• Keywords: 双生児 / 縦断データ / 胎内環境仮説 / 生殖補助医療 / 生活習慣病 / 遺伝疫学 / ライフコース / データベース / 出生体重 / 長期縦断データ

Research Abstract

Fetal Origins of Adult Disease(FOAD) hypothesis was studied using twin sample. Longitudinal twin database from perinatal to adult period was constructed. Next, preliminary genetic epidemiologic analyses were conducted. The influence of assisted reproductive technology and laterality were also analyzed as candidate new marker of perinatal and early life environment. It was suggested that FOAD hypothesis is not necessarily applicable in the same manner as singletons in twins. The reason was not clear whether the problem was based on the weakness of the statistic power or adoption mechanism specific to twins.

Research Products

• [Journal Article] Theoretical Model of the Relationship between Single Embryo Transfer Rate and Multiple Pregnancy Rate in Japan (2012)
  • Author(s): Syuichi Ooki
  • Journal Title: Journal of Pregnancy Volume: (in press)
  • Peer Reviewed
• [Journal Article] ライフコース疫学研究の興隆と展望 (2012)
  • Author(s): 大木秀一, 彦聖美
  • Journal Title: 石川看護雑誌 Volume: 9 Pages: 1-11
  • NAID: 120005615369
  • URL: http://www.ishikawa-nu.ac.jp/kenkyu/pdf/09_01.pdf
  • Peer Reviewed
• [Journal Article] Theoretical Model of the Relationship between Single Embryo TVansfer Rate and Multiple Pregnancy Rate in Japan (2012)
  • Author(s): Syuichi Ooki
  • Journal Title: Journal of Pregnancy Volume: (in press)
  • Peer Reviewed
• [Journal Article] Birth Defects in Singleton versus Multiple ART Births in Japan(2004-2008) (2011)
  • Author(s): Syuichi Ooki
  • Journal Title: Journal of Pregnancy Volume: 2011 Pages: 1-8
  • DOI: 10.1155/2011/285706
  • Peer Reviewed
• [Journal Article] Effect of Maternal Age and Fertility Treatment on the Increase in Multiple Births in Japan: Vital Statistics, 1974-2009 (2011)
  • Author(s): Syuichi Ooki
  • Journal Title: Journal of Epidemiology Volume: 21 Issue: 6 Pages: 507-511
  • DOI: 10.2188/jea.JE20100189
  • NAID: 130001090165
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed
• [Journal Article] Estimation of the Contribution of Assisted and Non-Assisted Reproductive Technology Fertility Treatments to Multiple Births During the Past 30 Years in Japan (2011)
  • Author(s): Syuichi Ooki
  • Journal Title: Twin Research and Human Genetics Volume: 14 Issue: 5 Pages: 476-483
  • DOI: 10.1375/twin.14.5.476
  • Peer Reviewed
• [Journal Article] 双生児家系縦断データに基づくライフコース遺伝疫学研究の展望 (2011)
  • Author(s): 大木秀一
  • Journal Title: 日本衛生雑誌 Volume: 66 Pages: 31-38
  • NAID: 10029363640
  • URL: https://www.jstage.jst.go.jp/article/jjh/66/1/66_1_31/_pdf
  • Peer Reviewed
• [Journal Article] 双生児家系縦断データに基づくライフコース遺伝疫学研究の展望 (2011)
  • Author(s): 大木秀一
  • Journal Title: 日本衛生学雑誌 Volume: 66 Pages: 31-38
  • NAID: 10029363640
  • Peer Reviewed
• [Presentation] 日本における妊娠の種類別に見た多胎出生の過去30年間(1979-2008年)の動向 (2012)
  • Author(s): 大木秀一、彦聖美
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京都
  • Year and Date: 2012-01-27
• [Presentation] 日本における妊娠の種類別に見た多胎出生の過去30年間(1979-2008年)の動向 (2012)
  • Author(s): 大木秀一、彦聖美
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 学術総合センター・一橋記念講堂(東京都)
  • Year and Date: 2012-01-27
• [Presentation] Estimation of the contribution of assisted and nonassisted reproductive technology fertility treatments to multiple births during the last thirty years in Japan (2011)
  • Author(s): Syuichi Ooki
  • Organizer: The 19th IEA World Congress of Epidemiology
  • Place of Presentation: Edinburgh Scotland
• [Presentation] Estimation of the contribution of assisted and non-assisted reproductive technology fertility treatments to multiple births during the last thirty years in Japan : 1977-2008 (2011)
  • Author(s): Syuichi Ooki
  • Organizer: The 19th IEA World Congress of Edidemiology
  • Place of Presentation: Edinburgh Scotland
• [Presentation] 双生児家系縦断データに基づくライフコース遺伝疫学研究 (2010)
  • Author(s): 大木秀一
  • Organizer: 第80回日本衛生学会双生児医学連携研究会
  • Place of Presentation: 仙台市
  • Year and Date: 2010-05-09
• [Presentation] 双生児家系縦断データに基づくライフコース遺伝疫学研究 (2010)
  • Author(s): 大木秀一
  • Organizer: 第80回日本衛生学会 双生児医学連携研究会
  • Place of Presentation: 仙体国際センター(宮城県)
  • Year and Date: 2010-05-09
• [Book] Human Handedness in Twins : An Overview (2012)
  • Author(s): Syuichi Ooki, Dutta T, Mandal MK, Kumar S
  • Publisher: Nova Science Publishers
• [Book] Strategy and Practice of Support for Families with Multiple Births Children : Combination of Evidence-Based Public Health(EBPH) and Community-Based Participatory Research(CBPR) Approach (2012)
  • Author(s): Syuichi Ooki, Kiyomi Hiko, Maddock J
  • Publisher: InTech
• [Book] Strategy and Practice of Support for Families with Multiple Births Children : Combination of Evidence-Based Public Health (EBPH) and Community-Based Participatory Research (CBPR) Aproach.(In : Public Health-Social and Behavioral Health)(Maddock J (ed)) (2012)
  • Author(s): Syuichi Ooki, Kiyomi Hiko(共著)
  • Publisher: InTech
• [Book] Human Handedness in Twins : An Overview.(In : Bias in Human Behavior)(Dutta T, Mandal MK, Kumar S (ed)) (2012)
  • Author(s): Syuichi Ooki(共著)
  • Publisher: Nova Science Publishers(in press)